Weirs are one of the most common hydraulic structures used to regulate the upstream approach flow depth and measure the flow discharge. The hydrofoil weirs are a type of short-crested weirs that are designed based on the airfoil theory. These weirs have some merits compared to other types, such as a higher discharge coefficient, more stability, better submergence limiting condition, and lower fluctuations of the pressure and the free-surface profile. In the present study, experimental models of hydrofoil weirs with different relative eccentricities, cambers, angles of attack, and upstream slope angles are applied to investigate their hydraulic characteristics under free and submerged flow conditions. The longitudinal profiles of static pressure over different hydrofoil weirs are compared to circular-crested and ogee weirs. The results indicate that the maximum bed negative pressure belongs to the circular-crested weir, and the lowest bed pressure over the hydrofoil and ogee weirs are approximately the same. Applying a hydrofoil weir with an appropriate curvature and angle of attack instead of a circular-crested weir not only increases the structural weir height as well as the upstream water depth but also results in the lowest values of bed negative pressure, thereby reduces the potential of cavitation over the weir body, being safer hydraulic structures. The results also show that the discharge coefficient of hydrofoil weirs is greater than that of the broad- and short-crested weirs for the upstream approach flow depth relative to the weir crest to weir length h1/L > 0.12 and is greater than that of the ogee weirs for 0.35 < h1/L < 0.45. Furthermore, the derived relationships for the discharge coefficient, threshold submergence, and the discharge reduction factor due to submergence accurately predict the hydraulic characteristics of hydrofoil weirs compared to the available developed empirical relationships for these weirs and can be used efficiently for design purposes.