Choriocarcinoma Of Lung Research Articles

Primary Pulmonary Choriocarcinoma and Caesarean Section Ectopic Pregnancy: A Case Report with an Emergency Department Diagnostic Pathway

Background:: Although most cases of choriocarcinoma are of gestational origin, rare cases of extrauterine origin (such as pulmonary) have been reported, which have a poor prognosis Case Presentation:: We present one such rare case involving a 35-year-old female patient who initially presented to the emergency department with hemothorax and was found to have primary lung choriocarcinoma after multiple biopsies. The patient was properly managed and discharged in a healthy condition. However, she subsequently returned to the hospital with an intracranial haemorrhage and, unfortunately, passed away despite all efforts. Conclusion:: Due to the life-threatening initial presentations of primary pulmonary choriocarcinoma, it is essential to conduct an intensive work-up and maintain close observation when a patient initially presents with such symptoms. Early diagnosis is crucial to initiate appropriate treatment and prevent further complications. Therefore, we aimed to discuss and establish an emergency medicine department-based diagnostic pathway to contribute to the early diagnosis of this deadly malignancy

Treatment of primary choriocarcinoma of lung

Treatment of primary choriocarcinoma of lung

Case Report: Multiple hemorrhagic metastases to the brain from primary lung choriocarcinoma.

Herein we report a very rare entity of multiple hemorrhagic metastases to the brain from a primary lung choriocarcinoma in a young woman. The patient presented with recent onset of progressive headache, decreased level of consciousness and multiple episodes of vomiting. CT of the head revealed multiple hemorrhagic lesions within the brain. The patient's serum B-human chorionic gonadotrophin was increased. A chest X-ray revealed a right lung mass. The patient urgently underwent operative excision of the lesion in the posterior fossa, so as to prevent impending tonsillar herniation. The histology from the lesion provided the diagnosis of choriocarcinoma. After surgery, ultrasonography of the abdomen and pelvis was normal, and a chest CT revealed an enhanced and highly vascular right apical lung lesion, suggestive of lung primary choriocarcinoma, with regard to the clinical background. The patient was then started on chemotherapy, following which her serum B-HCG level decreased rapidly. This case highlights the importance of keeping this entity in the differential diagnosis of hemorrhagic lesions in any patients of a child bearing age. Early diagnosis and rapid initiation of multimodal therapy is prudent for ensuring a good outcome from an otherwise rapidly metastasizing and highly vascular lesion.

Primary pulmonary choriocarcinoma combined with adenocarcinoma

An extremely rare autopsy case of primary pulmonary choriocarcinoma combined with adenocarcinomatous components in a 77-year-old Japanese man is described. The patient died of rapidly progressive respiratory dysfunction without ante-mortem diagnosis. Autopsy revealed necro-hemorrhagic areas of the primary lung tumor with a typical biphasic pattern of choriocarcinoma. Topographical analysis suggested that moderately to poorly differentiated adenocarcinoma components partially surrounded the choriocarcinomatous components. Moreover, dedifferentiated carcinomatous components were scattered next to both adenocarcinomatous and choriocarcinomatous areas, and a few cells of the dedifferentiated carcinomatous components had a similar immunoreaction to conventional adenocarcinomatous or choriocarcinomatous components, such as surfactant apoprotein A, placental alkaline phosphatase or beta-human chorionic gonadotropin. Additionally, epithelial membrane antigen-positive cytotrophoblastic cells were rarely found in choriocarcinomatous areas. The present case suggests that primary lung choriocarcinoma can occur closely related to conventional pulmonary adenocarcinoma, although collision tumor was not completely ruled out.

Recurrent Peripheral Arterial Embolism from Metastatic Lung Choriocarcinoma

A patient with choriocarcinoma, most likely of ovarian origin, with lung metastasis is presented. The disease manifested itself by recurrent embolism into the peripheral arteries. Literature on this topic is reviewed.

Unsuspected Metastatic Choriocarcinoma Presenting As Gastrointestinal Bleeding

Although metastatic lung choriocarcinoma causes respiratory symptoms, it can be manifested with atypical signs. A 20 years old patient is reported who presented with features of gastrointestinal bleeding due to polypoid choriocarcinoma of the stomach. Bloody vomiting are usually caused by peptic disease but may also be secondary to metastasis to the lung. Failure to recognize this as being to choriocarcinoma may led to a delay in diagnosis and effective treatment.

Embolia pulmonar decorrente de coriocarcinoma metastático com apresentação atípica

É apresentado o caso de uma paciente de 36 anos, com coriocarcinoma metastático pulmonar com apresentação clínica e radiológica atípica. O achado de hipertensão pulmonar indicou a possibilidade de tromboembolia pulmonar; todavia, o diagnóstico definitivo e causa da embolia pulmonar foram dados na autópsia. Discutem-se as formas de apresentação das metástases do coriocarcinoma, sua repercussão e o período de latência que pode existir até evidenciar a neoplasia.

Primary lung choriocarcinoma masquerading as a metastatic gestational neoplasm: Van Nostrand K.M.; Lucci J.A. III; Liao S.-Y.; DiSaia P.J. USA Gynecol Oncol 1994 53/3 (361–365)

International Journal of Gynecology & ObstetricsVolume 48, Issue 3 p. 351-351 Citations from the literature case report of general interest Primary lung choriocarcinoma masquerading as a metastatic gestational neoplasm Van Nostrand K.M.; Lucci J.A. III; Liao S.-Y.; DiSaia P.J. USA Gynecol Oncol 1994 53/3 (361–365) First published: March 1995 https://doi.org/10.1016/0020-7292(95)90342-9AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume48, Issue3March 1995Pages 351-351 RelatedInformation

Primary Lung Choriocarcinoma Masquerading as a Metastatic Gestational Neoplasm

Primary lung choriocarcioma has rarely been reported. In females, previous pregnancies and other sources of trophoblastic tissue such as a nongestational gonadal choriocarcinoma must be excluded before the diagnosis can be made. Here we present a young female patient initially diagnosed as having a metastatic gestational neoplasm who was unresponsive to standard single and multiagent chemotherapy. A total abdominal hysterectomy and bilateral salpingo-oopherectomy failed to reveal the source of production of β HCG. At the time of her thoracotomy and lobectomy, performed for a lung nodule, she was found to have a primary lung choriocarcinoma. The patient received no further chemotherapy and has remained disease free for more than 3 years. This is the first recorded case of a lung choriocarcinoma that has been successfully treated where the patient has remained free of disease for more than 1 year.