Complexes of chlorin e6 trimethyl ester (H2Chl-e6,), methylpyropheophorbidea (H2MePyroPheo) with indium(III) (InChl-e6, and InMePyroPheo) were obtained from the corresponding macrocyclic ligands by complexation reaction with InIII trisacetylacetonate in acetic acid. In the case of methylpheophorbidea (H2MePheo) the complexation reaction is accompanied by side-process of exo-cyclic ring oxidation leading to inseparable mixture of InMePheo, its 13(2)-hydroxy derivative and InMePyroPheo. Spectral-luminescence and photophysical properties of H2Chl-e6 and H2MePyroPheo and their InIII complexes were studied in DMF. Metal free chlorins have relatively long fluorescence lifetimes (τf ∼ 5.4–7.5 ns) and moderate fluorescence and singlet oxygen quantum yields (ФF ∼ 0.39 and 0.29, ФΔ ∼ 0.47 and 0.60, for H2Chl-e6 and H2MePyroPheo, respectively). It was revealed that insertion of the indium atom into the macrocyclic core strongly diminishes the fluorescence lifetimes (τf ∼ 0.5–0.9 ns) and quantum yields (ФF ∼ 0.04–0.06), but facilitates the conversion to the triplet state leading to enhanced singlet oxygen quantum yields. Therefore, InChl-e6 and InMePyroPheo having intense Q-band absorption in the therapeutic window (638 and 661 nm) and high values of ФΔ (0.84 and 0.76) can be considered as promising photosensitizers for PDT.