Changes In Hormonal Status Research Articles

Hormonal status in women with respiratory viral infections during critical periods

Pregnancy and menopause are critical periods in a woman’s life. Due to physiological changes in the neuroendocrine system regulation, susceptibility to respiratory viral infections increases in these periods, while affecting all organs and systems of the human body. The aim of this review was to analyze the literature data on the effect of acute respiratory viral infections on neuroendocrine regulation in women during pregnancy and menopause. We reviewed full-text publications in the public domain from the PubMed, eLibrary.ru, and Google Scholar databases with a coverage period of more than twenty years (2000–2023). Disruptions of the progesterone and estrogen production during infection with the influenza A (H1N1) and influenza B viruses have been shown in experimental studies. Hormonal status changes in pregnant women are detected during infection with the influenza A virus (H3N2) and depend on antiviral antibody titers and the presence of fetoplacental insufficiency. Pregnant women with COVID-19 may experience changes in the brain structure activities, as indicated by a high frequency of those in olfactory sensitivity and psychoemotional disorders. During menopause, infection with the SARS-CoV-2 virus leads to changes in the production of thyroxine, prolactin, estradiol, testosterone, cortisol, 17-hydroxyprogesterone, and dehydroepiandrosterone sulfate.

Gender cardiology: clinical and pathophysiological features of the course the main diseases in women

Coronary heart disease is the leading cause of death for both women and men. Older women, when coronary heart disease first appears, have more comorbidities and usually complain of atypical symptoms. Mortality and hospitalization rates caused by acute myocardial infarction are higher for women. It should be noted that adherence to secondary prevention for women is lower.Female predominance has been noted in idiopathic pulmonary arterial hypertension (IPAH), hereditary pulmonary hypertension, and collagenosisassociated pulmonary arterial hypertension. However, according to the latest data of the European register COMPERA, gender differences disappear for elderly patients and for the patients having concomitant diseases. The more frequent occurrence of cardiomyopathies among women is considered. Peripartum cardiomyopathy associated with pregnancy and childbirth, and Takotsubo cardiomyopathy due to psychoemotional status, in particular a stressful situation, determines a woman's further prognosis. Arrythmias are explained by changes in hormonal status during pregnancy, menopause, or are associated with the onset of the underlying disease.Heart failure usually affects both sexes equally, with women more likely to suffer from HFpEF and men from HFrEF. The classic cardiovascular, gender, and social risk factors for cardiovascular disease and heart failure have a different meaning for women than for men. It is necessary to take into account the parameters for EchoCG diagnostics for women, since the size of the women heart is smaller.

Genomic prediction of blood biomarkers of metabolic disorders in Holstein cattle using parametric and nonparametric models

BackgroundMetabolic disturbances adversely impact productive and reproductive performance of dairy cattle due to changes in endocrine status and immune function, which increase the risk of disease. This may occur in the post-partum phase, but also throughout lactation, with sub-clinical symptoms. Recently, increased attention has been directed towards improved health and resilience in dairy cattle, and genomic selection (GS) could be a helpful tool for selecting animals that are more resilient to metabolic disturbances throughout lactation. Hence, we evaluated the genomic prediction of serum biomarkers levels for metabolic distress in 1353 Holsteins genotyped with the 100K single nucleotide polymorphism (SNP) chip assay. The GS was evaluated using parametric models best linear unbiased prediction (GBLUP), Bayesian B (BayesB), elastic net (ENET), and nonparametric models, gradient boosting machine (GBM) and stacking ensemble (Stack), which combines ENET and GBM approaches.ResultsThe results show that the Stack approach outperformed other methods with a relative difference (RD), calculated as an increment in prediction accuracy, of approximately 18.0% compared to GBLUP, 12.6% compared to BayesB, 8.7% compared to ENET, and 4.4% compared to GBM. The highest RD in prediction accuracy between other models with respect to GBLUP was observed for haptoglobin (hapto) from 17.7% for BayesB to 41.2% for Stack; for Zn from 9.8% (BayesB) to 29.3% (Stack); for ceruloplasmin (CuCp) from 9.3% (BayesB) to 27.9% (Stack); for ferric reducing antioxidant power (FRAP) from 8.0% (BayesB) to 40.0% (Stack); and for total protein (PROTt) from 5.7% (BayesB) to 22.9% (Stack). Using a subset of top SNPs (1.5k) selected from the GBM approach improved the accuracy for GBLUP from 1.8 to 76.5%. However, for the other models reductions in prediction accuracy of 4.8% for ENET (average of 10 traits), 5.9% for GBM (average of 21 traits), and 6.6% for Stack (average of 16 traits) were observed.ConclusionsOur results indicate that the Stack approach was more accurate in predicting metabolic disturbances than GBLUP, BayesB, ENET, and GBM and seemed to be competitive for predicting complex phenotypes with various degrees of mode of inheritance, i.e. additive and non-additive effects. Selecting markers based on GBM improved accuracy of GBLUP.

Complementary and Alternative Medicine for Menopausal Symptoms Management

Menopause is the permanent cessation of menstruation for a complete 12 consecutive months while post-menopause is the period following menopause marked by changes in hormonal status. Studies stated that menopausal women experience symptoms like hot flashes/flushes, night sweats, sleep disturbances, sexual dysfunction, mood disorders, weight gain and cognitive decline which overall affect their lives. Though hormonal therapies are used for symptom management, it was found to have some side effects and increase the chance of cancer. Complementary and alternative medicines (CAM) have a positive impact on the same management. Relaxation, biofeedback, meditation, aromatherapy, use of mineral products and other methods like traditional Chinese medicines, reflexology, acupuncture, acupressure and homeopathy are found to be effective in controlling menopause-related symptoms. We should make them aware of these complementary and alternative medicines. Keywords: Menopause, post-menopause, complementary and alternative medicine.

Changes in hormonal status after restrictive bariatric interventions

The purpose of the work was to study the impact of bariatric surgeries on hormonal status in patients with morbid obesity. The ghrelin levels were evaluated in 26 morbidly obese patients who underwent restrictive bariatric surgeries (13 gastric plications and 13 gastric sleeve resections). The initial level of ghrelin in the blood of the patients with morbid obesity was lower compared to the levels observed with normal body weight. We did not observe the reduction of ghrelin level expected after the resection of the fundus ghrelin-producing part of the stomach. The clinical study indicates that changes in gastric volume after restrictive bariatric interventions (sleeve resection or gastric plication) are accompanied by a slight increase in blood ghrelin levels. This increase is greater the higher the percentage of body weight loss after surgery. More in-depth study of this topic will help identify new strategies for treating morbid obesity in the future.

Successful Management of Metastatic Lymph Nodes in the Chest by Laser Ablation via Endoscopic Ultrasound: A Case Report

Isolated spread of metastatic breast carcinoma to mediastinal lymph nodes is not an uncommon phenomenon. The prognosis worsens with the advent of any metastases in the chest. Conventional treatment mandates chemotherapy or radiotherapy as a control measures. Laser treatment has helped many patients with inaccessible or inoperable tumours, as it works on devascularisation and can benefit both benign and malignant tumours. This is a case report of a patient who did not respond to Trastuzumab and T-DM1 (Trastuzumab with Emtansine). She developed mediastinal lymph nodes during treatment with TDM1. Additionally, she had a documented change in hormonal status from Human Epidermal growth factor Receptor-2 (HER2) positive to negative. She underwent laser ablation of mediastinal lymph nodes around the trachea. A Positron Emission Tomography (PET) scan after six months showed a total resolution of the lymph nodes with no significant uptake in the chest or any other part of the body. Laser ablation of mediastinal lymph nodes is a very skillful and demanding procedure that can be attempted in refractory and isolated cases where chemotherapy and radiation have failed. Further studies are needed to assess the long-term results of this new procedure.

GENDER DIFFERENCES IN THE EFFECT OF ANTIULCER DRUGS AND PLACENTA CRYOEXTRACT ON THE INTENSITY OF LIPID PEROXIDATION AND THE ACTIVITY OF THE ANTIOXIDANT SYSTEM IN EXPERIMENTAL HEPATITIS WITH ETHANOL-INDUCED CIRRHOSIS

Introduction. It is well recognized that drug metabolism products in the liver can induce oxidative stress and mitochondrial dysfunction, leading to the development of hepatocellular injury. As a potential agent capable of counteracting the hepatotoxic effects of drugs, we focused our attention on a domestic biotechnological preparation – cryopreserved placental extract (CPE).
 The aim. To characterize gender differences in the effect of esomeprazole, clarithromycin, metronidazole (E/C/M), and CPE on the intensity of lipid peroxidation and the activity of the antioxidant system in tetrachloromethane (CCl4) hepatitis with a background of ethanol-induced cirrhosis (ETCM).
 Materials and methods. The study was conducted with varying levels of sex hormones on 112 male and female rats. Chronic ETCM was induced by administering a 50.0% oil solution of CCl4 at a dose of 8 ml/kg body weight of the animals twice a week, in combination with a 5.0% ethanol solution for drinking over a period of 45 days. The content of TBA-RP in liver homogenates was determined spectrophotometrically by the method described by Asakawa T. et al. Catalase activity in liver homogenates was determined spectrophotometrically according to the method of Korolyuk M.A. and co-authors.
 Results. The most pronounced increase in lipid peroxidation processes was observed in females with chronic ETCM-induced liver damage and administration of antiulcer drugs following ovariectomy, resulting in a TBA-RS content of 36.1±2.79 μmol/kg of tissue. Administration of E/C/M in animals with chronic liver damage led to a suppression of the antioxidant system, as evidenced by a decrease in catalase activity in liver tissues.
 Conclusion. The combined use of anti-ulcer drugs and CPE on the background of chronic ETCM mitigated the activation of lipid peroxidation processes, which was indicated by a statistically significant (p < 0.001) 2.7-fold lower content of TBA-RP in liver homogenates. Additionally, it was established that the administration of CPE was accompanied by a statistically significant increase in catalase activity in females, more prominently than in males. In females without changes in hormonal status, the introduction of CPE resulted in a growth (p < 0.001) of catalase activity by 75.0%, with the most significant increase observed in females after ovariectomy – catalase activity statistically significantly (p < 0.001) increased by 2.6 times compared to the indicators of females not administered with CPE. The administration of CPE in female rats without altering hormonal status was accompanied by a twofold (p < 0.01) increase in the antioxidant-prooxidant index compared to male rats, indicating more pronounced antioxidant properties of CPE in female rats.

The consequences of phytoestrogenization of the father and the effects of phytoestrogens during puberty for male offspring

Exposure to phytoestrogens (PE) during prepuberty and puberty can modulate the functioning of the reproductive axis, causing irreversible damage to reproductive programming.
 The aim of the study was to investigate the state of the reproductive system of male offspring of adult rats that were exposed to phytoestrogens in the pubertal period of ontogenesis.
 Materials and methods. The work was performed on adult male and female Wistar rats and their male offspring. In the experiment, the biological effect of PE was studied when applying a dose of 20 mg/kg of body weight for 30 days to the father and/or offspring of puberty age starting from the 45th day of postnatal life. Upon reaching the age of six months, male offspring of all studied groups were examined for reproductive function.
 Results. The effect of estrogen-like substances on male reproductive function is manifested not only under the conditions of their intake in the critical periods of the embryonic and postnatal periods, but also, even when acting on the germ cells of parents. In male offspring, androgen secretion is disturbed, the hormonal status changes in the direction of hyperestrogenization, fertility decreases due to the reduced quality of germ cells against the background of a normal spermogram.
 Conclusion. The reproductive function of sexually mature male offspring of a phytoestrogenized father who received a mixture of phytoestrogens during puberty is characterized by differences in sexual behavior, a decrease in the reproductive potential of males, which occurs due to a decrease in the share of effective fertilization, which indicates negative changes in spermatozoa, the development of which took place in conditions of absolute and relative hyperestrogeny. This indicates that phytoestrogens, as an environmental factor, have adverse consequences not only for individuals who directly use them, but also for their male offspring

Gender determinism of the effect of placenta cryoextract on the hepatotropic effects of esomeprazole, clarithromycin and metronidazole in chronic liver damage

Current regimens for the eradication of Helicobacter pylori infection include bismuth drugs, proton pump inhibitors, and a combination of 2–3 antibacterial drugs. Uncontrolled use of antibacterial agents as part of eradication schemes increases the risk of developing their unwanted drug reactions, in particular, hepatotoxicity. As a means with potentially hepatoprotective activity, our attention was drawn to placental cryoextract.
 The purpose of the study. To characterize the gender aspects of the hepatotropic action of placenta cryoextract in tetrachloromethane hepatitis with background ethanol-induced cirrhosis and liver damage by antiulcer agents.
 Materials and methods. Research was conducted on 112 male and female rats. Tetrachloromethane hepatitis with background ethanol-induced liver cirrhosis was reproduced by injecting an oil solution of CCl4 in combination with a 5.0% ethanol solution for 45 days. Modulation of the content of sex hormones was achieved by surgical ovariectomy or testectomy.
 Results and discussion. Administration of esomeprazole, clarithromycin, and metronidazole in chronic liver damage in animals without changes in hormonal status led to a statistically significant (p=0.01) 27.6% increase in the level of bilirubin in homogenates of liver tissues in female rats (78.7±4.5 mmol/l) than in males. The greatest decrease in the content of bilirubin (41.7%, p<0.001) with the use of cryoextract of the placenta was noted in castrated female rats with simulated tetrachlormethone hepatitis with background ethanol-induced cirrhosis of the liver, which were injected with antiulcer agents.
 Conclusions. Administration of cryoextract of the placenta has a pronounced hepatoprotective effect in animals of both sexes. In male rats with no change in hormonal status with simulated liver injury and the administration of antiulcer drugs, placenta cryoextract therapy was more effective than in female rats, as indicated by a more than 1.6-fold decrease in the content of bilirubin in the liver homogenates of male rats (43.1%, p<0.001) than in females (27.4%, p<0.01).

Sex differences in the hepatotropic effects of antiulcer drugs and placenta cryoextract in an experimental rat liver injury model

Background/Aim: Sex-related variances in drug metabolism provide a foundation for refining treatment protocols for prevalent conditions based on the patient's sex. Tailoring treatment strategies based on sex is particularly noteworthy among patients with comorbid illnesses due to the potential for drug interactions and the impact of concurrent diseases on clinical outcomes. Aim of this study was to assess the hepatotropic effects of antiulcer drugs (esomeprazole, clarithromycin and metronidazole - E/C/M) and placenta cryoextract (CEP) within a simulated model of tetrachloromethane (CCl4 )-induced hepatitis combined with underlying ethanol-induced liver cirrhosis (EILC), with a focus on the role of subjects' sex. Methods: Using 112 male and female rats, the research explored the effects of different sex hormone levels. Chronic EILC was induced by administering a 50.0 % CCl4 oil solution (8 mL/kg) twice a week, combined with a 5.0 % ethanol solution, over 45 days. Total protein (TP) levels and alkaline phosphatase (AP) activity were measured spectrophotometrically. Results: The research findings indicate that the onset of EILC and the administration of E/C/M resulted in a significantly greater 10.8 % (p = 0.03) reduction in TP levels among females compared to males, without altering hormonal status. Introducing CEP led to a noteworthy (p < 0.001) rise in TP levels, by 30.8 % in males and 33.9 % in females, in the context of EILC and E/C/M administration, while maintaining hormonal status. Among male rats, the most elevated AP activity was observed with excess testosterone propionate administration (5.0 [5.0; 5.9] mmol/L), while the lowest level was recorded in rats after testectomy, measuring 3.8 [2.5; 4.7] mmol/L, exhibiting a significant 20.8 % decrease (p < 0.05) compared to male rats without hormonal status changes. In female rats, the study revealed that against the backdrop of EILC and E/C/M administration, the highest AP level was seen in ovariectomised females, reaching 5.8 [5.1; 6.2] mmol/L, reflecting a substantial 9.4 % increase compared to rats without hormonal status changes. Conclusions: The administration of CEP under similar experimental conditions led to the recovery of the liver's protein-synthesising function in both male and female rats. When female sex hormones were introduced to sham-operated female rats, a significant 20.8 % greater reduction in AP levels was observed. Additionally, gonadectomy led to a more pronounced decrease in this enzyme's levels in male rats compared to female rats, indicating the cytoprotective properties of female sex hormones.

Changes in Hormonal Status of Aboriginal Fishes under the Impact of Agricultural Runoffs

Changes of cortisol, triiodothyronine, and thyroxine content in the blood plasma of perch, ruff, rudd and bleak under the impact of agricultural runoff from the adjacent territories to the water bodies were studied. Under the long-term exposure to the contaminated water, the weight and size of fish their growth rates specimens significantly decreased. The hormonal responses to the polluted waters impact are species-specific and partly depend on the ecological features of the species. Under the chronic impact of the polluted water, the cortisol content in blood plasma decreases and triiodothyronine content increases as compared to the control. The fishes occurring in the surface water layers create the thyroxine reserve in blood, and fishes which prefer the near-bottom layers use it to increase the triiodothyronine content. After treatment of the fields close to the reservoir with pesticides, the ruff and rudd develop the active stress reaction, the cortisol and thyroxine content in blood significantly increases. According to the considered indicators, the bleak is the most resistant to agricultural runoffs or possesses the ability to avoid toxic water pollution.

GENDER DIMORPHISM OF CHANGES IN THE SKIN MICROCIRCULATION OF RATS ON THE BACKGROUND OF ACUTE COLD TRAUMA

Gender factors play an important role in the prevention, preva- lence and specifics of the course of various pathological conditions, among which cold injury occupies an important place. The role of gender in its pathogenesis remains poorly understood. The aim. To assess sex-specific changes in the microcirculation of target organs exposed to extremely low temperatures during experimental acute cold trauma (ACT) in rats. Materials and methods. Experiments were performed on male and female sexually mature and castrated Wistar rats. Acute cold trauma (ACT) was modeled by keeping the animals at -180ºС for 2 hours. The microcirculation coefficients of the skin of the hind limbs, auricles, and tail of animals were determined using Biopas electrophysiological equipment (USA) non-invasively using a surface sensor. We compared the changes before and 30 minutes after the action of the cold factor. Statistical processing of the results was carried out using standard descriptive methods. The results. A 2-hour stay of animals under the influence of extremely low temperatures causes a significant drop in blood supply in animals of both sexes. The degree of changes has a clear sexual dimorphism with a predom- inance of pathological processes in male animals. In males, the coefficient of microcirculation of the lower limbs and auricles decreased by 72.2 and 55.3 %, and in the tail by 35.1 %, compared to this indicator before the effect of the cold factor (p < 0.05), on the other hand, in female rats changes in similar indicators were 66.5 and 44.3 % (lower limbs and auricles), and tail perfusion by 18.6 % (p < 0.05). ACT in castrated female rats caused more extensive hemoperfusion disorders compared to males: the microcirculation index of the tail, hind limbs, and auricle in male rats on the background of ACT decreased by 25.4, 66.4, and 40.7 %, respectively (p < 0.05), whereas in animals of the opposite sex – by 32.5, 78.8 and 47.4 %, respectively. Conclusion In sexually mature female rats without changes in hormonal status, a greater resistance to microcirculation disorders during experimental acute cold injury was found. The reason for these differences is the effect of sex hormones, since castration of males increases the resistance of the vascular system of animals to the action of a cold factor, while ovariectomy of females – on the contrary, increases the degree of microcirculatory lesions of the most vulnerable organs to the action of extremely low temperatures

Medicinal products as a causative agent of occupational diseases in pharmaceutical workers (literature review)

The issue of occupational diseases in chemical and pharmaceutical workers is urgent because it stems from the rapid pace of development, the functional features, and the high biological activity of raw materials used by that industry. The study is aimed at summarizing the information on preconditions and nature of occupational diseases among chemical and pharmaceutical workers based on the analysis of literature data. An important prerequisite for the emergence of occupational diseases is the shortcomings in the production process, leading to pollution of surfaces and workspace air with chemicals through the use of semi-automatic equipment in particular. The harmful substances then enter the bodies of workers through the respiratory system, which is the main and most harmful way. The most dangerous processes are the production and processing of substances with high pharmacological activity, and thus the active pharmaceutical ingredients maybe considered to be the leading causative agents of occupational diseases in the industrial production of medicinal products. The range of diseases diagnosed in pharmaceutical workers is diverse and includes acute intoxication, effects on internal organs, reproductive function, changes in hormonal status, and changes in the hemic system and nervous system. The most common are diseases of respiratory organs and diseases of allergic origin. As a result, influential international organizations and many authors emphasize the need to develop criteria and methods for assessing the harmful effects of medicinal products on the health of workers when authorizing their production.

Stress Responses to One-Day Athletic Tournament in Sport Coaches: A Pilot Study.

Simple SummaryJudo coaches respond to stress during one-day tournaments, as evidenced by significant changes in hormonal status. The cumulative effect of stressful stimuli was noticeable especially at the end of the day. The results of the present study indicate the usefulness of using tools and a way to study stress among coaches. A similar research protocol can be used to assess stress responses to single-day stimuli associated with other social and occupational roles in healthy middle-aged men.Background: Watching athletic tournaments induces emotional and physiological responses in sports fans and coaches. The aim of the study was to investigate hormonal and cardiovascular responses in judo coaches observing the fights of their athletes during one-day, high-level tournaments. Material and methods: We studied the biological responses of a group of seventeen judo club coaches between the ages of 39 and 57 years to a one-day judo tournament attended by the adult male and/or female athletes that they coached. At the time of the tournaments and also in neutral conditions, the coaches’ capillary blood and saliva samples were collected concurrently two times a day, both at 7:30 a.m. and after completion of the tournament (at about 8:00 p.m.). Cardiovascular parameters were also determined at the same times of day. Sleep quality (SQ) was assessed on a 6-point scale both on the night preceding the tournament and in neutral conditions. Cortisol (C) and testosterone (T) levels were determined from serum and saliva samples. The results for both days at different times of day were compared. Results: Statistical calculations showed higher concentrations of cortisol and a greater reduction of testosterone levels in serum and saliva at the end of the day during the tournament compared with those on a neutral day. Morning and evening cardiovascular indices were higher during the tournament. Conclusion: The study showed that during one-day tournaments, judo coaches were exposed to stress that induced intermittent hormonal changes in blood and saliva and activated the autonomic nervous system.

Changes in IL-16 Expression in the Ovary during Aging and Its Potential Consequences to Ovarian Pathology.

Aging in females is not only associated with the changes in hormonal status but is also responsible for dysregulation of immune functions in various organs including ovaries. The goal of this study was to determine whether the expression of interleukin 16 (IL-16), a proinflammatory and chemoattractant cytokine, changes during ovarian aging, to determine factors involved in such changes in IL-16 expression, and to examine if changes in IL-16 expression during aging predisposes the ovary to pathologies. Ovarian tissues from premenopausal women (30-50 years old), women at early menopause (55-59 years old), and late menopause (60-85 years old) were used. In addition, tumor tissues from patients with ovarian high-grade serous carcinoma at early stage (n = 5) were also used as reference tissue for comparing the expression of several selected markers in aging ovaries. The expression of IL-16, frequency of macrophages (a source of IL-16) and expression of microRNA (miR) 125a-5p (a regulator of IL-16 gene) were performed by immunohistochemistry, immunoblotting, and gene expression assays. In addition, we examined changes in nuclear expression of IL-16 expression with regards to exposure to follicle-stimulating hormone (FSH) by in vitro cell culture assays with human ovarian cancer cells. The frequencies of IL-16 expressing cells were significantly higher in ovarian stroma in women at early and late menopause as compared with premenopausal women (P < 0.0001). Similar patterns were also observed for macrophages. Expression of miR-125a-5p decreased significantly (P < 0.001) with the increase in IL-16 expression during aging. Furthermore, expression of nuclear IL-16 increased remarkably upon exposure to FSH. Consequently, ovarian aging is associated with increased expression of IL-16 including its nuclear fraction. Therefore, persistent high levels of FSH in postmenopausal women may be a factor for enhanced expression of IL-16. Effects of increased nuclear fraction of IL-16 need to be examined.

Dynamics of endocrine and metabolic changes among patients with coronary artery disease, type 2 diabetes mellitus and metabolic syndrome while treating with telmisartan

Dynamics of endocrine and metabolic changes among patients with coronary artery disease, type 2 diabetes mellitus and metabolic syndrome while treating with telmisartan

Качество жизни, связанное со здоровьем, у пациентов с акромегалией: новый фокус лечения

The assessment of the quality of life related to health (HRQoL) is an important parameter that informs the doctor about how the patient interacts with his illness in everyday life and how he reacts to certain aspects related to the disease. In addition to medical problems related to the consequences of the disease and treatment, the patient's expectations regarding the treatment, his subjective assessment of what is happening and the cultural level, as well as related life events, affect the HRQoL. This is especially important for patients with chronic diseases requiring long-term treatment, such as acromegaly. According to various studies, the normalization of hormonal parameters in acromegaly does not lead to a complete restoration of HRQoL. On the one hand, in patients with acromegaly, the HRQoL is worse than in the general population, and first of all it affects the area of physical manifestations. So, the indicators of appearance, general health and physical activity are most often affected. On the other hand, various parameters of the quality of life questionnaires for acromegaly may be more sensitive to detect changes in the condition of patients during treatment, even with optimal indicators of insulin-like growth factor 1. Further study of the relationship between the parameters of quality of life and changes in hormonal status should be the key to improving the long-term prognosis of treatment.

Primary hypothyroidism as a predictor of the hypogonadism development

Background. Human lifestyle significantly affects human health and reproductive functions. The presence of hypothyroidism negatively impacts the health, activity, and reproductive status. This study was aimed to assess hormonal status, metabolic and anthropometric parameters in men of active reproductive age with primary hypothyroidism. Materials and methods. Totally 60 males with primary hypothyroidism were included in the study. Acomparative analysis of hormonal, anthropometric, and metabolic parameters in 60 men with hypothyroidism (basic group) and 25 men without hypothyroidism and other chronic somatic diseases (control group) was performed. The mean age of the subjects was 42.4±2.7 years. Results. It has been established that hypothyroidism was accompanied by an increase in serum concentrations of cholesterol and low-density lipoprotein cholesterol in comparison with control group (25 men without hypothyroidism) indicating metabolic disturbance. The data shows the significant effect of hypothyroidism on testosterone and follicle-stimulating hormone (FSH) serum concentration but not on luteinizing hormone, estradiol levels. Patients with hypothyroidism had lower circulating testosterone and higher FSH level in comparison with the controls. The reproductive hormone changes in men with hypothyroidism can result in deleterious effects on sexual functions including erectile dysfunction, reduced libido, and alteration in spermatogenesis. Conclusions. In men with hypothyroidism, changes in hormonal status have been found, which manifested in a decrease in testosterone and an increase in the blood level of follicle-stimulating hormone. The effect of hypothyroidism on the blood level of other hormones (luteinizing, estradiol, cortisol) has not been established. Hypothyroidism in men is accompanied by changes in lipid metabolism (increased levels of total cholesterol and low-density lipoprotein cholesterol).

Role of proteoglycans in the treatment of alopecia of various genesis

Hair loss has always been and remains an urgent challenge in the world today. Although this condition is not life-threatening, it still has a strong impact on the patients’ quality of life. Hairlines are affected by multiple factors including age, family history, smoking, nutrition, etc. Alopecia can take many forms, and the specialist’s objective is to determine the correct cause of the disorder of hair growth cycle by taking a medical history from a patient.The key role in the pathogenesis of androgenetic alopecia is assigned to changes in hormonal status. Telogen effluvium can be triggered by stress, medication, pregnancy, or other medical conditions. For instance, the high number of patients who have had COVID-19 are now faced with hair loss a few months after recovery.Despite the variety of underlining causes of hair loss, the principle of therapy is the same – the elimination of the trigger and the selection of drugs to normalize the natural hair growth cycle. In this case, the use of drugs containing proteoglycans that are specific proteins involved in the regulation of the hair growth cycle looks promising. Numerous studies demonstrate the efficacy of such proteoglycans as versican, decorin, and syndecan. They activate hair growth and help prolong the anagen phase. This effect of proteoglycans affords to speak about their good therapeutic and even prophylactic properties applied to the problem of hair loss.

Changes in hormonal status of winter wheat (Triticum aestivum L.) and spelt wheat (Triticum spelta L.) after heat stress and in recovery period

Changes in hormonal status of winter wheat (Triticum aestivum L.) and spelt wheat (Triticum spelta L.) after heat stress and in recovery period