Changes In Axis Research Articles

Effect of Structure and Hydrogen on the Short-Term Creep of Titanium Ti-2.9Al-4.5V-4.8Mo Alloy.

In this paper, the effect of hydrogenation, in the amount of 0.15 wt.%, on the short-term creep of a titanium Ti-2.9Al-4.5V-4.8Mo alloy in fine-grained (FG) and ultrafine-grained (UFG) states is studied at 723 K. The UFG structure was formed by the method of pressing with the change of the deformation axis and gradual temperature decrease. Creep tests are performed under conditions of uniaxial tension at a constant load for the creep rates at an interval of (10−7 ÷ 10−6) s−1. The UFG alloy’s resistance to creep under the investigated conditions is revealed to be substantially lower than in the FG state. When hydrogen presents in the alloy in a solid solution, a 1.3–2.5-fold rise in the value of the steady-state creep rate for the hydrogenated FG and UFG alloys is observed. The creep of the non-hydrogenated FG and UFG alloys is described by the creep power law. The presence of dissolved hydrogen leads to a violation of the creep power law. The values of stress sensitivity indices, steady-state creep rate, and effective creep activation energy are determined. The relationships between the hydrogenation, structure, and creep mechanisms of the alloy at the steady-state are discussed.

Prenatal exposure to environmental pro-oxidants induces mitochondria-mediated epigenetic changes: a cross-sectional pilot study.

Mitochondria play a central role in maintaining cellular and metabolic homeostasis during vital development cycles of foetal growth. Optimal mitochondrial functions are important not only to sustain adequate energy production but also for regulated epigenetic programming. However, these organelles are subtle targets of environmental exposures, and any perturbance in the defined mitochondrial machinery during the developmental stage can lead to the re-programming of the foetal epigenetic landscape. As these modifications can be transferred to subsequent generations, we herein performed a cross-sectional study to have an in-depth understanding of this intricate phenomenon. The study was conducted with two arms: whereas the first group consisted of in utero pro-oxidant exposed individuals and the second group included controls. Our results showed higher levels of oxidative mtDNA damage and associated integrated stress response among the exposed individuals. These disturbances were found to be closely related to the observed discrepancies in mitochondrial biogenesis. The exposed group showed mtDNA hypermethylation and changes in allied mitochondrial functioning. Altered expression of mitomiRs and their respective target genes in the exposed group indicated the possibilities of a disturbed mitochondrial-nuclear cross talk. This was further confirmed by the modified activity of the mitochondrial stress regulators and pro-inflammatory mediators among the exposed group. Importantly, the disturbed DNMT functioning, hypermethylation of nuclear DNA, and higher degree of post-translational histone modifications established the existence of aberrant epigenetic modifications in the exposed individuals. Overall, our results demonstrate the first molecular insights of in utero pro-oxidant exposure associated changes in the mitochondrial-epigenetic axis. Although, our study might not cement an exposure-response relationship for any particular environmental pro-oxidant, but suffice to establish a dogma of mito-epigenetic reprogramming at intrauterine milieu with chronic illness, a hitherto unreported interaction.

Precession of a ball rolling in a circular path

If a ball rolls in a circular path on a horizontal surface at constant speed then its horizontal rotation axis changes direction with time. A simple experiment is presented showing that the torque applied to the ball is equal to the rate of change of its angular momentum, even though the magnitudes of its angular velocity and angular momentum remain constant in time.

The effect of the die rotation during extrusion on the shape of embedded markers

The introduction of die rotation during extrusion changes the material flow pattern. An initially straight flow marker embedded into a billet to visualise plastic flow is twisted into a spiral during rotation-assisted extrusion in addition to the reduction in the cross-sectional area. Moreover, the shape of the marker as observed on two-dimensional sections perpendicular to the extrusion axis changes from a circle to a teardrop. A simple model was proposed to describe these changes. The method is based on two transformations to account for the grid pattern distortion during conventional extrusion without rotation and for the torsion due to the die rotation. A good agreement was obtained between calculations and experimentally observed marker shape changes during high-pressure torsion extrusion and previously reported results for friction stir extrusion.

A graphical method for the analysis of a satellite’s in-orbit breakup through optical observations

The incessant overcrowding of the space around the Earth with new operative satellites is a critical issue in the Space Traffic Management (STM) framework, especially in last years with the beginning of the new space economy. The operative life of the active satellites is seriously endangered by the numerous uncontrolled objects, i.e., the space debris, which populate the outer space. The consequence of an impact between these objects may be catastrophic, as proved by the events in the recent past. In this context, the in-orbit explosions both of dismissed satellites and rockets stages are one of the main causes of space debris generation. For this reason, a suitable observation and detection strategy of the fragments generated by these events is necessary, e.g., by means of optical systems. In this work, the Sapienza Space Systems and Space Surveillance Laboratory (S5Lab) shows the results, by means of a graphical method, of the short-term analysis of the in-orbit explosions that involved the third stage of the Russian rocket FREGAT-SB and the fragmentation of the military Chinese satellite YUNHAI 1–02. In order to approach the study of a fragmentation event, an observation strategy and an analysis method have been developed. The research of fragments was focused on the orbital plane leading to estimation of fragments’ number and their distribution. The measurements obtained through the images were analyzed in order to understand if the objects present in the images are either included in the North American Aerospace Defense Command (NORAD) catalogue or not. The unknowns could be fragments. The next analysis follows the hypothesis of the isotropic explosion confined only on the tangential impulses. In first approximation, only semi-major axis and eccentricity change due to the impulse. Therefore, it is possible to generate a new Two-Line Elements (TLE) for each fragment leading to an association between the impulses and the affected TLEs. A new, simple, and fast analysis method was developed, specifically to improve the impulse association. It consists in a graphical method where it is possible to see the distribution of the fragments with respect to the original body using the angular distance trend between them.

THz Multi-Mode Q-Plate with a Fixed Rate of Change of the Optical Axis Using Form Birefringence.

We report the design, fabrication and experimental validation of a THz all-dielectric multi-mode q-plate having a fixed rate of change of the optical axis. The device consists of space-variant birefringent slabs manufactured by 3D printing using melt-extruded Acrylonitrile Butadiene Styrene (ABS). The desired form birefringence is analytically evaluated and experimentally measured by the THz time domain spectroscopy technique. The manufactured q-plate design is characterized using a polarization-sensitive imaging setup. The full electric field spatial maps are acquired from the beam propagating through the q-plate. The device enables the realization of both radial and azimuthal vector beams at discrete frequency intervals by controlling the space-dependent orientation of the ordinary and extraordinary axes in the transverse plane with a multi-mode sequence.

BMP4 Exerts Anti-Neurogenic Effect via Inducing Id3 during Aging.

Bone morphogenetic protein (BMP) signaling has been shown to be intimately associated with adult neurogenesis in the subventricular zone (SVZ) and subgranular zone (SGZ). Adult neurogenesis declines in aging rodents and primates. However, the role of BMP signaling in the age-related neurogenesis decline remains elusive and the effect of BMP4 on adult SVZ neurogenesis remains controversial. Here, the expression of BMP4 and its canonical effector phosphorylated-Smad1/5/8 (p-Smad1/5/8) in the murine SVZ and SGZ were found to be increased markedly with age. We identified Id3 as a major target of BMP4 in neuronal stem cells (NSCs) of both neurogenic regions, which exhibited a similar increase during aging. Intracerebroventricular infusion of BMP4 activated Smad1/5/8 phosphorylation and upregulated Id3 expression, which further restrained NeuroD1, leading to attenuated neurogenesis in both neurogenic regions and defective differentiation in the SGZ. Conversely, noggin, a potent inhibitor of BMP4, demonstrated opposing effects. In support of this, BMP4 treatment or lentiviral overexpression of Id3 resulted in decreased NeuroD1 protein levels in NSCs of both neurogenic regions and significantly inhibited neurogenesis. Thus, our findings revealed that the increased BMP4 signaling with age inhibited adult neurogenesis in both SVZ and SGZ, which may be attributed at least in part, to the changes in the Id3-NeuroD1 axis.

The Microbiome and Gut Endocannabinoid System in the Regulation of Stress Responses and Metabolism.

The endocannabinoid system, with its receptors and ligands, is present in the gut epithelium and enteroendocrine cells, and is able to modulate brain functions, both indirectly through circulating gut-derived factors and directly through the vagus nerve, finally acting on the brain’s mechanisms regarding metabolism and behavior. The gut endocannabinoid system also regulates gut motility, permeability, and inflammatory responses. Furthermore, microbiota composition has been shown to influence the activity of the endocannabinoid system. This review examines the interaction between microbiota, intestinal endocannabinoid system, metabolism, and stress responses. We hypothesize that the crosstalk between microbiota and intestinal endocannabinoid system has a prominent role in stress-induced changes in the gut-brain axis affecting metabolic and mental health. Inter-individual differences are commonly observed in stress responses, but mechanisms underlying resilience and vulnerability to stress are far from understood. Both gut microbiota and the endocannabinoid system have been implicated in stress resilience. We also discuss interventions targeting the microbiota and the endocannabinoid system to mitigate metabolic and stress-related disorders.

Corrective osteotomies in the treatment of lower limb deformities in deforming osteoarthritis of the knee joint

The paper presents the medium-term results of the use of periarticular osteotomies of the tibia and femur in the treatment of deforming knee arthrosis (KA) against the background of lower limb deformities. The aim of the study was to evaluate the effectiveness of osteotomy combined with one-stage endoscopic organ-sparing interventions in the treatment of gonarthrosis. The object of the study was 74 patients with deforming osteoarthritis (DOA) of KA II-III degrees. Selection criteria: changes in the load axis of the limb in the frontal and sagittal planes, degenerative changes of the joint predominantly in one department (medial, lateral), the presence of contracture not more than 10˚. The study group did not include patients with degenerative damage to two parts of the knee joint, pronounced patellofemoral arthrosis, and flexion contracture of more than 10°. Preoperative planning and selection were performed on the basis of clinical examination, radiography, MRI, and CT scan data. Surgical treatment was performed in one surgical session: when correcting a varus deformity, osteotomy was performed first, and arthroscopic intervention, including ligament plasty, was performed second; when correcting a valgus deformity with femoral osteotomy, primary KA arthroscopy followed by osteotomy was optimal. As a result of the treatment, excellent and good results were achieved in the majority of patients in the medium-term period.

Malposition of components and Femorotibial mechanical Axis changes on pressure distribution in Total knee arthroplasty

BackgroundTo the best of our knowledge, no report has analyzed the postoperative results of poor prosthesis position, particularly when the femoral and tibial components are abnormally positioned relative to neutral lower limb alignment. We aimed to investigate pressure distribution in the knee at different lower limb alignments with diverse positions of femoral and tibial components. MethodsWe established a three-dimensional model of the lower limb using computed tomography and simulated total knee arthroplasty. Tibial and femoral components were changed to 7°, 5°, and 3° of valgus and neutral and 3°, 5°, and 7° of varus positions in the coronal plane. Finite element analysis was performed after applying pressure to simulate weight-bearing, and pressure distribution on the tibial surface was analyzed. We also conducted biomechanical testing using a weight-bearing rig with six cadavers. We measured the pressure at the tibial surface with the position of different components and lower limb alignment. FindingsPeak pressure on the medial or lateral side of the tibia was determined by the mechanical axis. When tibial components are in 3°,5° and 7° of valgus/varus and femoral components are in 3°,5° and 7° of varus/valgus correspondence, no peak pressure was detected with normal alignment, despite malpositioned components. InterpretationLower limb alignment is more critical than the position of the component. Medial and lateral tibial compartment pressures were evenly distributed if the alignment was neutral. Malpositioned femoral or tibial components changed the femorotibial mechanical axis, and peak pressure of the proximal tibia was positively related to alignment.

The Short-Term Changes of the Sagittal Spinal Alignments After Acute Vertebral Compression Fracture Receiving Vertebroplasty and Their Relationship With the Change of Bathel Index in the Elderly.

IntroductionFragility vertebral compression fractures (VCFs) are of major concern due to aging populations worldwide, which may occur after a fall from standing or due to severe osteoporosis, impacting greatly the life quality of the elderly. This study thus determined the factors independently associated with poor functional recovery from a new VCF and changes in sagittal spinal alignment after vertebroplasty in elderly patients with osteoporosis.Materials and MethodsThe data were collected from patients older than 70 years and diagnosed with a new VCF. Logistic regression analysis was performed to determine factors independently associated with function and radiographic status.ResultsWe enrolled 8 male and 34 female patients with a mean age of 80.74 ± 8.31 years between January and July 2020. Compared with preoperative data, post-vertebroplasty lumbar sagittal alignments and functional scores improved significantly, and function recovered gradually over 12 weeks. Climbing stairs was the most influential performance indicator at the beginning of the recovery process. At each postoperative follow-up, changes in the C7-sacrum sagittal vertical axis exhibited an influence on functional recovery. Male patients were better able to move from a chair to a bed at the 2-week postoperative follow-up, and positive changes in the spino-sacral angle led to improved function in terms of stair climbing at the 6-week postoperative follow-up.ConclusionsVertebroplasty seemed to be effective for functional recovery related to sagittal spinal alignment improvement of the elderly with VCFs during postoperative 12 weeks, which may be a critical stage for the recovery for their life activities. The recovery rate for stair climbing after vertebroplasty was slower than for the other functional performance indicators in our study. In addition, if a patient was unable to demonstrate a marked improvement in sagittal alignment, they were likely to have ongoing impaired function and a poor prognosis after surgery.

Pubertal changes in the pituitary and adrenal glands of male and female rats: Relevance to stress reactivity

The hormonal stress response mediated by the hypothalamic-pituitary-adrenal (HPA) axis changes significantly during puberty in a variety of species, including humans. For example, stress-induced adrenocorticotropic hormone (ACTH) and corticosterone responses are greater in prepubertal compared to adult rats, yet the mechanisms that mediate these age-related differences are unclear. It is possible that the pituitary and adrenal glands have higher hormonal concentrations prior to puberty, thus enabling a greater hormonal response if a stressor were to occur. Thus, we tested the hypothesis that resting levels of ACTH, and its precursor, proopiomelanocortin (POMC), are higher in the pituitary, and corticosterone levels are higher in the adrenals, of prepubertal compared to adult rats. Furthermore, to investigate any potential sex differences in these parameters, both males and females were assessed. Here we report that despite similar circulating plasma ACTH and corticosterone levels, prepubertal males and females have greater ACTH levels in the pituitary and greater corticosterone concentrations in the adrenals compared to adult males and females. Moreover, we show that POMC protein levels are significantly greater in the pituitary gland of prepubertal than adult rats, particularly in prepubertal females. These data suggest that increased glandular production of ACTH and corticosterone during puberty in part mediate pubertal differences in hormonal stress reactivity and highlight how each node of the HPA axis may contribute to these developmental changes. Given the dramatic increase in stress-related dysfunctions during puberty, continued study of all parts of the HPA axis will be imperative.

Nearest Neighbor Density Analysis of the Stellate Ganglia

IntroductionThe so‐called heart‐brain axis is the neurological and physiological connection between the autonomic systems of both organs. The stellate ganglia and superior cervical ganglia are the location of the sympathetic neuronal cells that innervate the vasculature of the heart and brain, respectively. The paravertebral chain connects the ganglia on either side of the neck. Myocardial infarction is thought to cause remodeling of the sympathetic neurons in the stellate ganglia. In a recent qualitative study, the stellate ganglia were shown to remodel with regard to cell body number, size, density, and clustering in the presence of various cardiac diseases. We developed a tool to automatically quantify the nearest neighbor density of neurons weighted by size in pathology specimens of the stellate ganglia. This is the first step to quantifying sympathetic nervous system changes in the heart‐brain axis of cardiovascular pathology.MethodsBiopsies of the stellate ganglia were collected bilaterally from an opportunity sample of 17 willed body donors (34 total specimens) with and without histories of self‐reported myocardial infarction (MI) and/or cerebrovascular accident (CVA). The ganglia were stained with luxol fast blue and cresyl violet which allowed for histological analysis of local neurons. Images of the ganglia at its middle coronal slice after staining were processed using multiple libraries in python, primarily PIL and OpenCV. The images first underwent multiple filters: a high contrast filter and a smoothing filter. After this filter, the image passed through a color threshold that obtained the location of each neuron; the locations of each neuron were used to make a binary image. The binary image was passed through various parameters such as neuron area, radius of the minimum enclosing circle, and a ratio of the area of the neuron and area of the minimum enclosing circle. A heatmap was generated from this last image through a convolution calculation that takes into account the location of the neuron, size, and proximity of surrounding neurons‐ all variables that are needed to calculate nearest neighbor density. Quantitative and qualitative measurements are generated from this: a graphical map of high and low density areas and number of neurons per given threshold of density.ResultsA pipeline was created that generates heatmaps of the nearest neighbor density based on the location and size of neurons on the stellate ganglia. Quantitative data is also measured based on how many neurons are located in varying levels of density structures.ConclusionsHeatmaps of the nearest neighbor density and size of the neurons potentially show signs of cardiac diseases‐ regions of high density or patterns of where highly dense regions are located are indicators. Developments within computation pathology is an easily accessible and pioneering way for new technological innovation.

Moxifloxacin Induced Liver Injury by Causing Lachnospiraceae Deficiency and Interfering with Butyric Acid Production through Gut-Liver Axis.

Cases of unpredictable, idiosyncratic liver damage of moxifloxacin (MXF) have been occasionally reported. However, the health effects of MXF exposure remain controversial. The current study examined the metabolic phenotypes and intestinal flora characteristics of hepatotoxicity induced by MXF. Rats were administered moxifloxacin hydrochloride tablets at doses of 36, 72, and 108 mg/kg body weight/day for 21 days. The levels of tricarboxylic acid cycle intermediates were decreased, whereas those of lipids (arachidonic acid, hexadecanoic acid, and linoleic acid) were increased, reflecting disorders of energy–related and lipid metabolism. Enrichment analysis of the differential metabolites suggested that butanoate metabolism was associated with MXF–induced liver injury. 16S rRNA sequencing uncovered that the diversity of gut intestinal was decreased in MXF–treated rats. Specifically, the abundance of Muribaculaceae was increased, whereas that of Lachnospiraceae, a family of butyrate–producing bacteria, was decreased. The combined serum metabonomics and gut microbiome datasets illustrated the involvement of butanoic acid and energy metabolism in the regulatory changes of the gut–liver axis associated with MXF–induced liver injury. The regulation of endogenous small molecules and intestinal flora during drug–induced liver injury was first described from the perspective of the gut–liver axis, providing a research basis for the mechanism of clinical drug–induced liver injury.

Developmental neuroanatomy of the rosy bitterling Rhodeus ocellatus (Teleostei: Cypriniformes)-A microCT study.

Bitterlings are carp‐like teleost fish (Cypriniformes: Acheilanathidae) known for their specialized brood parasitic lifestyle. Bitterling embryos, in fact, develop inside the gill chamber of their freshwater mussel hosts. However, little is known about how their parasitic lifestyle affects brain development in comparison to nonparasitic species. Here, we document the development of the brain of the rosy bitterling, Rhodeus ocellatus, at four embryonic stages of 165, 185, 210, 235 hours postfertilization (hpf) using micro‐computed tomography (microCT). Focusing on developmental regionalization and brain ventricular organization, we relate the development of the brain divisions to those described for zebrafish using the prosomeric model as a reference paradigm. Segmentation and three‐dimensional visualization of the ventricular system allowed us to identify changes in the longitudinal brain axis as a result of cephalic flexure during development. The results show that during early embryonic and larval development, histological differentiation, tissue boundaries, periventricular proliferation zones, and ventricular spaces are all detectable by microCT. The results of this study visualized with differential CT profiles are broadly consistent with comparable histological studies, and with the genoarchitecture of teleosts like the zebrafish. Compared to the zebrafish, our study identifies distinct developmental heterochronies in the rosy bitterling, such as a precocious development of the inferior lobe.

Posture Estimation Using Surface Electromyography during Wheelchair Hand-Rim Operations.

This study examined competitive wheelchairs that facilitate sports participation. They can be moved straight ahead using only one arm. Our designed and developed competitive wheel-chairs have a dual hand-rim system. Their two hand-rims, attached to a drive wheel on one side, can be operated simultaneously for straight-ahead movement. Specifically, based on integrated electromyography (iEMG) data calculated from surface electromyography (sEMG), we examined the wheelchair loading characteristics, posture estimation, and effects on body posture during one-arm propulsion movement. The first experiment yielded insights into arm and shoulder-joint muscle activation from iEMG results obtained for two-hand propulsion and dual hand-rim system propulsion. Results suggest that muscle activation of one arm can produce equal propulsive force to that produced by two arms. The second experiment estimated the movement posture from iEMG during one-arm wheelchair propulsion. The external oblique abdominis is particularly important for one-arm wheelchair propulsion. The iEMG posture estimation validity was verified based on changes in the user body axis and seat pressure distribution. In conclusion, as confirmed by iEMG, which is useful to estimate posture during movement, one-arm wheelchair use requires different muscle activation sites and posture than when using two arms.

Factors associated with corneal astigmatism change after ptosis surgery.

To evaluate the predictive factors of postoperative corneal astigmatism change in ptosis patients who underwent ptosis surgical repair. Patients who underwent levator resection at Oculoplastic service of the Department of Ophthalmology, Naresuan University Hospital, Thailand between September 2017 and August 2019 were retrospectively evaluated. Changes in degree and axis of corneal astigmatism after ptosis surgery were compared based on patient factors consisting of age at operation, sex, preoperative margin-reflex distance (MRD) 1, and preoperative degree and axis of corneal astigmatism. Forty-two eyes of 28 patients were included in the study. Wilcoxon signed ranks test showed a significant postoperative corneal astigmatism change only in a subgroup of eyes with preoperative astigmatism of ≥1.5 diopters (D; P=0.006). Furthermore, 72.2% (13/18) of the eyes with preoperative astigmatism of ≥1.5 D showed a reduction of astigmatism after eyelid surgery, with the mean astigmatic change of 0.65 D. Majority of preoperative eyes demonstrated with-the-rule astigmatism pattern (45.2%), of which 57.9% showed a reduced degree of astigmatism. In patients undergoing ptosis surgery, the data demonstrate for the first time the association between postoperative corneal astigmatism change and a preoperative corneal astigmatism of ≥1.5 D. Thus, we encourage considering severity of corneal astigmatism prior to cataract or refractive surgery planning in ptosis patients, especially with toric-intraocular lens, to avoid the possibility of calculation error.

Biochemical assessment of adrenal insufficiency after adrenalectomy for non-cortisol secreting tumors: clinical correlation and recommendations.

Data regarding changes in cortisol axis after adrenalectomy for non-cortisol secreting tumors and their correlation with adrenal insufficiency are limited. Our aim was to analyze these changes and their clinical correlations to guide management after adrenalectomy for non-Cushing's tumors. Following IRB approval, postoperative cortisol axis changes were analyzed in patients who underwent unilateral adrenalectomy for non-Cushing's tumors. A morning serum cortisol of ≥ 10μg/dl was accepted as a sufficient adrenal response. 223 adrenalectomies were analyzed. In 63% of patients, POD1 serum cortisol was ≥ 10μg/dl and in 37% < 10μg/dl. No patient with a POD1 cortisol ≥ 10μg/dl developed AI symptoms, whereas symptoms of AI were observed in 4% of those with < 10μg/dl. In patients with a POD1 cortisol of < 10μg/dl, the rate of steroid replacement therapy initiation was 100%, 8%, and 25% when the decision was based on serum cortisol, clinical symptoms, and serum cortisol plus ACTH stimulation test results, respectively. In 90% of asymptomatic patients, hypocortisolemia resolved uneventfully within a week on repeat morning cortisol testing. 75% of patients with hypocortisolemia on POD1 demonstrated an adequate cortisol response to ACTH stimulation test. Although postoperative hypocortisolemia was observed in 37% of patients undergoing unilateral adrenalectomy for non-cortisol secreting tumors, majority did not develop symptoms of adrenal insufficiency. All three steroid initiation approaches appeared safe, with management based on clinical symptoms or selective ACTH stimulation testing sparing more patients from steroids compared to steroid initiation based on POD 1 cortisol levels alone.

Subtalar Joint Behavior After Total Ankle Arthroplasty

Category:Ankle Arthritis; HindfootIntroduction/Purpose:Proper prosthetic alignment for Total Ankle Arthroplasty (TAA) surgery has proven to improve implant survival and prevent complications. Unfortunately, most of the previously published data present information from non weight- bearing computed tomography (WBCT) scans or lack a correlation of the effects of TAA on hindfoot. To the author's knowledge, subtalar joint behavior after TAA is not completely understood. Therefore, the aim of this study is to assess subtalar joint alignment correction after TAA, and its correlation with the tibiotalar alignment correction using WBCT scan.Methods:After obtaining IRB approval, our prospectively collected surgical database was queried for patients undergoing TAA for end stage ankle osteoarthritis. Patients were included if they had preoperative WBCT scan and underwent TAA using an Infinity Prosthesis with standard instrumentation. Patients were excluded if supramalleolar osteotomy, calcaneal osteotomy or revision surgery had been performed. Twenty patients met the inclusion/exclusion criteria. All patients were brought back to the clinic for WBCT scan and to sign informed consent for the specific needs of this study. Eight coronal radiographic parameters were assessed pre and postoperatively on WBCT imaging. Three fellowship-trained musculoskeletal radiologists realized all measurements in two time-frames separated for one month each. Cohen's inter and intraclass coefficients were calculated to estimate the amount of agreement that occurred by chance.Results:Median age was 62 years (range 50-69), 37.5% female patients, median IMC 28 (range 25-33), 10 right feet. Good to excellent intraobserver (ICC 0.89, 0.75, 0.90) and interobserver (ICC 0.82) reliability were reported. Tibiotalar axis changed in 80% of patients, subtalar axis in 100% and hindfoot axis in 80%. Preoperative WBCT scan measurement showed median Medial Distal Tibial Angle (MDTA) of 93.6° (range 83.5°-105°) and median Talo-Calcaneal Angle (TCA) of 6.1° (range -2.4°-20.9°).Postoperative WBCT scan measurement showed median MDTA of 91.0° (range 82.6°-97.5°) and median TCA of 9.0° (range 0.8°- 15.7°). There was no correlation between the lower tibial platform axis (TAS) and subtalar or hindfoot axis. The change in the upper talus platform axis (TTS) showed a direct correlation with the change in the hindfoot axis (p <0.05). The change in joint congruence (TTAC) showed a direct correlation with change in subtalar axis (p <0.01).Conclusion:This is the first study that assesses subtalar joint alignment correction after TAA and its correlation with the tibiotalar alignment correction using WBCT scan. Tibiotalar alignment is often corrected after TAA. Subtalar joint axis and hindfoot axis change after TAA in response to tibiotalar axis, and this change occurs in the same direction as the tibiotalar correction. Future studies should focus on studying the cause of this lack of compensation.

Insight into anisotropic magnetocaloric effect of CrI[formula omitted

CrI3 is considered to be a promising candidate for spintronic devices and data storage. We derived the Heisenberg Hamiltonian for CrI3 from density functional calculations using the Liechtenstein formula. Moreover, the Monte–Carlo simulations with the Sucksmith–Thompson method were performed to analyze the effect of magnetic anisotropy energy on the thermodynamic properties. Our method successfully reproduced the negative sign of isothermal magnetic entropy changes when a magnetic field was applied along the hard plane. We found that the temperature dependence of the magnetocrystalline anisotropy energy is not negligible at temperatures slightly above the Curie temperature. We clarified that the origin of this phenomenon is attributed to anisotropic magnetic susceptibility and magnetization anisotropy. The difference between the entropy change of the easy axis and the hard plane is proportional to the temperature dependence of the magnetic anisotropy energy, implying that the anisotropic entropy term is the main source of the temperature dependence of the free energy difference when magnetizing in a specific direction other than the easy axis. We also investigated the magnetic susceptibility that can be used for the characterization of the negative sign of the entropy change in the case of a hard plane. The competition of the magnetocrystalline anisotropy energy and external magnetic field at a low temperature and low magnetic field causes a high magnetic susceptibility as the magnetization fluctuates. Meanwhile, the anisotropy energy is suppressed as a sufficient magnetic field is applied along the hard axis, and the magnetization is fully rotated to the direction of the external magnetic field.