Environmental Changes Research Articles

New insights into sodium phenylbutyrate as a pharmacotherapeutic option for neurological disorders.

Neurological disorders (NDs) are diseases of the central and peripheral nervous systems that affect more than one billion people worldwide. The risk of developing an ND increases with age due to the vulnerability of the different organs and systems to genetic, environmental, and social changes that consequently cause motor and cognitive deficits that disable the person from their daily activities and individual and social productivity. Intrinsic factors (genetic factors, age, gender) and extrinsic factors (addictions, infections, or lifestyle) favor the persistence of systemic inflammatory processes that contribute to the evolution of NDs. Neuroinflammation is recognized as a common etiopathogenic factor of ND. The study of new pharmacological options for the treatment of ND should focus on improving the characteristic symptoms and attacking specific molecular targets that allow the delay of damage processes such as neuroinflammation, oxidative stress, cellular metabolic dysfunction, and deregulation of transcriptional processes. In this review, we describe the possible role of sodium phenylbutyrate (NaPB) in the pathogenesis of Alzheimer's disease, hepatic encephalopathy, aging, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis; in addition, we describe the mechanism of action of NaPB and its beneficial effects that have been shown in various in vivo and in vitro studies to delay the evolution of any ND.

Líneas de investigación y perspectivas futuras de los estudios organizacionales: una revisión

Organizational studies allow us to analyze and understand the functioning of organizations, generate knowledge and improve their management and performance, from perspectives different from the classic ones with which the organizational phenomenon has been analyzed in a traditional way; These perspectives invite a critical look at this phenomenon. However, it is relevant to evaluate its potential to provide theories, models and tools that help advance the field of management and improve the effectiveness and sustainability of organizations. To date, no review has been identified in Scopus that synthesizes the literature on organizational studies from a bibliometric analysis, by doing so, this article provides a basis for researchers in organizational studies to learn about various future lines of research. The objective of this document is to review scientific documents published in Scopus(r) on organizational studies, to propose a structure of published scientific knowledge, so that different future lines of research are offered. 1091 documents were found that met the inclusion and exclusion criteria in the database that were processed with Bibliometrix, VosViewer and ToS. The main lines of research identified were: a) Leadership and management of organizational change; b) Changing, diverse and inclusive work environments; c) Legitimation, sustainability and organizational responsibility.

Credit risk and Tunisian bank stability in the Covid-19 wave

<p style="text-align:justify"><span style="font-size:16px"><span style="font-family:Times New Roman,Times,serif"><span dir="ltr" lang="EN-US"><span style="color:black">Banks are at the core of economic functioning in various countries and are the cause of their development in various fields. In a changing environment, they must deal with certain risks and maintain financial stability as the ultimate objective. The primary objective of this study is to examine the correlation between credit risk and bank stability within the Tunisian banking sector, with a specific focus on understanding the moderating impact of the COVID-19 pandemic. To achieve this, we employ several econometric techniques, including panel unit root and cointegration tests, panel Vector Error Correction Model (VECM), Fully Modified Ordinary Least Squares (FMOLS), and Dynamic Ordinary Least Squares (DOLS). Our empirical analysis relies on a panel dataset that encompasses a comprehensive sample of 8 Tunisian banks over 2000-2020. The results of our analysis unveil a significant negative relationship between credit risk and bank stability, indicating that higher levels of credit risk exert a detrimental effect on the overall stability of Tunisian banks. Furthermore, our study highlights that this adverse impact is further exacerbated during the COVID-19 pandemic, suggesting that the pandemic acts as a moderator. The findings of this study hold substantial implications for policymakers, regulators, and bank managers in Tunisia. They emphasize the critical importance of implementing robust risk management practices to mitigate credit risk and bolster bank stability. Additionally, the research underscores the need to consider the unique challenges introduced by external shocks, such as the COVID-19 pandemic, when assessing the overall stability of the banking system.</span></span></span></span></p>

Natural capital approaches for the optimal design of policies for nature recovery.

By embedding a spatially explicit ecosystem services modelling tool within a policy simulator we examine the insights that natural capital analysis can bring to the design of policies for nature recovery. Our study is illustrated through a case example of policies incentivising the establishment of new natural habitat in England. We find that a policy mirroring the current practice of offering payments per hectare of habitat creation fails to break even, delivering less value in improved flows of ecosystem services than public money spent and only 26% of that which is theoretically achievable. Using optimization methods, we discover that progressively more efficient outcomes are delivered by policies that optimally price activities (34%), quantities of environmental change (55%) and ecosystem service value flows (81%). Further, we show that additionally attaining targets for unmonetized ecosystem services (in our case, biodiversity) demands trade-offs in delivery of monetized services. For some policy instruments it is not even possible to achieve the targets. Finally, we establish that extending policy instruments to offer payments for unmonetized services delivers target-achieving and value-maximizing policy designs. Our findings reveal that policy design is of first-order importance in determining the efficiency and efficacy of programmes pursuing nature recovery. This article is part of the theme issue 'Bringing nature into decision-making'.

Digital transformation in adult education centres in Baden-Wuerttemberg

ABSTRACT The article discusses processes of digital transformation in adult education centres (AEC) in Baden-Wuerttemberg. It focuses on (a) environmental changes as perceived by specific actors, (b) topics and content related to the public education mandate, and (c) development and expansion of the organisation’s digital media repertoire. The data come from an explorative study in one German state, in which 34 managers were interviewed between November 2021 and May 2022 about key changes within their organisations. The results show that (a) different actors from the organisational environment are involved in shaping the digital transformation. A distinction can be made between enablers and inhibitors. In addition, (b) the AEC’s public education mission and thus the AEC’s efforts to promote digital inclusion are also changing. Finally, (c) digital transformation is also changing the organisation’s digital media repertoire. Ensuring basic infrastructure and new digital technologies for micro-didactic areas and exchange within and outside the AEC are seen as necessary. The results show that digital transformation is a multidimensional process with clear interrelations. These have hardly been explicitly considered in previous research. Pedagogical practice can gain suggestions from the results for improving cooperation with the organisational environment or for improving the organisational media repertoire.

Current strategies for the management of psoriasis with potential pharmacological pathways using herbals and immuno-biologicals.

Psoriasis is an acute to chronic multifunctional inflammatory skin disorder mediated through T-cell activation, dendritic cell intervention, local vascular variations, atypical keratinocyte proliferation, and neutrophil activation, leading to a skin disorder with no permanent cure. This review aims to find a potent, secure, and dependable medication, with a more scientific examination of herbal resources and recent targeted immunobiological therapies. Reports evaluating the effectiveness of biologics & herbal remedies for the topical therapy of psoriasis against control therapies were taken into consideration (placebo or active therapy). The work examined cellular circuits involved in inflammation with its immunogenetic mechanism behind various options available for treating psoriasis in addition to the role of agents inducing psoriasis. The extent of psoriasis can range from small, localized spots to total body coverage, and it can happen at any stage of life. Several theories exist for clarification however, the exact cause of psoriasis is not entirely understood. Researchers have discovered genetic loci linkages, environmental changes, drug induction, lifestyle conditions, some infections, etc. resulting in this disorder. There are numerous known conventional medical treatments for psoriasis, ranging from topical and systemic medicines to phototherapy or combinations of both with recent immunobiological treatment. However, the majority of these treatments are ineffective and have a variety of side effects that limit their long-term usage, such as cutaneous atrophy, tissue toxicity, mutagenicity, and immunosuppression. Herbal extracts or isolated compounds can be considered as a substitute for conventional psoriasis treatment. Unfortunately, many investigations often provide a small amount of facts about the safety and effectiveness of topically applied herbal remedies for the treatment of psoriasis. Thus, further factual evidences and validations are needed to promote herbal options, which must be supported by rigorous animal studies or clinical trials using standardised materials and compositions.

Membrane Proteins in Action Monitored by pH-Responsive Liquid Crystal Biosensors.

Liquid crystal (LC) biosensors have received significant attention for their potential applications for point-of-care devices due to their sensitivity, low cost, and easy read-out. They have been employed to detect a wide range of important biological molecules. However, detecting the function of membrane proteins has been extremely challenging due to the difficulty of integrating membrane proteins, lipid membranes, and LCs into one system. In this study, we addressed this challenge by monitoring the proton-pumping function of bacteriorhodopsin (bR) using a pH-sensitive LC thin film biosensor. To achieve this, we deposited purple membranes (PMs) containing a 2D crystal form of bRs onto an LC-aqueous interface. Under light, the PM patches changed the local pH at the LC-aqueous interface, causing a color change in the LC thin film that is observable through a polarizing microscope with crossed polarizers. These findings open up new opportunities to study the biofunctions of membrane proteins and their induced local environmental changes in a solution using LC biosensors.

Differences in RAD51 transcriptional response and cell cycle dynamics reveal varying sensitivity to DNA damage among Arabidopsis thaliana root cell types.

Throughout their lifecycle, plants are subjected to DNA damage from various sources, both environmental and endogenous. Investigating the mechanisms of the DNA damage response (DDR) is essential to unravel how plants adapt to the changing environment, which can induce varying amounts of DNA damage. Using a combination of whole-mount single-molecule RNA fluorescence in situ hybridization (WM-smFISH) and plant cell cycle reporter lines, we investigated the transcriptional activation of a key homologous recombination (HR) gene, RAD51, in response to increasing amounts of DNA damage in Arabidopsis thaliana roots. The results uncover consistent variations in RAD51 transcriptional response and cell cycle arrest among distinct cell types and developmental zones. Furthermore, we demonstrate that DNA damage induced by genotoxic stress results in RAD51 transcription throughout the whole cell cycle, dissociating its traditional link with S/G2 phases. This work advances the current comprehension of DNA damage response in plants by demonstrating quantitative differences in DDR activation. In addition, it reveals new associations with the cell cycle and cell types, providing crucial insights for further studies of the broader response mechanisms in plants.

Physiological responses of Atlantic cod to climate change indicate that coastal ecotypes may be better adapted to tolerate ocean stressors

Healthy ecosystems and species have some degree of resilience to changing conditions, however as the frequency and severity of environmental changes increase, resilience may be diminished or lost. In Sweden, one example of a species with reduced resilience is the Atlantic cod (Gadus morhua). This species has been subjected to overfishing, and with additional pressures such as habitat degradation and changing environmental conditions there has been little to no recovery, despite more than a decade of management actions. Given the historical ecological, economical, and cultural significance of cod, it is important to understand how Atlantic cod respond to global climate change to recover and sustainably manage this species in the future. A multi-stressor experiment was conducted to evaluate physiological responses of juvenile cod exposed to warming, ocean acidification, and freshening, changes expected to occur in their nursery habitat. The response to single drivers showed variable effects related to fish biometrics and increased levels of oxidative stress dependent parameters. Importantly, two separate responses were seen within a single treatment for the multi-stressor and freshening groups. These within-treatment differences were correlated to genotype, with the offshore ecotype having a heightened stress response compared to the coastal ecotype, which may be better adapted to tolerate future changes. These results demonstrate that, while Atlantic cod have some tolerance for future changes, ecotypes respond differently, and cumulative effects of multiple stressors may lead to deleterious effects for this important species.

Water availability and temperature as modifiers of evaporative water loss in tropical frogs.

Water plays a notable role in the ecology of most terrestrial organisms due to the risks associated with water loss. Specifically, water loss in terrestrial animals happens through evaporation across respiratory tissues or epidermis. Amphibians are ideal systems for studying how abiotic factors impact water loss since their bodies often respond quickly to environmental changes. While the effect of temperature on water loss is well known across many taxa, we are still learning how temperature in combination with humidity or water availability affects water loss. Here, we tested how standing water sources (availability) and temperature (26 and 36°C) together affect water loss in anuran amphibians using a Bayesian framework. We also present a conceptual model for considering how water availability and temperature may interact, resulting in body mass changes. After accounting for phylogenetic and time autocorrelation, we determined how different variables (water loss and uptake rates, temperature, and body size) affect body mass in three species of tropical frogs (Rhinella marina, Phyllobates terribilis, and Xenopus tropicalis). We found that all variables impacted body mass changes with greater similarities between P. terribilis and X. tropicalis, but only temperature showed a notable effect in P. terribilis. Furthermore, we describe how the behavior of P. terribilis might affect its water budget. This study shows how organisms might manage water budgets across different environments and is important for developing our models of evaporative water loss and species distributions.

Bacteria colonization and gene expression related to immune function in colon mucosa is associated with growth in neonatal calves regardless of live yeast supplementation

BackgroundAs Holstein calves are susceptible to gastrointestinal disorders during the first week of life, understanding how intestinal immune function develops in neonatal calves is important to promote better intestinal health. Feeding probiotics in early life may contribute to host intestinal health by facilitating beneficial bacteria colonization and developing intestinal immune function. The objective of this study was to characterize the impact of early life yeast supplementation and growth on colon mucosa-attached bacteria and host immune function.ResultsTwenty Holstein bull calves received no supplementation (CON) or Saccharomyces cerevisiae boulardii (SCB) from birth to 5 d of life. Colon tissue biopsies were taken within 2 h of life (D0) before the first colostrum feeding and 3 h after the morning feeding at d 5 of age (D5) to analyze mucosa-attached bacteria and colon transcriptome. Metagenome sequencing showed that there was no difference in α and β diversity of mucosa-attached bacteria between day and treatment, but bacteria related to diarrhea were more abundant in the colon mucosa on D0 compared to D5. In addition, qPCR indicated that the absolute abundance of Escherichia coli (E. coli) decreased in the colon mucosa on D5 compared to D0; however, that of Bifidobacterium, Lactobacillus, and Faecalibacterium prausnitzii, which could competitively exclude E. coli, increased in the colon mucosa on D5 compared to D0. RNA-sequencing showed that there were no differentially expressed genes between CON and SCB, but suggested that pathways related to viral infection such as “Interferon Signaling” were activated in the colon mucosa of D5 compared to D0.ConclusionsGrowth affected mucosa-attached bacteria and host immune function in the colon mucosa during the first 5 d of life in dairy calves independently of SCB supplementation. During early life, opportunistic pathogens may decrease due to intestinal environmental changes by beneficial bacteria and/or host immune function. Predicted activation of immune function-related pathways may be the result of host immune function development or suggest other antigens in the intestine during early life. Further studies focusing on the other antigens and host immune function in the colon mucosa are required to better understand intestinal immune function development.

The L3 Assessment Framework: what we do and do not know about the characterisation of activity component for primary school

Purpose The Listen to Learn for Life (L3) Assessment Framework is a framework that outlines how to systematically assess the links between the classroom environment, listening, learning and well-being. The purpose of this paper is to review the published literature to understand what is known about the characterisation of activity component of the L3 Assessment Framework and determine what is not known and needs to be investigated in future research. Design/methodology/approach Literature reviews (Web searches for systematic, scoping or general reviews; scoping reviews following the preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews protocol; and extended Web searches) were conducted to characterise lecture, group work and independent work activities in terms of the perceptual setting, source degradation and transmission degradation. Findings Most research that has been conducted is for classrooms in general and does not specify results specifically for lecture, group work and independent work, which is important for understanding how the learning environment changes with the different activities. What is known about the lecture, group work and independent work activities are discussed; however, it is noted that this often comes from only a few studies. Future research areas to contribute to this literature as well as fill current research gaps are proposed. Originality/value To the best of the authors’ knowledge, this paper is the first review paper to synthesize previous research characterising the classroom environment for different activities using the L3 Assessment Framework. It provides an analysis of the limitations of existing literature and proposes future research to help fill in these gaps.

Injectable ultrasonic sensor for wireless monitoring of intracranial signals.

Direct and precise monitoring of intracranial physiology holds immense importance in delineating injuries, prognostication and averting disease1. Wired clinical instruments thatuse percutaneous leads are accurate but aresusceptible to infection, patient mobility constraints and potential surgical complications during removal2. Wireless implantable devices provide greater operational freedom but include issues such as limited detection range, poor degradation and difficulty in size reduction in the human body3. Here we present an injectable, bioresorbable and wireless metastructured hydrogel (metagel) sensor for ultrasonic monitoring of intracranial signals. The metagel sensors are cubes 2 × 2 × 2 mm3in size that encompass both biodegradable and stimulus-responsive hydrogels and periodically aligned air columns with a specific acoustic reflection spectrum. Implanted into intracranial space with a puncture needle, the metagel deforms in response to physiological environmental changes, causing peak frequency shifts of reflected ultrasound waves that can be wirelessly measured by an external ultrasound probe. The metagel sensor can independently detect intracranial pressure, temperature, pH and flow rate, realize a detection depth of 10 cm and almost fully degrade within 18 weeks. Animal experiments on rats and pigs indicate promising multiparametric sensing performances on a par with conventional non-resorbable wired clinical benchmarks.

A hierarchical Bayesian model to monitor pelagic larvae in response to environmental changes

AbstractEuropean anchovies and round sardinella play a crucial role, both ecological and commercial, in the Mediterranean Sea. In this paper, we investigate the distribution of their larval stages by analyzing a dataset collected over time (1998–2016) and spaced along the area of the Strait of Sicily. Environmental factors are also integrated. We employ a hierarchical spatio-temporal Bayesian model and approximate the spatial field by a Gaussian Markov Random Field to reduce the computation effort using the Stochastic Partial Differential Equation method. Furthermore, the Integrated Nested Laplace Approximation is used for the posterior distributions of model parameters. Moreover, we propose an index that enables the temporal evaluation of species abundance by using an abundance aggregation within a spatially confined area. This index is derived through Monte Carlo sampling from the approximate posterior distribution of the fitted models. Model results suggest a strong relationship between sea currents’ directions and the distribution of larval European anchovies. For round sardinella, the analysis indicates increased sensitivity to warmer ocean conditions. The index suggests no clear overall trend over the years.

Eco-fertility: examining the climate change-total fertility rate nexus in the context of sustainable developmental goals in a systematic review approach

Abstract Sustainable Development Goals (SDGs) are paramount as the global community confronts the ramifications of climate alterations, especially its implications on population dynamics. Initial studies suggest an intricate relationship between environmental determinants and reproductive choices. This systematic review elucidates the complex interplay between climate-related challenges and observed global fertility rate variations. A comprehensive search and analysis of literature published in the last 10 years (2013–2023), available in the PubMed database, delineates the relationship between environmental changes and fertility patterns in both human and animal populations. The review highlighted significant effects of climatic fluctuations on reproductive health, manifested as either adaptive or maladaptive responses to environmental stressors. This relationship not only influences population trajectories but may also have complications for the SDGs, specifically those pertaining to health, well-being, and gender equality. The study emphasizes the importance of intertwining demographic insights with ecological considerations. A deeper understanding of the nexus between climate and fertility can augment strategies aimed at global sustainability. The synthesized evidence underscores the urgency for further research, which seeks to seamlessly incorporate eco-fertility perspectives into wider climate and sustainability discussions.

Improving the Growth and Productivity of Two Varieties of Mung Bean (Vigna radiata L.) by using Different Cultivation Methods and Dates

Background: Mung bean is characterized by its ability to withstand water scarcity due to its short life span, so it can be introduced into agricultural rotation systems and despite especially when there is a lack of humidity and contemporary environmental changes. Despite the importance of this crop, its productivity rate in Iraq is still low compared to global production. The dates and methods of cultivation of the mungbean crop must be determined accurately to suit the specifications of local varieties adapted to the changing environmental conditions. Methods: The field study was applied in two fields: the first in Nineveh Governorate and the second in Erbil Governorate / Republic of Iraq. Three factors included, first: two varieties of local mung bean (black and green), second: different cultivation methods (furrow and lines) and the third: planting dates (May 15, June 15 and July 15). The study was designed as a factor experiment a design (R.C.B.D) with three replicates. Result: The first variety superior significantly in the two sites with the qualities of (plant height, leaf area, leaf area index, seed yield, Biological yield and harvest index. From the results of the dates, we note a significant superiority of the first date number of seeds.pod-1 while the third date significantly outperformed the germination percentage for the two sites. First planting method significant superiority in most of the studied characterists and for the two research sites. Significant superiority was recorded for the interactions of research factors and their levels.

Should I stay or should I go? The influence of environmental conditions on green turtle residence time and outward transit in foraging areas

Foraging animals move through the environment to satisfy their requirements for food, rest, reproduction and risk-avoidance. Understanding how animals respond to changing environmental conditions can help to characterise favourable habitat and determine whether they might be motivated to depart when those habitats become unsuitable. Foraging green turtles are typically residents that scarcely move in response to environmental changes or disturbances. Some individuals though, exhibit high mobility at fine scales. We developed an analysis of Fastloc GPS tracks of 61 green turtles using cox regression models and generalised linear mixed models to investigate the influence of a suite of environmental characteristics on the length of residence time and probability of turtles transitioning between two behavioural modes, “stay” or “go”. Decisions to move (“go”) were influenced by short-term changes in the local environmental conditions. Individuals were more likely to “stay” when temperature increased during their stay and were more likely to “go” when turbidity decreased, and they entered deeper habitats. This result implies that foraging and resting (“staying”) primarily occurs in benthic, shallow, warm habitats, while transit (“going”) is facilitated in deeper, clear water. We also determined that individuals within the green turtle foraging aggregation respond differently to environmental cues to move and hypothesise that a diversity of strategies within a foraging aggregation could confer its resilience to disturbance events. Our study provides new evidence of the factors influencing movements in green turtles and can aid in predicting how they may respond to future changes and enhance risk mitigation efforts through dynamic and adaptive planning.

Characteristics of bare rocky land evolution in karst mountain areas of Southwest China based on socio-ecological system perspectives: The case study of Huajiang Canyon

Rock exposure is a prerequisite for the emergence of bare rocky land (BRL), a severe ecological and environmental problem in karst mountain areas (KMA) of Southwest China, severely restricting the region’s sustainable development. An in-depth analysis of the evolution of BRL in KMA of Southwest China based on socio-ecological perspectives is significant for promoting the region’s sustainable development. This paper firstly analyzes the evolution of the social-ecological system and BRL and the transition of human-land relations in KMA of Southwest China, then selects a typical KMA, Huajiang Canyon in Guizhou Province, for a case study and applies ArcGIS to analyze the dynamics of the BRL of Huajiang Canyon in the past 60 years from 1969 to 2020, and reveals the reasons for the evolution of BRL. The results show that: (1) The evolution of BRL in KMA of Southwest China is closely related to the changes in the local socio-ecological environment. (2) The number, spatial distribution, and landscape pattern of BRL in the Huajiang Canyon from 1969 to 2020 underwent significant changes, with the area of BRL transitioning from an expansion phase to an accelerated shrinking phase and with prominent spatial dispersion characteristics. (3) The transition of the BRL of the Huajiang Canyon into forest grassland and economic and fruity forest land, and the transition of land use from production to ecology and eco-economy, have proved the greening of the KMA of Southwest China from a microscopic perspective. (4) This paper shows that the expansion and contraction of BRL areas can reflect the human-land relations in KMA of Southwest China. Finally, the development path proposed in this paper has a certain positive effect on promoting the future sustainable development of the KMA of Southwest China and can also provide a reference for developing other mountainous areas with similar situations.

Development Pathways for Vocational Education and Training (VET) in China

In recent years, although the state has increased support for vocational education from multiple aspects, China's vocational education development still faces some challenges. This research aims to explore the significance of VET and the development pathway for VET in an employment-oriented context. This paper argues that it is necessary to adhere to the development direction of "employment and entrepreneurship" and provide innovative development and operation mechanisms for vocational education products or services in the field of vocational education. Its essence is the deep integration of industry and education, school-enterprise cooperation, and an innovative measure to cultivate qualified technical and skilled talents to meet the talent needs of the labor market. This paper emphasizes that to better adapt to the pressures brought about by changes in the employment environment, it is necessary to accelerate the construction of a high-quality vocational education system, effectively improve the quality of vocational education and training, and ensure that vocational education closely aligns with the economic and social development needs and seamlessly meets the actual employment standards of industries and enterprises.

The European Green Deal in Terms of Impacts on International Trade

Environment and climate change in the world gained importance at the end of the 20th century and the cooperation of countries in this area gradually increased. Especially the framework protocols signed under the umbrella of the United Nations (UN) made the subject a remarkable area in the international arena. The European Union (EU) became the first actor in the world to take concrete steps in this field with the European Green Deal. The Green Deal has introduced new regulations in a wide range of policy areas. The behaviors adopted by the EU, which maintains its role as a normative power in the international arena, draws paths that include behavioral patterns as implemented. The field of environment and climate change is also an area where the EU is active at the global level, and the effects of the determined rules expected to be seen at the global level. At this point, the trade relations will be a significant channel in the dissemination of the understanding and rules adopted by the EU. The fact that the EU has put provisions on the subject in the preferential trade agreements it has signed is the most substantial indicator of this situation