LAD Chronic Total Occlusion Research Articles

Abstract 12780: Impact of Target Vessel on the Procedural Techniques and Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention

Introduction: There is limited information on the impact of the target vessel on the procedural techniques and outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). Methods: We analyzed the baseline clinical and angiographic characteristics and procedural outcomes of 11,580 CTO PCIs performed between 2012 and 2022 at 44 centers. Results: The most common CTO target vessel was the right coronary artery (RCA) (53.1%) followed by the left anterior descending artery (LAD) (26.0%) and the left circumflex artery (LCX) (19.8%). RCA CTO lesions were longer and more complex with higher J-CTO score compared with LAD or LCX CTO lesions. Technical success was higher among LAD (88.8%) lesions when compared with RCA (85.7%) or LCX (85.8%) lesions (p<0.001). The incidence of major adverse cardiovascular events (MACE) was overall 1.9% (n=220) and was similar among target vessels (p=0.916). There was a tendency towards more frequent utilization of the retrograde approach for more proximal occlusions in all three target vessels. When compared with all other RCA lesions combined, distal RCA lesions had higher technical success (87.7% vs. 85.3%; p=0.048). Technical success was similar between various locations of LAD CTOs (p=0.704). First/second/third obtuse marginal branch had lower technical success when compared with all other LCX lesion locations (82.7% vs. 86.8%; p=0.014). There was no association between MACE and CTO location in all three target vessels. Conclusions: LAD CTO PCIs had higher technical and procedural success rates among target vessels. The incidence of MACE was similar among target vessels, and also among various locations within the target vessel.

Abstract 18560: External Calcium Modification Technique to Recanalize a Balloon Uncrossable Chronic Coronary Total Occlusion

Introduction: Despite improvements in equipment and techniques, uncrossable chronic total occlusion (CTO) coronary lesions remain challenging.Case: A 66-year-old male with typical angina and a history of failed CTO PCI was referred to our CTO tertiary center as he did not wish to undergo coronary artery bypass grafting. Transthoracic echocardiography revealed an ejection fraction of 45%, and cardiac MRI demonstrated viability in the LAD region. Coronary angiography revealed a long LAD CTO over 20 mm with heavy calcification (Figure 1a). The J-CTO score was calculated to be 4. The cap of the CTO was semi-ambiguous. The wire was advanced through the highly calcified lesion with the support of a microcatheter but the microcatheter and low-profile balloons were unable to be advanced despite backup with 7 French femoral access and an EBU catheter in place (Figure 1b) Upon failure on using Leopard crawl technique and grenadoplasty and with unfavorable side branch anatomy for STAR technique, cracking the calcification with a balloon advanced over a subintimal hydrophilic wire was considered. A fielder XT-A guidewire was advanced around the CTO lesion in the subintimal area (Figure 1c). A 2x12 mm balloon was inflated at 8 atm over the wire situated in the subintimal area in order the crack the calcification from outside. After extraluminal plaque modification, the wire and the balloon were withdrawn. A microcatheter was then able to be advanced with the support of an anchor balloon over the original true lumen wire (Figure 1d). Then the procedure was successfully completed with balloon dilatation and stent implantation (Figure 1e-f). Conclusion: External Calcium Modification technique which consists of plaque modification using a balloon in subintimal space (over an intentionally directed wire in subintima and around the calcium) and cracking the calcium from the outer vessel structure can be used as a last resort to overcome balloon uncrossable CTO lesions.

Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention of the Left Anterior Descending Artery

The left anterior descending artery (LAD) subtends a large myocardial territory. The outcomes of LAD chronic total occlusion (CTO) percutaneous coronary intervention (PCI) have received limited study. We performed a retrospective analysis of all patients who underwent LAD CTO PCI at a high-volume single center. Outcomes included in-hospital and long-term major adverse cardiovascular events (MACEs) and changes in left ventricular ejection fraction (LVEF). We performed a subgroup analysis of patients with ischemic cardiomyopathy, defined as an LVEF of 40% or less. From December 2014 to February 2021, 237 patients underwent LAD CTO PCI. The technical success rate was 97.4%, and the in-hospital MACE rate was 5.4%, A landmark analysis after hospital discharge showed an overall survival of 92% and 85% MACE-free survival at 2years. There was no difference in overall survival or MACE-free survival between those who had ischemic cardiomyopathy versus those who did not. In patients with ischemic cardiomyopathy, LAD CTO PCI was associated with significant improvement in LVEF (10.9% at 9months), which was further pronounced when these patients had a proximal LAD CTO and were on optimal medical therapy (14% at 6months). In a single high-volume center, LAD CTO PCI was associated with 92% overall survival at 2years, with no difference in survival between patients with or without ischemic cardiomyopathy. LAD CTO PCI was associated with an absolute 10% increase in LVEF at 9months in patients with ischemic cardiomyopathy.

Impact of target vessel on the procedural techniques and outcomes of chronic total occlusion percutaneous coronary intervention.

There is limited information on the impact of the target vessel on the procedural techniques and outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). We analyzed the baseline clinical and angiographic characteristics and procedural outcomes of 11,580 CTO PCIs performed between 2012 and 2022 at 44 centers. The most common CTO target vessel was the right coronary artery (RCA) (53.1%) followed by the left anterior descending artery (LAD) (26.0%) and the left circumflex artery (LCX) (19.8%). RCA CTOs were longer and more complex, with a higher Japanese CTO score compared with LAD or LCX CTOs. Technical success was higher among LAD (88.8%) lesions when compared with RCA (85.7%) or LCX (85.8%) lesions (P less than .001). The incidence of major adverse cardiovascular events (MACE) was overall 1.9% (n = 220) and was similar among target vessels (P=.916). There was a tendency toward more frequent utilization of the retrograde approach for more proximal occlusions in all 3 target vessels. When compared with all other RCA lesions combined, distal RCA lesions had higher technical success (87.7% vs 85.3%; P=.048). Technical success was similar between various locations of LAD CTOs (P=.704). First/second/third obtuse marginal branch had lower technical success when compared with all other LCX lesion locations (82.7% vs 86.8%; P=.014). There was no association between MACE and CTO location in all 3 target vessels. LAD CTO PCIs had higher technical and procedural success rates among target vessels. The incidence of MACE was similar among target vessels and among various locations within the target vessel.

Abstract 14701: Angiographic and Prognostic Difference of Acute Myocardial Infarction Patients With and Without Out of Hospital Cardiac Arrest Stratified by Killip Classification

Backgrounds: Although the mortality rates for AMI have declined, the mortality rate for AMI with out-of-hospital cardiac arrest (OHCA) remains high. It has been supposed that CTO (chronic total occlusion) in non-infarct related artery is associated with OHCA patients. However, the detailed angiographic and prognostic comparison between OHCA patients and non-OHCA patients stratified by Killip classification has not been well evaluated. Methods: Among 5662 AMI patients (5420 non-OHCA patients and 242 OHCA patient) who underwent emergency coronary angiography between 2013 and 2020 were enrolled from Mie ACS registry. Difference of culprit lesion and non-infarct related CTO lesion were analyzed between with and without OHCA. They were further stratified using Killip classification. Results: In-hospital mortality for AMI patients with OHCA was 31.4%, significantly higher than the 5.5% for AMI patients with non-OHCA (p<0.001), and mortality rates tended to be increased with increasing Killip class in each group(P<0.001). AMI patients with OHCA also had a significantly higher frequency of culprit artery with LMT and LAD and a higher frequency of CTO lesion in non-infarct related artery compared to the AMI patients with non-OHCA.(See Table) Multivariate analysis revealed that LAD CTO in non-infarct related artery(Odds ratio 2.3) culprit artery of LMT and LAD (Odds ratio 3.2 and 1.6), lower BMI(Odds ratio 0.96), younger age(Odds ratio 0.98) and male gender (Odds ratio 1.7)was significantly associated with OHCA(P<0.05, respectively). However, non-LAD CTO lesion in non-infarct related artery was not associated with OHCA Conclusions: Patients with OHCA had a higher incidence of culprit artery with LMT and LAD, and non-infarct-related LAD CTO lesion, suggesting that extensive myocardial ischemia with LAD lesion was strongly associated with OHCA.

Ischemic Burden Assessment Using Single Photon Emission Computed Tomography in Single Vessel Chronic Total Occlusion of Coronary Artery.

Studies evaluating the nature of ischemic burden of chronic total occlusion (CTO) vessels are still lacking. A total of 165 patients with single vessel CTO >2.5 mm in an epicardial coronary artery who underwent single photon emission computed tomography (SPECT) were enrolled in the study. Ischemic burden was calculated with the use of semi-quantitative SPECT analysis, and was defined as the summed difference score (SDS) divided by the maximal limit of the score (=SDS/68). The mean age of the participants was 59.5 years and the CTO of the left anterior descending coronary artery (LAD), left circumplex coronary artery (LCX), and right coronary artery (RCA) accounted for 93 (56.4%), 18 (10.9%), and 54 (32.7%) patients, respectively. The median ischemic burden of the total population was 8.8%, and it was highest in the LAD CTO (10.3%) compared with the LCX (5.9%) and RCA CTO (5.9%, p<0.001). High-ischemic burden (ischemic burden >10%) was observed in 66 patients (40.0%), and in 47 patients (50.5%) of the LAD CTO. Ischemic burden was different according to the CTO location only in LAD CTO. The statistically significant predictors for high-ischemic burden were hypertension, baseline ejection fraction >45%, LAD CTO, proximal CTO location, and de novo CTO. Japanese-CTO score and Rentrop scale collateral grade were not associated with high-ischemic burden. Only 40% of patients with single vessel CTO had ischemic burden >10%. For CTO vessels, measurement of ischemic burden using SPECT prior to revascularization may be helpful in identifying beneficial subjects.

Krónikus teljes koronáriaokklúzió transthoracalis echokardiográfiás diagnózisa

We report a case of a 59 years old male patient who reported chronic effort chest pain. Transthoracic Doppler echocardiography (TTDE) presented normal left ventricular systolic function with retrograde coronary artery blood flow in the distal and middle part of the left anterior descending artery (LAD). On the basis of findings of TTDE, we suspected chronic total occlusion (CTO) of the LAD, which was confirmed by invasive coronary angiography. The LAD CTO was successfully opened by a catheter-based intervention. After the percutaneous coronary intervention, the patient became completely free of symptoms. The repeated TTDE study showed the cessation of reverse coronary blood flow and the return of the physiological antegrade flow in the LAD.

Cardiac and sudden death after chronic total occlusion percutaneous coronary intervention: Prognostic role of the target vessel.

The role of the target vessel in percutaneous revascularization of chronic total occlusion (CTO) is unclear. We sought to assess the long-term results of percutaneous coronary intervention (PCI) for CTO lesions in each coronary artery and to investigate the impact of successful revascularization and previous myocardial infarction (MI) in the territory of the target vessel. Cohort observational study on 1,124 patients who have undergone CTO PCI attempt: 371 on left anterior descending artery (LAD), 485 right coronary artery, and 268 left circumflex. Patients were further stratified by successfully revascularized and not-revascularized CTO (CTO-NR). Vessels affected by a previous MI were defined as infarct-related artery (IRA). The primary endpoint was cardiac death; the secondary endpoint was the combined rate of sudden cardiac-death and sustained ventricular-arrhythmias (SCD/SVAs). Propensity score-matching was performed to evaluate LAD versus NON-LAD CTO. Up to 12-year follow-up, the clinical benefit associated with successful PCI was consistent across the three groups. CTO-NR had the greatest association with cardiac death and SCD/SVAs in each coronary artery and in IRA-CTO patients. Unsuccessful percutaneous CTO revascularization was associated with lower cardiac survival and freedom from SCD/SVAs, irrespective of the vessel treated. This result was mainly driven by patients with an IRA CTO.

Clinical impact of successful recanalization for chronic total occlusion: insights from stress myocardial perfusion imaging.

The clinical benefits of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) is still controversial. The purpose of this study is to assess the quantitative therapeutic benefits of successful PCI for CTO from the clinical data acquired by myocardial perfusion imaging (MPI). Consecutive 42 patients, who were successfully revascularized of CTO between August 2013 and March 2018, were examined. A stress MPI was performed before CTO PCI and at follow-up, and the changes in quantitative gated and perfusion single photon emission computed tomography parameters were examined. The follow-up interval was 18 ± 9 (median 14) months, during which 36 patients were maintained patency (patent CTO), while 6 were re-occluded (R/O CTO). The reduction in the % myocardial ischemia and the improvement in the ejection fraction were significantly higher in the patent CTO group than those in the R/O CTO group (67.5 ± 37.0% vs. - 56.4 ± 84.9%, p < 0.0001, 20.7 ± 49.8% vs. - 9.2 ± 20.6%, p = 0.0247, respectively). Interestingly, the improvements we observed were predominantly in the patients with LAD CTO rather than those with RCA or LCx CTO. Successful CTO PCI was able to reduce myocardial ischemia and improve the cardiac function when the patency after CTO PCI was maintained, with the most notable significance in the patients with LAD CTO.

TCTAP C-039 Chronic Total Occlusion of LAD and Left Main Bifurcation Lesion: What Should We Do?

### Patient Initials or Identifier Number BS ### Relevant Clinical History and Physical Exam A 53 years old patient was referred to National Cardiovascular Center Harapan Kita with symptoms of stable angina pectoris for 3 months before. He had a history of hypertension and diabetes mellitus. He

PERCUTANEOUS CORONARY INTERVENTION VERSUS LEFT INTERNAL MAMMARY ARTERY ROBOTIC-ASSISTED CORONARY ARTERY BYPASS FOR LEFT ANTERIOR DESCENDING ARTERY CHRONIC TOTAL OCCLUSION

Revascularization for left anterior descending artery (LAD) chronic total occlusion (CTO) lesions remains a challenge. Currently, no studies exist in the literature comparing revascularization of LAD CTO lesions via PCI versus LIMA Robotic-Assisted Coronary Artery Bypass (RACAB). The Emory CTO

TCTAP C-124 Intervention to Chronic Total Occlusion of LAD S/P CABG

TCTAP C-124 Intervention to Chronic Total Occlusion of LAD S/P CABG

PP-184 [AJC » Coronary stents and advances in stent technology] Successful Stent Implantation of LAD Chronic Total Occlusion by Passing of Septal Branch Retrogradely

PP-184 [AJC » Coronary stents and advances in stent technology] Successful Stent Implantation of LAD Chronic Total Occlusion by Passing of Septal Branch Retrogradely

TCTAP C-122 Intervention for LAD Chronic Total Occlusion with Bifurcation Lesion

TCTAP C-122 Intervention for LAD Chronic Total Occlusion with Bifurcation Lesion

Percutaneous Intervention of Circumflex Chronic Total Occlusions Is Associated With Worse Procedural Outcomes: Insights From a Multicentre US Registry

BackgroundWe sought to determine whether outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) vary according to CTO target vessel: left anterior descending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA). MethodsWe evaluated the clinical and angiographic characteristics and procedural outcomes of 636 patients who underwent CTO PCI at 6 high-volume centres in the United States between January 2012 and March 2014. ResultsThe CTO target vessel was the RCA in 387 cases (61%), LAD in 132 (21%), and LCX in 117 (18%). LCX lesions were more tortuous and RCA lesions had greater occlusion length and Japanese Chronic Total Occlusion (J-CTO) score, but were less likely to have a side branch at the proximal cap and had more developed collateral circulation. The rate of procedural success was lower in LCX CTOs (84.6%), followed by RCA (91.7%), and LAD (94.7%) CTOs (P = 0.016). Major complications tended to occur more frequently in LCX PCI (4.3% vs 1.0% for RCA vs 2.3% for LAD; P = 0.07). LCX and RCA CTO PCI required longer fluoroscopy times (45 [interquartile range (IQR), 30-74] minutes vs 45 [IQR, 21-69] minutes for RCA vs 34 [IQR, 20-60] minutes for LAD; P = 0.018) and LCX CTOs required more contrast administration (280 [IQR, 210-370] mL vs 250 [IQR, 184-350] mL for RCA and 280 [IQR, 200-400] mL for LAD). ConclusionsIn a contemporary, multicentre CTO PCI registry, LCX was the least common target vessel. Compared with LAD and RCA, PCI of LCX CTOs was associated with a lower rate of procedural success, less efficiency, and a nonsignificant trend for higher rates of complications.

TCTAP C-099 Achieve a Middle LAD Chronic Total Occlusion with Ipsilateral Double Guide Catheter

TCTAP C-099 Achieve a Middle LAD Chronic Total Occlusion with Ipsilateral Double Guide Catheter

A patient with anomalous right coronary artery originating from the left anterior descending artery who underwent complex percutaneous coronary intervention: A case report

An anomalous right coronary artery (RCA) arising from the left anterior descending artery (LAD) is an extremely rare coronary anomaly. A 71-year-old patient presented with severe exertional angina for 10 days. Coronary angiography revealed that an anomalous RCA originated from the proximal LAD. The anomalous RCA had also critical ostial stenosis and the LAD had a critical lesion before origin of RCA (95%) and chronic total occlusion (CTO) at DII branch level. Furthermore, extremely tortuous circumflex (Cx) artery had critical tandem lesions at the mid portion. Surgical treatment was offered, but the patient refused the surgery. We decided to perform percutaneous coronary intervention (PCI). The first stage of PCI was on Cx artery. Two floppy guide wires were placed into the Cx artery and a long drug-eluting stent (DES) could be placed. Secondly, the LAD CTO lesion could be crossed by Confianza pro 9 wire. After the predilatation, another DES was placed into the LAD CTO region. Then all other significant lesions were successfully treated with PCI in a single session.<Learning objective: An anomalous right coronary artery (RCA) arising from the left anterior descending artery (LAD) is an extremely rare coronary anomaly. This is the first report of case of a patient with an anomalous RCA originating from the proximal LAD and complex coronary atherosclerosis, who underwent successful complex percutaneous coronary intervention (PCI) in a single session. PCI may be an alternative treatment choice to surgery, especially in patients with high surgical risk and complex coronary anatomy.>

Radial approach and single wiring as first intentional strategies in chronic total occlusions of the left anterior descending coronary artery

BackgroundPercutaneous coronary intervention (PCI) for chronic total occlusion (CTO) of the left anterior descending coronary artery (LAD) specifically is associated with improved long-term 5years survival as compared to PCI failure. Simpler PCI techniques may be successful and safer than complex techniques which are perceived to have high failure rates and technical complexity.We aimed to describe the safety and effectiveness of first intentional single wiring and radial approach in the treatment of patients with a CTO of the native LAD coronary artery at Toulouse Rangueil university hospitals. Patients and methodsThe study was a single center prospective registry. All patients showed evidence of myocardial viability in LAD territory. The operators’ initial strategy was to start by a radial access as a first choice whenever feasible; if not, a femoral access was chosen. The initial strategy for lesion crossing in either antegrade or retrograde approaches was single wiring by lesion crossing using one guidewire (GW) as a simple technique. ResultsA total of 30 patients with 30 LAD CTO lesions (100%) were recorded. Mean age was 71.6+15years, 77% were males and 23% were females. The access route was radial 66% of the time and femoral 54% of the time and with double access for contralateral injection in 40% of the patients. Sheaths and catheters sizes 6F were used in 53% of the patients, and 7F in 73% of the patients.Overall lesion success rate was 83% of lesions. Single wiring was the prevailing technique used in 97% of successful lesions (83% of total cases), while only 3% were by multiple wiring techniques. Successful single antegrade wiring represented 63% of our total study cases with a GW success rate of 92% of cases. Successful single retrograde wiring represented 13% of our cases with a GW success rate of 67%. Q-wave myocardial infarction (MI), stent thrombosis, stroke, emergency coronary artery bypass graft (CABG), major bleeding, radiation dermatitis, cardiac tamponade or clinical perforation requiring any hemostatic maneuvers did not occur. There was a post-procedural Troponin rise of 3x normal levels in 30% of patients, and contrast induced nephropathy in 7%. Intra-aortic balloon counterpulsation (IABCP) was used in 3% of patients and cardiac death occurred in 3% of patients. ConclusionSingle wiring and radial access as initial strategies in PCI for LAD-CTO lesions in either approaches antegrade or retrograde are associated with a high procedural success rate and an acceptable incidences of adverse events.

How should I treat a patient with left main disease and a totally occluded left anterior descending artery with a diseased saphenous venous graft?

A 60-year-old man with history of coronary bypass surgery in 2000 with three saphenous venous grafts (SVG) to left anterior descending artery (LAD), diagonal and obtuse marginal branches, presented by worsening chest tightness of one month duration. He had a clinical history of hypertension, dyslipidaemia and chronic renal impairment. Physical examination, electrocardiography, laboratory tests, echocardiography and coronary angiography. Significant aorto-ostial stenosis of the SVG to LAD, left main stenosis, chronic total occlusion of LAD from its origin and significant stenosis of the mid portion of left circumflex artery. Percutaneous intervention re-do bypass surgery, dual anti-platelet therapy.