Chronic Relapsing Experimental Encephalomyelitis Research Articles

The development of periventricular lesions in chronic relapsing experimental allergic encephalomyelitis in guinea-pigs: a light and scanning electron microscopic study.

Periventricular lesions in the centrum semiovale are the most frequent changes in the brain in chronic relapsing experimental encephalomyelitis in guinea-pigs. They are generally distributed symmetrically at the lateral angle of the ventricular wall. The number of lesions and their size increases in anterior-posterior direction. Typically periventricular lesions in the later chronic stages are similar to those in multiple sclerosis. Earlier lesions generally originate in the depth of the white matter and secondarily, by extension, reach the ventricular surface. Lesions developing at later stages after sensitization may also originate from the ventricular wall and extent into the centrum semiovale. In these latter, severe structural changes in the ventricular ependyma may generally be found. Increased intracranial pressure in these animals may be one of the possible mechanisms leading to the peculiar topographical distribution of the periventriuclar lesions.

Ultrastructural variability of demyelinating lesions in experimental allergic encephalomyelitis and multiple sclerosis.

The pathology of chronic relapsing experimental encephalomyelitis (EAE) and multiple sclerosis are similar in several essential aspects. The similarities include the perivenous inflammation, primary segmental demyelination, formation of large, macrosco-pically visible demyelinated plaques, reactive gliosis and variable degree of remyelination (5). Differences, however, were stressed by several authors mainly regarding size of the lesions, growth of actively demyelinating lesions, involvement of inflammatory cells in the demyelinating process with special emphasis on macrophage response, role of local cells in demyelination and removal of debris and vascular (capillary) pathology.