Multiple studies have focused on the role of psychosocial factors as predictors of COVID-19 vaccination willingness and uptake, with less attention paid to whether vaccination itself could influence wellbeing. The current study evaluated this possibility with respect to sense of purpose, the perception one has goals and a direction in life, building on previous evidence this factor may influence vaccination willingness and decision-making. Across seven waves of monthly data from February to August 2021, participants (n = 2169, mage = 48.0 years) across Canada and the United States reported on their sense of purpose and vaccination status. Using piecewise regression models, results indicated that sense of purpose did not appear to fluctuate in the month prior to, during, or following COVID-19 vaccination. However, across most months of the survey, vaccinated participants did report greater sense of purpose relative to unvaccinated participants. These findings are discussed with respect to whether health behaviors, such as vaccination, should be viewed as behaviors indicative of leading a purposeful life.