Abstract The Cenozoic collision of India and Eurasia clearly built the high-elevation Tibetan Plateau, but how this collision was accommodated, and the Tibetan Plateau uplifted, remains an area of study. The widespread occurrence of Cenozoic potassic-ultrapotassic lavas provides a valuable opportunity to constrain the relationship between surface deformation and underlying geodynamic processes. In this study, we report sanidine Ar–Ar dating, whole-rock geochemical and clinopyroxene Sr–Nd isotope analyses on pseudoleucite phonolites from the Yulinshan area of south Qiangtang (central Tibet) to determine their petrogenesis and regional tectonic significance. Sanidine Ar–Ar dating yields an Early Oligocene age of ca. 30 Ma, in agreement with previous studies. A high modal abundance of pseudoleucite in the samples indicates their ultrapotassic and silica-undersaturated composition. All of the rocks have typical arc-like geochemical signatures and enriched whole rock and clinopyroxene Sr–Nd isotope signatures. Based on thermodynamic phase equilibria modeling and our detailed study of the textural and in-situ compositional information of clinopyroxene, the intermediate to felsic potassic magmas are interpreted to have been formed through differentiation of primitive, mantle-derived, potassic magmas at shallow crustal levels. The inferred enrichment of the lithospheric mantle is probably related to subduction of the Songpan-Ganze continental lithosphere beneath Qiangtang after India-Asia collision. Voluminous Late Eocene-Early Oligocene magmatism in central Tibet may reflect partial removal of the mantle lithosphere, perhaps triggered by instabilities associated with previous lithospheric thickening. Our work provides additional constraints on the timing of mantle root loss that likely contributed to the surface uplift of central Tibet, which post-dated the cessation of upper crustal shortening and deformation.