The Sayan-Tuva Upland is the northernmost positive relief of Central Asia, associated with the India-Asia collision. It formed on the boundary of the Siberian Craton in late Miocene-early Pliocene time and is characterized by uplift and shear displacement of lithospheric blocks. In this study, we answer the question of how deformation is distributed within the Sayan-Tuva Upland and what are the rates and age of horizontal displacements. Using morphotectonic and palaeoseismological analyses, we have calculated the displacement rates and onset of activation of three faults: Erzin-Agardag, Sayan-Tuva and Kaakhem, which are fragments of large strike-slip fault systems that cut across the entire Sayan-Tuva Upland. For the Erzin-Agardag Fault, the rate of left-lateral displacement is 0.7–1.4 mm/yr and the age of strike-slip reactivation is estimated to be 2.1–1.1 Ma. For the Sayan-Tuva and Kaakhem faults, the minimum horizontal displacement rates are 0.9 ± 0.1 and 0.6 ± 0.1 mm/yr, and the maximum ages of the onset of strike-slip displacements are 2.4 Ma and 5 Ma, respectively. We propose that 1.1–2.1 Ma ago there was a kinematic change that activated left-lateral strike-slip faults, leading to the formation of the modern kinematic model, characterized by eastward movement of lithospheric blocks along inherited fault systems between the Hangay Dome and the Siberian Craton. Analysis of slip distribution and trenching across the Erzin-Agardag Fault allowed estimating the mean recurrence interval of the ∼ M7.8 earthquakes between 9.4 and 4.7 ka. The Erzin-Agardag Fault has produced multiple displacements with an amplitude of ∼ 6.6 m and follows a characteristic slip model.