This study was carried out to determine whether the changes in dust concentration (DC) in Iran were attributed to changes in aridity index (AI) from 1990 to 2018. Long-term precipitation and potential evapotranspiration were used to compute the United Nations Environment Program AI and horizontal visibility data were used to calculate the DC in the study area. The DC spatial distribution maps were prepared to better identify areas affected by sand-dust events. Pearson’s correlation analysis was performed to explore the association between DC and AI in Iran and study stations during the monitoring period. Spatiotemporal variations in DC showed that more than 60 percent of Iran’s area experienced severe wind erosion events in 2001, 2008, and 1990 when AI was less than 0.2. The results also showed that approximately 45 percent of Iran’s area has suffered from the average DC over the study period (565 µg/m3). The incremental changes in DC were observed in almost half of the entire area of Iran during the second period (2000–2008) and one third of this area during the third period (2009–2018). Areas affected by decreasing changes in AI during the second and third periods were 90 percent and 73 percent of the area affected during the previous period, respectively. Overall, there was a significant negative correlation between AI and DC in Iran over the monitoring period (r = −0.51, p value < 0.01). Insignificant positive correlations were observed in humid regions, whereas negative correlations were mostly detected in arid and semiarid regions of Iran.