Features Of Acute Myocardial Infarction Research Articles

The Clinical Profile and Hospital-based Outcome of Acute Myocardial Infarction in Elderly Patients More than 60 Years and Patients Younger than 60 Years: A Comparative Study

Background: Acute myocardial infarction refers to a pathological state characterized by the obstruction of blood supply to the myocardium, resulting in the subsequent necrosis of cardiac tissue. It constitutes a significant etiological factor contributing to the development of heart failure and global mortality rates. Objective: The purpose of this study was to conduct a comparative analysis of the clinical characteristics of acute myocardial infarction in old and young individuals who sought medical attention at a tertiary care hospital. Methods: This cross-sectional observational study was done from January 2023 to June 2023 at the Mymensingh Medical College Hospital, Mymensingh, Bangladesh. A total of 100 people were observed in this study. Result: We have two age groups: under 60 (60%) and over 60 (40%). We name them A and B. Group A patients are 86.7% male and 13.3% female. Group A patients are 88.3% Muslim and 7% Hindu. This patient group includes 30% service workers and 20% businesses. The remaining 28.3% were patients from diverse jobs and 1.7% were farmers. With 55% male and 45% female Muslim patients, Group B includes domestic workers (45%) and businessmen (22.5%). Service workers 17%, farmers 2.5%, and other patients 12.5%. Group A had 85% chest pain, 46.7% dyspnea, 90% palpitations, and 86.7% nausea and vomiting. Ischemic chest pain, dyspnea, palpitations, nausea, and vomiting affected 87.5% of Group B.Top MI risk factors. Group A had dyslipidemia (95%), family history of MI (93.3%), sedentary lifestyle (91.7%), smoking (88.3%), hypertension (86.7%), and diabetes (78.3%). The sedentary lifestyle, 100% family history of ischemic heart disease, 97.5% dyslipidemia, and 77.5% diabetes and hypertension characterized Group B. Lastly, our study reports patients' average pulse and blood pressure. In Group A, the average pulse was 81.73 ± 14.60, systolic blood pressure was 129.50 ± 20.28 mmHg, and diastolic blood pressure was 89.41 ± 12.35. Group B had an .......

Features of the myocardial infarction course in convalescents of the new coronavirus infection COVID-19

Acute myocardial injury is one of the possible complications of the new coronavirus infection COVID-19 and can be diagnosed both in the acute phase of the infection, and also after stabilization or clinical improvement of the patient's condition. This review is devoted to the actual problem of the acute myocardial infarction development during the period of COVID-19 convalescence. The pathophysiological mechanisms of acute myocardial infarction during recovery from COVID-19 are diverse. The key role belongs to the state of hypercoagulation and the systemic inflammatory response, which can provoke destabilization and rupture of unstable atherosclerotic cardiac plaques. Type 2 acute myocardial infarction is most often diagnosed in COVID-19 convalescents against the background of intact coronary arteries. In this case, acute myocardial infarction develops due to an imbalance between increased myocardial oxygen demand (increased levels of cytokines in the blood, hypercatecholaminemia, hyperthermia and tachycardia) and a decrease in oxygen supply to cardiomyocytes due to hypoxemia and hypotension. Subclinical myocardial injury may be present despite normal coronary arteries on angiography and intact left ventricular ejection fraction. There is no clear relationship between the development of acute myocardial infarction during the period of COVID-19 convalescence and the severity of the infection, the time from the initial diagnosis, and the presence of traditional risk factors for cardiovascular diseases in the patient. Cardiac complaints in COVID-19 convalescents are often interpreted as a post-COVID syndrome, especially given the absence of a history of coronary heart disease in many patients, which can lead to late diagnosis. Further study of the features of acute myocardial infarction during the period of COVID-19 convalescence is needed.

Clinical predictors and angiographic features of acute myocardial infarction due to systemic embolism

Clinical predictors and angiographic features of acute myocardial infarction due to systemic embolism

Differences between Men and Women in Terms of Clinical Features of ST-Segment Elevation Acute Myocardial Infarction

Background: Several research have investigated further into differences in clinical characteristics of acute myocardial infarction between men and women (AMI). Prospective studies, on the other hand, are few, and sex-related variations in AMI symptoms are unknown. We studied at the variations in clinical characteristics of ST-segment elevation AMI between men and women.Material & Methods:We evaluated at 151 patients with ST-segment elevation AMI who were hospitalized within 24 hours of symptom onset (70 women and 81 males). Within 48 hours of hospitalization, all patients were interviewed by many of the same cardiologist.Results:Women exhibited higher rates of hypertension (70 vs 56 percent, p=0.010), diabetes mellitus (36 vs 26 %, p=0.047), and hyperlipidemia (51 vs 38 %, p=0.019) than males (72 vs 62 years, p0.001). Non-specific symptoms (45 vs 34%, p=0.033), non-chest discomfort (pain in the mouth, throat, neck, shoulder, arm, hand, and back), moderate pain (20 vs 7%, p0.001), and nausea (49 vs 36 percent, p=0.013) were all more common in women than in males. The severity of coronary artery lesions was equal in both sexes on coronary angiography. Women had a considerably greater in-hospital death rate than males (6.6 vs. 1.4%, p=0.003).Conclusions:Women and men with AMI have different clinical profiles and presentations. AMI symptoms are less common in women than in males.

Atypical Presentation of Acute Myocardial Infarction

Introduction: Chest pain has been reported as the cardinal clinical feature of Acute Myocardial Infarction (AMI). However, a substantial number of patients may have atypical or no symptoms on initial evaluation. The absence of typical chest pain and the vagueness of symptoms might result in a delay in seeking medical care. In this study atypical presentations of AMI and in-hospital mortality and outcome were evaluated. Material and Methods: A hospital based cross sectional study was performed among 110 patients of AMI admitted in the CCU who fulfilled the inclusion criteria. The Study was done from July, 2013 to January, 2014 in Dhaka Medical College Hospital, Dhaka, and National Institute of Cardiovascular Diseases (NICVD), Dhaka. Results: Among the 110 patients with AMI, 22 (20%) patients presented with atypical presentation. The maximum incidence of AMI with atypical presentations was in the age group of 65-74 years (28.57%). Dyspnoea (36.36%) was the most among the atypical symptom followed by vomiting 22.72% and the least incident with vertigo 4.54%. Inferior MI being the highest 46% among atypical MI where as mortality rate was high among the antero-septal MI (22.86%). The in hospital mortality of myocardial infarction patients who presented with typical and atypical symptoms were 15% and 36.36 %. Conclusion: The patients without chest pain represent a substantial segment of the MI population. Older patients presented with more atypical symptoms with breathlessness being the commonest atypical symptoms. Mortality was high among the patients who presented with atypical symptoms, increasing age, and who presented lately. J MEDICINE 2021; 22: 88-94

Risk of acute myocardial infarction in sarcoidosis: A population-based cohort study from Sweden

Due to conflicting findings in previous studies, it remains unclear whether individuals with sarcoidosis are at a higher relative risk of acute myocardial infarction. In this cohort study, individuals with sarcoidosis and matched general population comparators were followed for acute myocardial infarction in Swedish nationwide registers. A small (20%) risk increase associated with sarcoidosis was identified, which did not markedly vary by age at diagnosis, sex, treatment status around diagnosis, and time since diagnosis. The highest relative risk (1.4) was observed in individuals who received immunosuppressant treatment around the time of sarcoidosis diagnosis. Future studies should examine the clinical characteristics of acute myocardial infarction in these patients and investigate whether early diagnostic or preventive interventions might be beneficial for these patients.

The Clinical Characteristics of Acute Myocardial Infarction with Ventricular Septal Perforation and the Prognosis Comparison of Different Treatment Methods

To explore the clinical characteristics of acute myocardial infarction (AMI) with ventricular septal perforation (VSR), the prognosis comparison of different treatment methods, and analysis of related risk factors. From January 2006 to February 2020, 29 patients with AMI and VSR diagnosed in the People's Hospital of Peking University were selected as the study group. Among them, 16 cases were male (55.2%), 13 cases were female (44.8%), and the average age was 64.69 ± 10.32 years old. They were divided into two groups: the survival group (N = 16) and non-survival group (N = 13), according to whether they survived within 30 days of surgical or drug conservative treatment. The clinical characteristics, coronary angiography, and treatment of the two groups were summarized, and the prognosis and related risk factors were analyzed. There was no significant difference in the basic clinical characteristics between the two groups (P > 0.05). Compared with the results of coronary angiography in the two groups, the proportion of the culprit vessel, which was a simple anterior descending branch in the non-survival group, was higher than that in the survival group. There was a statistical difference between the two groups (P < 0.05). The perioperative data of the two groups showed that the proportion of patients with complete revascularization, simultaneous bypass, and recanalization of culprit vessels in the survival group was significantly higher than that in the non-survival group (P < 0.05). However, the incidence of postoperative low cardiac output and mortality during hospitalization in the survival group were significantly lower than those in the non-survival group (P < 0.05). Logistic regression analysis showed that complete revascularization (OR = 0.021, 95% CI 0.001-0.374, P = 0.009) and recanalization of culprit vessels (OR = 0.045, 95% CI 0.004-0.548, P = 0.015) were independent risk factors for 30-day mortality. Kaplan-Meier survival curve showed that during the follow-up period, the long-term survival rate of patients with operation and complete revascularization was significantly higher than that of patients with drug conservative treatment and incomplete revascularization. There was a statistical difference between the two groups (P < 0.05). Complete revascularization and recanalization of culprit vessels are independent risk factors for 30-day mortality in patients with AMI and VSR. The long-term survival rate of patients after surgery and complete revascularization is significantly higher than that of patients with conservative medical treatment and incomplete revascularization. Surgery and complete revascularization are important factors affecting the long-term prognosis of patients with AMI and VSR.

Post-mortem Gross Detection of Early Myocardial Infarction using Triphenyl Tetrazolium Chloride Test

Background: Ischemic heart disease is the leading cause of mortality in the world. More than 17 millionpeople die each year as a result of myocardial infarctions. Post-mortem histochemical detection of earlymyocardial infarction using 2,3,5-Triphenyl Tetrazolium Chloride (TTC) technique is based on the factthat ischemic myocardial cells lose their membrane integrity and release dehydrogenase enzyme into theblood stream, resulting in decrease or total depletion of these enzymes within the necrotic areas of themyocardium, and so, after immersion in TTC solution, enzyme depleted necrotic myocardium will notretain TTC dye and therefore appears as pale/yellow areas. Materials and Methods: This prospectivepostmortem study was conducted at Medicolegal Directorate in Baghdad city during the period fromMarch 2020 to December 2020. Myocardial specimens were isolated from 75 cases of sudden natural deathand were subjected to 1% TTC solution staining for gross assessment, and subsequently, tissue samples weretaken from suspected areas, processed and stained with H&amp;E for histopathological evaluation and detectionof a possible acute myocardial infarction. Results: The mean age of studied cases was 50.3 ±12.57 years,ranging from 18 to 78 years, median age was 53 years. Males constituted the majority of cases (80%). Caseswere predominantly within 40-59 years age group (58%). The postmortem interval was ranging from 2 to17 hours (mean= 8.6 ±3.6 hours). After immersion in 1% TTC solution, 45 myocardial specimens showedmacroscopic pale/yellow areas which were indicative of acute myocardial infarcts within the ventricularwall, while histopathological examination of specimens revealed features of acute myocardial infarction(AMI) in 62 specimens. TTC stain was found to have a diagnostic sensitivity of 69.4% and specificity of76.9% in postmortem detection of AMI. Conclusion: The TTC technique allows identification of earlymyocardial necrosis. It’s practical, reliable and valid method that promises to be of considerable value. Itcan be used together with histopathology for postmortem detection of visually unapparent acute myocardialinfarcts.

ВЗАИМОСВЯЗЬ СТРУКТУРНЫХ ИЗМЕНЕНИЙ МИОКАРДА У БОЛЬНЫХ ОСТРЫМ ИНФАРКТОМ МИОКАРДА С ПОДЪЕМОМ СЕГМЕНТА ST ПО ДАННЫМ КОНТРАСТНОЙ МРТ С ОСОБЕННОСТЯМИ КОРОНАРНОГО ПОРАЖЕНИЯ И ВРЕМЕНЕМ РЕПЕРФУЗИОННОЙ ТЕРАПИИ

Purpose. To study the relationship between the characteristics of acute myocardial infarction and ST-segment elevation (infarction size, microvascular obstruction) according to contrast cardiac MRI data with the features of coronary lesion and the time of percutaneous coronary intervention. Methods. The study included 52 patients with acute ST-segment elevation myocardial infarction (MI) who were admitted to the hospital in the first 48 hours after the onset of the disease and underwent primary percutaneous coronary intervention (pPCI). On Days 3-7 contrast-enhanced cardiac MRI was done. Tissue analysis of scans was performed evaluating infarct size, presence and size of microvascular obstruction (MVO). Results. Patients were divided into 2 groups separated by the median time to reperfusion treatment (3 hours). There were no significant differences between groups in MRImeasured ejection fraction (EF) (in the group with later pPCI &gt;3 hours of symptom onset EF was 49.0 ± 11.0%, and in the comparison group – 45.7 ± 10.5%, р=0,2). MRI-measured infarct size was significantly higher in the group where pPCI was done &gt;3 hours of symptom onset: 18.1 ± 1.7% of the left ventricular mass, compared to the early reperfusion group – 10.9 ± 1.9% (р=0.009). MVO magnitude was also higher in the later pPCI group (2.6 ± 0.64% vs 0.03 ± 0.3% in the comparator group), (р&lt;0,027). Correlation analysis also revealed a reliable relationship between infarct size and time to reperfusion (R 0.381, p=0.006). LAD lesions were associated with higher infarct size values (p=0.02) and higher risk of MVO (odds ratio 2.9, CI 0.83-10.0, р=0.03). Complete occlusion of infarct-related artery (IRA) was associated with higher infarct size (16,97±3.3 vs 12.05±1.4, р=0.02). There was no reliable correlations between IRA patientcy and MVO magnitude (р=0.7). Conclusions. In this study timing primary percutaneous coronary intervention, in groups of below and more than 3 hours after symptom onset, had no significant impact on ejection fraction, as determined by MRI. However, primary percutaneous coronary intervention timing exceeding 3 hours significantly influenced infarct size, the occurrence and magnitude of microvascular obstruction. LAD being the infarct-related artery was associated with larger infarct size, higher risks of microvascular obstruction development. The absence of complete occlusion of the infarct-related artery was associated with a smaller myocardial infarction size according to MRI data.

2146-PUB: Features of Acute Myocardial Infarction in Patients with Diabetes Mellitus of the Buryat Population

The inflammatory processes that develop in patients with type 2 diabetes mellitus (T2DM) vary in different ethnic groups. The level of cytokines in the peripheral blood characterizes the severity of the disease and the dynamics of the pathological process in the acute period of myocardial infarction. The study included 34 individuals of the Buryat population. The Buryats are the main northern group of Mongolians, they are a core population of Siberia with a compact residence close to Lake Baikal. The first group included 14 patients with T2DM and ST-elevation acute myocardial infarction (STEMI) (5 men and 9 women), with a median age was of 62.5 years. The second group consisted of 20 individuals of the control group without diabetes and STEMI (11 men and 9 women), a median age was of 62 years. We studied levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α), high sensitivity C-reactive protein (hs-CRP) admitted within 24 h after the symptoms onset (Table 1). In Buryat patients with T2DM and STEMI, production of pro-inflammatory cytokines IL-1β and IL-6 relative to the control group without diabetes and STEMI (p &amp;lt;0.05) is reduced. In addition, in Buryat patients with T2DM and STEMI, a significant increase in the level of hs-CRP was registered relatively to the control group (p&amp;lt;0.05). Disclosure T. Bardymova: None. T. Belokhvostikova: None. S. Tsyretorova: None.

Predicting preventive strategies of acute myocardial infarction in young patients in Egypt: An observational analytical study in the form of cross-sectional study

Background: In the developing countries, coronary artery disease commonly occurred in younger people and is the main cause of mortality worldwide. Aim: This study aims to identify risk factors and characteristics of acute myocardial infarction (AMI) in young patients. To clarify the risk factors for AMI in young patients and the prevention for it, is very important problem worldwide. Patients and Methods: 650 ST-elevation myocardial infarction (STEMI) patients were included in our study. History taking, clinical examination, electrocardiography, echocardiography, and cardiac enzymes and coronary angiography were done to all patients; demographic data and risk factors including mental stress measured by the Standard Stress Scale, left ventricular (LV) dimensions, LV systolic and diastolic function, and angiographic characteristics were measured. We excluded patients with familial dyslipidemia and Type I diabetes. We classified the patients into two groups according to age: Group I – young – 142 patients 45 years. Statistical Analysis: Variables were expressed as the mean ± standard deviation. Percentage was used for categorical variables. t-test was used for comparison. Then, the significant univariate predictors were assessed by multivariate linear regression analysis to find the independent predictors for unfavorable outcome. Data analyses were performed with SPSS (version 21.0, Chicago Inc., Chicago, Illinois, USA). Results: Young patients were 142 (21.8%); males were majority between both groups. Smoking (56.3%), addiction (17.6%), mental stress (79.6%), and family history (4.2%) were significantly associated with young age group. Spontaneous coronary dissection (SCAD) (6.3%) and coronary spasm (10.5%) are relatively common cause of young AMI patients. SCAD and spasm has its specific risk factors such as young female and smoking, respectively. Anterior STEMI occurred in 59.1% of young patients and was the most common followed by Inferior STEMI in 31%. 14.8% of young patients presented late after 12 h of onset of symptoms. The multivariate logistic regression for independent predictors of unfavorable outcome showed that hypertension, Type II diabetes mellitus, Killip class, and multiple-vessel disease were significant predictors of unfavorable outcome. Conclusion: The prevalence of STEMI in young patients is increasing due to sedentary and stressful lifestyle and bad habits as smoking and addiction. Young patients have unique risk factor profile. STEMI in young occurred most often in males. Smoking is the most common risk factor. Anterior STEMI is the most common followed by inferior STEMI.

Characteristic of myocardial infarction in young subject

The myocardial infarction (MI) of the young subject is a singular entity. The objective of our study was to analyze the epidemiological, clinical and progressive features of acute myocardial infarction in the young adult in the Monestir _ Tunisia Cardiology B department. This is a study that included 1525 patients (1433 men and 92 women) hospitalized for Acute Coronary Syndrome with ST segment elevation in the Fattouma Bourguiba Monastir Heart Hospital B ward from January 1998 to September 2015. In our series, 1475 (94.4%) patients were older than 40 years old so 77.4% were men. Eighty-seven patients (5.6%) were under the age of 40, so 90.8% were men ( P = 0.003). Diabetes, arterial hypertension and antecedent coronary pathology are the predominant risk factors in the elderly group with p respectively equal to 0.003; < 0.001 and 0.022. Active smoking was present in 85.1% of young people with IDM and 65.7% in older adults ( P < 0.001). The inaugural presentation is more frequent in the youth group (75.9% vs. 56.9%, P < 0.05). MI was complicated of atrioventricular block in 9.9% of the elderly vs. 2.3% of the youth ( P = 0.019); of ventricular tachycardia (VT) in 3.7% of the elderly, while no youth presented a TV ( P = 0.05) and OAP in 37.3% in the elderly vs. 14% in the young ( P = 0.01). Mortality was 8.6% in the elderly group and 3.4% in the youth group. Males and tobacco are the two leading risk factors in the group of young people presenting a MI. The clinical presentation is often inaugural. The complications are rare but serious with a risk of mortality that remains high.

Shock in Takotsubo Cardiomyopathy and Myocardial Infarction

Takotsubo cardiomyopathy (TC), also known as stress cardiomyopathy, can mimic features of acute myocardial infarction (MI), including hemodynamic

Clinical and coronary angiography characteristics of acute myocardial infarction occurring during sport activities: 2011–2017 data from the “obseRvatoire des Infarctus de Côte d’Or” (RICO) survey

Coronary artery disease (CAD) is involved in most acute cardiac events occurring during sport activities. We addressed clinical and coronary angiography characteristics of patients with acute myocardial infarction (AMI) during sport activities. From the RICO database, we retrospectively analyzed all the consecutive patients admitted in a university hospital for sport-related AMI and who underwent coronary angiography from 2011 to 2017 ( n = 100). AMI occurred during or within the 1st hour after cycling (41%), jogging (14%), soccer (13%) and other team sports (7%). Median age was 58 (50–67) y, most were male (86%), with body mass index at 25 (24–28) kg/m 2 , a high rate of smoking (37%), hypercholesterolemia (31%), familial or personal history of CAD (29% and 10%, respectively), and diabetes (9%). Strikingly, 30% reported prodromal symptoms. Out-of-hospital (OH) sudden cardiac arrest (SCA) was experienced by 20%; at admission, 11% had Killip > 1 and 54% were STEMI. Most had one-vessel disease (50%) and 14% had no significant stenosis. SYNTAX score was 8 (5–14). More than half (52%) had associated non-significant stenosis. Culprit lesion (87%) was found on LAD or branches (43%) and on RCA (40%), proximal in 47% of patients. One culprit lesion was reported on LM (1%) artery. Thrombus, calcification and ulceration were often found on culprit lesion (53%, 17% and 34% respectively). An occlusion (TIMI 0) was observed in 55% of culprit lesions. Only 5% and 2% had chronic total occlusion and dissection, respectively. Only 26% had lesion length > 20 mm on culprit artery. One patient had an anomalous origin of LM and one had a small coronary fistula. Our works highlight a high rate of risk factors, history of CAD and prodromal symptoms. STEMI counted for 54% of cases and OHSCA occurred in 20% of patients. Their CAD extent was low to moderate, and characterized by a majority of single significant, proximal and short stenosis.

TCT-786 Clinical Features of Subacute Myocardial Infarction - Multicenter Registry from Tokyo CCU Network Database

Although the patient characteristics of acute myocardial infarction (AMI) have been investigated, those of subacute myocardial infarction (SMI) have not been fully evaluated. To assess clinical features of SMI, we compared 1898 SMI patients and 9251 AMI patients from Tokyo CCU network database in

474Clinical and coronary angiographic characteristics of acute myocardial infarction occurring during sport practice: contemporary data from the RICO survey

474Clinical and coronary angiographic characteristics of acute myocardial infarction occurring during sport practice: contemporary data from the RICO survey

Characteristics of acute myocardial infarction caused by spontaneous coronary artery dissection in young female patients

Objective: To investigate the characteristics of acute myocardial infarction caused by spontaneous coronary artery dissection(SCAD) in young female patients. Methods: In this casecontrolstudy,127 young(≤55 years) female patients with acute myocardial infarction onset within 1 week in Nanjing first hospital, Xuzhou central hospital, affiliated hospital of Xuzhou medical university, and Lianyungang first people's hospital were enrolled between January 2013 and February 2017,and the clinical data were retrospectively analyzed. According to their clinical manifestations and coronary angiography(CAG) results,the patients were divided into coronary atherosclerosis disease(CAD) group(CAG evidenced atherosclerosis, n=83) and SCAD group(CAG detected coronary artery dissection,n=44).The SCAD patients were subdivided into definite group (the results affirmed from intravenous ultrasound or optical coherence tomography, n=21) and probable group (the CAG results highly confirmed to characteristics of SCAD,but no intravenous ultrasound or optical coherence tomography image affirmation,n=23). Then, according to the different treatment strategies, the SCAD patients were subdivided into conservative treatment group(treated with drugs,n=19) and interventional therapy group(treated with percutaneous coronary intervention,n=25). Results: (1)Compared to CAD group, patients in the SCAD group had less risk factors, such as hypertension history (25.0% (11/44) vs. 45.8% (38/83) , P=0.022) and diabetes history (6.8% (3/44) vs. 21.7% (18/83) , P=0.043),and had lower levels of fasting blood glucose (5.34(4.59,5.87) mmol/L vs. 7.12(5.18,8.60)mmol/L, P=0.001),total cholesterol((3.94±1.14) mmol/L vs. (4.91±1.50) mmol/L, P=0.001),triglyceride(1.42 (0.91,1.64) mmol/L vs. 1.89 (1.23,2.45) mmol/L, P=0.005),and low density lipoprotein cholesterol ((2.24±0.91) mmol/L vs. (2.94±1.16) mmol/L, P=0.001),CAG results showed that patients in the SCAD group had more single vessel lesion (88.6% (39/44) vs. 39.8% (33/83) , P=0.001), and their target lesion stenosis was less severe ( (79.2±22.4) % vs. (91.5±12.1) %, P=0.001). (2) The clinical risk factors such as hypertension history, diabetes history, smoking history, family history of cardiology disease, fasting blood glucose,total cholesterol,triglyceride and low density lipoprotein cholesterol were similar between definite group and probable group (all P>0.05). CAG results showed that prevalence of single vessel lesion (100% (21/21) vs. 78.3% (18/23) , P=0.050) and percent of target lesion stenosis ( (76.9±20.6) % vs. (81.2±24.1) %, P=0.529) were similar between definite group and probable group.(3)There were no significant difference in single vessel(84.0% (21/25) vs. 94.7% (18/19) , P=0.370), target lesion stenosis(85.0(70.0,100.0)% vs. 75.0(50.0,90.0)%, P=0.186),and survival rates in hospital(96.0% (24/25) vs. 100% (19/19) , P=1.000) between interventional therapy group and conservative treatment group. Conclusions: Prevalence of SCAD is highin young female patients with acute myocardial infarction. Acute myocardial infarction patients with less risk factors of CAD and with CAG showing smooth lesion of narrowing segment and normal finding in the other vessels, are more likely to be diagnosed with SCAD.Acute myocardial infarction patients caused by SCAD have high survival rate either receiving percutaneous coronary intervention or drug treatment.

TCTAP A-017 Difference of Clinical and Prognostic Characteristics of Acute Myocardial Infarction in Patients with Hemodialysis and Without Hemodialysis

Cardiovascular events are known as poor prognostic factors for hemodialysis (HD) patients. The purpose of this study was to evaluate the clinical and prognostic characteristics of acute myocardial infarction (AMI) in HD patients compared to non-HD patients. From Mie ACS registry, consecutive 2412

Correlation of rs1122608 SNP with acute myocardial infarction susceptibility and clinical characteristics in a Chinese Han population: A case-control study.

Objective:The correlation of the BRG1 rs1122608 single nucleotide polymorphism (SNP) with acute myocardial infarction (AMI) has been reported in American and European populations. However, whether rs1122608 acts as a protective factor or a risk factor for AMI is controversial. In this study, we aimed to detect the associations between rs1122608 and the clinical characteristics of AMI as well as susceptibility, gene–environment interactions, and risk factors for AMI in a Chinese Han population.Methods:In this study, 300 AMI patients and 300 healthy controls of Chinese Han ancestry were enrolled. PCR-RFLP was used to genotype rs1122608 SNPs. Genotypic and allelic frequencies of rs1122608 were compared between the AMI and control groups and among four AMI subgroups, which were subdivided by typical symptom, diagnosis time (DT), infarction location andserious complication.Results:Significant differences were detected between the AMI patients and the controls in both the genotypic and allelic frequencies of rs1122608 (p<0.001 for each). There were also interactions between the subjects with a minor T allele and smoking or alcohol consumption (p<0.001 for each).Conclusion:In the Chinese Han study population, the mutant GT and TT genotypes and minor T allele of rs1122608 were positively correlated with the risk of AMI. For the first time, we discovered that the GT genotype of the rs1122608 SNP is significantly correlated with diagnosis time of AMI. In addition, the interactions between the minor T allele of rs1122608 and smoking or alcohol use and between the rs1122608 CC genotype and alcohol use appear to increase the risk of AMI.

Clinical Manifestation, Management and Prognosis of Acute Myocardial Infarction in Autosomal Dominant Polycystic Kidney Disease

Background/Aims: Cardiovascular complications are the most common cause of death in individuals with autosomal dominant polycystic kidney disease (ADPKD), yet there is no substantial data concerning the clinical characteristics of acute myocardial infarction (AMI) in this population. This study thus aimed to investigate AMI in persons with ADPKD. Methods: A retrospective analysis of ADPKD patients admitted to our hospital over a 13 year period was conducted. Age and gender-matched control patients without ADPKD were also selected at a ratio of 1: 10. Results: A total of 52 ADPKD and 520 non-ADPKD patients were enrolled in the present study, with those in the former group exhibiting significantly poorer kidney function. The distribution of AMI types differed significantly between these two groups. The incidence of ST-segment elevation myocardial infarction (STEMI) was higher (75.0%) and the incidence of non-ST segment elevation myocardial infarction (NSTEMI) was lower (25.0%) in the ADPKD group. At the onset of AMI, sudden cardiac death (SCD) was more common in ADPKD patients (11.5% vs. 4.6%). In terms of risk factors, the occurrence of hypertension was greater in ADPKD patients (78.8% vs. 39.6%). With regard to subsequent management, ADPKD patients had a higher prevalence of triple-branch coronary lesions (21.1% vs. 11.2%), undergoing more coronary artery bypass grafting (CABG) (7.7% vs. 5.4%) and fewer percutaneous coronary interventions (PCI) (73.1% vs. 84.6%). Overall, ADPKD patients had higher rates of mortality (13.5% vs. 6.2%). Conclusion: ADPKD patients with AMI suffer from more severe conditions and difficult therapies, resulting in a poorer prognosis.