The construction of an island airport on a coral reef will inevitably encounter wave, tidal and aircraft takeoff and landing loads. To study the dynamic response of the coral sand island airport under these loads, a 1:50 laboratory model test was conducted with Meiji Reef Airport as the engineering background. The model test studied the pore water pressure characteristics of the coral sand strata beneath the airport runway under wave loads with different wave heights, tidal loads with different tidal heights, and aircraft impact loads with different cyclic loading times. Additionally, the displacement characteristics of the coral sand strata beneath the airport runway under the aircraft impact loads with different cyclic loading times were also studied. The results show that the pore water pressure of coral sand strata under the airport runway decreases with the increasing offshore distance under the wave and tidal loads. The change of wave height has little influence on the pore water pressure of coral sand strata, while the change of tidal water level has a significant effect on it. As the number of aircraft impact load cycles increases, the cumulative excess pore pressure in the coral sand strata under the airport runway no longer increases and plastic deformation occurs. The research can provide a reference for the runway foundation treatment of the island airport under construction and planning.