ObjectiveMaintaining plasma glucose homeostasis is vital for mammalian survival, but the masticatory function, which influences glucose regulation, has been overlooked. Research Methods & ProceduresIn this study, we investigated the relationship between the glycaemic response curve and chewing performance in a group of 8 individuals who consumed 80 grams of apple. A device called "Chewing" utilizing electromyographic (EMG) technology quantitatively assesses chewing pattern, while glycemic response is analysed using continuous glucose monitoring. We assessed chewing pattern characterizing chewing time (tchew), number of bites (nchew), work (w), power (wr), and chewing cycles (tcyc). Moreover, we measured the principal features of the glycaemic response curve, including the area under the curve (α) and the mean time to reach the glycaemic peak (tmean). We used linear regression models to examine the correlations between these variables. Resultstchew, nchew, and wr were correlated with α (R2 = 0, 44, p < 0, 05 for tchew and nchew, p < 0, 001 for wr), and tmean was correlated with tchew (R2 = 0, 25, p < 0, 05). These findings suggest that increasing chewing time and power, while reducing the number of chews, resulted in a wider glycaemic curve and an earlier attainment of the glycemic peak. ConclusionsThese results emphasize the influence of proper chewing techniques on blood sugar levels. Implementing correct chewing habits could serve as an additional approach to managing the glycaemic curve, particularly for individuals with diabetes.