On 6 February 2023, at 1:17:34 UTC, a powerful Mw = 7.8 earthquake shook parts of Turkey and Syria. Investigating the behavior of different earthquake precursors around the time and location of this earthquake can facilitate the creation of an earthquake early warning system in the future. Total electron content (TEC) obtained from the measurements of GPS satellites is one of the ionospheric precursors, which in many cases has shown prominent anomalies before the occurrence of strong earthquakes. In this study, five classical and intelligent anomaly detection algorithms, including median, Kalman filter, artificial neural network (ANN)-multilayer perceptron (MLP), long short-term memory (LSTM), and ant colony optimization (ACO), have been used to detect seismo-anomalies in the time series of TEC changes in a period of about 4 months, from 1 November 2022 to 17 February 2023. All these algorithms show outstanding anomalies in the period of 10 days before the earthquake. The median method shows clear TEC anomalies in 1, 2 and, 3 days before the event. Since the behavior of the time series of a TEC parameter is complex and nonlinear, by implementing the Kalman filter method, pre-seismic anomalies were observed in 1, 2, 3, 5, and 10 days prior to the main shock. ANN as an intelligent-method-based machine learning also emphasizes the abnormal behavior of the TEC parameter in 1, 2, 3, 6, and 10 days before the earthquake. As a deep-learning-based predictor, LSTM indicates that the TEC value in the 10 days prior to the event has crossed the defined permissible limits. As an optimization algorithm, the ACO method shows behavior similar to Kalman filter and MLP algorithms by detecting anomalies 3, 7, and 10 days before the earthquake. In a previous paper, the author showed the findings of implementing a fuzzy inference system (FIS), indicating that the magnitude of the mentioned powerful earthquake could be predicted during about 9 to 1 day prior to the event. The results of this study also confirm the findings of another study. Therefore, considering that different lithosphere–atmosphere–ionosphere (LAI) precursors and different predictors show abnormal behavior in the time period before the occurrence of large earthquakes, the necessity of creating an earthquake early warning system based on intelligent monitoring of different precursors in earthquake-prone areas is emphasized.