Changes In Different Systems Research Articles

Impact of diet-induced maternal obesity on the reproductive capacity of F1 female offspring and the early development of the second generation

The aim of this study was to examine the impact of maternal obesity on the reproductive capacity of the female offspring (F1) and on the early development of the second generation (F2). To this end, rats were fed either standard (SD) or cafeteria (CD) diet. CD rats and their offspring were divided into 2 groups: rats with 18% and ≥25% overweight (CD18 and CD25, respectively) and offspring from CD18 and CD25 rats (OCD18 and OCD25, respectively). Both OCD groups achieved greater weight gain than controls, without changes in the serum levels of glucose, cholesterol or triglycerides. However, they showed increased gonadal cholesterol concentration and fat content compared to controls. Female OCD groups showed a slight prolongation of the estrous cycle and different pattern of changes in the weight gain during pregnancy. The OCD25 group displayed an increased fertility index and preimplantation losses, and changes in some fetal measurements. Some OCD25 dams gave birth to a larger litter of pups and displayed a lower viability index and lactation rate than controls. OCD25 dams also showed an increase in estradiol and a decrease in testosterone and anti-Müllerian hormone. OCD25 rats showed increased mRNA levels of steroidogenenic enzymes. The offspring from OCD25 females (F2OCD25 offspring) showed early vaginal opening and higher ovulation rate in females, and lower ano-genital distances in males, compared to controls. In conclusion, these results reflect that maternal obesity impacts on the reproductive health of successive generations, probably as a result of epigenetic changes in different systems, including germ cells.

ПРОБЛЕМЫ ЗДОРОВЬЕСБЕРЕЖЕНИЯ СТУДЕНТОВ СЕВЕРНОГО ВУЗА В УСЛОВИЯХ ЦИФРОВИЗАЦИИ ОБРАЗОВАНИЯ

Informational competence is one of the priority areas of modern education. However, any scientific or technological progress has inevitable negative aspects along with the certain positive ones. The purpose of the study is to evaluate the functional state of northern undergraduates when using information and communication technologies. As the result of the research, it has been found out that the students of Surgut State University are on the computer during the major part of their time. This is one of the causes for hypodynamia, obesity, and maladaptive changes in different systems of the body. The visual analyzer, the musculoskeletal system, the cardiovascular and central nervous systems suffer from considerable workload. The students have noted the increased ervousness, which may lead to malicious behavior and emotional tension. It prevents students from effective studying.

Assessment of Liver Enzymes in Pregnant Women Attending Antenatal Clinic in Ikere-Ekiti

Pregnancy is a physiological condition which brings about changes in different systems of the body to support the growing foetus in the uterus. This study was designed to evaluate some of the liver enzymes (AST, ALT, ALP and GGT) activities in the different trimesters of pregnancy. A total of 120 subjects consisting of ninety [90] pregnant women at different trimesters thirty [30] and apparently healthy non-pregnant women (control) in Ikere-Ekiti [30] were recruited for this study. Blood samples were collected from the subjects after obtaining their consents. Liver function enzymes assay were determined using kinetic methods. Data analysis was done using SPSS computer software version 21.0 and results were presented in tables and figures as mean ± standard deviation. The result showed that the mean AST of non-pregnant women (control), pregnant women in the 1st, 2nd and 3rd trimesters were 3.44±1.88, 12.60±5.34, 10.20±4.93 and 8.67±3.37 (IU/L) respectively. The mean ALT of non-pregnant women (control), pregnant women in the 1st, 2nd and 3rd trimesters were 3.27±1.75, 14.56±8.71, 11.46±6.08 and 9.33±6.34 (IU/L) respectively. The mean GGT of non-pregnant women (control), pregnant women in the 1st, 2nd and 3rd trimesters was 3.60±1.88, 15.14±9.11, 13.22±5.27 and 10.35±7.19 (IU/L) respectively. The mean ALP of non-pregnant women (control), pregnant women in the 1st, 2nd and 3rd trimesters was 24.63±10.84, 58.73±24.71, 69.55±25.13 and 82.31±35.69 (IU/L) respectively. The study concludes that there was no significant difference (p>0.05) in the mean ALT, AST and GGT of pregnant women (subjects) in the three trimesters compared to non-pregnant women (control). However, there was significant difference (p<0.05) in the ALP of pregnant women in the 3rd trimester compared to non-pregnant women (control). Liver function tests are important biomedical indicators that reflect any changes in an adult person, and should be routinely investigated during pregnancy to outline any pathologic changes.

Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy

The placebo effect can be defined as the improvement of symptoms in a patient after the administration of an innocuous substance in a context that induces expectations regarding its effects. During recent years, it has been discovered that the placebo response not only has neurobiological functions on analgesia, but that it is also capable of generating effects on the immune and endocrine systems. The possible integration of changes in different systems of the organism could favor the well-being of the individuals and go hand in hand with conventional treatment for multiple diseases. In this sense, classic conditioning and setting expectations stand out as psychological mechanisms implicated in the placebo effect. Recent advances in neuroimaging studies suggest a relationship between the placebo response and the opioid, cannabinoid, and monoaminergic systems. Likewise, a possible immune response conditioned by the placebo effect has been reported. There is evidence of immune suppression conditioned through the insular cortex and the amygdala, with noradrenalin as the responsible neurotransmitter. Finally, a conditioned response in the secretion of different hormones has been determined in different studies; however, the molecular mechanisms involved are not entirely known. Beyond studies about its mechanism of action, the placebo effect has proved to be useful in the clinical setting with promising results in the management of neurological, psychiatric, and immunologic disorders. However, more research is needed to better characterize its potential use. This review integrates current knowledge about the psycho-neuro-endocrine-immune basis of the placebo effect and its possible clinical applications.

Physiological changes during pregnancy: a mimic of medical disease and risk to existing ones

During pregnancy; multiple physiological adaptations are encountered. Their aim is to protect and nurture the developing fetus and prepare the mother for labor and delivery. They are mediated by an orchestra of maternal and placental hormones. Some of these changes influence normal biochemical values while others may mimic symptoms of medical disease. It is important to differentiate between normal physiological changes and disease pathology. The present review summarizes the changes in different systems of the body and its metabolism in an attempt to assist clinicians caring for pregnant women during health and disease.
 Keywords: adaptations, changes, hormones, metabolism, physiology, pregnancy.

Re-defining the clinicopathological spectrum of neuronal intranuclear inclusion disease.

BackgroundThe rapidly increasing case reports revealed that neuronal intranuclear inclusion disease (NIID) had concomitant other system symptoms besides nervous system symptoms. In this study, we systematically evaluated the symptoms, signs, auxiliary examination, and pathological changes in different systems in NIID patients.MethodsNIID patients were confirmed by examining GGC repeats in the NOTCH2NLC gene. Clinical data of NIID patients including symptoms, signs, and auxiliary examinations were collected for analysis. Ubiquitin and p62 were detected in different tissues from previous surgical samples.ResultsFifty‐one NIID patients from 17 families were included in this study. Except neurological symptoms, clinical manifestations from other systems were very notable and diverse. The proportions of different system symptoms were 88.2% in nervous system, 78.4% in respiratory system, 72.5% in circulatory system, 72.5% in locomotor system, 66.7% in urinary system, 64.7% in digestive system, 61.5% in reproductive system, and 50.0% in endocrine system. In addition, other common symptoms included sexual dysfunction (43.1%), pupil constriction (56.9%), blurred vision (51.0%), and hearing loss (23.5%). Ubiquitin and p62‐positive cells were found in different tissues and systems in 24 NIID patients with previous surgery. Initial symptoms of NIID and median onset age in different systems also revealed system heterogeneity of NIID.InterpretationFor the first time, we systematically demonstrated that NIID is a heterogeneous and systemic neurodegenerative disease by providing clinical and pathological evidence. In addition to the nervous system, the clinical symptomatic and pathological spectrum of NIID has been extended to almost all systems.

Male hypogonadism with its systemic complications

Introduction and purpose: Total lack of testosterone or its level lower than 9-12 mmol/L (250-350 ng/dL) of serum in men is called hypogonadism. Due to the importance of testosterone in male body, hypogonadism usually causes a variety of symptoms, mostly of sexual nature – lack of libido, erectile dysfunction, infertility and associated psychological problems, it can though be the cause of more dangerous changes in the male body. The purpose of this study is to review possible systemic complications of male hypogonadism (with the emphasis on hypogonadotropic hypogonadism) apart from those sex-related.State of knowledge: The lack of testosterone and gonadotropins was proven to cause a number of negative changes in different systems and various clinical situations. It can negatively impact the condition of skeletal system. Although testosterone is widely thought to increase cardiovascular risk some studies show that the hypogonadism has a negative impact on it as well. Some studies hypothesised the role of hypogonadism in anaemia development, but generally it isn’t taken into account in investigation of this condition. Some studies show the impact of hypogonadism on higher risk of some metabolic and endocrine diseases. The most interesting conclusions were found in literature on oncological implications of testosterone and lack of it. It turns out that there is a number of studies showing the positive impact of relatively higher testosterone concentrations while androgen deprivation therapy is the main therapeutic option in advanced prostate cancer.Conclusions: Due to very unpleasant and possibly dangerous complications of hypogonadism endocrinologists should stay alert to signs of hypogonadism to be able to start testosterone replacement in the right moment.

The advantages and barriers in the implementation of a substance dependence treatment information system (SDTIS)

Addiction is a phenomenon that causes structural changes in different systems of society. Studies show for planning of addiction prevention and treatment, it is necessary to create an information management system. Substance dependence information systems refer to systems which collect, analyse and report data related to substance dependence information. The aim of this study was to identify advantages and barriers to implement Substance Dependence Treatment Information System (SDTIS). This study was a narrative review. Our review divided into three phases: literature collection, assessing, and selection. We employed the following keywords and their combinations in different areas of articles. In this study, 22 of collected articles and reports were selected based on their relevancy. We found many advantages for a substance dependence treatment information system such as recording sufficient, complete and accurate information and easy and timely access to them and monitoring and enhancing the quality of care received by patients. But we may face some concerns for implementing this information system like taking time and funds from client services, being expensive or even problems regarding the quality of data contained in these information systems. There are some important problems in the way of implementing. In order to overcome these issues, we need to raise community awareness.

Design Strategies in Different Narrative Frames

Introduction During its evolution, design—both as a discipline and as a practice—has expanded its sphere of influence and its typical object of intervention, acknowledged until 20 years ago above all as the industrial product. In recent years, because of causes linked to the evolution of organized production systems and social and cultural consumption market dynamics, the design core moved progressively from tangible objects—where design was responsible for the technological aspects of the product to fix the use value—to intangible offerings—where the value for users became a variable of other additional factors. These intangible offerings not only included the use of the product but also aspects linked to the purchase experience, product access dynamics, product availability, and connections with other services and offerings. The productservice system became a consolidated approach in science and project practice, where integration between tangible and intangible components of the offering is becoming an important area for design.1 In designing a product-service system, design includes not only the identification and organization of each component but also the links and connections between the tangible and intangible parts that create value for users.2 The broadening of the design spectrum went beyond the systemic composite concept of offering. Accordingly, design became a thinking form—design thinking3—an approach and a series of tools serving changes in different systems, including economic, social, and environmental systems. For many decades, the discipline of design considered the user to be the primary reference of its action. A rich literature linking user-centered design and ergonomics emphasized user centrality for design action,4 until more recent theories started regarding user involvement in the various design phases.5 The basic concept of the user-centered design paradigm seems to be sound when design creates products and product-service systems for existing markets and known consumers, which take into account, a priori, defined cognitive and cultural patterns and needs, purchase models, logics, and use contexts. However, this favorable condition of 1 Stephen L. Vargo and Robert F. Lush, “Evolving to a New Dominant Logic for Marketing,” Journal of Marketing 68 (2004): 1–17; Susan M. Goldstein, Robert Johnston, JoAnn Duffy, and Jay Rao, “The Service Concept: The Missing Link in Service Design Research?” Journal of Operations Management 20, no. 2 (2002): 121–34; Ezio Manzini and Carlo Vezzoli, “A Strategic Design Approach to Develop Sustainable Product Service Systems: Examples Taken from the ‘Environmentally Friendly Innovation’ Italian Prize,” Journal of Cleaner Production 11 (2003): 851–57; Rajkumar Roy and David Baxter, “The Product–Service System,” Journal of Engineering Design 20 (2009): 327–28; Ezio Manzini, Carlo Vezzoli, and Garrette Clark, “Product–Service Systems. Using an Existing Concept as a New Approach to Sustainability,” Journal of Design Research 1 (2001): 12-18. 2 Roy and Baxter, “The Product–Service System,” 327–28; Manzini, Vezzoli, and Clark, “Product-Service Systems;” Francesco Zurlo, Le Strategie del Design. Disegnare il Valore Oltre il Prodotto (Milano: Il Libraccio, 2012). 3 Roger Martin, The Design of Business (Boston: Harvard Business School Press, 2009); Tim Brown, Change by Design. How Design Thinking Transforms Organizations and Inspires Innovation (New York: Harper Collins, 2009). 4 Donald Norman, “Human-Centered Design Considered Harmful,” Interaction 12 (2005): 14-19; Donald Norman, The Psychology of Everyday Things (New York: Basic Books, 2002); Jodi Forlizzi, John Zimmerman, and Shelley Evenson, “Interaction Design Research in HCI, a Research Through Design Approach,”

Early diet and growth: impact on ageing.

The modification of ageing by nutritional intervention is well recognised. Post-weaning diet restriction is the only widely reproducible method to slow ageing, but the effects of prenatal and preweaning diet restriction have been less well characterised. There is some evidence that diet restriction instituted in utero or shortly after birth may have an opposite effect and be associated with increased ageing, and recent work suggests that it may shorten lifespan. Interest in this area has been rekindled by the growing body of epidemiological evidence showing that a number of age-related diseases are associated with poor growth and inadequate nutrition in early life. The relevance of this association to structural and functional ageing changes in different systems is now being considered. Work on musculo-skeletal ageing has demonstrated that loss of muscle strength and bone mass is greater in individuals who did not grow well in early life, and a range of studies suggests that maternal, developmental and nutritional factors are important. The underlying mechanisms remain speculative, and it remains to be determined whether they are system-specific or universal throughout the body. A new cohort of subjects aged between 60 and 70 years is being established to investigate how genetic factors interact with growth and nutritional influences to programme musculo-skeletal ageing in later life.