Changes In Psychomotor Function Research Articles

Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study over 12 months

Digital measures may provide objective, sensitive, real-world measures of disease progression in Parkinson’s disease (PD). However, multicenter longitudinal assessments of such measures are few. We recently demonstrated that baseline assessments of gait, tremor, finger tapping, and speech from a commercially available smartwatch, smartphone, and research-grade wearable sensors differed significantly between 82 individuals with early, untreated PD and 50 age-matched controls. Here, we evaluated the longitudinal change in these assessments over 12 months in a multicenter observational study using a generalized additive model, which permitted flexible modeling of at-home data. All measurements were included until participants started medications for PD. Over one year, individuals with early PD experienced significant declines in several measures of gait, an increase in the proportion of day with tremor, modest changes in speech, and few changes in psychomotor function. As measured by the smartwatch, the average (SD) arm swing in-clinic decreased from 25.9 (15.3) degrees at baseline to 19.9 degrees (13.7) at month 12 (P = 0.004). The proportion of awake time an individual with early PD had tremor increased from 19.3% (18.0%) to 25.6% (21.4%; P < 0.001). Activity, as measured by the number of steps taken per day, decreased from 3052 (1306) steps per day to 2331 (2010; P = 0.16), but this analysis was restricted to 10 participants due to the exclusion of those that had started PD medications and lost the data. The change of these digital measures over 12 months was generally larger than the corresponding change in individual items on the Movement Disorder Society—Unified Parkinson’s Disease Rating Scale but not greater than the change in the overall scale. Successful implementation of digital measures in future clinical trials will require improvements in study conduct, especially data capture. Nonetheless, gait and tremor measures derived from a commercially available smartwatch and smartphone hold promise for assessing the efficacy of therapeutics in early PD.

Identification of Hippuric Acid and Phenols in the Urine of Workers with Occupational Exposure

The current study was conducted on workers in the printing industry in Addis Ababa, the capital and largest city of Ethiopia, which has grown significantly in recent years, providing work for a large number of people whose health motivates us to carry out this work. Because these workers handle substances that appear innocuous but are toxic to human health, such as paint products like VOCs, inhaling these volatile and organic solvents is involuntary. If chronic, it manifests in various symptomatic forms in humans, such as changes in psychomotor function or organ damage, highlighting the need to investigate and evaluate their toxicity depending on the degree of aversion and repercussions experienced by those exposed to this type of solvent. The study was conducted on 40 workers who work in randomly selected locations in Addis Ababa, Ethiopia. For the quantification of total hippuric acid and phenols in urine, two different methods were used. Finally, a survey was carried out to obtain information on the level of knowledge of the toxicity of the chemical substances that use the degree of protection; once the results of the quantitative analyses were obtained and supplemented with the data made by the personal interview, it allowed us to obtain the necessary information to carry out the statistical evaluation and thus to interpret the real substance of the occupational exposure of contamination to which these workers are exposed. The total phenols found averaged [Formula: see text], and hippuric acid is [Formula: see text]. These values indicate benzene and toluene exposure because they exceed WHO reference values in urine.

The Effect of ECT On Brain Grey Matter, Insights From Longitudinal MRI

Despite the highly beneficial effects of ECT in the elderly, the close relationship between brain structure and LLD and the possible predictive value of structural changes on ECT response in LLD, no study has addressed the effects of ECT on gray matter volume (GMV) in the elderly so far. In this presentation we review recent studies elucidating neural effects of ECT in non-elderly cohorts and present a longitudinal structural neuroimaging study in a cohort of 28 elderly subjects to compare GMV before and after ECT. Given the different cortical and subcortical areas implicated in LLD and the absence of previous studies revealing specific regions of interest, we applied a whole brain approach (voxel-based morphometry (VMB)) to explore structural changes. We also investigated the correlation between structural changes and changes in mood, cognition and psychomotor function (given their clinical relevance in LLD). We observed significant right-hemispheric GMV increase in the caudate nucleus, medial temporal lobe (including hippocampus and amygdala), insula and posterior superior temporal cortex. Furthermore, a correlation was found between the increase of GMV in the caudate nucleus region and the change in psychomotor function scores indicating interesting and potentially specific clinical associations. Potential neurobiological mechanisms underlying these GMV increases will be discussed.

Short term oxygen therapy effects in hypoxemic patients measured by drawing analysis

BackgroundChronic hypoxemia has deleterious effects on psychomotor function that can affect daily life. There are no clear results regarding short term therapy with low concentrations of O2 in hypoxemic patients. We seek to demonstrate, by measuring the characteristics of drawing, these effects on psychomotor function of hypoxemic patients treated with O2. MethodsEight patients (7/1) M/F, age 69.5 (9.9)yr, mean (SD) with hypoxemia (Pa O2 62.2 (6.9)mmHg) performed two drawings of pictures. Tests were performed before and after 30min breathing with O2. ResultsStroke velocity increased after O2 for the house drawing (i.e. velocity 27.6 (5.5)mm/s basal, 30.9 (7.1)mm/s with O2, mean (SD), p<0.025, Wilcoxon test). The drawing time ‘down’ or fraction time the pen is touching the paper during the drawing phase decreased (i.e. time down 20.7 (6.6)s basal, 17.4 (6.3)s with O2, p<0.017, Wilcoxon test). ConclusionsThis study shows that in patients with chronic hypoxemia, a short period of oxygen therapy produces changes in psychomotor function that can be measured by means of drawing analysis.

Motor activity and autonomic cardiac functioning in major depressive disorder

Background: The daily pattern of motor activity and the autonomic cardiovascular regulation were studied in major depression to quantify changes in psychomotor function and autonomic cardiac functioning. Additionally, relationships between motor activity parameters, cardiovascular measures and specific clinical features were examined. Methods: Wrist-actigraphy was used to monitor 24-h motor activity for 67 unmedicated (unipolar) depressed inpatients and 64 control subjects. During supine rest, spectral analysis was applied to assess HR and SBP variability, a baroreflex sensitivity (BRS) index and the respiratory frequency, in addition to mean heart rate (HR) and blood pressure (BP) levels for the patient group and a second control group ( N=51). Results: The patients showed a lower motor activity level and a reduced fragmentation of motor activity during wake, and a higher motor activity level and a decreased immobility during sleep. The mean HR and DBP level and the respiratory frequency were higher in the patient group than in the control group, but no differences in HR and SBP variability or BRS were found. Furthermore, motor activity parameters and cardiovascular measures of the patients were related to agitation and retardation and overall, patients with lower motor activity levels demonstrated lower SBP levels. Conclusions: This study confirms that the 24-h pattern of motor activity is altered in unmedicated depressed inpatients, but limited evidence was found for an autonomic cardiac dysfunction. Within the patient group there were relationships between motor activity parameters, cardiovascular measures, and clinical features, but the underlying neurobiological pathways need to be further explored.

Estimating age-related changes in psychomotor function: influence of practice and of level of caloric intake in different genotypes☆

This article presents a discussion of some key considerations in the measurement of age-related changes in psychomotor function of mice. We illustrate that “standard” measures of psychomotor performance, such as running speed on a rotorod task, are highly sensitive to practice effects. Examples are cited in which failure to assess practice effects can influence conclusions regarding the magnitude and rate of change in psychomotor capacity as a function of age. A second set of examples is focused on estimating the effect of an experimental intervention, caloric restriction, on age-related changes in psychomotor performance. These examples show that psychomotor performance at a given age may vary directly, and reversibly, with the level of caloric intake. Independent of such reversible effects, the level of caloric intake can also modulate the rate of change in capacity as a function of age. It is concluded that reversible, short-term effects must be considered in estimating the effect of an experimental intervention on the rate of age-associated change in psychomotor function.

Fluctuations in salivary carbamazepine and carbamazepine-10,11-epoxide concentrations during the day in epileptic children.

Hourly salivary concentrations of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (EP) were studied during 2 consecutive days in a group of epileptic children receiving twice daily CBZ monotherapy either as the tablet or syrup formulation. Relatively large fluctuations were observed for both CBZ (mean, 57%; range, 32-100%) and EP (mean, 97%; range, 19-189%) during a dosage interval. However, concentrations of EP were generally much lower, approximately 34% of corresponding CBZ levels, and in absolute terms the concentration-time curves for EP appeared much less variable. Further evidence supporting extensive CBZ concentration fluctuations during the day was provided by an additional group of 30 epileptic children receiving CBZ monotherapy whose time of dosage was manipulated to achieve peak and trough concentrations during assessment with a psychomotor test battery. Changes in salivary CBZ concentrations within subjects ranged from 4 to 272% (median, 65%), excluding two atypical cases who showed greater than 10-fold increases in the expected high concentration. These results suggest that in children there is a substantial risk of error in the interpretation of CBZ concentrations from a single sample without consideration of the time of last dose. The implications of these findings for clinical treatment with regard to the appearance of side effects and changes in psychomotor function are discussed.