<i>Chrysaora fuscescens</i> is a kind of ornamental jellyfish with high economic value, and become to be a very popular giant medusa in aquarium. In the process of captive breeding, it was found that there are a significant number of deformed individuals In this study, we expected to select more suitable feeding combinations by comparing the differences in nutrient composition, we chose two groups of Chrysaora fuscescens domesticated in aquarium, one is the deformity group, and the other is normal group. We measured the conventional nutrients (water content, protein content, fat content, ash content), fatty acid composition and amino acid composition of the two groups. The results showed that the water content, ash content and protein content of deformity group were higher than those of normal group (P < 0.05). The contents of unsaturated fatty acids (C16:1n7, C18:1T, C18:3n3 and C20:4n6) in the deformity group were significantly lower than those in the normal group (P < 0.05). Sixteen kinds of amino acids were detected in both groups, among which the contents of Gly and Glu were the highest. The contents of Phe, Ala, Met and other amino acids in malformed group were lower than those in normal group (P < 0.05). The results showed that there were some differences in nutrient composition between normal and deformity group. In order to achieve the daily requirements, the supplementation of unsaturated fatty acids and the fortification of Glu should be increased in the selection of bait in the future.