Amplification Characteristics Research Articles

Seismic Wave Amplification Characteristics in Slope Sections of Various Inclined Model Grounds

The collapse of slopes caused by earthquakes can lead to landslides, resulting in significant damage to both lives and structures. Seismic reinforcement of these slopes can protect social systems during an earthquake. In South Korea, where more than 70% of the land is mountainous, the stability of slopes is of paramount importance compared to other countries. While many seismic designs are based on peak ground acceleration (PGA), there is relatively little consideration given to the extent of PGA’s influence, and few studies have been done. This study aims to assess the seismic amplification of slopes with multilayers using a 1 g shaking table and verify the results through numerical analysis after confirming the impact of PGA at specific points. Typically, slope model experiments are conducted on single-layered ground models. However, actual ground conditions consist of multiple layers rather than a single layer, so a multi-layered model was created with different properties for the upper and lower layers. Two multi-layered ground models consisting of two layers were created, one with a flat ground surface and the other with a sloped surface. The properties of the two layers in each model were configured as a single layer to create the slope models. The peak ground acceleration (PGA) of the four ground models was compared, revealing that seismic wave amplification increases as it moves upward, and the amplification is even greater when transitioning from the lower to the upper ground layers, leading to different dynamic behavior of the slope. Through the contour lines, the influence of PGA was further confirmed, and it was found that approximately 60% of the PGA impact occurs at the topmost part of the slope on average. Analysis of the earthquake waves showed that the top of the slope experienced an average amplification of about 31.75% compared to the input motion, while the lower part experienced an average amplification of about 27.85%. Numerical analysis was performed using the ABAQUS program, and the results were compared with the 1 g shaking table experiments through spectral acceleration (SA), showing good agreement with the experimental results.

Quantum-limited transmission distance of optically repeating systems using a hybrid EDFA/Raman-amplifier.

The transmission distance of optically repeating systems is ultimately bounded by quantum noises arising from attenuation and amplification. It is known that fiber Raman amplifiers (FRAs) can achieve longer quantum-limited distances than other amplification schemes owing to their distributed amplification characteristics. However, all-FRA systems are difficult to implement in practice. Therefore, a hybrid erbium-doped fiber amplifier (EDFA)/FRA system may be a reasonable solution for long-haul transmission. In this study, the quantum-limited transmission distance of hybrid EDFA/FRA systems is investigated. A formula for the quantum fluctuation variance during transmission was derived based on quantum mechanical treatment. Calculation results obtained with the derived formula quantitatively indicate that the quantum-limited transmission distance increases as the EDFA/FRA hybrid ratio varies from EDFAs alone to FRAs alone.

Amplification characteristics of N<i/>2+ lasing at multiple wavelengths generated by polarization-modulated femtosecond laser fields

Multiple gain routes complicate the amplification behaviors of N2+ lasing. A direct comparison of the amplification processes of various lasing lines of N2+ is still lacking to date, mainly because the efficient generation of different lasing lines requires different experimental conditions. In this work, to overcome the limitation, we use an intense polarization-modulated femtosecond laser pulse to simultaneously produce high-intensity N2+ lasing signals at 391 nm and 428 nm, permitting us readily performing their time-domain characterizations. Our results show that the primary amplification of 428-nm lasing is always retarded by a few picoseconds with respect to the probe pulse while the amplification of 391-nm lasing can be basically completed within the probe pulse duration at a relatively high gas pressure, and besides, the time duration of the former sustains several times longer than that of the latter. These observations indicate the non-negligible contribution of the initial electronic coherence established by the pump laser, apart from the external triggering pulse. For the 391-nm lasing, the seed amplification and superradiance can fiercely interplay within the probe pulse duration. However, for the 428-nm lasing, its amplification is in essence Raman-assisted superfluorescence due to the lacking of the initial electronic coherence and a direct triggering pulse. Our findings not only shed light on the physics of N2+ lasing but also promote the relevant studies on the collective emissions in the cascaded multi-level molecular ion system.

Seismic response characteristics of offshore sites in the Sagami Bay, Japan—Part I: Comparison of spectral inversion and ratio under weak motions

Understanding offshore site amplification (AF) characteristics is crucial for marine engineering. Thus far, the spectral ratio (SR) has been widely used to analyze offshore AF characteristics, despite its reliability not yet being fully investigated. In this study, we used 826 ground-motion data recorded at 6 offshore and 19 onshore stations in the Sagami Bay region to reveal the source, path, and AF characteristics using the generalized inversion technique (GIT). The average stress drops for the shallow crustal, subduction interface, and subduction slab earthquakes were 3.55, 6.59, and 7.07 MPa, respectively. The offshore sites were categorized into flat and steep stations based on the local slope gradient (LSG), and systematic AF characteristics were observed. We found that the topography had a negligible influence on the flat free-field station KNG205. AFs obtained using the GIT and SR were analyzed and compared, revealing two main differences: (1) SR-obtained AF values were significantly larger than GIT-obtained AF values above 0.5 Hz and 5 Hz at the flat and steep sites, respectively; (2) resonant frequencies estimated using the SR drifted to lower and higher frequencies for flat and steep sites, respectively. The ineffectiveness of the SR for flat and steep stations was attributed to the effects of topography and seawater pressure on low- and high-frequency vertical ground-motions, respectively. These results suggest that the SR is only reliable for estimating AF curves at marine free-field sites and low-frequency AFs at steep sites. The LSG may play an important role in offshore ground-motion studies.

Biomarkers of auditory cortical plasticity and development of binaural pathways in children with unilateral hearing loss using a hearing aid

Congenital or early-onset unilateral hearing loss (UHL) can disrupt the normal development of the auditory system. In extreme cases of UHL (i.e., single sided deafness), consistent cochlear implant use during sensitive periods resulted in cortical reorganization that partially reversed the detrimental effects of unilateral sensory deprivation. There is a gap in knowledge, however, regarding cortical plasticity i.e. the brain's capacity to adapt, reorganize, and develop binaural pathways in milder degrees of UHL rehabilitated by a hearing aid (HA). The current study was set to investigate early-stage cortical processing and electrophysiological manifestations of binaural processing by means of cortical auditory evoked potentials (CAEPs) to speech sounds, in children with moderate to severe-to-profound UHL using a HA. Fourteen children with UHL (CHwUHL), 6-14 years old consistently using a HA for 3.5 (±2.3) years participated in the study. CAEPs were elicited to the speech sounds /m/, /g/, and /t/ in three listening conditions: monaural [Normal hearing (NH), HA], and bilateral [BI (NH + HA)]. Results indicated age-appropriate CAEP morphology in the NH and BI listening conditions in all children. In the HA listening condition: (1) CAEPs showed similar morphology to that found in the NH listening condition, however, the mature morphology observed in older children in the NH listening condition was not evident; (2) P1 was elicited in all but two children with severe-to-profound hearing loss, to at least one speech stimuli, indicating effective audibility; (3) A significant mismatch in timing and synchrony between the NH and HA ear was found; (4) P1 was sensitive to the acoustic features of the eliciting stimulus and to the amplification characteristics of the HA. Finally, a cortical binaural interaction component (BIC) was derived in most children. In conclusion, the current study provides first-time evidence for cortical plasticity and partial reversal of the detrimental effects of moderate to severe-to-profound UHL rehabilitated by a HA. The derivation of a cortical biomarker of binaural processing implies that functional binaural pathways can develop when sufficient auditory input is provided to the affected ear. CAEPs may thus serve as a clinical tool for assessing, monitoring, and managing CHwUHL using a HA.

Risk amplification effect of multilayer financial networks: Feedback mechanism or cyclic structure?

This paper analyzes the amplification characteristics of risk propagation in multi-layer financial networks from the perspective of network topologies. The research finds that, even without feedback pathways, cross-layer links alone can lead to more severe risk contagion than in single-layer networks. More importantly, with increasing connectivity, the formation of cyclic structures in multi-layer networks will significantly exacerbate the systemic risk.

Modeling optimization design and amplification characteristics of O-band irregular Bragg bismuth-doped fiber amplifier

In recent years, O-band bismuth-doped fiber amplifier (BDFA) have been rapidly developed due to the fluorescence properties of bismuth-doped glass in the near-infrared (NIR) band, while there are still few studies on bismuth-doped fibers (BDF) with large mode fields as of now. In addition, although the use of a double-pass structure on the amplifier can lead to gain improvement, this also deteriorates the noise figure (NF). Therefore, the study of bismuth-doped fibers with large mode-field areas is a promising path to develop high-performance BDFA. In this work, taking a commercial bismuth-doped fiber as an instance, we first measured the refractive index distribution of the BDF in the O-band using a self-developed fiber refractive index tester, and thereby obtained its actual mode-field area. Then, based on this we further propose an irregular Bragg bismuth-doped fiber with the refractive index growing layer by layer. The results suggests that the effective mode-field area of this fiber reaches 401 um2 at 1320 nm, which is nearly 5.8 times that of a common single-mode BDF. Finally, we performed numerical simulations of the amplification performance based on this fiber. Under the condition of total pumping power of 8 W, the signal with −20 dBm input power obtains a gain of more than 54 dB and an NF of less than 5 dB at 1320 nm wavelength. This work demonstrates the great potential of this Bragg bismuth-doped fiber as an O-band high-gain amplifier and high-power laser.

A purely centered and non-redundant piezoelectric stick-slip rotary stage with force amplification

This paper proposes a purely center-rotation and non-redundant piezoelectric stick–slip rotary stage with force magnification. A bridge driving mechanism with centrosymmetric actuation feet is proposed, and its tilt angle can be adjusted to regulate the clamping force amplification characteristics, thus improving load capacities. Meanwhile, only a single piezoelectric actuator is used, and the driving mechanism is built in the circular slider, hence achieving non-redundant, purely centered rotation and improving the structural compactness. Theoretical calculations and simulation analyses of single-step rotation angles and force amplification of the rotary stage are carried out. In addition, a system dynamics model with electromechanical, rigid-flexible, and friction coupling properties is established. Finally, a prototype is fabricated, and various experiments are conducted. The designed bridge driving mechanism amplifies the piezoelectric actuation force by 2.8 times, and the stick–slip rotary stage has a maximum load of up to 9 kg. Also, the stage can rotate more than 360°, and the angular resolution is 0.1265 μrad, demonstrating superior performances of the non-redundant center-rotation stage.

Clinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer.

Introduction. MYC overexpression is a known phenomenon in breast cancer. This study investigates the correlation of MYC gene copy number amplification and MYC protein overexpression with coexisting genetic abnormalities and associated clinicopathologic features in breast cancer patients. Methods. The study analyzed data from 81 patients with localized or metastatic breast cancers using targeted next-generation sequencing and MYC immunohistochemical studies, along with pathological and clinical data. Results. Applying the criteria of MYC/chromosome 8 ratio ≥5, MYC copy number amplified tumors (n = 11, 14%) were associated with invasive ductal carcinoma (91% vs 68%, P = .048), poorly differentiated (grade 3, 64% vs 30%, P = .032), mitotically active (Nottingham mitotic score 3, 71% vs 20%, P = .004), estrogen receptor (ER)-negative (45% vs 12%, P = .008), and triple-negative (56% vs 12%, P = .013) compared to MYC non-amplified tumors. Among MYC-amplified breast cancer patients, those with triple-negative status showed significantly shorter disease-free survival time than non-triple negative MYC-amplified patients (median survival month: 25.5 vs 127.6, P = .049). MYC amplification is significantly associated with TP53 mutation (P = .007). The majority (10 of 11; 91%) of MYC-amplified tumors showed positive c-MYC immunostaining. Conclusion. Breast cancers with MYC copy number amplication display distinct clinicopathologic characteristics indicative of more aggressive behavior.

Detection of Staphylococcus aureus virulence gene pvl based on CRISPR strip.

Staphylococcus aureus (S. aureus) is a prominent pathogen responsible for both hospital-acquired and community-acquired infections. Among its arsenal of virulence factors, Panton-Valentine Leucocidin (PVL) is closely associated with severe diseases such as profound skin infections and necrotizing pneumonia. Patients infected with pvl-positive S. aureus often exhibit more severe symptoms and carry a substantially higher mortality risk. Therefore, it is crucial to promptly and accurately detect pvl-positive S. aureus before initiating protective measures and providing effective antibacterial treatment. In this study, we propose a precise identification and highly sensitive detection method for pvl-positive S. aureus based on recombinase-assisted amplification and the CRISPR-ERASE strip which we previously developed. The results revealed that this method achieved a detection limit of 1 copy/μL for pvl-positive plasmids within 1 hour. The method successfully identified all 25 pvl-positive and 51 pvl-negative strains among the tested 76 isolated S. aureus samples, demonstrating its concordance with qPCR. These results show that the CRISPR-ERASE detection method for pvl-positive S. aureus has the advantages of high sensitivity and specificity, this method combines the characteristics of recombinase-assisted amplification at room temperature and the advantages of ERASE test strip visualization, which can greatly reduce the dependence on professional laboratories. It is more suitable for on-site detection than PCR and qPCR, thereby providing important value for rapid on-site detection of pvl.

Nonlinear Evolution of Instabilities in a Laminar Separation Bubble at Hypersonic Speeds

The development of both convective stationary perturbation and global instabilities in the vicinity of a laminar separation bubble above an axisymmetric compression corner in hypersonic flow was investigated using numerical simulations. The flow configuration of interest corresponded to the cone–cylinder–flare model used in experimental measurements in the Boeing/U.S. Air Force Office of Scientific Research Mach-6 Quiet Tunnel (BAMQT) at Purdue University. For a flare angle of 10 deg and unit Reynolds number of 11.5×106 m−1, their surface flow visualizations identified the presence of streamwise elongated thermal streaks near the reattachment location that had a dominant azimuthal wave number m=36. Previous linear stability analyses predicted that the amplification characteristics of small-amplitude, unsteady, and convective instabilities within this flow were consistent with the surface pressure fluctuations measured in the experiment. However, their accompanying investigation of global instabilities showed that the separation bubble was weakly unstable at the 10 deg flare angle, with the most unstable global mode corresponding to a stationary disturbance with m≈5–6 (i.e., well below the measured wave number of m=36. Besides characterizing the global instability for selected flare angles, the present numerical simulations quantify the details of the stationary equilibrium state associated with supercritical bifurcation resulting from the nonlinear saturation of the unstable global mode. Although velocity perturbations associated with the saturated global mode are dominated by the fundamental spanwise wavelength associated with the linear global instability, the surface heat flux downstream of the reattachment is dominated by m=36, in agreement with the experimental measurements.

Establishment and application of a rapid molecular diagnostic platform for the isothermal visual amplification of group B Streptococcus based on recombinase polymerase.

With growing concerns about Group B streptococcal (GBS) infections and their adverse effects on perinatal pregnancies, including infection, premature delivery, neonatal septicemia, and meningitis, it is urgent to promote GBS screening at all pregnancy stages. The purpose of this study is to establish a device-independent, fast, sensitive, and visual GBS detection method. Taking advantage of the characteristics of the recombinase polymerase isothermal amplification (RPA), the activity of the nfo nuclease cleavage base analog (tetrahydrofuran, THF) site, and the advantages of visual reading of the lateral flow chromatography strip (LFS), a GBS detection method was developed. This method focused on the conservative region of the Christie-Atkins-Munch-Petersen factor encoded by the cfb gene, a virulence gene specific to GBS. Two forward primers, two biotin-labeled reverse primers, and one fluorescein isothiocyanate (FITC)-labeled and C3spacer-blocked probe were designed. The study involved optimizing the primer pair and probe combination, determining the optimal reaction temperature and time, evaluating specificity, analyzing detection limits, and testing the method on 87 vaginal swabs from perinatal pregnant women. The results showed that the visual detection method of GBS-RPA-LFS, using the cfb-F1/R2/P1 primer probe, could detect GBS within 15 min at the temperature ranging from 39°C to 42°C. Furthermore, the method specifically amplified only GBS, without cross-reacting with pathogens like Lactobacillus iners, Lactobacillus crispatus, Candida albicans, Listeria monocytogenes, Yersinia enterocolitica, Klebsiella Pneumoniae, Enterobacter cloacae, Citrobacter freundii, Vibrio alginolyticus, Vibrio parahaemolyticus, Salmonella typhimurium, Staphylococcus aureus, Pseudomonas aeruginosa, or Trichomonas vaginalis. It could detect a minimum of 100 copies per reaction. In clinical 98 samples of vaginal swabs from pregnant women, the agreement rate between the GBS-RPA-LFS method and TaqMan real-time fluorescence quantification method was 95.92%. In conclusion, this study successfully established a combined RPA and LFS GBS in situ detection platform, with short reaction time, high sensitivity, high specificity, portability, and device independence, providing a feasible strategy for clinical GBS screening.

Bandgap engineering and amplification in photonic time crystals

Recently, there has been a growing interest in time-varying photonic media owing to their significant potential in the field of wave manipulation. Here, we explore the exotic characteristics of wave amplification in a photonic time crystal (PTC) made of a spatially homogeneous medium where the refractive index varies periodically in time. Based on qualitative and quantitative analysis of the amplification, we show that the amplification not only depends on the choice of wave vector of a propagating light but also attains different values in different bandgaps. Our approach further extends towards achieving the minimum amount of variation of permittivity required to open momentum gaps to facilitate the phase-dependent amplification of PTCs. Further, we investigate the impact of permittivity variation and choice of number of temporal unit cells to truncate a PTC to mimic the properties of infinite PTC and offer new opportunities to manipulate and control the amplification of light for applications including highly tunable PTC lasers and devices.

A MoS2 nanosheet-based CRISPR/Cas12a biosensor for efficient miRNA quantification for acute myocardial infarction

Acute myocardial infarction (AMI) represents the leading cause of cardiovascular death worldwide, and it is thus pivotal to develop effective approaches for the timely detection of AMI markers, especially possessing the characteristics of antibody-free, signal amplification, and manipulation convenience. We herein construct a MoS2 nanosheet-powered CRISPR/Cas12a sensing strategy for sensitive determination of miR-499, a superior AMI biomarker to protein markers. The presence of miR-499 at a trace level is able to induce a significantly enhanced fluorescence signal in a DNA-based molecular engineering platform, which consists of CRISPR/Cas12a enzymatic reactions and MoS2 nanosheet-controllable signal reporting components. The MoS2 nanosheets were characterized by using atomic force microscopy (AFM) and transmission electron microscope (TEM). The detection feasibility was verified by using polyacrylamide gel electrophoresis (PAGE) analysis and fluorescence measurements. The detection limit is determined as 381.78 pM with the linear range from 0.1 ⅹ 10−9 to 13.33 ⅹ 10−9 M in a fast manner (about 30 min). Furthermore, miRNA detection in real human serum is also conducted with desirable recovery rates (89.5 %–97.6 %), which may find potential application for the clinic diagnosis. We describe herein the first example of MoS2 nanosheet-based signal amplified fluorescence sensor for effective detection of AMI-related miRNA.

Numerical investigation of seismic amplification characteristics in loess ridge region of Xiji, northwest China.

The seismic effects on sloped terrain, which are of paramount importance for engineering design and earthquake risk mitigation, have always been a central focus of earthquake engineering research. In this study, generalized geometric models of loess ridges at varying heights were created, and a three-dimensional nonlinear numerical model was established using FLAC3D. Seismic ground motion time histories at different frequencies and actual earthquake ground motion records were input into the model to analyze the peak acceleration amplification effects experienced by the surface of loess ridges when subjected to SV waves. The study's outcomes reveal that seismic amplification on the slopes of loess ridges is characterized by non-linearity with respect to slope height. Instead, it exhibits rhythmic variations, with the rate of change in these rhythms increasing in correspondence with the frequency of seismic motion and the height of the slope. Under low-intensity seismic motion, a linear increase in acceleration amplification is observed at the ridge's crest concerning the height of the loess ridge. However, under high-intensity seismic motion, the relationship between amplification and slope height becomes less significant. Typically, the peak acceleration at the ridge's crest is reported to be 1.5 to 2.5 times that observed at the slope's base. The amplification effect at the ridge's crest is more pronounced in the low-frequency and high-frequency segments when compared to the mid-frequency range. Conversely, significant amplification is observed in the high-frequency range in the lower sections of the slope near the base. It is further noted that the amplification effect at the ridge's crest displays distinct behavior at different frequencies, characterized by narrow frequency bands of maximum amplification, with peak amplification factors exceeding 10 in some cases. These research findings have practical significance and provide valuable references for engineering construction and seismic risk mitigation planning in loess regions.

Primary Resonance in a Weakly Forced Oscillator With Both Parametric Damping and Stiffness

Abstract We study the primary resonance of a parametrically damped Mathieu equation with direct excitation. Potential applications include wind-turbine blade vibration with cyclic stiffening and aeroelastic effects, which may induce parametric damping, and devices with designed cyclic damping for resonance manipulation. The parametric stiffness, parametric damping, and the direct forcing all have the same excitation frequency, with phase parameters between these excitation sources. The parametric amplification at primary resonance is examined by applying the second-order method of multiple scales. With parametric stiffness and direct excitation, it is known that there is a primary parametric resonance that is an amplifier under most excitation phases, but can be a slight suppressor in a small range of phases. The parametric damping is shown to interact with the parametric stiffness to further amplify, or suppress, the resonance amplitude relative to the resonance under parametric stiffness. The effect of parametric damping without parametric stiffness is to shift the resonant frequency slightly, while inducing less significant resonance amplification. The phase of the parametric damping excitation, relative to the parametric stiffness, has a strong influence on the amplification or suppression characteristics. There are optimal phases of both the direct excitation and the parametric damping for amplifying or suppressing the resonance. The effect of the strength of parametric damping is also studied. Numerical simulations validate the perturbation analysis.

A Sub-Picosecond Laser System Based on High-Energy Yb:YAG Chirped-Pulse Regenerative Amplification

In this study, we have successfully demonstrated a high-energy subpicosecond Yb:YAG laser system based on chirped-pulse regenerative amplification. Our experimental results demonstrate a pulse energy of 3 mJ with a pulse duration of 829.8 fs and a repetition rate of 1 kHz. Additionally, we conducted an extensive investigation into the system’s recompression capability under various modulation and seeding conditions. Our findings suggest that the system can achieve effective recompression over a broad range of parameters, with the ability to compensate for a considerable degree of chirp. Our study provides valuable insights into the fundamental physic of high-energy laser systems and the performance characteristics of chirped-pulse regenerative amplification.

Ground motion models for regions with limited data: Data‐driven approach

AbstractThe ground motion model (GMM) for response spectra is crucial to hazard studies and structural design. GMM developed for regions with abundant data can capture appropriate spectral attenuation characteristics. However, several seismically active regions, such as the Himalayas, have limited recorded data, and thus, traditionally, simulated, or other regional data are supplemented with the available data for developing a GMM. Despite data augmentation, GMMs developed for such regions cannot appropriately depict attenuation characteristics. Therefore, the paper presents a comprehensive study encompassing the development of data‐driven approaches to obtain GMM for response spectra using the Himalayan crustal data with inputs: magnitude, distance, site class, depth, and a flag corresponding to the horizontal and vertical components. In this regard, GMM using transfer learning is initially developed from a pre‐trained model using global crustal data. Additionally, GMM using the XGBoost approach with monotonic constraints enforced on inputs is developed. These approaches could not capture trends appropriately. Finally, a monotonic constrained transfer learning model is developed to appropriately depict magnitude saturation and scaling, magnitude‐dependent geometric spreading, anelastic attenuation, depth scaling, site amplification, and other desired characteristics.

Erbium‑Ytterbium Co‑Doped Fiber and Its Amplification Characteristics in L‑Band

Erbium‑Ytterbium Co‑Doped Fiber and Its Amplification Characteristics in L‑Band

Prevalence and treatment of human epidermal growth factor receptor 2-altered non-small cell lung cancer: a retrospective analysis and systematic literature review.

Human epidermal growth factor receptor 2 (HER2) is known for its oncogenic activities in diverse cancers, including non-small cell lung cancer (NSCLC). However, the prevalence of HER2 alterations in Malaysian NSCLC patients remains unreported. This study examined the prevalence and characteristics of HER2 mutations and amplification in a Malaysian cohort. Additionally, a systematic review was conducted to evaluate the global prevalence of HER2 alterations in NSCLC, as well as the efficacy of HER2-targeted therapies observed in clinical trials. NSCLC tumour samples received from October 2019 to December 2022 for next-generation sequencing diagnostics were included in the retrospective analysis. In this patient cohort, HER2 alteration was present in 5.8% of patients; 3.9% had HER2 mutations, 1.5% had HER2 amplifications and 0.4% were both HER2-mutated and amplified. HER2 exon 20 insertions were the most common HER2 variants, detected in 47/59 (79.7%) of HER2-mutated patients. Among cases with HER2 exon 20 insertions, the Y772_A775dup variant was found in 34 patient samples. HER2-mutated patients were significantly younger than non-HER2-mutants (61 versus 64 years old; p = 0.046) and were inclined to be female and never-smokers, albeit not statistically significant. Patients with HER2 amplification were more likely to have progressed post-tyrosine kinase inhibitor therapy (p = 0.015). The systematic review highlighted a global variation in the prevalence of HER2 alterations in NSCLC, ranging from 0.3% to 9.1% for mutations and 0.2% to 19% for amplification. Finally, phase II clinical trials involving HER2-altered NSCLC patients demonstrated promising treatment outcomes with trastuzumab deruxtecan, trastuzumab emtansine, pyrotinib, pyrotinib + apatinib and trastuzumab + pertuzumab + docetaxel. In conclusion, the prevalence of HER2 alteration among Malaysian NSCLC patients falls within the global range. A systematic review of clinical trials revealed promising treatment outcomes and Malaysian NSCLC patients with HER2 alterations are anticipated to similarly benefit from HER2-targeted therapies.