Background and Study Aim: Most of this study focused on endurance, power, and anthropometric measurements but no research declared isokinetic strength changes during two years. The purpose of this study was to assess the effect of resistance exercises on two seasonal alters in isokinetic strength of knee muscles at different angular velocities, in college volleyball players. Material and Methods: Thirteen college volleyball players, (age: 21.75 years, body mass: 78.60 kg, and height: 187.0 cm) participated in the study. All college volleyball players take part in the two-year (8 month each year) volleyball-specific training and competitions. The measurement of peak isokinetic concentric knee extension and knee flexion torque in both legs were taken at 2 angular velocities of movement, low at 60° s-1, and intermediate at 180° s-1. Results: The pre- and post-test values of the peak isokinetic strength found that statistical significance difference, at 60° s-1 and 180° s-1 for knee extensor-flexor both dominant and non-dominant in favor of post-tests. Significant enhances were observed in the baseline dominant knee extensor-flexor muscle strength (extensor knee strength 60° s-1: 19.0%, 180° s-1: 20.5%, flexor knee strength, 60° s-1: 33.4%, 180° s-1: 31.4%) respectively. Non-dominant knee extensor-flexor muscle strength increased significantly over the two-year period (extensor knee strength 60° s-1: 21.3%, 180° s-1: 23.0%, flexor knee strength, 60° s-1: 37.4%, 180° s-1: 33.9%) respectively. Conclusion: As a result, our data suggests that the two-year planned program of specific volleyball and resistance training can increase the knee muscle extensor-flexor strength and H:Q ratios of volleyball players. Especially, at a 60° s-1 and 180° s-1 angular velocities, whilst the knee muscle extensor-flexor strength and H:Q ratios for dominant and non-dominant legs were increasing, also H:Q ratios disproportion were decreasing. Therefore, these alters indicated that regular specific-volleyball and resistance training can increase knee muscle extensor-flexor strength and H:Q ratios for dominant and non-dominant legs.