Features Of EEG Signals Research Articles

Sparse discriminant manifold projections for automatic depression recognition

In recent years, depression has become an increasingly serious problem globally. Previous research have shown that EEG-based depression recognition is a promising technique to serve as auxiliary diagnosis methods that provide assistance to clinicians. Typically, in clinical studies, due to the multichannel nature of EEG, the extracted features usually are high-dimensional and contain many redundant information. Therefore, it is necessary to perform dimensionality reduction before classification to improve the performance of machine learning algorithms. However,existing dimensionality reduction techniques do not design the objective function based on the characteristics of EEG signal and the goal of depression recognition, so they are less suitable for dimensionality reduction of EEG features. To solve this problem, in this paper we propose a novel dimensionality reduction technique called sparse discriminant manifold projections(SDMP) for depression recognition. Specifically, the use of the ℓ2-norm instead of the squared ℓ2-norm as a similarity measure in the objective function reduces sensitivity to noise and outliers. Moreover, the local geometric structure and global discriminative properties of data are integrated, which makes the extracted features more discriminative. Finally, the ℓ2,1-norm regularization is introduced to achieve feature selection. Furthermore, The formulation is extended to the ℓ2,p-norm regularization case, which is more likely to offer better sparsity when 0<p<1. Extensive experiments on EEG data show that the SDMP achieves the competitive performance compared with other state-of-the-art dimensionality reduction methods. It also shows the practical application value of our method in detecting depression.

EEG-based patient-specific seizure prediction based on Spatial–Temporal Hypergraph Attention Transformer

Background and Objectives:Patient-specific seizure prediction based on Electroencephalogram (EEG) is a challenging and significant neuromedicine study, which could potentially safeguard drug-resistant patients from unforeseen risks in their daily lives. However, prevalent seizure prediction frameworks based on convolutional neural networks (CNNs) prioritize local information while overlooking long-range global dependencies and high-order spatial correlations prevalent among brain leads. Methods:To address the limitations above, we propose a novel Spatial–Temporal Hypergraph Attention Transformer (STHAT) framework for extracting the key features in EEG signals. Aimed at the characteristics of epilepsy EEG data, our framework comprises two primary branches: (1) Long-range Temporal Feature Dependencies: This branch aims to capture temporal dependencies within EEG signals by leveraging Swin Transformer and 2D-CNN. Utilizing shifting windows and convolution operations, we encode local and global content dependencies within segmented EEG samples. (2) High-Order Spatial Information Correlations: We construct a raw graph structure using the Pearson correlation coefficient, enabling the extraction of initial node embeddings through graph convolution operations (GCO). Subsequently, a dynamic hypergraph is formed using K-Nearest Neighbors (KNN) and K-means clustering, allowing us to employ a Hypergraph Attention Network (HAN) to capture structural context relationships among brain regions. By integrating information from both branches, we utilize a linear layer to derive the final seizure prediction outcome. Experiment and Results:Extensive evaluations are conducted on the widely used CHB-MIT dataset. Our comprehensive experimental results demonstrate the effectiveness of the proposed framework in achieving superior performance in automatic seizure data prediction, outperforming state-of-the-art algorithms. The STHAT framework effectively exploits both temporal and spatial information within EEG signals, enhancing seizure prediction accuracy.

Time–frequency domain machine learning for detection of epilepsy using wearable EEG sensor signals recorded during physical activities

Epilepsy is a neurological ailment in which there is a disturbance in the nerve cell activity of the brain, causing recurrent seizures. The electroencephalogram (EEG) signal is widely used as a diagnostic modality to detect epilepsy ailment. The automated detection of epilepsy using wearable EEG sensor data recorded during various physical activities is interesting for continuous monitoring of brain health. This paper proposes a time–frequency (TF) domain machine learning (ML) approach for the automated detection of epilepsy using wearable sensor-based EEG signals. The Gaussian window-based Stockwell transform (GWST) is employed to evaluate the TF matrix from the EEG signal. The features such as the L1-norm and the Shannon entropy are extracted from the TF matrix of the EEG signal. The ML and deep learning (DL) models are employed to detect epilepsy using the TF domain features of EEG signals. The publicly available database containing wearable sensor-based EEG signals recorded from the subjects while performing different physical activities is used to evaluate the performance of the proposed approach. The results show that the random forest (RF) classifier coupled with GWST domain features of EEG signals has obtained an overall accuracy value of 90.74% for detecting epilepsy with hold-out validation using the EEG signals from different physical activity cases. For the 10-fold cross-validation (CV) case, the GWST domain features of EEG signal and multi-layer long short-term memory (LSTM) classifier have produced the average accuracy value of 74.44%. For jogging, running, and idle sitting activities, the GWST-based TF domain entropy features coupled with the multi-layer LSTM model have obtained accuracy values of 82.72%, 82.41%, and 87.30%, respectively. The proposed approach has achieved higher classification accuracy than existing methods to detect epilepsy using wearable sensor-based EEG signals using a 10-fold CV strategy. The suggested approach is compared with existing methods to classify seizure and seizure-free classes using resting-state EEG signals.

Research on underwater target recognition based on auditory EEG signal features and deep learning

Target recognition is a key technical link in hydroacoustic detection, which has a broad application prospect in the fields of marine safety and resource exploration. In recent years, artificial involvement of underwater target recognition methods based on analysis of line spectra, auditory spectra and other characteristics are broadly utilized in actual engineering applications, with their unique characteristics. Meanwhile, the learning tasks of human-computer interaction have been widely used, for machine learning and deep learning are also developing rapidly. Therefore, in this paper, auditory EEG signals under the excitation of underwater targets' signals are used to carry out recognition research by combining human brain perception, artificial analysis, SVM and ResNet with atrous convolution. The results show that the recognition rate of four types of ship radiated noise can reach 94.35% using the ResNet with atrous convolution, which can effectively classify and recognize underwater targets.

MAS-DGAT-Net: A dynamic graph attention network with multibranch feature extraction and staged fusion for EEG emotion recognition

In recent years, with the rise of deep learning technologies, EEG-based emotion recognition has garnered significant attention. However, most existing methods tend to focus on the spatiotemporal information of EEG signals while overlooking the potential topological information of brain regions. To address this issue, this paper proposes a dynamic graph attention network with multi-branch feature extraction and staged fusion (MAS-DGAT-Net), which integrates graph convolutional neural networks (GCN) for EEG emotion recognition. Specifically, the differential entropy (DE) features of EEG signals are first reconstructed into a correlation matrix using the Spearman correlation coefficient. Then, the brain-region connectivity-feature extraction (BCFE) module is employed to capture the brain connectivity features associated with emotional activation states. Meanwhile, this paper introduces a dual-branch cross-fusion feature extraction (CFFE) module, which consists of an attention-based cross-fusion feature extraction branch (A-CFFEB) and a cross-fusion feature extraction branch (CFFEB). A-CFFEB efficiently extracts key channel-frequency information from EEG features by using an attention mechanism and then fuses it with the output features from the BCFE. The fused features are subsequently input into the proposed dynamic graph attention module with a broad learning system (DGAT-BLS) to mine the brain connectivity feature information further. Finally, the deep features output by DGAT-BLS and CFFEB are combined for emotion classification. The proposed algorithm has been experimentally validated on SEED, SEED-IV, and DEAP datasets in subject-dependent and subject-independent settings, with the results confirming the model's effectiveness. The source code is publicly available at: https://github.com/cvmdsp/MAS-DGAT-Net

Enhancing Motor Imagery Classification in Brain–Computer Interfaces Using Deep Learning and Continuous Wavelet Transform

In brain–computer interface (BCI) systems, motor imagery (MI) electroencephalogram (EEG) is widely used to interpret the human brain. However, MI classification is challenging due to weak signals and a lack of high-quality data. While deep learning (DL) methods have shown significant success in pattern recognition, their application to MI-based BCI systems remains limited. To address these challenges, we propose a novel deep learning algorithm that leverages EEG signal features through a two-branch parallel convolutional neural network (CNN). Our approach incorporates different input signals, such as continuous wavelet transform, short-time Fourier transform, and common spatial patterns, and employs various classifiers, including support vector machines and decision trees, to enhance system performance. We evaluate our algorithm using the BCI Competition IV dataset 2B, comparing it with other state-of-the-art methods. Our results demonstrate that the proposed method excels in classification accuracy, offering improvements for MI-based BCI systems.

Detection of sleep arousal from STFT-based instantaneous features of single channel EEG signal.

Sleep arousal, a frequent interruption in sleep with complete or partial wakefulness from sleep, may indicate a breathing disorder, neurological disorder, or sleep-related disorders. These phenomena necessitate the detection of sleep arousals. Uses of deep learning methods to detect features inhibits the scope to understand the specific distinctive nature of the signals and reduces the interpretability of the model. To evade these inconsistencies and to improve the classification performance of the sleep arousal detection model, a model has been proposed in this study on the prospect of understandable features that are useful in detecting sleep arousals. &#xD;Approach: Time-frequency analysis of the electroencephalogram (EEG) signals was performed using Short-Time Fourier Transform (STFT). From the STFT coefficients, the spectrogram and instantaneous properties (frequency, bandwidth, power spectrum, band energy, local maxima, and band energy ratios) were investigated. From these properties, instantaneous features were generated by statistical analysis. Additive feature sets and reduced feature sets, formed by adding features successively and reducing features using the analysis of variance test respectively, were subjected to a tri-layered neural network classifier to evaluate the capability of the features to detect sleep arousal and normal sleep segments. &#xD;Main results: The reduced feature set (Set 6) has proved to be efficacious in facilitating superior classification performance metrics (accuracy, sensitivity, specificity, and AUC of 89.14%, 83.52%, 89.49%, and 93.84% respectively). &#xD;Significance: This efficient model can be incorporated with an automatic sleep apnea detection system where the estimation of hypopnea requires the detection of sleep arousal.&#xD;&#xD.

Fatigue Driving State Detection Based on Spatial Characteristics of EEG Signals

Fatigue Driving State Detection Based on Spatial Characteristics of EEG Signals

Comprehensive EEG Signal Feature Extraction for Neurological Disorder Diagnosis: Focus on Alzheimer's, Parkinson's, and Seizure Disorders

This research paper examines the use of Electroencephalogram (EEG) signal feature extraction for diagnosing neurological disorders, specifically Alzheimer's, Parkinson's, and seizure disorders. It evaluates various methods for categorizing EEG signals, including time-domain, frequency-domain, and statistical transformations emphasizing their effectiveness in distinguishing relevant brainwave patterns (beta, alpha, theta, delta) from artifacts like eye blinks and muscle movements. The study highlights the challenges in artifact removal and provides an overview of key feature extraction techniques, particularly in the time and frequency domains. The implementation section details the application of machine learning algorithms to classify mental states using statistical features from EEG signals. The research identifies specific EEG patterns associated with Alzheimer's, Parkinson's, and seizure disorders, noting alterations in alpha, theta, and delta waves. The paper underscores the critical role of EEG feature extraction in diagnosing neurological disorders and recommends incorporating additional frequency-based methods to enhance predictive accuracy in future research.

A Comprehensive Review of Hardware Acceleration Techniques and Convolutional Neural Networks for EEG Signals.

This paper comprehensively reviews hardware acceleration techniques and the deployment of convolutional neural networks (CNNs) for analyzing electroencephalogram (EEG) signals across various application areas, including emotion classification, motor imagery, epilepsy detection, and sleep monitoring. Previous reviews on EEG have mainly focused on software solutions. However, these reviews often overlook key challenges associated with hardware implementation, such as scenarios that require a small size, low power, high security, and high accuracy. This paper discusses the challenges and opportunities of hardware acceleration for wearable EEG devices by focusing on these aspects. Specifically, this review classifies EEG signal features into five groups and discusses hardware implementation solutions for each category in detail, providing insights into the most suitable hardware acceleration strategies for various application scenarios. In addition, it explores the complexity of efficient CNN architectures for EEG signals, including techniques such as pruning, quantization, tensor decomposition, knowledge distillation, and neural architecture search. To the best of our knowledge, this is the first systematic review that combines CNN hardware solutions with EEG signal processing. By providing a comprehensive analysis of current challenges and a roadmap for future research, this paper provides a new perspective on the ongoing development of hardware-accelerated EEG systems.

A Machine Learning Approach to Classifying EEG Data Collected with or without Haptic Feedback during a Simulated Drilling Task.

Artificial Intelligence (AI), computer simulations, and virtual reality (VR) are increasingly becoming accessible tools that can be leveraged to implement training protocols and educational resources. Typical assessment tools related to sensory and neural processing associated with task performance in virtual environments often rely on self-reported surveys, unlike electroencephalography (EEG), which is often used to compare the effects of different types of sensory feedback (e.g., auditory, visual, and haptic) in simulation environments in an objective manner. However, it can be challenging to know which aspects of the EEG signal represent the impact of different types of sensory feedback on neural processing. Machine learning approaches offer a promising direction for identifying EEG signal features that differentiate the impact of different types of sensory feedback during simulation training. For the current study, machine learning techniques were applied to differentiate neural circuitry associated with haptic and non-haptic feedback in a simulated drilling task. Nine EEG channels were selected and analyzed, extracting different time-domain, frequency-domain, and nonlinear features, where 360 features were tested (40 features per channel). A feature selection stage identified the most relevant features, including the Hurst exponent of 13-21 Hz, kurtosis of 21-30 Hz, power spectral density of 21-30 Hz, variance of 21-30 Hz, and spectral entropy of 13-21 Hz. Using those five features, trials with haptic feedback were correctly identified from those without haptic feedback with an accuracy exceeding 90%, increasing to 99% when using 10 features. These results show promise for the future application of machine learning approaches to predict the impact of haptic feedback on neural processing during VR protocols involving drilling tasks, which can inform future applications of VR and simulation for occupational skill acquisition.

An Improved EEG Signal Feature Selection Paradigm for Migraine Detection

An Improved EEG Signal Feature Selection Paradigm for Migraine Detection

SFT-SGAT: A semi-supervised fine-tuning self-supervised graph attention network for emotion recognition and consciousness detection

Emotional recognition is highly important in the field of brain-computer interfaces (BCIs). However, due to the individual variability in electroencephalogram (EEG) signals and the challenges in obtaining accurate emotional labels, traditional methods have shown poor performance in cross-subject emotion recognition. In this study, we propose a cross-subject EEG emotion recognition method based on a semi-supervised fine-tuning self-supervised graph attention network (SFT-SGAT). First, we model multi-channel EEG signals by constructing a graph structure that dynamically captures the spatiotemporal topological features of EEG signals. Second, we employ a self-supervised graph attention neural network to facilitate model training, mitigating the impact of signal noise on the model. Finally, a semi-supervised approach is used to fine-tune the model, enhancing its generalization ability in cross-subject classification. By combining supervised and unsupervised learning techniques, the SFT-SGAT maximizes the utility of limited labeled data in EEG emotion recognition tasks, thereby enhancing the model’s performance. Experiments based on leave-one-subject-out cross-validation demonstrate that SFT-SGAT achieves state-of-the-art cross-subject emotion recognition performance on the SEED and SEED-IV datasets, with accuracies of 92.04% and 82.76%, respectively. Furthermore, experiments conducted on a self-collected dataset comprising ten healthy subjects and eight patients with disorders of consciousness (DOCs) revealed that the SFT-SGAT attains high classification performance in healthy subjects (maximum accuracy of 95.84%) and was successfully applied to DOC patients, with four patients achieving emotion recognition accuracies exceeding 60%. The experiments demonstrate the effectiveness of the proposed SFT-SGAT model in cross-subject EEG emotion recognition and its potential for assessing levels of consciousness in patients with DOC.

A radial basis deformable residual convolutional neural model embedded with local multi-modal feature knowledge and its application in cross-subject classification

In the spatial cognition and emotion recognition tasks based on electroencephalography (EEG), the signal information representation of the single modal is incomplete because of the significant inter-subject differences in the EEG signals, resulting in low generalization performance of classification models. To address this issue, we propose a radial basis deformable residual convolutional neural networks model embedded with local multi-modal feature knowledge (RBDRCNN-LMFK). The RBDRCNN leverages Euclidean distance alignment, deformable convolution, depth-separable convolution, and residual connection modules for effective EEG feature extraction. The embedded local feature knowledge algorithm enables the effective combination of multi-modal information. To further validate the effectiveness of the algorithm, we used the left-one-subject-out cross-validation algorithm on the virtual city walking (VCW), SJTU Emotion EEG Dataset IV (SEED IV), and Building block gesture recognition (BBGR) datasets for spatial cognition and emotion recognition tasks. The average accuracy of the VCW was 97.84 % using the kNN classifier, surpassing the Concate fusion method’s 96.62 %. The average accuracy for the SEED IV dataset was 87.56 %, higher than the Concate Fusion’s 69.97 %. On the BBGR dataset, the kNN classifier achieved an average accuracy of 87.80 %, compared to 85.31 % with the Concate fusion. The results show that the model enhances the recognition of biologically significant features in EEG signals by embedding local features and increases the correlation between different brain regions associated with the task. This work illustrates a promising direction of using deep learning models to discover effective task-related features from highly diverse EEG signals and enhance brain regions’ correlation through multi-modal knowledge embedding.

PaFESD: Patterns augmented by Features Epileptic Seizure Detection.

The detection of epileptic seizures can have a significant impact on the patients' quality of life and on their caregivers. In this paper we propose a method for detecting such seizures from electroencephalogram (EEG) data named Patterns augmented by Features Epileptic Seizure Detection (PaFESD). The main novelty of our proposal consists in a detection model that combines EEG signal features with pattern matching. After cleaning the signal and removing artifacts (as eye blinking or muscle movement noise), time-domain and frequency-domain features are extracted to filter out non-seizure regions of the EEG. Jointly, pattern matching based on Dynamic Time Warping (DTW) distance is also leveraged to identify the most discriminative patterns of the seizures, even under scarce training data. The proposed model is evaluated on all patients in the CHB-MIT database, and the results show that it is able to detect seizures with an average F1 score of 98.9%. Furthermore, our approach achieves a F1 score of 100% (no false alarms or missed true seizures) for 20 of the patients (out of 24). Additionally, we automatically detect the most seizure/non-seizure discriminative EEG channel so that a wearable with only two electrodes would suffice to warn patients of seizures.

An efficient channel recurrent Criss-cross attention network for epileptic seizure prediction

Epilepsy is a chronic disease caused by repeated abnormal discharge of neurons in the brain. Accurately predicting the onset of epilepsy can effectively improve the quality of life for patients with the condition. While there are many methods for detecting epilepsy, EEG is currently considered one of the most effective analytical tools due to the abundant information it provides about brain activity. The aim of this study is to explore potential time-frequency and channel features from multi-channel epileptic EEG signals and to develop a patient-specific seizure prediction network. In this paper, an epilepsy EEG signal classification algorithm called Channel Recurrent Criss-cross Attention Network (CRCANet) is proposed. Firstly, the spectrograms processed by the short-time fourier transform is input into a Convolutional Neural Network (CNN). Then, the spectrogram feature map obtained in the previous step is input into the channel attention module to establish correlations between channels. Subsequently, the feature diagram containing channel attention characteristics is input into the recurrent criss-cross attention module to enhance the information content of each pixel. Finally, two fully connected layers are used for classification. We validated the method on 13 patients in the public CHB-MIT scalp EEG dataset, achieving an average accuracy of 93.8 %, sensitivity of 94.3 %, and specificity of 93.5 %. The experimental results indicate that CRCANet can effectively capture the time-frequency and channel characteristics of EEG signals while improving training efficiency.

Driving Attention State Detection Based on GRU-EEGNet.

The present study utilizes the significant differences in θ, α, and β band power spectra observed in electroencephalograms (EEGs) during distracted versus focused driving. Three subtasks, visual distraction, auditory distraction, and cognitive distraction, were designed to appear randomly during driving simulations. The θ, α, and β band power spectra of the EEG signals of the four driving attention states were extracted, and SVM, EEGNet, and GRU-EEGNet models were employed for the detection of the driving attention states, respectively. Online experiments were conducted. The extraction of the θ, α, and β band power spectrum features of the EEG signals was found to be a more effective method than the extraction of the power spectrum features of the whole EEG signals for the detection of driving attention states. The driving attention state detection accuracy of the proposed GRU-EEGNet model is improved by 6.3% and 12.8% over the EEGNet model and PSD_SVM method, respectively. The EEG decoding method combining EEG features and an improved deep learning algorithm, which effectively improves the driving attention state detection accuracy, was manually and preliminarily selected based on the results of existing studies.

An automated sleep staging tool based on simple statistical features of mice electroencephalography (EEG) and electromyography (EMG) data.

Electroencephalogram (EEG) and electromyogram (EMG) are fundamental tools in sleep research. However, investigations into the statistical properties of rodent EEG/EMG signals in the sleep-wake cycle have been limited. The lack of standard criteria in defining sleep stages forces researchers to rely on human expertise to inspect EEG/EMG. The recent increasing demand for analysing large-scale and long-term data has been overwhelming the capabilities of human experts. In this study, we explored the statistical features of EEG signals in the sleep-wake cycle. We found that the normalized EEG power density profile changes its lower and higher frequency powers to a comparable degree in the opposite direction, pivoting around 20-30 Hz between the NREM sleep and the active brain state. We also found that REM sleep has a normalized EEG power density profile that overlaps with wakefulness and a characteristic reduction in the EMG signal. Based on these observations, we proposed three simple statistical features that could span a 3D space. Each sleep-wake stage formed a separate cluster close to a normal distribution in the 3D space. Notably, the suggested features are a natural extension of the conventional definition, making it useful for experts to intuitively interpret the EEG/EMG signal alterations caused by genetic mutations or experimental treatments. In addition, we developed an unsupervised automatic staging algorithm based on these features. The developed algorithm is a valuable tool for expediting the quantitative evaluation of EEG/EMG signals so that researchers can utilize the recent high-throughput genetic or pharmacological methods for sleep research.

Characterization and classification of kinesthetic motor imagery levels

Objective. Kinesthetic Motor Imagery (KMI) represents a robust brain paradigm intended for electroencephalography (EEG)-based commands in brain-computer interfaces (BCIs). However, ensuring high accuracy in multi-command execution remains challenging, with data from C3 and C4 electrodes reaching up to 92% accuracy. This paper aims to characterize and classify EEG-based KMI of multilevel muscle contraction without relying on primary motor cortex signals. Approach. A new method based on Hurst exponents is introduced to characterize EEG signals of multilevel KMI of muscle contraction from electrodes placed on the premotor, dorsolateral prefrontal, and inferior parietal cortices. EEG signals were recorded during a hand-grip task at four levels of muscle contraction (0%, 10%, 40%, and 70% of the maximal isometric voluntary contraction). The task was executed under two conditions: first, physically, to train subjects in achieving muscle contraction at each level, followed by mental imagery under the KMI paradigm for each contraction level. EMG signals were recorded in both conditions to correlate muscle contraction execution, whether correct or null accurately. Independent component analysis (ICA) maps EEG signals from the sensor to the source space for preprocessing. For characterization, three algorithms based on Hurst exponents were used: the original (HO), using partitions (HRS), and applying semivariogram (HV). Finally, seven classifiers were used: Bayes network (BN), naive Bayes (NB), support vector machine (SVM), random forest (RF), random tree (RT), multilayer perceptron (MP), and k-nearest neighbors (kNN). Main results. A combination of the three Hurst characterization algorithms produced the highest average accuracy of 96.42% from kNN, followed by MP (92.85%), SVM (92.85%), NB (91.07%), RF (91.07%), BN (91.07%), and RT (80.35%). of 96.42% for kNN. Significance. Results show the feasibility of KMI multilevel muscle contraction detection and, thus, the viability of non-binary EEG-based BCI applications without using signals from the motor cortex.

A predictive model combining connectomics and entropy biomarkers to discriminate long-term vagus nerve stimulation efficacy for pediatric patients with drug-resistant epilepsy.

To predict the vagus nerve stimulation (VNS) efficacy for pediatric drug-resistant epilepsy (DRE) patients, we aim to identify preimplantation biomarkers through clinical features and electroencephalogram (EEG) signals and thus establish a predictive model from a multi-modal feature set with high prediction accuracy. Sixty-five pediatric DRE patients implanted with VNS were included and followed up. We explored the topological network and entropy features of preimplantation EEG signals to identify the biomarkers for VNS efficacy. A Support Vector Machine (SVM) integrated these biomarkers to distinguish the efficacy groups. The proportion of VNS responders was 58.5% (38/65) at the last follow-up. In the analysis of parieto-occipital α band activity, higher synchronization level and nodal efficiency were found in responders. The central-frontal θ band activity showed significantly lower entropy in responders. The prediction model reached an accuracy of 81.5%, a precision of 80.1%, and an AUC (area under the receiver operating characteristic curve) of 0.838. Our results revealed that, compared to nonresponders, VNS responders had a more efficient α band brain network, especially in the parieto-occipital region, and less spectral complexity of θ brain activities in the central-frontal region. We established a predictive model integrating both preimplantation clinical and EEG features and exhibited great potential for discriminating the VNS responders. This study contributed to the understanding of the VNS mechanism and improved the performance of the current predictive model.