Chorionic Gonadotropin In Early Pregnancy Research Articles

8645 An Exploratory Analysis to Understand the Race Difference in Serum Levels of Human Chorionic Gonadotropin in Early Pregnancy

8645 An Exploratory Analysis to Understand the Race Difference in Serum Levels of Human Chorionic Gonadotropin in Early Pregnancy

Associations of Serum Perfluoroalkyl Substances and Placental Human Chorionic Gonadotropin in Early Pregnancy, Measured in the UPSIDE Study in Rochester, New York.

Per- and polyfluoroalkyl substances (PFAS) are widely detected in pregnant women and associated with adverse outcomes related to impaired placental function. Human chorionic gonadotropin (hCG) is a dimeric glycoprotein hormone that can indicate placental toxicity. Our aim was to quantify the association of serum PFAS with placental hCG, measured as an intact molecule (hCG), as free alpha-() and beta-subunits (), and as a hyperglycosylated form (h-hCG), and evaluate effect measure modification by social determinants and by fetal sex. Data were collected from 326 pregnant women enrolled from 2015 to 2019 in the UPSIDE study in Rochester, New York. hCG forms were normalized for gestational age at the time of blood draw in the first trimester [multiple of the median (MoM)]. Seven PFAS were measured in second-trimester maternal serum. Multivariate imputation by chained equations and inverse probability weighting were used to evaluate robustness of linear associations. PFAS mixture effects were estimated by Bayesian kernel machine regression. Perfluorohexane sulfonic acid (PFHxS) [: 0.29 log MoM units per log PFHxS; 95% confidence interval (CI): 0.08, 0.51] and perfluorodecanoic acid (PFDA) (hCG: ; 95% CI: , ) were associated with hCG in the single chemical and mixture analyses. The PFAS mixture was negatively associated with and positively with . Subgroup analyses revealed that PFAS associations with hCG differed by maternal race/ethnicity and education. Perfluoropentanoic acid (PFPeA) was associated with only in Black participants (; 95% CI: , ) and in participants with high school education or less (; 95% CI: , ); conversely, perfluorononanoic acid (PFNA) was negatively associated with only in White participants (; 95% CI: , ) and with only in participants with a college education or greater (; 95% CI: , ). These findings were robust to testing for selection bias, confounding bias, and left truncation bias where PFAS detection frequency was . Two associations were negative in male (and null in female) pregnancies: Perfluoroundecanoic acid (PFUnDA) with , and PFNA with h-hCG. Evidence was strongest for the association between PFHxS and PFDA with hCG in all participants and for PFPeA and PFNA within subgroups defined by social determinants and fetal sex. PFAS mixture associations with and differed, suggesting subunit-specific types of toxicity and/or regulation. Future studies will evaluate the biological, clinical and public health significance of these findings. https://doi.org/10.1289/EHP12950.

Trophectoderm biopsy reduces the level of serum β-human chorionic gonadotropin in early pregnancy

To assess whether trophectoderm biopsy has any impact on the level of serum β-human chorionic gonadotropin (β-hCG) in early pregnancies. Retrospective cohort study. University-affiliated reproductive medical center. Three hundred and eighty-three women undergoing 396 frozen embryo transfer (FET) cycles with preimplantation genetic testing (PGT), and 353 women undergoing 465 FET cycles with invitro fertilization or intracytoplasmic sperm injection, all women having positive serum β-hCG results on the 12th day after blastocysts transfers. None. Serum β-hCG levels on the 12th day after warmed blastocyst transfer and perinatal outcomes of clinical pregnancy. The diagnostic threshold of serum β-hCG levels on the 12th day after FET for prediction of a live birth was 368.55 mIU/mL with an area under the curve of 0.791 (0.729∼0.853) in the biopsy group, which was lower than the 411.45 mIU/mL in the control group. The average level of serum β-hCG in the biopsy group with clinical pregnancies was statistically significantly lower than that of the control group: 703.10 (569.63) versus 809.20 (582.00), respectively. No statistically significant differences in perinatal outcomes, including gestational age, hypertensive disorder in pregnancy, and neonatal malformation, were found between the two groups. Trophectoderm biopsy may reduce the level of serum β-hCG in early pregnancies (the 12th day after embryo transfer), but no increased risk was found of adverse perinatal outcomes after trophectoderm biopsy.

ОПТИМІЗАЦІЯ МЕТОДІВ ДІАГНОСТИКИ ПРИ ЗАТРИМЦІ РОСТУ ПЛОДА У ВАГІТНИХ.

У статті представлені результати пошуку маркерів ранньої діагностики затримки росту плода та оцінка їх ефективності. Проведено дослідження 45 вагітних з затримкою росту плода, що перебували на лікуванні у Тернопільській комунальній міській лікарні № 2. Контрольну групу склали 25 вагітних з фізіологічним перебігом вагітності, які народили живих доношених дітей з масо-ростовими характеристиками відповідно до гестаційного віку. Вивчали стан фетоплацентарного комплексу у вагітних на основі дослідження рівнів гормонів (ПАПП-А, β-хоріонічного гонадотропіну людини (β-ХГЛ), естріолу (Е3), плацентарного лактогену (ПЛ) та прогестерону). Стан внутрішньоутробного плода оцінювали за даними ультразвукового дослідження, кардіотокографії, визначення біофізичного профілю плода. Виявлено, що ранніми ознаками розвитку затримки росту плода є визначення ПАПП, естріолу та хоріонічного гонадотропіну в ранні терміни вагітності та рівні естріолу, прогестерону, плацентарного лактогену в другому триместрі. Використання гравідограми як скринінгового маркера дозволив діагностувати затримку росту й у 95,4 % випадків був підтверджений УЗД та виставлено діагноз затримки росту плода у вагітних. За даними УЗД визначали біометричні маркери затримки росту.

Factors Affecting Rise of Human Chorionic Gonadotropin in Early Pregnancy

Determining the viability of early pregnancies can be challenging, especially in women presenting with abdominal pain with or without vaginal bleeding.

Administration of human chorionic gonadotropin in early pregnancy increases ovarian activity in sows

Animal Production Science (continuing Australian Journal of Experimental Agriculture) publishes original research into applied agriculture including animal production, animal-plant interactions, pasture and fodder crops, field crops, extension and horticulture

Maternal age and serum concentration of human chorionic gonadotropin in early pregnancy.

To study whether maternal age is associated with serum concentration of human chorionic gonadotropin in early pregnancy. Cross-sectional study. Oslo University Hospital in Oslo, Norway. All vital pregnancies in gestational week 8 conceived by in vitro fertilization between February 1996 and February 2013 (n = 4472). Serum concentrations of human chorionic gonadotropin were measured on day 12 after embryo transfer/day 16 following ovulation induction. Trends in geometric means of human chorionic gonadotropin concentrations by maternal age group were tested by linear regression analysis. We also studied the association of maternal age (years) with log-transformed human chorionic gonadotropin concentrations, and adjustments were made for number of embryos transferred, method of in vitro fertilization and year (period) of embryo transfer. Serum concentration of human chorionic gonadotropin. Geometric mean concentrations of human chorionic gonadotropin decreased with increasing maternal age (p = 0.024, test for trend by weighted linear regression). Also, we estimated a significant negative association of maternal age with log-transformed human chorionic gonadotropin concentrations (adjusted regression coefficient -0.011, standard error 0.003, p < 0.001). Serum concentrations of human chorionic gonadotropin in very early pregnancy decreased with maternal age. Since human chorionic gonadotropin is synthesized in trophoblast cells only, the lower human chorionic gonadotropin concentrations in women of advanced age may reflect functional impairment or delayed proliferation of trophoblast cells in early pregnancy in these women.

Maternal age and serum concentration of human chorionic gonadotropin in early pregnancy

Objective To study whether maternal age is associated with serum concentration of human chorionic gonadotropin in early pregnancy. Design Cross-sectional study. Setting Oslo University Hospital in Oslo, Norway. Population All vital pregnancies in gestational week 8 conceived by in vitro fertilization between February 1996 and February 2013 (n = 4472). Methods Serum concentrations of human chorionic gonadotropin were measured on day 12 after embryo transfer/day 16 following ovulation induction. Trends in geometric means of human chorionic gonadotropin concentrations by maternal age group were tested by linear regression analysis. We also studied the association of maternal age (years) with log-transformed human chorionic gonadotropin concentrations, and adjustments were made for number of embryos transferred, method of in vitro fertilization and year (period) of embryo transfer. Main outcome measure Serum concentration of human chorionic gonadotropin. Results Geometric mean concentrations of human chorionic gonadotropin decreased with increasing maternal age (p = 0.024, test for trend by weighted linear regression). Also, we estimated a significant negative association of maternal age with log-transformed human chorionic gonadotropin concentrations (adjusted regression coefficient −0.011, standard error 0.003, p < 0.001). Conclusions Serum concentrations of human chorionic gonadotropin in very early pregnancy decreased with maternal age. Since human chorionic gonadotropin is synthesized in trophoblast cells only, the lower human chorionic gonadotropin concentrations in women of advanced age may reflect functional impairment or delayed proliferation of trophoblast cells in early pregnancy in these women.

Addendum to: Yoshida Y (2005) Secretion of human chorionic gonadotropin in early pregnancy. Med Mol Morphol 38:104–111

Addendum to: Yoshida Y (2005) Secretion of human chorionic gonadotropin in early pregnancy. Med Mol Morphol 38:104–111

Secretion of human chorionic gonadotropin in early pregnancy

Remarkable secretion from the syncytial trophoblast of chorionic villi was observed in early pregnancy. Histology and histochemistry revealed many cytoplasmic protrusions containing numerous secretory granules, which were of basophilic glycoprotein in nature. Also, immunohistochemistry proved that these were human chorionic gonadotropin (hCG). Electron microscopy clarified the overall secretory process, which started with the production of small granules in the Golgi complex; then, the granules migrated toward the cell surface, increasing their size by fusing with each other, and gathered in cytoplasmic protrusions, then liquefied to be liberated by a mode of exocytosis into the maternal bloodstream (intervillous space). This remarkable hCG secretion, morphologically represented by the many cytoplasmic protrusions containing numerous secretory granules, arose synchronously on the surface of almost all chorionic villi. This phenomenon was limited to the eighth and ninth weeks of gestation, concurring with the maximal hCG concentration of maternal blood serum during pregnancy.

26 Fetal gender impact on maternal serum human chorionic gonadotropin in early pregnancy

26 Fetal gender impact on maternal serum human chorionic gonadotropin in early pregnancy

Serum levels of human placental lactogen and human chorionic gonadotropin in early pregnancy: A maturational index of the placenta

Between weeks 10 and 20 of gestation, there are rapid and opposing changes in blood levels of two hormones produced by the syncytiotrophoblast: hPL increases and hCG decreases. In this study, the relationship between these two changing hormone levels was examined, rather than the serum concentrations themselves, as a potential test for placental maturation. The relationship between the hCG and hPL concentrations and GA determined in a selected group of patients was described by the following equation: GA (in days) =97.3 + 24.8 ln [hPL] − 14.5 ln [hCG]. The endocrine evaluation of placental maturation by comparison of [hCG] and [hPL] in early pregnancy shows promise as a simple, safe, and inexpensive clinical tool for GA assessment.