Purpose. Determination of the dependencies of spatial relationships between landslides in the Carpathian region of Ukraine and the factors causing them, taking into account the differences in geomorphological, geological, climatic conditions and natural and geographical zoning according to the landscape principle. Methodology. The morphometric analysis of the territory was carried out using QGIS tools to determine the slope angles and exposure; linear characteristics were calculated: distances to the river, road, and houses. Based on the image interpretation data, we calculated the total annual rainfall and average annual air temperature. The impact of the factors considered on landslide formation was assessed using multivariate statistical analysis: factor analysis and linear multiple regression. Findings. Studies on the impact of natural and topographical conditions and anthropogenic activity on the development of landslide processes have been conducted. Orographic and climatic factors play the most important role. Construction of business facilities results in a decrease in the slope stability in 14–19 % of cases. The analysed independed factors showed good consistency between the distribution of existing landslides and the parameters under consideration: the share of the total variance of the factors under consideration is 71–76 %, the coefficient of determination of the regression model is 0.7. Based on the results of geoinformation and statistical analyses, it is proved that differences in geomorphological conditions and human activity (construction of roads, economic facilities) are dominant in the formation of landslides in different landscape zones. Originality. It is established that there is a dynamic coherence between the spatial change in natural conditions and human settlement and activity, which interact with each other to create prerequisites for the development of landslides. Practical value. This study is important from the point of view of understanding and mitigating the cause-and-effect relationship of landslide development for certain territories, and the results obtained can be useful in developing land use planning strategies, infrastructure development, and planning new construction works.