Chronic Throat Research Articles

Discussion on the Treatment of Chronic Pharyn-Gitis Based on the Theory of "Fire Depressing is Treated by Diffusing"

Chronic pharyngitis is a recurrent chronic inflammatory disease that belongs to the category of chronic throat obstruction in traditional Chinese medicine. "Fire depression" refers to the blockage of all visible or invisible evils, which leads to the stagnation of qi and changes into fire. The treatment should remove evil qi and regulate qi, that is, "Diffusing". Through the analysis of the etiology and pathogenesis of chronic pharyngitis in Chinese medicine, the article believes that this disease is a syndrome characterized by deficiency of viscera, depression of throat and stagnation of throat meridians, which is characterized by deficiency of the root and excess of heat. It also discusses the "Diffusing" method from four aspects, namely, pungent cool and clear, pungent warm and rising powder, phlegm and blood stasis elimination, and strengthening the right and benefiting the pharynx, focusing on the local treatment of throat, in order to expand the dialectical thinking and improve the clinical efficacy of chronic pharyngitis.

Isolation, Identification, and Antimicrobial Susceptibility Testing of Bacterial Pathogens at Chronic Sore Throat Patients Attending Outpatient Department of a Tertiary Care Hospital

Abstract: Sore throat manifested by throat pain is a troublesome issue or discomfort for which physicians are used to prescribing antibiotics, but most often, it is found that the patient is not responding to the drug, which gives rise to the question of drug-resistant or whether there is any infection at all? Nonspecific throat pain also imparts serious public health problems. Self-medication, inadvertent and inadequate doses of antibiotics frequently prescribed by both village doctors and registered MBBS doctors is really a public health problem in developing countries like Bangladesh.
 Aims: The aims of this study are to isolate the common organisms in chronic throat infection and to find out the effectiveness of various commonly used antibiotics.
 Methods: The samples were collected randomly from sore throat patients via a throat swab in 5 ml of 1% sterilized saline water, and the sample was brought to the laboratory and was inoculated within two hours in both blood agar and nutrient agar (NA) media and samples were incubated at 37°C overnight. Then pure colonies were transferred to Mueller Hinton agar, and antimicrobial susceptibility testing was done by the Kirby Bauer disc diffusion method.
 Results: A total of 27(24%) out of 111 samples yield positive growth. In a large number of samples, 84 (76%) did not show any isolation of the pathogenic organism. The predominant organism is a Staphylococcus aureus (55.55%). Thereafter, streptococcus (18.51%), Klebsiellapneumone (14.81%)and Pseudomonas (11.11%).Amoxiclav is the most resistant drug, along with cefuroxime, azithromycin, and doxycycline, respectively. Levofloxacin and ciprofloxacin show intermediate sensitivity. The most sensitive drug used in chronic sore throat found is linezolid though not frequently used, and other sensitive drugs are moxifloxacin and ceftriaxone.
 Conclusion: Throat pain or soreness does not always indicate that patient has been infected by bacteria. Rationale and ethical prescription, as well as microbiological sensitivity testing, are considered to avoid drug-resistant strains.
 TAJ 2022; 35: No-1: 25-31

OPULATION AT DANGER ZONE: ANALYSIS OF YOUTH CONSUMPTION OF PSYCHOTROPIC SUBSTANCES IN APAPA LOCAL GOVERNMENT, LAGOS STATE

Consumption of substances constitutes a health problem, especially among youth globally. Substances become a problem when they are consumed against professionals’ advice. Thus, this study analyses youth involvement in the consumption of psychotropic substances in Apapa Local Government, Lagos State. The study focused on the following objectives: to determine the predisposing factors to the harmful consumption of psychotropic substances; find out the types of psychotropic substances commonly consumed; examine the health problems associated with harmful consumption of psychotropic substances by the youths in Apapa Local Government Area of Lagos State. The Edwin Sutherland’s Differential Association theory was adopted as the theoretical framework for the subject matter. A qualitative narrative research design with the use of an in-depth interview guide was employed to gain insight and understanding about the experiences of thirty-two (32) psychotropic users, who were selected from across six wards of the study area through purposive and snowball sampling techniques. Findings revealed that lack of parental supervision; availability of drugs; and the need to gather extra energy to work for long hours, among others were largely responsible for harmful consumption of the substances. The various types of psychotropic substances consumed by youths in the study area include cannabis [popularly known as Indian hemp], alcohol, tramadol and codeine. The study further reveals that the youth involvement in harmful consumption of psychotropic substances had made them suffer health challenges, such as chronic cough, weight loss, tooth decay, bad breath, dry mouth and throat and headache. The study concludes that harmful consumption of psychotropic substances exposes youth to terminal illnesses and premature deaths. The study therefore recommends that treatment programs such as counselling, medication and other behavioural therapies should be readily available and be effective in attending to the multiple needs of addicted psychotropic users’ problems to mitigate their involvement in the consumption of the psychotropic substances.

Supraglottic Botulinum Toxin Improves Symptoms in Patients with Laryngeal Sensory Dysfunction Manifesting as Abnormal Throat Sensation and/or Chronic Refractory Cough.

Laryngeal sensory dysfunction (LSD) encompasses disorders of the vagal sensory pathways. Common manifestations include chronic refractory cough (CRC) and abnormal throat sensation (ATS). This study examined clinical characteristics and treatment outcomes of LSD using a novel approach of laryngeal supraglottic Onabotulinum toxin Type A injection (BTX). This was a retrospective review of clinical data and treatment outcomes of supraglottic BTX in patients with LSD. Between November 2019 and May 2021, 14 patients underwent 25 injection cycles of supraglottic BTX for treatment of symptoms related to LSD, including ATS and CRC. Primary outcome measures included the Newcastle Laryngeal Hypersensitivity Questionnaire (LHQ), Cough Severity Index (CSI), Reflux Symptom Index (RSI), and Voice Handicap Index-10 (VHI-10) at baseline and within three months of treatment. Pre- and post-treatment data were compared using a linear mixed model. After supraglottic BTX, LHQ scores improved by 2.6. RSI and CSI improved by 8.0 and 5.0, respectively. VHI-10 did not change as a result of treatment. Short-term response to SLN block was significantly associated with longer term response to BTX treatment. These findings suggest that LSD presents clinically as ATS and CRC along with other upper airway symptoms. Supraglottic BTX injection is a safe and effective technique in the treatment of symptoms of LSD.

Laryngopharyngeal Reflux Disease: Outcome of Patients After Treatment in Otolaryngology Clinics.

IntroductionLaryngopharyngeal reflux (LPR) is a different entity from gastroesophageal reflux disease (GERD). Patients with LPR usually present with a variety of symptoms such as hoarseness, voice fatigue, burning sensation in the throat, persistent cough, sore throat, dysphagia, a sensation of a lump in the throat, and chronic throat clearing. The management of LPR is based on medications (proton pump inhibitors) along with lifestyle and dietary modifications. It has been suggested that the Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) are useful parameters to assess patients with LPR.The aim of this study is to assess the subjective and objective benefits of RFS and RSI for diagnosing and management of LPR in the tertiary care center and to find the difference in RSI and RSI scoring with respect to gender.MethodsA prospective study was performed and 102 patients were included according to inclusion criteria. RFS and RSI questionnaires were filled on the first visit of patients and then treatment with proton pump inhibitors was started along with lifestyle modification instructions. Questionnaires were filled after four weeks and then 12weeks post-treatment. Repeated measure analysis of variance (ANOVA) was performed to compare the mean RFS and RSI from baseline to the end of treatment. The post hoc analysis was done using the Bonferroni test of multiple comparisons. An independent sample t-test was also used to compare the mean RFS and RSI between genders. P-values less than 0.05 were considered statistically significantResultsRFS and RSI were found to be significantly decreased post-treatment after four weeks and 12 weeks post-treatment (p-value- <0.01). Eight point eight percent (8.8%) side effects were observed in the study, the change in quality of life after a three-month treatment was significantly improved among 62.7% patients, and 75.5% did lifestyle modifications. In the mean comparison of RFS and RSI with respect to gender, it was observed that the mean RFS of females samples after one month and three months of treatment were significantly less as compared to male samples, p<0.01. There was no significant mean difference observed for RSI after one month and three months of treatment with respect to gender (p>0.05).ConclusionRFS and RSI are convenient and helpful for diagnosing LPR, and they can be easily implemented in ear, nose, throat (ENT) clinics for the subjective and objective assessment of LPR. Females showed greater improvement on laryngoscopy findings (RFS scores) post-treatment as compared to males.

Clinical Assessment of Weight Gain in Pediatric Patients Post-Tonsillectomy: A Retrospective Study.

BackgroundTonsillectomy is one of the most commonly performed surgeries among children. It is indicated for the treatment of obstructive sleep apnea and chronic throat infections. Although a relatively safe surgery, post-operative complications have been reported in multiple studies. Over the past century, tonsillectomy has played a role in post-operative weight gain.AimTo measure weight gain in pediatric patients post-tonsillectomy.MethodsA retrospective study was conducted in the Al-Ahsa region in Saudi Arabia. Overall, 240 children (male, 110 [44.2%]; female, 130 [52.2%]; mean±SD age, 7.45±2.89 years) from tertiary hospitals were included in the study. The height (m2) and weight (kg) of the children were measured, and the BMI (body mass index) was calculated preoperatively and one and six months post-operatively.ResultsThere were significant differences observed between the mean weight one-month and six months post-operation (P = 0.0001) and the mean BMI measured at the baseline one month and six months post-operation (P = 0.0001). In addition, a positive linear correlation between the BMI six months post-operation and the weight at the same period (R = 0.375) was noted.ConclusionThe findings of this study suggest an increase in weight post-tonsillectomy, mostly six months post-operation. Future studies, however, are warranted to evaluate the risk factors associated with weight gain in children and its relation to tonsillectomy.

EP32 Gastroparesis in Sjögren’s syndrome

EP32 Gastroparesis in Sjögren’s syndrome

Eagle Syndrome- An Entity Often Misdiagnosed

Introduction&#x0D; Throat pain is one of the most common complaints that an otolaryngologist encounters in daily practice, there can be numerous aetiologies to it. Eagle Syndrome is one such entity which is characterized by chronic throat pain due to elongation of the styloid process or mineralization of the stylohyoid ligament. The vague symptomatology of this condition often leads to delayed diagnosis and treatment.&#x0D; &#x0D; Case Reports&#x0D; We report 5 cases of Eagle Syndrome. All the patients presented to us with complaints of chronic throat radiating to neck which did not relieve on taking medications, for the same they have been consulting multiple specialities. The diagnosis of Eagle Syndrome was confirmed by palpation in tonsillar fossa and orthopantomogram revealed enlarged styloid process measuring more than 30mm. Upon confirmation, all the 5 patients underwent tonsillo-styloidectomy and on consequent follow ups, they were symptomatically improved.&#x0D; Discussion&#x0D; Eagle Syndrome is a diagnosis of exclusion and should raise high index of suspicion in patients with nonspecific throat and neck pain not responding to any conservative treatment. With an increasing incidence of side effects following injudicious treatment given in such cases, this condition requires attention, as it a rare entity and often misdiagnosed.

Eagle syndrome- An underdiagnosed diagnosis

Eagle syndrome occurs when an elongated styloid process or calcified stylohyoid ligament causes recurrent throat pain or foreign body sensation, dysphagia, or facial pain. Diagnosis is usually made on physical examination by digital palpation of styloid process in tonsillar fossa.To study the significance of chronic throat pain and elongated styloid process. 60 patients with chronic throat pain (excluding other causes) were assessed by palpation of styloid process was recorded according to age, gender of patients. The prevalence of elongated styloid process in age groups and gender determined correlation and significance of chronic throat pain, along with palpable styloid process in tonsillar fossa and length of styloid process in tonsillar fossa and length of styloid process was determined..The maximum number of patients having chronic throat pain were between 40-49 years age group. The male to female ratio was 0.62:1. The prevalence of elongated styloid process was seen more in 50-70 years of age. There was a higher prevalence of elongated styloid process with moderate to severe pain. 76% patients with elongated styloid process had tonsillar fossa tenderness. 96.4% of patients with elongated styloid process had palpable styloid process in tonsillar fossa. There is a significant correlation between patients having chronic throat pain and elongated styloid process. X ray Skull-Towne’s view is very cost effective as a baseline radiological investigation to diagnose elongated styloid process in patients with chronic throat pain for which cause is unknown.

P33 UPPER ESOPHAGEAL SPHINCTER (UES) ABNORMALITIES ARE SIGNIFICANT DIAGNOSTIC FINDINGS IN PATIENTS WITH ATYPICAL GERD UNDERWENT PH-IMPEDANCE AND HIGH RESOLUTION MANOMETRY (HRM)

Abstract Aim To investigate UES function in patients underwent esophageal testing with pH-impedance and HRM for suspected GERD Background &amp; Methods GERD is a complex condition with a typical: heartburn, regurgitation or epigastric pain and an atypical presentation with symptoms such as chronic cough, hoarseness, globus, dysphagia or throat clearing caused by the retrograde movement of gastric contents above the UES into the laryngopharynx. The association between GERD and abnormalities of UES and esophageal motility is not clearly known. HRM has allowed accurate measurement and evaluation of UES and esophageal function. We evaluate the UES function of the HRM exams in patients underwent pH-impedance for suspected GERD with typical or atypical symptoms. Results HRM tracings of 60 patients (35F, median age 53,08 R23-74), 35 with typical (20F, m.a 51,42 R24-74) and 25 with atypical (15F, m.a 51,73 R29-74) symptoms who underwent Ph-impedance for suspected typical and atypical GERD were evaluated. 40% of those with typical presentation had a positive pH-impedance for GERD versus 8% of those with atypical symptoms. Patients with typical symptoms presented in 42,85% UES abnormalities versus 60% of the patients with atypical presentation. From those patients with typical GERD symptoms that had a positive pH-impedance the 40% had a concomitant UES abnormality versus 100% of the patients with atypical presentation and a confirmed GERD diagnosis. Statistical analysis revealed a significant association between positive pH-impedance result and LES residual pressure in patients with typical (p=0,045) and atypical (p=0,038) symptoms. Conclusion UES abnormalities is the prevalent diagnostic finding in patients with atypical GERD underwent pH-impedance. UES dysfunction characterize all patients diagnosticated with atypical GERD by Ph-impedance.

Role of upper endoscopy with Multi-slice computed tomography in the diagnosis of patients with chronic throat symptoms

Role of upper endoscopy with Multi-slice computed tomography in the diagnosis of patients with chronic throat symptoms

Voice and speech signs and symptoms in individuals exposed to chemical agents: an analysis of medical records

ABSTRACT Objective: to identify voice and speech signs and symptoms in patients exposed to chemical agents. Methods: an exploratory and descriptive study analyzing the data from the medical records of patients who sought health services at a toxicology outpatient clinic located in Southeastern Brazil. Results: a total of 139 medical records were obtained, 75 being selected. Twelve of the records selected contained data regarding voice and speech symptoms, including hoarseness (3), loss of voice (2), chronic throat inflammation (1), sore throat (1), secretion and burning in the throat (1), dry throat and mouth (1), lump in the throat associated with difficulty in swallowing (1), difficulty in articulating words (1), and difficulty in verbal expression (1). Diseases capable of causing phono-articulatory problems were detected in 6 cases. These symptoms affected individuals with occupational exposure to different substances, particularly community health agents (7) and pesticide applicators (7). Conclusion: individuals exposed to chemical substances experienced voice and speech problems, either due to a possible irritation caused by chemical agents or due to diseases developed during or after the exposure.

Tonsillostyloidectomy for Eagle’s syndrome: a study of 20 cases

&lt;p class="abstract"&gt;&lt;strong&gt;Background:&lt;/strong&gt; Eagle’s syndrome is a pain syndrome which occurs due to elongated and misdirected styloid process. It is commoner than generally thought.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Methods:&lt;/strong&gt; 20 cases of styalgia were diagnosed and prospectively studied at two hospitals. The characteristic symptoms were chronic throat pain and foreign body sensation in throat. Diagnosis was made with clinical symptoms, physical examination in form of intraoral palpation of styloid and radiological correlation. All patients underwent Tonsillostyloidectomy for affected sites under General anaesthesia. The patients were followed up for 12 weeks post-operatively and relief of symptoms was noted. &lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Results:&lt;/strong&gt; Chronic throat pain was the commonest symptom. Most cases were associated with chronic tonsillitis or Laryngopharyngeal reflux disease (LPRD). 19 (95%) patients were symptom free by 4 weeks postoperatively.&lt;/p&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; In an established case of Styalgia with intraoral palpable styloid tip, tonsillostyloidectomy by intra-oral approach gives good results. Also, LPRD may be a possible aetiology of the disease. Incidentally, it was found that position of head over neck should be intraoperatively adjusted in order to suit easy approach to the styloid depending on antero-posterior angulation of styloid.

Curative Therapy of an Acid Secreting Inlet Patch Producing Chronic Sore Throat

Curative Therapy of an Acid Secreting Inlet Patch Producing Chronic Sore Throat

P006. Clinical management of migraine attributed to cerebral venous sinus thrombosis.

Background Cerebral venous sinus thrombosis (CVST) is the presence of a blood clot in the dural venous sinuses. Symptoms include migraine, abnormal vision, strokelike signs, seizures, and abnormalities of consciousness and mental status. CVST incidence is 3-4 cases per million adults with a higher frequency among younger people < 40 years old, thrombophilia patients, women who were pregnant and using hormonal contraceptives. Other risk factors are chronic inflammatory diseases, blood disorders, meningitis, ear, nose and throat infections, venous sinuses injuries, surgical procedures in the head and neck area, homocystinuria. Diagnosis requires neuroimaging. Recommended treatment is with anticoagulants [1]. The aims of our retrospective study were to detect CVST incidence among patients accessing our outpatient headache day service (DS) programme, whose main symptom was headache, to compare data with pre-existing estimation, and to identify diagnostic and therapeutic procedures in our clinical management of CVST.

Tonsillar colonisation of Fusobacterium necrophorum in patients subjected to tonsillectomy.

BackgroundFusobacterium necrophorum is a well-known cause of Lemirre’s disease and accumulating evidence support its pathogenic role in peritonsillar abscess while its role in recurrent and chronic tonsillitis is uncertain. The objective of this study was to assess the prevalence of oropharyngeal colonisation with F. necrophorum and Beta-haemolytic streptococci in a cohort of patients scheduled for tonsillectomy due to recurrent or persistent throat pain, and to evaluate the dynamics of colonisation with repeated sampling during a follow-up time of 6 to 8 months.MethodsFifty-seven (57) patients aged 15–52 years scheduled for tonsillectomy due to chronic/recurrent tonsillitis or recurrent peritonsillar abscess were included. Throat swabs for the detection of F. necrophorum and Beta-haemolytic streptococci and clinical data was collected at inclusion, at the time of surgery and 6 to 8 months after surgery. Statistical analysis was performed using the Chi-square, Fisher’s exact and Mc Nemar tests.ResultsFusobacterium necrophorum was found in 28, 30 and 16 % of the patients at inclusion, surgery and follow up respectively. The corresponding results for beta-haemolytic streptococci were 5, 9 and 5 %. Patients colonised with F. necrophorum at follow-up, after tonsillectomy, were equally relieved from their previous throat pain as non-colonised patients. Looking at individual patients, the culture results for F. necrophorum varied over time, indicating a transient colonisation.ConclusionFusobacterium necrophorum was frequently found in throat cultures in this cohort of patients with recurrent or chronic throat pain leading to tonsillectomy. Colonisation was equally frequent in the asymptomatic cohort post-tonsillectomy, indicating that F. necrophorum is not alone causative of the symptoms. In an individual perspective, colonisation with F. necrophorum was transient over time.

Descriptive Epidemiology of Voice Disorders in Rheumatoid Arthritis: Prevalence, Risk Factors, and Quality of Life Burden

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease which may adversely affect phonatory function. This study aimed to establish the prevalence, risks, and quality of life effects of voice disorders in RA. This is a cross-sectional, descriptive epidemiology study. One hundred individuals with RA underwent a telephone interview to determine the frequency, severity, risks associated with, and quality of life burden of voice disorders. The results were analyzed using summary statistics, frequencies, chi-square tests, regression analysis, and risk ratios (P < 0.05). Thirty-five percent of participants with RA reported a current voice disorder which was chronic and long-standing in most cases. The prevalence of a current voice disorder did not significantly differ across age, sex, medication use, voice use patterns, medical history, or RA severity. These chronic voice disorders produced significant adverse effects on both voice-related quality of life and short form 36 health-related quality of life scales. Specific voice symptoms such as "voice-related discomfort" and "chronic throat dryness" contributed disproportionately to the quality of life burden. Of those participants with a voice disorder, only 37% had ever sought professional help to improve their voice. These results indicate that voice disorders are common in RA and produce significant adverse effects on quality of life. Further research is necessary to better understand the origin of these disorders and their potential response to treatment.

Su2039 Radiofrequency Ablation of Symptomatic Cervical Inlet Patch Using a ‘Thorugh the Scope’ Device - A Pilot Study

Introduction The Cervical Inlet patch (CIP) is an area of heterotopic gastric mucosa at the proximal oesophagus, which can secrete both acid and mucus. Attributable symptoms include chronic globus sensation and sore throat. Previous studies have demonstrated improvement in symptoms following ablation with argon plasma coagulation.1,2The aim of this study was to assess a novel through the scope Radiofrequency Ablation (RFA) catheter, that may be advantageous for this indication. Method Ten patients with endoscopically and histologically proven CIP, and symptoms of globus or sore throat, were included in the study. All had laryngoscopy, high resolution manometry and 24-hour dual-channel pH/impedance studies prior to enrolment. An ablation protocol of 3 ablations at 12J/cm2, without removal of coagulated tissue between ablations, was employed. Patients were discharged on twice daily proton pump inhibitor (PPI) for 6 weeks, and a follow up endoscopy was undertaken at 3 months. A maximum of 2 RFA sessions, 3 months apart, were allowed. A visual analogue score (VAS; 0–100) was completed at baseline, then at 6 weeks (on PPI), 3 months (off PPI), 6 months and 12 months after treatment. Wilcoxon test was used for statistical analysis. Results The mean age was 56 years (+/- 3 years, SEM), 60% male, 80% Causcasian. Barrett’s oesophagus was present in 50%. Mean number of CIP was 2 (range, 1–4) with a median surface area of 2 cm2(range, 0.5–14cm2). After a median of 2 RFA sessions, 80% achieved complete endoscopic and histological resolution (CR-IP), with >90% visual resolution for remainder. Globus, sore throat and cough were significantly improved from baseline (p Conclusion This prospective pilot study demonstrates that RFA using the BarrxTMChannel Catheter is safe and effective for treating patients with symptoms of chronic globus sensation, secondary to cervical inlet patch. Disclosure of interest J. Dunn Grant/Research Support from: Covidien GI Solutions, G. Sui: None Declared, A. Angiannsah: None Declared, T. Wong: None Declared. References Meining A et al. Argon plasma ablation of gastric inlet patches in the cervical esophagus may alleviate globus sensation: a pilot trial. Endosc. 2006;38:566–570 Bajbouj M et al. Argon plasma coagulation of cervical heterotopic gastric mucosa as an alternative treatment for globus sensations. Gastroenterol. 2009;137:440–444

Voice disorders in Sjögren's syndrome: Prevalence and related risk factors.

Sjögren's Syndrome (SS) is an autoimmune disease that causes sicca (dryness) symptoms by affecting secretions most notably of the lacrimal and salivary glands. Voice disorders have been documented in patients with SS, but the true prevalence and relationships among possible contributing factors remain unknown. This preliminary epidemiological investigation examined prevalence and risk factors for voice disorders in SS. Self-report epidemiological questionnaire. One hundred and one (101) patients with SS (94 females, 7 males; M age = 59.4 years; standard deviation [SD] = 14.1 years) completed an extensive interview using a previously validated questionnaire involving the patient's medical, family, occupational, psychosocial, social/lifestyle, voice use, and general health histories. Summary statistics, chi-squares, risk ratios, and multiple logistic regression were used to determine the frequency and severity of voice disorders in individuals with SS, as well as associations with demographic, lifestyle, health, disease severity, and voice use factors. The prevalence of a current voice disorder in individuals with SS was 59.4%. In general, voice disorders began gradually; were chronic; and correlated with SS disease severity independent of age, sex, duration of the disease, comorbid autoimmune conditions, and use of SS-related medication. Specific voice symptoms including chronic throat dryness and soreness were significantly associated with SS disease severity. Voice disorders are relatively common in SS and are more frequent as disease severity worsens. These findings have important implications for evaluation and treatment of patients with SS. 4.

Excessive professional singing lead to chronic throat diseases, 176 cases of clinical research

目的 分析职业用嗓过度导致慢性喉部疾病的治疗效果.方法 2012年1月至2013年12月收治的职业用嗓过度导致的慢性喉部疾病患者176例,根据入院先后顺序不同分为观察组和对照组各88例,观察组予以噤声、口服或静脉使用激素、激素雾化、口服金嗓散结丸、口服或静脉使用抗生素、手术治疗,对照组仅予以禁声、口服或静注抗生素和手术治疗,比较两组患者的治疗有效率、症状改善时间和不良反应的发生率.结果 观察组治疗有效率96.6％(85/88)显著高于对照组67.0％(59/88),临床症状和体征改善时间(6.8±2.0)d显著短于对照组(10.4±2.8)d,差异均有统计学意义(P＜0.05);观察组喉部干痒发生率18.2％(16/88)显著低于对照组36.4％(32/88),差异有统计学意义(P＜0.05).结论 综合治疗职业用嗓过度所致慢性喉部疾病疗效确切,迅速改善症状,减少不良反应。