Although health education is incorporated in tuberculosis treatment in Kenya, its role in improving quality of life of the patient is unknown. The main objective of the study was to determine effect of health education on the health related quality of life of tuberculosis patients in Kenya. To achieve this goal the health education program was designed using the PRECEDE-PROCEED model of study. Randomized controlled trial design with pre- and post-test assessments was adopted. The study was conducted between September 2019 and February 2020 in Nairobi and Murang’a Counties. A sample size of 450 patients was calculated with 373 meeting the eligibility criteria. Before introducing health education the patients were assigned into experimental and control groups. Health education was administered to the experimental group but no such intervention was given to the control group. After six months the two groups were compared. A standard questionnaire was used to collect demographic data while data on health related quality of life adopted EQ-5D-5L and EQ-VAS instruments. MANOVA was used to analyze domains of health and scores on the test of perceived poor health. 15% of the changes in the domains of health were accounted for by health education while 39.3% of changes in health scores were attributed to health education. The study concluded that improved knowledge on TB by patients as a result of health education enhanced the health related quality of life. It was recommended that the health education model be adapted in other health facilities providing tuberculosis services in Kenya.