Changes In System Research Articles

Spastic Equinovarus Foot Deformity.

Acute brain injuries are caused by a variety of etiologies, each potentially disrupting neurological function. The neurologic impairments are on a spectrum of severity often creating functional barriers to completing activities of daily living. Initial treatment starts immediately upon diagnosis and requires a multimodal approach working to prevent systemic changes. Therapy, bracing treatment, injections, and pharmacologic treatments are the mainstay of early intervention. Worsening upper motor neurological impairment associated with involuntary muscle hyperactivity can lead to a spastic equinovarus foot deformity. Spastic equinovarus foot deformities secondary to anoxic brain injuries or traumatic brain injury pose a challenging situation for orthopaedic surgeons because of associated cognitive impairment, spastic tone, and extensive soft-tissue contractures prohibiting bracing treatment. Tendon releases and transfers in combination with functional bracing treatment are initially attempted, and selective fusions are performed for severe cases. Surgical indications are primarily focused on obtaining a balanced, braceable, functional lower extremity with a plantigrade foot.

An Assessment of Convergence of Climate Reanalyses from Two Coupled Data Assimilation Systems with Identical High-Efficiency Filtering

Abstract Coupled data assimilation (CDA) uses coupled model dynamics and physics to extract observational information from measured data in multiple Earth system domains to reconstruct historical states of the Earth system, forming a reanalysis of climate variability. Due to imperfect numerical schemes in modeling dynamics and physics, models are usually biased from the real world. Such model bias is a critical obstacle in the reconstruction of historical variability by combining model and observations and, to some degree, causes divergence of CDA results because of individual model behavior in each system. Here, based on a multitime-scale high-efficiency filtering algorithm which includes a deep-ocean bias relaxing scheme, we first develop a high-efficiency online CDA system with the Community Earth System Model (CESM-MSHea-CDA). Then, together with the other previously established CDA system within the Coupled Model, version 2.1 (CM2-MSHea-CDA), that is developed by the Geophysical Fluid Dynamics Laboratory, we conduct climate reanalysis for the past 4 decades (1978–2018). Evaluations show that due to improved representation for multiscale background statistics and effective deep-ocean model bias relaxing, both CDA systems produce convergent estimation of variability for major climate signals such as variability of basin-scale ocean heat content, El Niño–Southern Oscillation (ENSO), and Pacific decadal oscillation (PDO). Particularly, both CDA systems generate similar time mean of global and Atlantic meridional overturning circulations that converge to the geostrophic velocity estimate from climatological temperature and salinity data. The CDA-estimated mass transport at typical measurement sections is mostly consistent with the observations. Significance Statement A coupled climate model simulates the interactions of the atmosphere, ocean, sea ice, and land processes and derives change and variations of the climate system by combining these components. Due to imperfect numerical schemes, a model usually has systematic biases to the real world. Coupled data assimilation (CDA) combines coupled model dynamics and physics with atmospheric and oceanic observations to reconstruct the historical states of Earth’s climate system, forming the analysis of climate change and variability. However, because of the existence of model errors and individual data assimilation algorithm behaviors, currently, the ocean variability of reanalysis produced by different numerical systems is basically divergent. Here, we first apply an identical coupled data assimilation algorithm and effective model error relaxing scheme to two widely used IPCC coupled models to establish two CDA systems. Then, we use both CDA systems to assimilate historical atmospheric and oceanic observations to form two sets of climate reanalyses for the past 4 decades. We found, by some degree, that the results of these multimodel coupled climate reanalyses converged to what historical states ought to be in observational estimation. These convergent climate reanalyses are expected to significantly increase our understanding of CDA and climate assessment.

Toward a Public Health Approach to Farmer Suicide Prevention: The Potential Power of Systems Change

ABSTRACT Objective Suicide among farmers has, over the past 20 years, garnered attention from scholars around the world. The purpose of this paper is twofold. First, this paper will present a framework for considering farmer suicide that builds upon the Interpersonal-Psychological Theory of Suicidal Behavior and extends our current explanations of suicide to include a multilevel, multifactorial focus on individual, interpersonal, community and systemic factors at the root of stressors contributing to suicide among farmers. Secondly, a blueprint for farmer suicide prevention, leveraging the Water of Systems Change Model, is proposed. Method In the spirit of conveying multi-layered influence on farmer suicide while highlighting relevant levels for prevention a parsimonious, prevention-based model of farmer suicide is presented. Results The Water of Systems Change (WSC) model incorporates research to bring attention to the community, organizational, and societal conditions that keep a problem, such as farmer suicide, from being eradicated. Conclusion Suicide is a societal issue that requires a multi-level response. Farmer suicide is a particular concern, as farmers provide for and support all of us. It is incumbent upon public health and the community-at-large to improve our policies, systems, and contexts to create an environment in which farmers are also provided for and supported.

Local synthesis of estradiol in the rostral ventromedial medulla protects against widespread muscle pain in male mice.

Animal studies consistently demonstrate that testosterone is protective against pain in multiple models, including an animal model of activity-induced muscle pain. In this model, females develop widespread muscle hyperalgesia, and reducing testosterone levels in males results in widespread muscle hyperalgesia. Widespread pain is believed to be mediated by changes in the central nervous system, including the rostral ventromedial medulla (RVM). The enzyme that converts testosterone to estradiol, aromatase, is highly expressed in the RVM. Therefore, we hypothesized that testosterone is converted by aromatase to estradiol locally in the RVM to prevent development of widespread muscle hyperalgesia in male mice. This was tested through pharmacological inhibition of estrogen receptors (ER), aromatase, or ER-α in the RVM which resulted in contralateral hyperalgesia in male mice (C57BL/6J). ER inhibition in the RVM had no effect on hyperalgesia in female mice. As prior studies show modulation of estradiol signaling alters GABA receptor and transporter expression, we examined if removal of testosterone in males would decrease mRNA expression of GABA receptor subunits and vesicular GABA transporter (VGAT). However, there were no differences in mRNA expression of GABA receptor subunits of VGAT between gonadectomized and sham control males. Lastly, we used RNAscope to determine expression of ER-α in the RVM and show expression in inhibitory (VGAT+), serotonergic (tryptophan hydroxylase 2+), and μ-opioid receptor expressing (MOR+) cells. In conclusion, testosterone protects males from development of widespread hyperalgesia through aromatization to estradiol and activation of ER-α which is widely expressed in multiple cell types in the RVM.Significance Statement This study's findings reveal, for the first time, that testosterone protects males from development of widespread muscle hyperalgesia through aromatization to estradiol and activation of ER-α within the RVM. The findings also show, for the first time, ER-α expression in the RVM in male mice, and the distribution patterns of this expression among multiple cell types. Thus, together our data suggest a unique endogenous mechanism in the RVM for protection against widespread pain in males only.

Citizens’ perspectives on healthy weight approaches in low SEP neighborhoods: a qualitative study from a systems perspective

BackgroundThe physical and the social environment are important predictors of healthy weight, especially in low socioeconomic position (SEP) neighborhoods. Many Dutch municipalities have implemented a healthy weight approach (HWA). Yet, there is room for improvement. This system science study examined what influences the utilization of HWA facilities and activities, and what aspects can help to achieve a desired systems change (also called leverage point themes (LPTs)) in the HWA system as perceived by citizens living in low SEP neighborhoods.MethodAll research phases were performed with four citizens co-researchers. Forty-seven citizens living in low SEP neighborhoods were semi-structurally interviewed about the neighborhood HWA facilities and municipal HWA activities. A rapid coding qualitative analysis approach was applied per topic. The topics were citizens’ healthy living description, personal circumstances, and satisfaction with foot and cycle paths, sports facilities, playgrounds, green spaces, museums and theaters, community centers, churches, healthcare, school, food supplies, contact with neighborhood, unfamiliar and/or unused activities, familiar and used activities, unavailable but desired (lacking) activities, and reaching citizens.ResultsThe utilization of HWA facilities and activities was influenced by the overarching themes of social cohesion, familiarity, reaching citizens, maintenance, safety, physical accessibility, financial accessibility, social accessibility, fit with personal context, and fit with the neighborhood’s specific needs. Different overarching themes stood out across different facilities and activities. LPTs indicated the overarching themes needed in combination with one another for a specific activity or facility to increase utilization. For example, the LPT regarding foot and cycle paths was “accessible, safe, and maintained foot and cycle paths”. The LPTs regarding familiar and used activities were “customized activities; information provision (e.g., about possibilities to join without paying); social contact, meeting others, and everyone feels included”.ConclusionConducting inclusive qualitative research from a systems perspective among citizens living in low SEP neighborhoods has contributed valuable insights into their needs. This enables practical implementation of HWAs by providing a deeper understanding of the LPTs within the HWA system. LPTs can help HWA stakeholders to further develop current HWAs toward systems approaches. Future research could study the leverage points that may contribute to LPT implementation.

Advancing Equity in Health Care Among Dalits and Tribal People in India: The Progress, Current Realities, and the Way Forward.

The caste system and resulting social exclusion are important social determinants of health inequity in India. This article critically analyzes the influence of the caste system on health inequity in India, starting with a historical perspective and moving to the current status. The article argues that the caste system has deprived Dalits and tribal people in India of achieving health equity. The programs to promote health are often disease-specific and not culturally informed, leading to poor attention at the policy level to the intersecting disadvantages that make Dalits and tribal communities vulnerable, resulting in poor health. The authors suggest strengthening and promoting primary care, improving health access for Dalit and tribal populations, and the need for pivotal changes in the medical education system, shifting the emphasis from specialized care to training family physicians to be oriented toward community health needs, keeping health equity in perspective.

Development and psychometric evaluation of the Implementation Support Competencies Assessment

BackgroundImplementation support practitioners (ISPs) are professionals that support others to implement evidence-informed practices, programs, and policies in various service delivery settings to achieve population outcomes. Measuring the use of competencies by ISPs provides a unique opportunity to assess an understudied facet of implementation science—how knowledge, attitudes, and skills used by ISPs affects sustainable change in complicated and complex service systems. This study describes the development and validation of a measure—the Implementation Support Competencies Assessment (ISCA)—that assesses implementation support competencies, with versatile applications across service contexts.MethodsRecently developed practice guide materials included operationalizations of core competencies for ISPs across three domains: co-creation and engagement, ongoing improvement, and sustaining change. These operationalizations, in combination with recent empirical and conceptual work, provided an initial item pool and foundation on which to advance measurement development, largely from a confirmatory perspective (as opposed to exploratory). The measure was further refined through modified cognitive interviewing with three highly experienced ISPs and pilot-testing with 39 individuals enrolled in a university-based certificate program in implementation practice. To recruit a sample for validation analyses, we leveraged a listserv of nearly 4,000 individuals who have registered for or expressed interest in various events and trainings focused on implementation practice offered by an implementation science collaborative housed within a research-intensive university in the Southeast region of the United States. Our final analytic sample included 357 participants who self-identified as ISPs.ResultsAssessments of internal consistency reliability for each competency-specific item set yielded evidence of strong reliability. Results from confirmatory factor analyses provided evidence for the factorial and construct validity of all three domains and associated competencies in the ISCA.ConclusionsThe findings suggest that one’s possession of high levels of competence across each of the three competency domains is strongly associated with theorized outcomes that can promote successful and sustainable implementation efforts among those who receive implementation support from an ISP. The ISCA serves as a foundational tool for workforce development to formally measure and assess improvement in the skills that are required to tailor a package of implementation strategies situated in context.

The Role of Melatonin in the Inflammatory Process in Patients with Hyperglycemia and Leishmania Infection

Type 2 diabetes mellitus is a metabolic disorder that causes chronic high blood sugar levels, and diabetic patients are more susceptible to infections. American cutaneous leishmaniasis is an infectious disease caused by a parasite that affects the skin and mucous membranes, leading to one or multiple ulcerative lesions. Chronic inflammation and functional changes in various organs and systems, including the immune system, are the primary causes of both diseases. Melatonin, an essential immunomodulatory, antioxidant, and neuroprotective agent, can benefit many immunological processes and infectious diseases, including leishmaniasis. Although, limited reports are available on diabetic patients with leishmaniasis. The literature suggests that melatonin may play a promising role in inflammatory disorders. This study was designed to assess melatonin levels and inflammatory mediators in diabetic patients affected by leishmaniasis. Blood samples from 25 individuals were analyzed and divided into four groups: a control group (without any diseases), a Leishmania-positive group, patients with type 2 diabetes mellitus, and patients with a combination of both diseases. This study measured the serum levels of melatonin through ELISA, while IL-4 and TNF-α were measured using flow cytometry, and C-reactive protein was measured through turbidimetry. This study found that patients with leishmaniasis significantly increased TNF-α and decreased melatonin levels. However, the group of diabetic patients with leishmaniasis showed higher melatonin levels than the control group. These observations suggest that TNF-α may influence melatonin production in patients with American cutaneous leishmaniasis, potentially contributing to the inflammatory characteristics of both diseases.

Fold-Fold Singularity in a Piecewise Smooth Mathematical Model Describing the Dynamics of a Stockless Market

Fold-fold singularities are critical points or singularities in piecewise smooth dynamical systems (PWS) where both the stability and the structure of the system change. These singularities are of great importance in the study of specific dynamics, such as those in markets, as they indicate significant transformations in their evolution, including sudden variability in prices or changes in the behavior of offers and demand. Despite the substantial increase in the use of mathematical and computational tools applied to market dynamics, the current literature does not thoroughly address the study of the existence of fold-fold singularities in piecewise smooth systems within this context. Therefore, due to the importance of markets as economic activities, this paper proves the existence of such a singularity in a mathematical model that describes the dynamics of a stockless market, which is represented by a system of ordinary differential equations defined with piecewise smooth functions.

Assessment of the quality of life of pregnant women with pubic and lower back pain when using kinesiotaping

Physiologically determined changes in the musculoskeletal system during pregnancy lead to the development of pain syndrome in the pubic area and lower back, which in turn lead to a decrease in the quality of life. Materials and methods: Evaluation of the effectiveness of kinesiotaping in symphysiopathy and dorsopathy during pregnancy with respect to the level of quality of life using the validated SF-36 questionnaire "Quality of Life Assessment", the Oswester questionnaire of disability in lower back pain and the Roland – Morris questionnaire "Lower Back pain and disability". Results: In both groups (control and observation), there is a decrease in the level of individual components of quality of life, while the "Physical component" has statistically significant differences between the groups, excluding "Role functioning due to physical condition", which shows a higher level of quality of life in group 2. When assessing the Psychological component, statistical differences between the groups were not revealed it was. According to the results of statistical analysis conducted on the basis of the Oswestry questionnaire, the level of quality of life in group 2 was also significantly higher than in group 1. According to the Roland-Morris questionnaire, it was revealed that despite the higher level of quality of life in group 2, confirmed in our study, disorders in both groups they are still defined as expressed. The most common complaints that reduce the quality of life in pregnant women with pain in the womb and lower back were also identified. Conclusions: Since the quality of life is an integral indicator of most aspects of life, this indicator can be considered the most successful for evaluating the effectiveness of treatment.

Voxelwise analysis of the central hearing pathway in senior dogs reveals changes associated with fractional lifespan

Presbycusis, or age-related hearing loss, affects both elderly humans and dogs, significantly impairing their social interactions and cognition. In humans, presbycusis involves changes in peripheral and central auditory systems, with central changes potentially occurring independently. While peripheral presbycusis in dogs is well-documented, research on central changes remains limited. Diffusion tensor imaging (DTI) is a useful tool for detecting and quantifying cerebral white matter abnormalities. This study used DTI to explore the central auditory pathway of senior dogs, aiming to enhance our understanding of canine presbycusis. Dogs beyond 75% of their expected lifespan were recruited and screened with brainstem auditory evoked response testing to select dogs without severe peripheral hearing loss. Sixteen dogs meeting the criteria were scanned using a 3 T magnetic resonance scanner. Tract-based spatial statistics was used to analyze the central auditory pathways. A significant negative correlation between fractional lifespan and fractional anisotropy was found in the acoustic radiation, suggesting age-related white matter changes in the central auditory system. These changes, observed in dogs without severe peripheral hearing loss, may contribute to central presbycusis development.

IMPACT OF GENDER, LOCATION AND PARENTAL EDUCATION ON AWARENESS OF NEW EDUCATION POLICY -2020 AMONGST STUDENTS OF HIGHER EDUCATION INSTITUTIONS OF GUJARAT

Education plays a pivotal role in the economic growth and development of any nation. It not only educates the people but also plays an important role in building character, compassion, ethics in an individual and at the same time prepares them for gainful & fulfilling employment which in turn contributes to the overall development of the nation. With the rapid development in the technical demand globally, it will be required that technically & skilled human beings having sound multidisciplinary knowledge remain available. Hence, the Government of India has changed the way we study by introducing “New Education Policy – 2020”. It will bring foundational change in the education system and will bring innovative changes that will meet global requirement of qualified individuals. The success of the policy depends on the cooperation and awareness amongst all the stakeholders who are going to be affected by the change. Hence, it is essential that the objectives, features, benefits and outcomes of the policy are known to the individual. The present study aims to understand the awareness of NEP-2020 amongst the students of higher education institutions based on structured questionnaire and the information was collected through survey having sample size of 230 respondents. The study focus on awareness based on various criteria and the outcome is distinguished based on gender, residential location & background of parents’ education. On verifying the feedback & statistical result of chi-square analysis, it indicates that there is no significant association between the gender, location and parental education on awareness about the NEP – 2020. The success of the policy depends on the cooperation and awareness amongst all the stakeholders who are going to be affected by the change. Hence, it is essential that the objectives, features, benefits and outcomes of the policy are known to the individual. The present study aims to understand the awareness of NEP-2020 amongst the students of higher education institutions based on structured questionnaire and the information was collected through survey having sample size of 230 respondents. The study focus on awareness based on various criteria and the outcome is distinguished based on gender, residential location & background of parents’ education. On verifying the feedback & statistical result of chi-square analysis, it indicates that there is no significant association between the gender, location and parental education on awareness about the NEP – 2020.

Immune response, oxidative stress, and histological changes of Wistar rats after being administered with Parascaris equorum antigen

Worldwide, particularly in developing nations, helminth infections are the leading causes of livestock illness and mortality. Parascaris (P.) equorum, a parasitic worm from the Ascarididae family, significantly impacts the production, health, and working performance of equines. This study aimed to investigate the impact of intraperitoneal sensitization of P. equorum on the immune system, oxidative stress, and histology in Wistar rats. After acclimatization for 7 days, we divided the rats into five groups, each consisting of six rats. Group I, serving as the control, was administered distilled water, followed by groups II (day 7), III (day 14), IV (day 21), and V (day 33). The rats were euthanized every day mentioned (Days 7–33). On day 0, a dosage of 1ml/100 gm rat (containing 500 μg/ml protein content) emulsified crude antigen extract with an incomplete Freund’s adjuvant (1:1 volume), followed by a second dose of the same antigen concentration on day 7. To assess the allergenicity of this nematode, we measured a whole blood profile, serum levels of IFN-γ, IL-5, IL-10, IL-13, and IL-33, total immunoglobulins IgE and IgG, and oxidative stress markers. Also, we examined histological changes in the liver, kidney, and spleen. The results showed that values of total leukocyte count, granulocytes, monocytes, and lymphocytes were significantly (P < 0.05) increased on day 14 post-infection relative to other days of investigation. It was found that the levels of total immunoglobulins (IgE and IgG) and cytokines (INF-γ, IL-5, IL-13, and IL-33) on days 14 and 21 were significantly higher than in the control group. At all periods of the experiment, the injected group exhibited significantly higher concentrations of MDA and NO compared to the control group (P < 0.05). Conversely, GSH and CAT levels (P < 0.05) dropped significantly on days 7, 14, and 21. Different rat tissues showed alterations. Ultimately, this study described the detrimental effects of P. equorum crude antigen administration on the immune system, oxidative states, and histological changes of Wistar rats at various intervals.

Leaving Performance-Oriented Goal (Ranking) Based Education To Improve Student Learning Motivation

Society believes that ranking can be extrinsic motivation for students to improve learning performance, achievement, and student achievement. Ranking also makes it easier for schools to find out the quality of schools, formulate policies, and select colleges to enter. On the other hand, ranking triggers "competition" not only among students, but also between parents. The pressure that children feel to always "achieve" in this case to win in class, is also getting higher. However, reflecting on the quality of Indonesian education, the rankings did not function as expected. This can be seen from the results of the 2018 PISA test which showed Indonesia was ranked 72nd out of 77 countries. The research aims to understand the purpose and effectiveness of the learning process based on performance-oriented goals in education and to find alternative learning methods that are more effective in motivating students through learning process orientation. The method used in this research is library research, namely research carried out by reading, studying and recording various literature or reading materials that are appropriate to the subject matter. The results of the study explain that basically ranking is no longer relevant for use in schools because it will encourage performance-oriented goals in students. This condition is exacerbated by the infrastructure, facilities, and number of teaching staff that are not in line with the existing learning demands. There is a need for a system change that is more oriented towards learning-oriented goals to maximize the learning process and revive students' interest in learning.

Determinants of possible inflammatory myocardial damage in acute intestinal infections in children

BACKGROUND: Non-coronary cardiomyopathies, including inflammatory cardiomyopathies, are one of the leading causes of disability and mortality in children and adults. Inflammatory cardiomyopathy in most cases is an outcome of myocarditis as a result of direct agent-dependent myocardial damage or autoimmune reactions in the absence of genetic predisposition. AIM: On the basis of clinical assessment of cardiovascular system changes, to develop a discriminant model to predict the possibility of myocardial damage of inflammatory genesis in acute intestinal infections (AII) in children. MATERIALS AND METHODS: In the Intestinal Infections Department of the Children’s Research and Clinical Center for Infectious Diseases of FMBA of Russia in the period 2020-2022, 33 children aged from 1 month to 13 years with AII of different etiology were consecutively observed, in whom, according to clinical, laboratory and instrumental examination data, for the first time in their lives, changes in cardiovascular system were detected. The sample was formed using an algorithm for diagnosing inflammatory myocardial lesions in points, the sum of which concluded that there were no or presence of such, which allowed us to identify group 1 (n = 24) and group 2 (n = 9), respectively. Etiological diagnosis of acute intestinal infections was performed in all children, clinical and laboratory data, results of a 12-channel electrocardiogram (ECG), transthoracic echocardiography (EchoCG) were evaluated. The differences in the groups were revealed using the Pearson chi-squared test and the Mann–Whitney test, which were considered reliable at p 0.05. The method of discriminant analysis was used. RESULTS: Functional systolic noise and increased cardiospecific enzymes were observed less frequently in group 1 than in group 2 (4.2%; 22.2% and 67%; 100%). Of the pathological ECG changes, violations of the repolarization process were observed (16.7%; 33.3%). No significant changes in the Echo-KG were detected. The viral etiology of acute intestinal infections dominated (79.2%; 88.9%). Changes in the hemogram were characterized by a high frequency of leukocytosis in group 1 (29.2%; 0%) and leukopenia in group 2 (4.2%; 22.2%). In group 1, there was a higher frequency of neutrophilosis (79.2%; 44.4%), rod-shaped shift (62.5%; 22.2%), thrombocytosis (29.2%; 0%), lymphocytopenia (95.8%; 55.6%; p 0.05), monocytosis (8.3%; 0%); increased C-reactive protein (41.7%; 33.3%), ALT (29.2%; 11.1%), urea (29.2%; 11.1%), leukocyturia (16.7%; 0%). CONCLUSIONS: Clinical evaluation of cardiovascular system changes in children with acute intestinal infections using a discriminant model allows to exclude myocardial damage of inflammatory genesis with high probability (95.7%), which is of practical importance.

Decreased vascular contraction and changes in oxidative state in middle–aged Wistar rats after exposure to increased levels of dietary zinc

Both copper and zinc are known to be important for maintaining health, but most research has focused on deficiencies of these elements. Recent studies have shown that high levels of Cu can be toxic, especially to the cardiovascular (CV) system. However, little research has been done on the effects of higher levels of Zn on the CV system. In this study, male Wistar rats aged 12 months were given a diet with twice the recommended daily allowance of zinc (31.8 mg/kg of diet) and compared to a control group (15.9 mg/kg of diet) after 8 weeks. Blood plasma and internal organs of both groups were examined for levels of copper, zinc, selenium and iron, as well as several key enzymes. Aortic rings from both groups were also examined to determine vascular functioning. There were very few changes in the vascular system functioning after chronic exposure to zinc, and only one enzyme, heme oxygenase–1 (HO–1) was elevated, whereas vascular contraction to noradrenaline decreased with no changes in vasodilation to acetylcholine. Of the micronutrients, zinc and selenium were elevated in the blood plasma, while copper decreased. Meanwhile, the total antioxidant status increased. These were not observed in the liver. Therefore, it is proposed that there is a mechanism in place within the vascular system to protect against the overproduction of heme, caused by chronic zinc exposure.

When UK academics decide to disclose mental distress to employers in the HEI workplace: identity conflict, organisational context and the need for systemic change

ABSTRACT UK academics currently report increased workplace stress and workload, with decreased work-life balance, but often feel reluctant to disclose mental distress. We distributed an anonymous online qualitative survey to explore factors which lead academics to decide whether to disclose mental distress in the workplace. Thirty-one participants responded, providing qualitative data about institutional and psychosocial factors that informed academics’ decision to disclose, supplemented by information on role position. Data was analysed thematically. Our study reports the individual struggles of academics as they manage their professional identity alongside the demands of the HEI workplace and explores the individual processes of identity conflict that leads to a re-construction of the professional identity after disclosing mental distress. Our findings reinforce the evidence that this decision occurs within the context of an increasingly business-focussed work culture of over-commitment and strain in this sector in which academics are made responsible for their own wellbeing. These findings lead us to recommend further research into disclosure using the lens of identity integration. We endorse important systemic changes by suggesting that universities need to consider factors contributing to poor mental wellbeing as structural issues, which require institutional action. Furthermore, we highlight the need for HEIs to value the hybrid identity of those who are both academics and experts-by-experience. Finally, we advocate for universities to adopt the social model of disability, which promotes inclusion and equality of opportunity for people who experience mental distress. The small study sample size makes the findings tentative, but they are nevertheless significant and intriguing.

Investigating biological mechanisms of colour changes in sustainable food systems: The role of Starmerella bacillaris in white wine colouration using a combination of genomic and biostatistics strategies

This study explores the biological mechanisms behind colour changes in white wine fermentation using different strains of Starmerella bacillaris. We combined food engineering, genomics, machine learning, and physicochemical analyses to examine interactions between S. bacillaris and Saccharomyces cerevisiae. Significant differences in total polyphenol content were observed, with S. bacillaris fermentation yielding 6 % higher polyphenol content compared to S. cerevisiae EC1118. Genomic analysis identified 12 genes in S. bacillaris with high variant counts that could impact phenotypic properties related to wine color. Notably, SNP analysis revealed numerous missense and synonymous variants, as well as stop-gained and start-lost variants between PAS13 and FRI751, suggesting changes in metabolic pathways affecting pigment production. Besides that, high upstream gene variants in SSK1 and HIP1R indicated potential regulatory changes influencing gene expression. Fermentation trials revealed FRI751 consistently showed high antioxidant activity and polyphenol content (Total Polyphenol: 299.33 ± 3.51 mg GAE/L, DPPH: 1.09 ± 0.01 mmol TE/L, FRAP: 0.95 ± 0.02 mmol TE/L). PAS13 exhibited a balanced profile, while EC1118 had lower values, indicating moderate antioxidant activity. The Weibull model effectively captured nitrogen consumption dynamics, with EC1118 serving as a reliable benchmark. The scale parameter delta for EC1118 was 23.04 ± 2.63, indicating moderate variability in event times. These findings highlight S. bacillaris as a valuable component in sustainable winemaking, offering an alternative to chemical additives for maintaining wine quality and enhancing colours profiles. This study provides insights into the biotechnological and fermented food systems applications of yeast strains in improving food sustainability and supply chain, opening new avenues in food engineering and microbiology.

The role of pulse wave analysis indexes for critically ill patients: a narrative review.

Arterial pulse wave analysis (PWA) is now established as a powerful tool to investigate the cardiovascular system, and several clinical studies have shown how PWA can provide valuable prognostic information over and beyond traditional cardiovascular risk factors. Typically these techniques are applied to chronic conditions, such as hypertension or aging, to monitor the slow structural changes of the vascular system which lead to important alterations of the arterial PW. However, their application to acute critical illness is not currently widespread, probably because of the high hemodynamic instability and acute dynamic alterations affecting the cardiovascular system of these patients. In this work we propose a review of the physiological and methodological basis of PWA, describing how it can be used to provide insights into arterial structure and function, cardiovascular biomechanical properties, and to derive information on wave propagation and reflection. The applicability of these techniques to acute critical illness, especially septic shock, is extensively discussed, highlighting the feasibility of their use in acute critical patients and their role in optimizing therapy administration and hemodynamic monitoring. The potential for the clinical use of these techniques lies in the ease of computation and availability of arterial blood pressure signals, as invasive arterial lines are commonly used in these patients. We hope that the concepts illustrated in the present review will soon be translated into clinical practice.

Long-term trends of pH, alkalinity, and hydrogen ion concentration in an upwelling-dominated coastal ecosystem: Ría de Vigo, NW Spain

The present study focuses on the Ría de Vigo (NW Spain), a coastal embayment influenced by the Canary Current Upwelling System, which is among the world’s significant Eastern Boundary Upwelling Ecosystems. The research assesses historical changes in the marine carbonate system by generating 25-year weekly time series at six stations . Assessing ocean acidification in the region is complex due to diverse factors influencing coastal carbon dynamics, making predictions more challenging. To capture the specific dynamics in Ría de Vigo, ensembles of Neural Networks were applied. These networks were trained with a data set obtained in several oceanographic cruises, in order to retrieve pH, hydrogen ion concentration and alkalinity, achieving a root mean square error of 0.0272 pH units, 0.588 nmol kg-1\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\hbox {kg}^{-1}$$\\end{document}, and 10.6 μ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\upmu$$\\end{document}mol kg-1\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\hbox {kg}^{-1}$$\\end{document}, respectively. Subsequently, time series of the selected variables were generated, applying data of predictors measured at the aforementioned stations . An increase in normalized alkalinity was observed for all stations, except in the surface layer at the innermost location. A decrease in pH and an increase in hydrogen ion concentration were observed for all points, with trends that exceed reported rates of ocean acidification in the open ocean.