Abstract Introduction/Objective As of March 5th, 2022, the novel coronavirus disease 2019 (COVID-19) has been confirmed in 464,809,377 people worldwide, with an approximately 1.31% mortality rate. COVID-19 infection is associated with an aggressive inflammatory response and release of a large amount of pro-inflammatory cytokines known as “cytokine storm.” Cytokine storm is the release of interferons, interleukins, tumor necrosis factors, chemokines, and several other mediators. Chemokines are small protein molecules that act as chemoattractants, leading to the migration of immune cells to an infection site so they can target and destroy invading bodies such as microbes. The Duffy antigen is a broad receptor of chemokines in human blood. Early on, it was found that the overwhelming majority of people of African descent had the erythrocyte phenotype Fy(a-b-) (henceforth Duffy (-)): 68% in African Americans and 88-100% in African people (including more than 90% of West African people). Methods/Case Report Subjects under study: This retrospective cohort study analyzed the data from total patients with confirmed COVID-19 infection in the US through March 5th, 2022.The US population 13.4% black, non-Hispanic, 76.3% white, non-Hispanic, Asian 5.9%, 18.5% Hispanic or Latino, and 4.3 all other races. The primary outcomes were hospitalization and in-hospital death. Results (if a Case Study enter NA) Results: A total of 79,555,007 patients in the US were tested Covid-19 positive and 968,839 mortalities with a death rate of 1.21%. 661,678 deaths were excluded because they did not have racial details. Among the 968,839 patients who died of Covid-19, 411,078 (62.1%) were white, 89,784 (13.6%) were black, 114,455 (17.3%) were Hispanic or Latino, 5,970(4.2%) were Asian and 7,045(4.8%) all other races. The actual death rate per 100,000 is 313 in white, 330 in black, 254 in Hispanic or Latino, 156 in Asian, and 276 in all other races. Conclusion Despite black Americans representing only 13.4% of the total population, they have been heavily hit by the COVID-19 pandemic. The reasons for the especially severe forms of the disease in Black Americans have not been fully uncovered. People with the Duffy (-) phenotype are a high-risk group for the Chemokine Storm. One hypothesis that arguably gives the blood group marker and chemokine decoy receptor Duffy protein plays a central role in stimulating the Chemokine Storm as present in the severe forms of the COVID-19 disease.