An experiment on repetitive decision-making was conducted to explore the interaction between cognitive and motivational processes in decision-making. The gain-loss framing of risky choice options was manipulated to investigate cognition, and participants’ chronic regulatory focus was measured to assess motivation. Risky choice demonstrated interactive effects between gain-loss framing and regulatory focus. Participants made less risky or riskier choices in the gain or loss condition, respectively. Furthermore, promotion or prevention-focused individuals chose the risky option more frequently in the gain or loss condition, respectively. The results for response times showed the main effects for the two factors, with no interaction. These results, along with supplementary post-hoc analyses, provide evidence that cognitive and motivational processes are simultaneously involved in risky decision-making.