Las manifestaciones neuropsiquiatricas en los pacientes con lupus eritematoso sistemico (LES) y sindrome antifosfolipido (SAF) secundario son muy frecuentes. En ambos casos, la fisiopatologia se correlaciona con vasculopatia asociada a anticuerpos antifosfolipido y neurotoxicidad por anticuerpos y citocinas. La corea es el unico trastorno del movimiento incluido en los 19 sindromes neuropsiquiatricos del LES segun el American College of Rheumatology, con presentacion inusual (prevalencia del 2%), y puede ocurrir como primera manifestacion de la enfermedad. Se describe el caso de una paciente de 17 anos con corea desencadenada durante el embarazo como manifestacion inicial de LES y SAF. Neuropsychiatric symptoms of systemic lupus erythematosus (SLE) and secondary antiphospholipid syndrome (APS) are very common. In both cases, pathophysiology is correlated to vasculopathy associated to antiphospholipid antibodies as well as neurotoxicity mediated by antibodies and cytokines. Chorea, instead, is the only movement disorder included in the 19 SLE’s neuropsychiatric syndromes described by the American College of Rheumatology. Nevertheless, its presence is unusual with a prevalence of about 2%, and could appear as an early manifestation of the disease. The case of a 17-year-old pregnant woman in whom chorea was an early manifestation of SLE and APS.