The present study endeavors to design and develop a self-nanoemulsifying drug delivery system to improve the solubility and dermatological absorption of curcumin and naringin. CUR and NRG-loaded SNEDDS formulations were developed using aqueous phase titration. Phase diagrams were used to pinpoint the SNEDDS zones. Tween 80 and Labrasol (surfactants), Transcutol (co-surfactant), and cinnamon oil were chosen from a large pool of surfactants, co-surfactants, and oils based on their solubility and greatest nano-emulsion region. FTIR, zeta sizer and atomic force microscopy were used to characterize the optimized formulations and tested for dilution and thermodynamic stability. The optimized CUR-NRG-SNEDDS demonstrated the following characteristics: PDI (0.412 ± 0.03), % transmittance (97%), particle size (212.5 ± 05 nm), Zeta potential (-25.7 ± 1.80 mV) and having a smooth and spherical droplets' shape as shown by AFM. The ability of their combined formulation to cure wounds was tested in comparison to pure curcumin suspension, empty SNEDDS and standard fusidic acid. Upon topical administration, the optimized CUR-NRG-SNEDDS demonstrated a significant wound healing activity in comparison with pure curcumin suspension, empty SNEDDS and standard fusidic acid. Based upon this result, we assume that skin penetration was increased by using optimized CUR-NRG-SNEDDS with enhanced solubility.