Circular Manner Research Articles

Differential inflammatory conditioning of the bone marrow by acute myeloid leukemia and its impact on progression

AbstractInflammation promotes solid tumor progression, but how regulatory mechanisms of inflammation may affect leukemia is less well studied. Using annexin A5 (ANXA5), a calcium-binding protein known for apoptosis, which we discovered to be differentially expressed in the bone marrow microenvironment (BMM) of mice with acute myeloid (AML) vs chronic myeloid leukemia, as a model system, we unravel here a circuit in which AML–derived tumor necrosis factor α (TNF-α) dose-dependently reduces ANXA5 in the BMM. This creates an inflammatory BMM via elevated levels of prostaglandin E2 (PGE2). Via binding to its EP4 receptor, PGE2 increases β-catenin and hypoxia-inducible factor 1α signaling in AML cells, thereby accelerating PGE2-sensitive AML. Human trephine biopsies may show lower ANXA5 expression and higher PGE2 expression in AML than other hematologic malignancies. Furthermore, syngeneic and xenogeneic transplantation models suggest a survival benefit after treatment with the inhibitor of prostaglandin-endoperoxide synthase 2 (cyclooxygenase 2 [COX2]), celecoxib, plus cytarabine in those AML types highly sensitive to PGE2 compared with cytarabine alone. Taken together, TNF-α/ANXA5/NF-κB/COX2/PGE2–mediated inflammation influences AML course in a highly differential and circular manner, and patients with AML with “inflammatory AML” may benefit from antiphlogistic agents as adjunct therapy.

Cyclic quantum teleportation of two-qubit entangled states by using six-qubit cluster state and six-qubit entangled state

Cyclic quantum teleportation schemes requires at least the existence of three collaborators acting all as senders and receivers of quantum information, each one of them has an information to be transmitted to the next neighbour in a circular manner. Here, new cyclic quantum teleportation scheme is proposed for perfectly transmitting cyclically three arbitrary unknown two-qubit states (α\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\alpha $$\\end{document}, β\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\beta $$\\end{document} and γ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\gamma $$\\end{document}) among the three collaborators. In this scheme, Alice can send to Bob the quantum information contained in her two-qubit state α\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\alpha $$\\end{document} and receive from Charlie the quantum information contained in the two-qubit state in his possession γ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\gamma $$\\end{document} and similarly, Bob can transmit to Charlie the quantum information contained in his two-qubit state β\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\beta $$\\end{document} through a quantum channel of twelve-qubit state consisting of a six-qubit cluster state and a six-qubit entangled state by sequentially and cyclically performing Bell state measurements. Subsequently, each one of the three participants can afterwards retrieve his own desired two-qubit state using classical channel and by performing appropriate unitary Pauli operators and we have shown that our proposed scheme performs efficiently.

Biologia de nidificação de Euglossa cordata (Apidae: Euglossini) em áreas abertas no Extremo Sul Baiano

The genus Euglossa comprises a group of approximately 110 cataloged bee species found throughout the Neotropical region. Among these species, Euglossa cordata (Linnaeus, 1758) has a wide distribution in different environments. This research aimed to analyze aspects of the nesting biology of E. cordata in open areas near Atlantic Forest fragments in the Extreme South of Bahia, Brazil. Collections were carried out using PET bottle traps, a methodology commonly employed for capturing Meliponini but adapted for the first time in this study, presenting a low cost and good applicability for studies on Euglossa bees. Ten traps were randomly distributed in open environments at the Federal Institute of Bahia. Three nests of E. cordata were found, with a total of thirteen brood cells and six female emergences in traps 2 and 3. In all nests, the cells were constructed in a circular manner and arranged close to each other. The cells were built with resin and had a scalene trapezoid shape with variations in diameter and length. Studies on bees of the Euglossini tribe, popularly known as orchid bees, often focus on males collected using odor baits. Conversely, studies on females and nesting biology are scarce. Thus, methodologies that facilitate the capture of females and Euglossini nests are extremely relevant for enhancing our understanding of the group.

A renewably sourced, circular photopolymer resin for additive manufacturing

The additive manufacturing of photopolymer resins by means of vat photopolymerization enables the rapid fabrication of bespoke 3D-printed parts. Advances in methodology have continually improved resolution and manufacturing speed, yet both the process design and resin technology have remained largely consistent since its inception in the 1980s1. Liquid resin formulations, which are composed of reactive monomers and/or oligomers containing (meth)acrylates and epoxides, rapidly photopolymerize to create crosslinked polymer networks on exposure to a light stimulus in the presence of a photoinitiator2. These resin components are mostly obtained from petroleum feedstocks, although recent progress has been made through the derivatization of renewable biomass3–6 and the introduction of hydrolytically degradable bonds7–9. However, the resulting materials are still akin to conventional crosslinked rubbers and thermosets, thus limiting the recyclability of printed parts. At present, no existing photopolymer resin can be depolymerized and directly re-used in a circular, closed-loop pathway. Here we describe a photopolymer resin platform derived entirely from renewable lipoates that can be 3D-printed into high-resolution parts, efficiently deconstructed and subsequently reprinted in a circular manner. Previous inefficiencies with methods using internal dynamic covalent bonds10–17 to recycle and reprint 3D-printed photopolymers are resolved by exchanging conventional (meth)acrylates for dynamic cyclic disulfide species in lipoates. The lipoate resin platform is highly modular, whereby the composition and network architecture can be tuned to access printed materials with varied thermal and mechanical properties that are comparable to several commercial acrylic resins.

Circularity of Polymers Used in Hospitals: Current Status, Challenges, and Future Solutions

AbstractPolymers are applied extensively in the healthcare sector and enable a variety of different applications. In addition to packaging and personal protective equipment, a large number of medical devices are also coated with or consist of polymers. Today's medicine is therefore inconceivable without these materials. However, the huge challenge is to design these polymers more sustainable and to find new possibilities for the future of medicine with polymers. This study therefore highlights potential ways, in how polymers applied in the healthcare sector and in particular in hospitals can be utilized in a circular manner, but also indicates what risks and challenges this entails.

Challenges in Achieving Coherence and Cohesion: A Discourse Analysis of Chinese EFL Students’ Essays

This paper aims to highlight the prevalent challenges faced by Hong Kong Chinese students in utilizing connectives and ensuring coherence in their English academic writing. Research indicates that constructing fluent, effective, and cohesive English written texts that maintain logical flow poses a significant challenge for Chinese learners studying English as a foreign language (EFL). This difficulty is likely attributed to the substantial cultural differences between the English and Chinese languages, regardless of the learners’ grasp of English grammar and vocabulary usage. In order to raise awareness among EFL teachers regarding the struggles Chinese students encounter in mastering connectives and cohesion in English writing, this qualitative study analyses five sample English term papers written by Hong Kong university students majoring in English in 2023. The findings reveal that the Hong Kong EFL participants tend to present their arguments in an indirect and circular manner within their English essay assignments. Additionally, due to cultural norms and politeness, the true intent of their writing is often withheld, and the thesis statement is implicitly inferred towards the end of the essay rather than being explicitly stated at the beginning in the introduction. Furthermore, a focus group interview with the student participants conducted after the written analysis demonstrated that their English academic essays reflect the influence of Chinese social interaction norms on rhetorical patterns. The relevance of this study lies in its potential to inform EFL instruction, enabling educators to better support Hong Kong Chinese students in navigating the complexities of English academic writing and to adapt pedagogical approaches that bridge cultural and linguistic gaps.

중년 상담자의 박사과정 학업경험에 대한 자전적 내러티브 탐구

Objectives This study was conducted with the purpose of understanding the doctoral academic experience of middle-aged counselors. Specifically, we sought to explore the motivation for entering the doctoral program, the academic experiences and dilemmas of the doctoral program, and the experience of life change through study from the perspective of a student currently pursuing his or her studies.
 Methods The experiences of five research participants were studied using the autobiographical narrative inquiry method of Clandinin & Connelly (2000/2007). The research process was conducted in five stages: being in the field, moving from the field to field text, composing field text, from field text to research text, and writing research text. Based on the story reported by one person as a research participant, four other researchers synthesized the meaning and repeated this process in a circular manner to present the research results.
 Results The meaning of the experiences of ‘middle-aged’, ‘counselor’, and ‘doctoral student’ to the research participants is as follows. First, they overcame the ‘midlife’ crisis, demonstrated flexibility and adaptability and experienced a life transition. Second, as a middle-aged ‘counselor’, I faced economic problems such as my family's livelihood, and experienced my family's support and cooperation in the process of solving the problem. Third, as counselors, we seek to develop through academic experience in the doctoral program and discover our calling within our own lives.
 Conclusions The conclusions drawn from the three results are as follows. Research participants who are middle-aged, counselors, and doctoral students have lived lives of growth, are maintaining those lives, and are preparing for their future lives. In other words, it was confirmed that the researchers and research participants of this study formed a research group, maintained a doctoral program, sought self-growth through self-healing through mutual assistance, and grew together by repeating this process.

PENERAPAN AKUPRESUR PERIKARDIUM 6 TERHADAP MUAL MUNTAH PADA IBU HAMIL TRIMESTER I

Based to WHO, it reaches 12.5% ​​of all pregnancies in the world. Nausea and vomiting causes a decrease in appetite and changes in electrolyte balance which also results in changes in the body's metabolism. Pericardium 6 acupressure point is considered useful for reducing complaints of nausea and vomiting. The aim of the research is to provide midwifery care for pregnant women in a comprehensive and sustainable manner, with management of midwifery care in accordance with midwifery service standards. The midwifery care that is applied is the application of pericardium 6 point acupressure for nausea and vomiting of pregnant women. The type of research used in the preparation of practice reports is descriptive research using the case study method. The research was conducted at the Tanjung Balai Karimun Health Center in March 2023. The subjects were pregnant women by applying pericardial point 6 acupressure. P6 acupressure was carried out by 3 fingers under the wrist in a circular manner, carried out for 7 minutes every morning. After reviewing the case and evaluating the case, there is no gap between theory and practice in the field. This is consistent with the theory that pericardial acupressure can reduce emesis gravidarum.

MSLR: A Self-supervised Representation Learning Method for Tabular Data Based on Multi-scale Ladder Reconstruction

Tabular data are widely used for prediction tasks, but they often suffer from the curse of dimensionality and noise, leading to degradation in the performance and robustness of prediction models. Self-supervised representation learning has emerged as a promising technique to overcome these challenges, but most existing methods are applicable to images, text, and others rather than tabular data. In this study, we propose a novel self-supervised representation learning method for tabular data based on multi-scale ladder reconstruction (MSLR). The method effectively learns low-dimensional and noise-resistant representations, thereby improving the prediction performance across various tabular datasets. The idea of MSLR is to employ a binning method to generate a sequence of fuzzy data with different noise scales, followed by training a neural network to recover the raw data from the most corrupted data in a circular manner. This process allows MSLR to learn fine-grained changes caused by noise while maintaining consistency and similarity at a coarse granularity. The proposed method is evaluated on five real-world datasets, namely, MIMIC-IV, Thyroid, Heart, Pima, and Adult, and compared with several baselines. The experimental results of downstream prediction tasks show that MSLR is robust to noisy data and performs better than other existing baseline methods.

영아의 생태친화적 오감놀이에 대한 의미 탐색

This study is to develop alternative eco-friendly programs for daycare centers that do not have the conditions to practice eco-friendly childcare, such as daycare facilities and natural environments applying eco-friendly five sense play using an ethnography study. For this study, eco-friendly five-sensory play was conducted for infants aged 0 to 2 years old at a home-based daycare center, and participant observation was conducted. The development of eco-friendly five senses play was carried out in the first stage of becoming familiar with the subject matter, the second stage of leading integrated play, and the third stage of connection and expansion play, and was developed in a circular manner. The research results were derived from the meaning that infants' eco-friendly five-sensory play has on the infants and teachers in the daily routine of the daycare center. The research results are as follows. First, the meaning of eco-friendly five-sensory play for infants was summarized as imitating the play of teachers and peers, opportunities for more interactions, connecting previous and current experiences, expanding the concept of specific objects, and artistic experience. Second, the meaning of eco-friendly play to teachers is learning together with infants, becoming a playmate for infants, being a person who shares infants' experiences, providing learning opportunities through recognition of experiences, and opportunities for natural integration of the contents of the play-centered Standard Child Care Curriculum. The significance of the study is daycare centers in residential areas and small home daycare centers can provide opportunities for interaction and play that fully utilizes the five senses by providing natural objects in the classroom.

ARCHITECTURAL AND ECONOMIC APPROACH TO LOW-RISE HOUSING TO ACHIEVE ECONOMIC STABILITY AND SUSTAINABLE DEVELOPMENT

Sustainable construction, in the context of sustainable development at economic, social and environmental levels, is a proven strategy that responds to the challenges of the modern construction industry. It is an approach that focuses on balanced development, taking into account the needs of the present without compromising the needs of future generations. At the economic level, sustainable construction contributes to the creation of efficient and energy-saving buildings, which helps to reduce heating and cooling costs. It also reduces the impact of construction on financial resources through the use of more cost-effective materials and technologies. This research aims at identifying theoretical concepts and practical ways of economic, environmental and construction development of architectural and economic concept of low-rise buildings for achieving economic stability and sustainable development of the country. In order to create the concept of sustainable development, it is recommended to base it on the circular economy model. This model provides for the reuse of materials. The unacceptability of using materials that cannot be reused is the main principle of this model. This means that, without producing waste or polluting the environment, resources should be used efficiently and in a circular manner. It should be noted that the cost of building houses and apartments in this type of development needs to be identified in detail when analysing the cost of low-rise development. The cost of developing infrastructure such as engineering and transport, and the cost of maintaining engineering networks and transport communications must also be considered. In general, the feasibility study also includes the cost of land and legal regulation. According to the authors, maximum economic efficiency can be achieved by concentrating on developing two to four-storeyed buildings. In low-rise residential buildings, there are two ways to save energy. Firstly, by reducing energy consumption from external sources through the installation of autonomous or local technical systems. Secondly, by using energy-efficient buildings that use alternative energy sources, energy savings can be achieved. One of the key concepts of modern housing is considered to be the active house. This means that modern economic concepts need to be applied. For example, the principle of “zero waste” and the model of a circular economy based on this principle require that the generation of waste be reduced or avoided as much as possible. In the case of old buildings, the principle of zero waste means that these buildings should be easy to dismantle without generating a significant amount of waste. One of the possible uses of these materials is to create new building materials or to produce other goods. The conclusions show that economic resilience, sustainable development and improved quality of life in the country can be achieved by using the architectural and economic concept of low-rise buildings. This has great potential to create a sustainable and prosperous society in the future, but requires an integrated approach and collaboration between different stakeholders.

MEREDUKSI BAYANGAN PADA OBYEK FOTOGRAFI MELALUI REKAYASA PENCAHAYAAN KOMPAK

This research focuses on lighting techniques that reduce shadows resulting from lighting effects. This is done by arranging the lighting in a circular manner outside of the camera lens, so that the angle of the light hitting the object results in the shadow of the lamp is invisible through the lens as it is hidden behind the object. The lighting engineering is made to resemble a ringflash using an L.E.D light source available at any electrical store, making it easier for anyone who wants to make one. The advantage of this lighting engineering is the significant cost savings because ring flashes available in the photography market with certain brands are worth hundreds of millions of rupiah. This lighting engineering is made larger with a diameter of 50 centimetres and is flexible so that it can be used dynamically for fashion, product and other shoots. The achievement of this research is a compact lighting prototype, this research also presents a guide to making lighting engineering so that it can be used by photo studio creative industry players in improvingshooting results

A C-Lean framework for deploying Circular Economy in manufacturing SMEs

The adoption of Circular Economy (CE) is challenging, especially for manufacturing SMEs. Without SMEs, CE’s full spectrum cannot be realised, since they contribute to around 50% of the national GDP, globally. This research proposes a novel framework (C-Lean) to facilitate the implementation of CE in manufacturing SMEs by combining the principles of CE and Lean, as both foci on waste elimination and value creation/preservation. The framework utilises Lean tools/methods mingled with CE principles to achieve circularity, efficiency and effectiveness in manufacturing SMEs. The proposed framework was conceptually developed based on an extensive review of the existing scholarly literature and verified by a panel of field experts, through a Delphi study, from academia and industry. The model was further validated to assess its practical relevance through a case study approach in an SME manufacturing company. The results derived from the verification and validation of the proposed C-Lean framework suggest that CE can be effectively and efficiently adopted through its amalgamation with Lean. The C-Lean framework provides a systematic approach for manufacturing SMEs to simultaneously adopt CE and Lean practices in their existing operations. The proposed C-Lean framework can support and guide managers in the concurrent deployment of CE and Lean for their organisations to enhance both their operational and sustainability performance. This research provides a novel framework that converges CE and Lean as no such framework exists to date. C-Lean is attractive for manufacturing SMEs due to its dual nature of achieving operations excellence in a sustainable circular manner.

Re-enacting the Trauma: Ritualising Turbo-Folk

Turbo-folk, a popular music genre originating in 1990s’ Serbia, still enjoys an immense popularity among Viennese residents with origins in the former Yugoslavia. The pilot study outlined here attempted to determine why a 25-year-old repertoire of songs is of such central importance to many listeners in the Austrian capital. As the research showed, informants view the interaction with turbo-folk as an experience outside their everyday lives requiring a particular time and space in order to unfold. To channel and express the strong emotions elicited by turbo-folk, actors employ a variety of strategies, one of which is singing along to the music. This practice is interpreted here as a ritual aiming to process the collective trauma constituted by a double loss of home. This ritual results in the construction of a collective “Yugo” identity that at the same time enables and ensues the process in a circular manner.

When Is a Belief Formed in an Epistemically Circular Way?

Abstract While there has been a great deal of discussion of whether and when beliefs formed in an epistemically circular manner can be justified, there has been almost no discussion of exactly which beliefs are formed in a circular manner. These discussions have tended to focus on an extremely limited number of intuitively-identified paradigm examples concerning attempts to establish the reliability of a method of belief formation. Here, I seek to answer a prior analytical question about the nature of epistemic circularity by developing a criterion which sorts epistemically circular beliefs from non-epistemically circular beliefs.

Computational Analysis of Some More Rectangular Tessellations of Kekulenes and Their Molecular Characterizations.

Cycloarene molecules are benzene-ring-based polycyclic aromatic hydrocarbons that have been fused in a circular manner and are surrounded by carbon-hydrogen bonds that point inward. Due to their magnetic, geometric, and electronic characteristics and superaromaticity, these polycyclic aromatics have received attention in a number of studies. The kekulene molecule is a cyclically organized benzene ring in the shape of a doughnut and is the very first example of such a conjugated macrocyclic compound. Due to its structural characteristics and molecular characterizations, it serves as a great model for theoretical research involving the investigation of π electron conjugation circuits. Therefore, in order to unravel their novel electrical and molecular characteristics and foresee potential applications, the characterization of such components is crucial. In our current research, we describe two unique series of enormous polycyclic molecules made from the extensively studied base kekulene molecule, utilizing the essential graph-theoretical tools to identify their structural characterization via topological quantities. Rectangular kekulene Type-I and rectangular kekulene Type-II structures were obtained from base kekulene molecules arranged in a rectangular fashion. We also employ two subcases for each Type and, for all of these, we derived ten topological indices. We can investigate the physiochemical characteristics of rectangular kekulenes using these topological indices.

Pattern of Utilization of Public Open Space in the Gorontalo Simpang Lima Roundabout Area

Gorontalo City is a developing city, has several public spaces to support all community activities, such as city parks, street corners, markets, terminals and buildings. As one of the efforts to provide public open space, the Simpang Lima Roundabout Area was built which has a positive impact on the development of regional and surrounding activities, the existence of this area is experiencing congestion caused by several factors, such as traffic density, the emergence of formal activities. The purpose of this study was to determine the pattern of utilization of public open space at the Simpang Lima Roundabout. This study uses a positivistic paradigm with a descriptive qualitative approach supported by survey methods. The results showed that this pattern of open space utilization occurred in a circular or radial manner and linearly followed the circulation path, the use of open space at the intersection of five detected was shopping, meeting and chatting. Keywords: Public Open Space; Simpang Lima; Utilization Pattern

The Role of Biogas Production in Circular Economy Approach from the Perspective of Locality

The circular economy is an economic concept opposite to the current linear system. One of its main principles is to seek to minimise waste by reusing seemingly useless raw materials. Biogas plants are places where energy can be recovered from waste. In order to boost the environmental benefits of this concept, it is important to rely on local systems (including supply chains). Therefore, the aim of this study was to examine whether biogas plants in Poland operate in a circular manner from the perspective of locality. The analysis was based on questionnaire surveys concerning the nature of the facilities’ operations, divided into biogas plants located at sewage treatment plants, biogas plants based on municipal waste and agricultural biogas plants. On the basis of the data obtained, statistical and spatial analyses were carried out to verify the installed capacity of the facilities, the distance from which they obtain their substrate and the use of the biogas produced. The results of the study confirm that the functioning of biogas plants located in Poland is, in most cases, of a local character, fitting into the objectives of a circular economy. Biogas plants that are characterised by the lowest transportation needs are biogas plants located next to sewage treatment plants.

Parent Communication Models in Character Education Teenagers in Manado City

The results showed that parents gave messages (decoding) to adolescents related to character education: religious, hard work, creative, independent, democratic, curiosity, love of the motherland, mutual respect, communicative, peace-loving, honest , diligent, care for the environment, responsible and social spirit. Parents convey character education to teenagers when they are relaxed, when children are happy, when there is togetherness in the family room, when watching TV or movies, and when playing sports together. Decoding and interpreting adolescents' responses to character education from parents, namely: accepting and rejecting on the grounds that parents consider them like small children, messages that are conveyed are too repetitive, dictate, and are conveyed in front of many people. Communication barriers in parents: style of speaking, time and place. Barriers to communication in adolescents: Mood / Situation, and do not want to act under threat. The Model of Parental Communication in the Character Education of Adolescents in Manado City is a Circular Communication Model, in which the process of parental communication in the character education of adolescents takes place continuously in a circular manner. Each communicator, namely parents and adolescents, will be involved in the process of encoding the message, interpreting the message, as well as receiving and decoding the message in turn.

The results of designing a new prototype device and algorithm in closed method intraperitoneal hyperthermia model in rats.

There is currently no standard medical device and method available for hyperthermic intraperitoneal therapy studies in rats. In this study, we present our designed device and algorithm that operates based on our own protocol for hyperthermic intraperitoneal treatment in rats. The aim was to demonstrate the effectiveness of the designed device, algorithm, and hyperthermia protocol by showing that the device can achieve the desired temperature inside the rat's abdomen, does not cause rat loss due to complications, operates autonomously, and provides warnings to the operator in case of emergencies. A closed method for intraperitoneal hyperthermia protocol was established for 6 female 8-week-old (280-310 g) albino Wistar rats. Fluid inlet and outlet tubes and a temperature probe were inserted through a 1 cm vertical incision between the xiphoid and bladder in the rat's abdomen, and the skin was sutured in a circular manner. A protocol for intraperitoneal hyperthermic treat-ment was established using a saline solution at a flow rate of 100 mL/min for 60 min, maintaining a temperature of 41°C±0.5 inside the rat's abdomen. During the study, a temperature of 41°C±0.5 was successfully achieved in the abdomen of all rats at a flow rate of 100 mL/min±5 for 60 min. Due to three rats reaching a rectal temperature above 38.5°C during the hyperthermia protocol, external cooling was applied to the rat's tail base using ice. There were no losses until the postoperative 72nd h, and the study was successfully completed. Our designed device and algorithm, which prioritize animal welfare, operate rapidly, safely, and with high accuracy sensitivity, have been successful in hyperthermic intraperitoneal treatment studies in rats. We believe that they can be used as a stan-dard method and approach in hyperthermic intraperitoneal studies in rats.