Chi-square Test Research Articles

Factor related to preterm premature rupture of membrane among pregnant women

The incidence rate of premature rupture of membranes in Yogyakarta, Indonesia was 10.1%, the highest rate in Indonesia. This study's goal was to determine factors related to premature rupture of membranes among pregnant women in Sardjito Hospital. There were 220 pregnant women, 110 in the premature rupture of membranes or case group and 110 no premature rupture of membranes as control group. Urinary tract infection, anemia, and preterm premature rupture of membrane and the characteristics were the research factors. The Chi-square test and logistic regression were used to examine the data. Secondary data from medical records for the period January 2021 December 2022 was taken. Result of this study showed that 49.1% of the pregnant women in the case group had anemia, and 47.3% had urinary tract infections. In the control group had anemia 30.9% of pregnant women, while urinary tract infections infected 61.8% of them. Urinary tract infections and anemia were associated with a greater incidence of preterm premature rupture of membranes, according to a bivariate analysis with p-values of 0.042 and 0.009 (p-value=0.05). Anemia was the most significant factor associated with the incidence of preterm premature rupture of membranes (OR=2.26).

Factors associated with toddler development

Introduction: Children are the nation's next generation; therefore, they need quality children to achieve a good future for the nation. Growth and development experience a rapid increase at an early age, namely from 0-5 years. Objective: This study knows the factors related to toddler development. Method: The research design uses correlational with a cross-sectional approach. The population of this study was all toddlers, as many as 250 toddlers. The sample of 71 toddlers used the sampling technique of proportionate random sampling. Test data analysis using the chi-square test, continue correction, and alternative Fisher’s exact test. Results: This study showed a significant association between nutritional status (p = 0.04), history of chronic disease (p = 0.01), education (p = 0.04), history of childbirth (p = 0.03), stimulation (p = 0.04) with toddler development and there was no significant relationship between socioeconomic (p = 0.71) and toddler development. Conclusion: there is a relationship between nutritional status, history of chronic disease, education, history of childbirth, and stimulation with toddler development. Health workers should be advised to detect child growth and development early by looking at the history of chronic diseases suffered and stimulating toddlers for optimal development.

Expression of LC3A, LC3B and p62/SQSTM1 autophagy proteins in hepatocellular carcinoma (HCC) tissues and the predicted microRNAs involved in the autophagy-related pathway.

Autophagy plays multifaceted roles in regulating hepatocellular carcinoma (HCC) and the mechanisms involved are under-explored. Regulatory microRNAs (miRNAs) have been reported to target autophagy proteins but their roles in HCC is not well studied. Using HCC patient tissues, this study aims to investigate the association of autophagy with several clinicopathological parameters as well as identifying the autophagy-related miRNAs and the possible pathways. Autophagy level in the HCC patient-derived cancer and non-cancer tissues was determined by immunohistochemistry (IHC) targeting SQSTM1, LC3A and LC3B proteins. Significance tests of clinicopathological variables were tested using the Fisher's exact or Chi-square tests. Gene and miRNA expression assays were carried out and analyzed using Nanostring platform and software followed by validation of other online bioinformatics tools, namely String and miRabel. Autophagy expression was significantly higher in cancerous tissues compared to adjacent non-cancer tissues. High LC3B expression was associated with advanced tumor histology grade and tumor location. Nanostring gene expression analysis revealed that SQSTM1, PARP1 and ATG9A genes were upregulated in HCC tissues compared to non-cancer tissues while SIRT1 gene was downregulated. These genes are closely related to an autophagy pathway in HCC. Further, using miRabel tool, three downregulated miRNAs (hsa-miR-16b-5p, hsa-miR-34a-5p, and hsa-miR-660-5p) and one upregulated miRNA (hsa-miR-539-5p) were found to closely interact with the abovementioned autophagy-related genes. We then mapped out the possible pathway involving the genes and miRNAs in HCC tissues. We conclude that autophagy events are more active in HCC tissues compared to the adjacent non-cancer tissues. We also reported the possible role of several miRNAs in regulating autophagy-related genes in the autophagy pathway in HCC. This may contribute to the development of potential therapeutic targets for improving HCC therapy. Future investigations are warranted to validate the target genes reported in this study using a larger sample size and more targeted molecular technique.

Incidence of contrast-associated acute kidney injury: a prospective cohort.

Contrast-associated acute kidney injury (CA-AKI) is a deterioration of kidney function that occurs after the administration of a iodinated contrast medium (ICM). Most studies that defined this phenomenon used older ICMs that were more prone of causing CA-AKI. In the past decade, several articles questioned the true incidence of CA-AKI. However, there is still a paucity of a data about the safety of newer ICM. To assess the incidence of CA-AKI in hospitalized patients that were exposed to computed tomography (CT) with and without ICM. Prospective cohort study with 1003 patients who underwent CT in a tertiary hospital from December 2020 through March 2021. All inpatients aged > 18 years who had a CT scan during this period were screened for the study. CA-AKI was defined as a relative increase of serum creatinine of ≥ 50% from baseline or an absolute increase of ≥ 0.3 mg/dL within 18 to 48 hours after the CT. Chi-squared test, Kruskal-Wallis test, and linear regression model with restricted cubic splines were used for statistical analyses. The incidence of CA-AKI was 10.1% in the ICM-exposed group and 12.4% in the control group when using the absolute increase criterion. The creatinine variation from baseline was not significantly different between groups. After adjusting for baseline factors, contrast use did not correlate with worse renal function. The rate of CA-AKI is very low, if present at all, with newer ICMs, and excessive caution regarding contrast use is probably unwarranted.

Determinants associated with carpal tunnel syndrome complaints

Introduction: Carpal Tunnel Syndrome (CTS) is one of the most common problems in the upper extremities caused by the narrowing of the carpal tunnel, which results in pressure on the median nerve. Increased pressure in the carpal tunnel causes compression and damage to the median nerve. Objective: determinants associated with carpal tunnel syndrome . Methods: quantitative research with a cross-sectional research design. The sampling technique in this study used a total sampling technique in which the entire population is equal to the number of samples, namely 36 people. Data obtained by using a questionnaire. The analytical method used was univariate and bivariate analysis using the chi-square test. Result: showed that there was a relationship between length of work and carpal tunnel syndrome (p-value = 0.0190. There is a relationship between age and complaints of carpal tunnel syndrome (p-value = 0.032. There is no relationship between personal protective equipment and complaints of carpal tunnel syndrome (p-value = 0.759). There is no relationship between repetitive movements and carpal tunnel syndrome (p-value = 0.787. Conclusion: It was concluded that there is a relationship between length of service and carpal tunnel syndrome complaints, there is a relationship between age and carpal tunnel syndrome complaints and there is no relationship between body mass index and carpal tunnel syndrome complaints . In this study, researchers suggest to companies to pay more attention to employees who have a long working period so as not to do excessive work and for employees to take advantage of adequate rest time to minimize the occurrence of complaints of Carpal Tunnel Syndrome (CTS).

Enhancing vehicular platoon stability in the presence of communication Cyberattacks: A reliable longitudinal cooperative control strategy

This study proposes a reliable longitudinal distributed control strategy for connected and automated vehicles (CAVs) in the presence of communication cyberattacks. The proposed strategy is designed to utilize dependable measurements from onboard sensors to evaluate the reliability of vehicle-to-vehicle (V2V) information and enhance the platoon string stability in an integrated manner. Specifically, this paper proposes a real-time reliability evaluation mechanism for the ego vehicle based on sensing and communication information from multiple predecessors, employing an upper-tailed chi-squared test. The mechanism is then incorporated into a distributed multi-predecessor linear feedback controller to adaptively weigh the preceding vehicles’ information, ensuring robustness against cyberattacks and maintaining the string stability of the vehicular platoon. To better understand the whole framework, sufficient conditions of true string stability and pseudo string stability are theoretically derived, unveiling the disturbance amplification jointly impacted by measurement accuracy of onboard sensors, cyberattack severity in V2V communication, and control parameters. Numerical experiments are conducted to validate the controller across various types of communication cyberattacks. The results suggest that the proposed control strategy can significantly alleviate the impact of cyberattacks and simultaneously dampen traffic oscillations effectively.

Education has a significant effect on the performance of implementing nurses in hospitals

Introduction: Higher education typically gives nurses a more profound knowledge of healthcare practices and recent developments and enhances nurses' analytical and problem-solving abilities, enabling them to provide more effective care. Aim: Knowing education significantly affects the performance of implementing nurses in hospitals. Methods: The research design is qualitative analytical descriptive research with a cross-sectional approach. The population is all nurses working in the internal care room, and as many as 50 responses using the sampling technique are total sampling. Results: Showing the chi-square test with the level of meaning (α) = 0.05, obtained p value = 0.003, education significantly influences the implementing nurse's performance. Conclusion: Education significantly influences the performance of implementing nurses, and continuing education can be an effective strategy for improving the standard of health care in hospitals. Nurses with higher education tend to have better clinical knowledge and skills, enabling them to provide higher-quality care.

Bone mineral density and osteoporosis related risk factors in type 2 diabetes mellitus

Diabetes mellitus negatively affects bone tissue and unfavourably impacts bone mineral density (BMD), therfore increasing the probability of fractures through pathological mechanisms. This study aimed to explore the factors associated with BMD and osteoporosis risk in individuals with a diagnosis of type 2 diabetes mellitus (T2DM). An investigation was undertaken involving 49 patients diagnosed with T2DM who fulfilled the specified criteria. These individuals underwent BMD assessment as part of a cross-sectional study. The analysis encompassed both univariate and bivariate approaches, utilizing the Chi-square test (X2) and binary logistic regression methods. A total of 30 participants (61%) have decreased BMD. Among the participants aged 60 years and above, 83.4% exhibited a decreased BMD status (osteopenia and osteoporosis), in contrast to the under 60 years age group, in which 40% displayed decreased BMD status. Older age (>60 years) is a risk factor for decreasing bone density onset of diabetes mellitus (DM) diagnosis, duration of DM, glycemic control, body mass index (BMI), use of thiazolidinediones (TZD) drugs, kidney function, were not associated with lower BMD in T2DM patients.

Association of genetic polymorphism of interleukin 1-alpha and interleukin 1-beta with external apical root resorption in orthodontic patients

Objective > To assess the allele rs 1143634 in IL-1β and rs1800587 in IL-1α in patients for orthodontically induced external apical root resorption (EARR).Material and methods > Intra-oral periapical radiograph (IOPA) of maxillary incisors of 142 Patients were evaluated for resorption at two time points; before the start of fixed mechanotherapy (T1) and after one year of treatment (T2). The individuals with root resorption< 2mm were categorized as a control group(Group 1; n=90), and resorption >2mm were categorized as case group (Group 2; n=52). Buccal swabs of all patients were taken and DNA could be isolated in 95 out of 142 samples (group 1 {n=58}, group 2 {n=37}) which were then screened for the selected two polymorphic targets to determine the nucleotide status of these targets. Tetra-primer ARMS PCR reactions were carried out using all 4 primers for each polymorphism.Results > rs11800587 was not associated with risk of EARR in any inheritance model. Chi-square test for association of alleles with EARR revealed that rs1143634 was associated with the risk of EARR in an allelic model in such a way that A allele of this SNP increased the risk of EARR 4 folds [OR = 4.375; p=0.016]. However, the adjusted level of significance using the Holm-Bonferroni method for rs1143634 was p<0.010 for A and G comparison rendering the results non-significant.Conclusion > SNP rs1143634 and SNP rs11800587 were not associated with risk of EARR in any inheritance model.

Family's Perceived Needs and Satisfaction with Intensive Care Services: A Questionnaire-based Prospective Observational Study.

Holistic intensive care management involves the treatment of critically ill patients in the intensive care unit (ICU) as well as catering to family psychosocial needs helping in bettering satisfaction/perception of care. There is scarce data in the Indian intensive care setting regarding the same, especially in times of increasing end-of-life practices. Our study aimed to determine the factors impacting family perception/satisfaction with intensive care. A total of 336 family bystanders of patients in ICU with more than 72 hours of stay were surveyed using family satisfaction in the ICU 24 revised (FS-ICU 24R) questionnaire. Multivariable logistic regression analysis showed that the significant factors associated with the satisfaction among bystanders of ICU patients were the treatment of patient's physical symptoms like pain/breathlessness (Adjusted OR 3.73, p = 0.003), ICU staff's approach to family's need consideration (Adjusted OR 4.44, p < 0.001), concern and care towards patients' family (Adjusted OR 2.67, p = 0.023). Participation in patient care, ICU waiting room atmosphere, and emotional support are the other factors independently associated with satisfaction with ICU care. Family satisfaction was not associated with the patient's survival (p = 0.331, Chi-square test) or the length of ICU (p = 0.328, Chi-square test) and hospital stay (p = 0.865, Chi-square test). Treatment of a patient's physical symptoms like pain, approach to family's needs consideration, and concern/care towards the patient's family are independent factors associated with optimal satisfaction among family members of ICU patients, which even takes precedence over the survival outcomes or length of ICU stay. Atri V, Bhatt MT, Chaudhuri S, Mitra A, Maddani SS, Ravindranath S. Family's Perceived Needs and Satisfaction with Intensive Care Services: A Questionnaire-based Prospective Observational Study. Indian J Crit Care Med 2024;28(5):483-494.

Relationship between body mass index and degree of adult psoriasis

Because of the current inconsistencies in the association between body mass index (BMI) and psoriasis severity, this study aimed to determine aforementioned association. This analytical observational study was conducted in a private hospital in West Java between August and December 2023 using data from medical records of 108 psoriasis cases recruited by simple random sampling. Data were collected on demographic characteristics (age, gender), BMI, and psoriasis severity. BMI was divided into categories following the WHO Asia Pacific region classification. Psoriasis severity was categorized as mild, moderate, and severe, and determined by means of Psoriasis Area and Severity Index (PASI) scores. Data were analyzed by independent t test and Chi-squared tests. Mean age (± SD) of psoriasis subjects was 40.1 ±12.4 years, the most frequent gender was female with 73 (67.6%) subjects, and mean BMI was 25.2 ± 3.3 kg/m2. Fifty-six (51.9%) subjects were obese according to BMI, 24 (22.2%) subjects were overweight, and 28 (25.9%) subjects were of normal weight. A total of 47 (43.5%) subjects had severe psoriasis, followed by moderate psoriasis in 36 (33.3%) subjects, and mild psoriasis in 25 (23.1%) subjects. There was no significant correlation of BMI with psoriasis severity in subjects of productive age (p = 0.249). Healthy lifestyle and weight control are necessary in the management strategy of persons with psoriasis, because of the high prevalence of persons with psoriasis and obesity.

Mother's intention to provide balanced nutritious food to children 6-24 months

Context: The nutritional problem in Indonesia based on SSGI in 2021 is 24.4%, while underweight is 17% and wasted is 7.1% [1]. When compared to the WHO standard regarding the amount of stunting prevalence that is not a problem, which is 20%, the prevalence rate is still considered high and efforts are needed to reduce the prevalence. In Surabaya City, it is known that there are underweight toddlers (BB/U) as much as 7.5%, short toddlers (TB/U) as much as 4.8%, wasting toddlers (BB/TB) as much as 6.1%, and overweight toddlers (BB/TB) as much as 3.4% [2]. Methodology: This research is a cross-sectional descriptive study. The sample size in this study used a saturated sample or the entire population was used as a sample, namely 61 people. Data analysis used in this study is using the chi-square test. Results: Statistical test results of knowledge with intention showed a ρ-value (0.349) &gt; 0.05 which means that there is no relationship. Data analysis regarding the relationship between respondents' attitudes and intentions shows a ρ-value (&lt;0.001) &lt;0.05, which means that there is a relationship. Data analysis regarding the relationship between respondents' subjective norms and intentions shows a ρ-value (0.008) &lt; 0.05, which means that there is a relationship. Data analysis regarding the relationship between respondents' perceived behavioral control and intention shows a ρ-value (0.004) &lt;0.05, which means that there is a relationship. Conclusion: From the results of the study it can be concluded that there is a relationship between attitude, subjective norms, perceived behavioral control with maternal intention. Conversely, the results showed no relationship between knowledge and mothers' intention in providing balanced nutritious food to children.

Efficacy of antioxidants in the management of psoriasis: A case control study

Introduction: Psoriasis is a chronic, immune-mediated inflammatory dermatosis. The pathophysiology of the disease is still incompletely elucidated and multiple factors are said to be involved in its initiation and perpetuation, e.g., stressors, genetic factors, environmental factors. In the last decade, a new theory is trying to explain the pathophysiology of this disease by looking at the role played by oxidative stress and chronic inflammation in the initiation of keratinocyte proliferation and differentiation. Keeping in consideration the increased oxidative stress in the patients of psoriasis, the anti-oxidant drugs can form an important part of the therapeutic ladder of psoriasis. Materials and Methods: The aim of this study was to measure the possible role of oxidative stress in psoriasis patient by measuring SOD level and comparing it with normal individuals and administer antioxidants supplements to the patients group to see the efficacy. It was a Case- Control study (1st part) and Clinical Trial without control group (2nd part). The study was carried out in Psoriasis awareness Club from June 2023 to December 2023. Purposive sampling done who fulfill the inclusion &amp; exclusion criteria. 23 patients with psoriasis and 23 age and sex matched control subjects were recruited for this study. Clinical severity of the disease was determined by PASI score. All patients and control subjects were examined for plasma SOD level. 23 psoriatic patients were given antioxidant therapy in the form of once daily tablet for 30 days. PASI score, DLQI and SOD (Superoxide dismutase) level were measured before therapy (day 0) and after therapy (day 30) in patients group. Statistical analysis and Results: Data were expressed as mean ± standard deviation (SD) for quantitative variables and numbers. For comparison of two means (t test) and (ANOVA "F") test were used for several means. Chi-square (χ2 ) or fisher exact test were used when appropriate, (P&lt;0.05) was considered statistically significant. The mean age of the patients and control subjects were 37.64 (±5.89) and 33.6 (11.02) years, respectively. The mean duration of the disease was 12.43 (±8) years. No significant difference was observed between SOD level of psoriatic patients &amp; controls. No significant correlations of SOD level with severity of psoriasis and duration of disease were found. We observed no statistically significant difference in PASI and DLQI scores before and after antioxidant therapy but there was significant increase in the level of SOD after treatment. Conclusion: It is indisputable that antioxidant supplementation can reduce the overall morbidity, enhance the prognosis of psoriasis. Notably, in most cases, antioxidants alone are not able to induce significant clinical changes in the aspect and/or course of the disease, except perhaps in mild forms. They must be used in conjunction with standard pharmacological treatments to achieve measurable results.

The ABO blood group antigens in patients with oral lichenoid reaction.

Evaluating the association of ABO blood group with different delayed hypersensitivity reactions, such as oral lichenoid reaction (OLR), can provide a new perspective for clinical practice. Therefore, this study designed to investigate ABO blood group antigens in OLR patients. In this case-control study, the ABO blood group of 112 OLR patients and 117 individuals without oral lesions were included. Gender, age, characteristics of the lesions, medications and restorative materials recorded. Chi-square test used to compare the frequency of ABO blood groups in OLR patients with controls. The O blood group was significantly higher in OLR patients and all its subtypes. Also, there were significant relation between O blood group, and severity of lesions. The frequency of dysplasia was non-statistically significant higher in OLR patients with O blood group than other blood group. Based on the results of the present study, O blood group was significantly more in patients with lichenoid reaction than control group, and AB blood group was the lowest. Also, O blood group showed a positive association with the more severe form of OLR lesions and frequency of dysplasia.

Self-medication of Dental Pain amongst Medical Students in Jeddah, Saudi Arabia: Determinants, Attitude and Clinical Aspects

Abstract Introduction: Healthcare students are becoming increasingly concerned about self-medication (SM), which can have major health repercussions. It affects how future physicians make professional decisions about medications. Such a mindset has an indirect impact on providing their patients with appropriate counselling. The study was planned to investigate the attitude, determinants and different clinical aspects associated with SM of dental pain amongst medical students in Jeddah, Saudi Arabia. Materials and Methods: The present descriptive cross-sectional study was conducted exclusively on the 400 medical students from the 1st year and interns pursuing bachelor’s degrees from various medical colleges in Jeddah, Saudi Arabia. A convenient non-probability sampling technique was employed, and a pre-tested/pre-validated questionnaire was loaded on Google Forms and sent to the medical students of medicine, dentistry, pharmacy and nursing programmes. Qualitative characteristics were assessed using the Chi-square test. The significance level (P value) chosen for the various comparisons was P &lt; 0.05. Results: The results of this study show that 65.5% of students self-medicate. It was significantly more common in women (74.9%), pharmacists (76.9%) and dental students (72.7%). Students who self-medicated less often were in the 1st and 2nd years (49.2% and 57.1%). Toothache was the most common cause for which they self-medicated (79.8%). Conclusion: The results of the present study have shed light on the fact that SM was high amongst medical students in Jeddah. The potential problems associated with self-medication should be highlighted to students to reduce the risk of inappropriate SM, which can seriously harm both students and others to whom they prescribe medication.

Is Chinese Medicine Facing a Potential Workforce Crisis in Australia? Demographic Changes in the Profession over the Last Decade.

Background: As a prominent part of complementary and alternative medicine, Chinese Medicine (CM) has proved its strengths in treating a diverse range of acute and chronic medical conditions and is at present recognized in 196 countries and territories worldwide. In 2012, Australia regulated the CM profession under the National Regulation and Accreditation Scheme (NRAS) by legislation and reports quarterly demographic information about individual CM practitioners so to ensure public interest, although research examining the change of CM workforce in Australia has been scarce. Objective: This study aims to investigate the construction of the CM workforce in Australia and more importantly, evaluated its development in the last decade to capture the trajectory and trend in the present period and future potential changes. Methods: Data were sourced from the Australian Health Practitioner Regulation Agency (AHPRA) annual reports and the Chinese Medicine Board of Australia (CMBA) registration statistics from 2012 to 2023. A descriptive analysis was conducted with demographic variables, including profession, age, and gender, and chi-square tests and linear regression modeling were carried out to assess the variations between regions and across years. Results: The population of CM practitioners in 2022/2023 stagnated with slight decrease to 4,823, in contrast to the increase rate of 2.9% in the whole health care community. The number of young CM registrants (<35 y) shrank by 37.5% from 691 in 2012 to 432 in 2023. In comparison with other health care professions, CM comprises the smallest proportion of the population aged younger than 25 (0.2%) and the largest proportion aged older than 65 years (16.2%), advancing into an aging era. Conclusions: This study indicates a worrying potential decline in CM workforce in Australia, which is likely to be further exacerbated by the lack of new graduates and rise of median age among practitioners. Meanwhile, continued advancement in Western medicine technology and standards requires substantial efforts to increase both a better understanding of CM and demonstration of its efficacy. Furthermore, greater effort is needed to recruit and educate new young CM practitioners in Australia and to broaden the international training pipeline for a sustainable development of CM practice.

Survival outcomes of radium-223 therapy for metastatic castration-resistant prostate cancer following national health insurance reimbursement in Taiwan.

Radium-223 dichloride (Ra-223) prolongs overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) with symptomatic bone metastases. However, there is considerable variation in outcomes among individuals. We aimed to evaluate the prognostic determinants associated with patient survival following National Health Insurance (NHI) reimbursement for Ra-223 therapy in Taiwan. Patients with mCRPC who underwent Ra-223 treatment at Taipei Veterans General Hospital were retrospectively enrolled. Each intravenous Ra-223 dose was administered at 55 kBq/kg at four-week intervals. Clinical outcomes were obtained from medical records; potential prognostic factors for survival were assessed. Kaplan-Meier analysis was used to generate cumulative survival curves; between-group differences were evaluated using the Chi-squared test. Statistical significance was set at p < 0.05. Seventy-six patients underwent Ra-223 therapy; 62 patients received NHI reimbursement and the remainder self-paid. Fifty patients (65.8%) completed six cycles of treatment; 26 (34.2%) received 1‒5 cycles. Mortality occurred in 47 patients. Factors significantly associated with survival included ≦ five bone metastases (p = 0.0018), baseline prostate-specific antigen (PSA) ≦ 36 ng/mL (p = 0.0004), baseline alkaline phosphate (ALP) < 115 U/L (p = 0.0007), and baseline hemoglobin (Hb) > 12 g/dL (p = 0.0029). Patients who completed six cycles of treatment achieved significantly higher OS compared to those who did not (p < 0.0001). There has been a 4.4-fold increase in the number of patients since reimbursement began; there was no significant difference in OS between patients who received NHI reimbursement and those who self-paid. Administration of Ra-223 demonstrates considerable potential to extend the survival of patients with mCRPC. Survival outcomes may be influenced by various prognostic factors. However, no significant difference in OS was observed subsequent to reimbursement of Ra-223 therapy for mCRPC through the NHI system in Taiwan.

Distinct CT imaging features of new liver metastases from primary genitourinary cancers.

To apply natural language processing (NLP) to a large volume of structured radiology reports in the investigation of CT imaging features of new liver metastases from primary genitourinary cancers. In this retrospective study, a previously reported NLP model was applied to consecutive structured CT reports from 2016 to 2022 to predict those patients with primary genitourinary cancer who developed liver metastasis. Pathology or imaging follow-up served as the reference standard for validating NLP predictions. Subsequently, diagnostic CTs of the identified patients were qualitatively assessed by two radiologists, whereby several imaging features of new liver metastasis were assessed. Proportions of the assessed imaging features were compared between primary genitourinary cancers using the Chi-square or Fisher's exact test. In 112 patients (mean age = 72years; 83 males), the majority of new liver metastases were hypovascular (73.2%), well defined (76.6%), homogenous (66.9%), and without necrotic/cystic component (73.2%). There was a higher proportion of iso- to hyperdense liver metastases for primary kidney cancer vs other primary genitourinary cancers (42.5% in kidney cancer; 2.3% in ureter/bladder cancer, 8% in prostate cancer, and 0% in testicular cancer; p < 0.05) and a higher proportion of new liver metastases with ill-defined margin for primary prostate cancer vs other primary genitourinary cancers (44.0% in prostate cancer, 15.0% in kidney cancer, 18.6% in ureter/bladder cancer, and 25.0% in testicular cancer; p < 0.05). New liver metastases from primary genitourinary cancers tend to be hypovascular and show several distinct imaging features between different primary genitourinary cancers.

Antepartum Intimate Partner Violence: Development of a Risk Prediction Model.

Objectives: To explore socio-behavioral, clinical, and imaging findings associated with antepartum intimate partner violence (IPV) and aid in risk stratification of at-risk individuals. Methods: We analyzed electronic medical records during indexed pregnancies for 108 pregnant patients who self-reported antepartum IPV (cases) and 106 age-matched pregnant patients who did not self-report antepartum IPV (controls). Sociodemographic, clinical, and radiology data were analyzed via chi-squared and Fisher's exact tests with p < 0.05 as the threshold for significance. Stepwise logistic regression was applied to derive a risk prediction model. Results: The proportion of cases reporting emotional IPV (76% vs. 52%) and/or physical IPV (45% vs. 31%) during pregnancy significantly increased from prior to pregnancy. Cases were significantly more likely to report prepregnancy substance use (odds ratio [OR] = 2.60; 95% confidence interval [CI]: 1.13-5.98), sexually transmitted infections (OR = 3.48; 95%CI: 1.64-7.37), abortion (OR = 3.17; 95%CI: 1.79, 5.59), and preterm birth (OR = 5.97; 95%CI: 1.69-21.15). During pregnancy, cases were more likely to report unstable housing (OR = 5.26; 95%CI: 2.67-10.36), multigravidity (OR = 2.83; 95%CI: 1.44-5.58), multiparity (OR = 3.75; 95%CI: 1.72-8.20), anxiety (OR = 3.35; 95%CI: 1.85-6.08), depression (OR = 5.58; 95%CI: 3.07-10.16), substance use (OR = 2.92; 95%CI: 1.28-6.65), urinary tract infection (UTI) (OR = 3.26; 95%CI: 1.14-9.32), intrauterine growth restriction (OR = 10.71; 95%CI: 1.35-85.25), and cesarean delivery (OR = 2.25; 95%CI: 1.26-4.02). Cases had significantly more OBGYN abnormalities on imaging and canceled more radiological studies (OR = 5.31). Logistic regression found housing status, sexually transmitted infection history, preterm delivery history, abortion history, depression, and antepartum UTI predictive of antepartum IPV. The risk prediction model achieved good calibration with an area under the curve of 0.79. Conclusions: This study identifies significant disparities among patients experiencing antepartum IPV, and our proposed risk prediction model can inform risk assessment in this setting.

Relationship between Social Participation and Cognitive Impairment in Low-Educated Older Adults Based on Indonesian Family Life Survey-5.

The increasing older adult population requires attention in terms of education and health, as higher education levels contribute to cognitive reserve and may protect against age-related cognitive impairment. Cognitive reserve is an individual's cognitive flexibility in using cognitive functions affected by brain aging, neurological diseases, and injury. Indonesia has a high prevalence of low-educated older adults, which strongly correlates with progressive cognitive impairment. Identifying risk factors for cognitive decline in this population is crucial. This study determines the factors affecting cognitive impairment in low-educated older adults using cross-sectional data from the Indonesian Family Life Survey-5. This descriptive study analyzed 2,313 low-educated older adults ≥60 years old. Univariate and bivariate analyses were used to describe the sample and identify the relationships between categorical variables. Logistic regression identified the most significant factor affecting cognitive impairment. The prevalence of cognitive impairment in low-educated older adults is 22.6%. The chi-square test revealed significant relationships between those who are aged 75 years, a status other than married, female, living in rural areas, and not participating in social activities. Age is the most prominent factor affecting cognitive impairment in such adults (P<0.001; adjusted odds ratio, 3.232; 95% confidence interval, 2.500-4.180). Cognitive impairment in the aforementioned adults is associated with being ≥75 years old, being a status other than married, being female, living in rural areas, and not participating in social activities. After controlling other variables, low-educated older adults who participated in at least ≥1 social activity in the last 12 months experienced cognitive impairment 0.64 times compared to those who did not participate in social activities.