Skin Color Changes Research Articles

Type I Branchial Cyst of the Sedunda Cleft Uncommon presentation: Case Report

Introduction: The cyst branchial is a rare tumor as well known as cysts lymphoepithelial, are dysembryological rare and benign second cleft tumors. Tumors cystic that HE develop in the part anterolateral of the neck; represent he 2% of the tumors laterocervical of the neck [1]. Clinical Case: We present he clinical case of a patient male of 37 years, does not report personal pathological history, with a clinical picture of approximately 8 months of evolution approximately characterized by a laterocervical tumor right with progressive growth in size, not accompanied by any other symptoms. Upon examination Physical: A mobile, fluctuating tumor of approximately 5 cm in diameter is observed in the right cervical region III, with no changes in skin color. No symptoms of a sinus or fistulous tract are observed. Discussion: The cyst branchial is a rare tumor and benign second cleft tumors. Tumors cystic that HE develop in the part anterolateral of the neck, represent he 2% of the tumors laterocervical of the neck, proper physical examination determines its prompt diagnosis and surgical treatment [6]. Conclusion: In conclusion, despite their low incidence, third branchial cleft cysts should be included in the differential diagnosis of laterocervical tumors. An adequate history and physical examination, complemented by the indicated imaging tests, will allow establishing a presumptive diagnosis that should be confirmed histologically after surgical resection.

A Wide Color Gamut and Noniridescent Zinc-Anode Asymmetric Electrochromic Device for Self-Sustaining Color-Adaptive Bio-Camouflage System.

Inspired by camouflage-colored organisms, the development of bio-camouflage systems using electrochromic (EC) technology has gained significant interest. However, existing EC systems struggle with achieving a wide color gamut, noniridescent colors, and self-sustainability. Herein, a self-sustainable color-adaptive bio-camouflage system integrating EC and nanogenerator (NG) technologies, enabling environmental color adaptation, and thermal regulation without an external power source is proposed. The system is based on a zinc-anode EC device (ZECD) with an asymmetric structure, incorporating flexible tungsten oxide and vanadium oxide electrodes. During the EC process, tungsten oxide shifts between blue and transparent, allowing near-infrared thermal modulation, while the vanadium oxide transitions from yellow to transparent. This design enables reversible near-infrared modulation and noniridescent color conversion among black, blue, green, yellow, and transparent. For the self-sustainability of the system, an electromagnetic and triboelectric hybrid NG that collects biomechanical energy is developed. In a typical driven cycle, the integrated system transitions colors and achieves significant near-infrared spectral modulation, demonstrating environmental adaptability and thermal regulation. Experiments on human skin and simulated chameleon color changes further confirm the system's effectiveness. This work highlights the potential of integrating EC and NG technologies to advance color-adaptive camouflage systems, opening new an avenue for bio-camouflage design.

Characterization of Prickly Pear plantations in semi-arid zones! A green revolution in East Algeria: Case of the Tébessa region

The study carried out on the prickly pear shrub, in three potential production sites belonging to the commune of Ain Zerga district of Tébessa in the extreme east of the Algerian arid zone. The aim of this study was to try to interpret the main characteristics and sources of variability of this shrub of multiple interests. Carried out in 2023 on orchards planted with adult Opuntia ficus indica, developed in 45 orchards divided into 15 per site located in three localities, namely Henchir Lahdid, El Guefaifia, and Ouled Mebarek. The trees are grown extensively, with production starting in the last week of May. The cactus shrub reaches an equivalent production (10.23) kg and a production of 11,137.65kg/ha. At the time of the commercial harvest, indicated by the change in skin color, we carried out a random collection of 05 fruits per orchard, i.e. 75 fruits per site (225 fruits); these fruits were evaluated by various measurements. Shrub-specific variables such as fruit position in the canopy, cladode length, width, density, and inter-line spacing, number and weight of fruits per tree and per cladode, and annual productivity were studied. These variables per cactus shrub and fruit changed significantly as a function of climatic and edaphic environmental conditions, i.e. site and altitude, while the number of seeds/fruits was conditioned by volume. Fruit weight varied greatly within the same tree, influenced by the number of fruits per tree and the surface area of the cladodes; this variability decreased for cladodes bearing more than six fruits. Interception of climatic conditions (light) and cladode dry weight were the sources of variability in fruit weight, whereas Opuntia plant/hectare density had no effect on fruit quality.

Giant cellulitis-like Sweet syndrome mimicking cellulitis: a case report

BackgroundSweet syndrome (acute febrile neutrophilic dermatosis) is an uncommon inflammatory disorder characterized by the abrupt appearance of painful, edematous, and erythematous papules, plaques, or nodules on the skin. There are various subtypes, such as classical, drug-induced, malignancy-associated, and the less common variant giant cellulitis-like Sweet syndrome. This case is unique due to its presentation of the giant cellulitis-like variant of Sweet syndrome in a patient from Ethiopia. The unusual distribution of the skin lesions and the initial lack of response to antibiotics make this case particularly noteworthy. It underscores the importance of considering Sweet syndrome in differential diagnoses when faced with atypical skin manifestations and ineffective antibiotic treatment. This contribution adds valuable insights to the scientific literature by highlighting the need for heightened awareness of this rare variant and improving diagnostic accuracy in similar clinical scenarios.Case presentationA 60-year-old Ethiopian male patient who presented to the accident and emergency department with a 5-day history of fever, chills, sweating, and rigor accompanied by a reddish skin color change around the anterolateral region of the right chest wall. On physical examination, there were erythematous, indurated tender plaques with ill-defined borders over the right antero- and posterolateral chest wall with extension to the lateral part of the right neck and medial aspect of the right arm. Subsequently, the patient was started on antibiotics, but there was a suboptimal response. Skin biopsy revealed features suggestive of giant cellulitis-like Sweet syndrome. He was then started on steroids, which significantly improved his symptoms.ConclusionA cautious stance is essential when identifying Sweet syndrome in individuals displaying erythematous plaque-like skin lesions in atypical areas of the body with uneven distribution. Such presentation may signal Sweet syndrome rather than a common infection. If conventional treatments, such as antibiotics, fail to resolve symptoms, consider Sweet syndrome as a potential diagnosis. This approach ensures timely and appropriate treatment, preventing treatment delay and misdiagnosis.

Skin Necrosis Due to Misuse of a COVID-19 Antigen Home Test Kit: A Case Report

Background: Many people are still infected with coronavirus disease 2019 (COVID-19), and the use of home test kits for diagnosis is becoming common. The misuse of the kits may cause unexpected patient harm. Purpose: The purpose of this case study was to report a rare case of facial skin necrosis caused by contact with a reagent in a COVID-19 Ag home test kit due to misuse of the kit. Case Study: A 50-year-old male patient with pain, redness, and swelling throughout the nose, right ocular area, and forehead visited the emergency room of the hospital. The symptoms were caused by using a COVID-19 Ag home test kit in the wrong way. Initially, partial skin color change and ulcerative skin lesions with pus-like discharge were observed throughout the wound. Finally, partial skin necrosis progressed and was treated using appropriate dressing treatment, antibiotics, and steroids. Conclusion: The use of COVID-19 Ag home test kits that can be easily used will gradually increase. As in this case, it should be kept in mind that problems due to incorrect use of COVID-19 Ag home test kits can occur, and initial treatment is important to prevent systemic infection or scar formation.

Successful Microablative Fractional Carbon Dioxide Laser Therapy for Vulvar Lichen Sclerosus: A Case Report and Mini-review

Vulvar lichen sclerosus (VLS) is a chronic inflammatory skin disorder affecting the vulvar region. VLS predominantly affects women, and most cases occur after menopause. Common symptoms include itching, skin-whitening, pain, discomfort, fissures, and scarring. Treatment options include topical steroids, emollients, lifestyle modifications, regular follow-up, and surgical interventions. Carbon dioxide (CO2) laser treatment is a therapeutic option for managing lichen sclerosus. We report a case of VLS successfully treated with a fractional microablative CO2 laser. A 72-year-old female presented with a dry vagina and vulvar itching for 6 months. She visited a local medical clinic, and oral anti-itching medication and topical anti-itching ointment were administered. However, the condition did not improve, and she felt itching. She visited our outpatient department, and a pelvic examination showed bilateral labia minor, revealing a white skin color change and a hardening sensation. The patient was diagnosed with VLS. Microablative fractional CO2 laser therapy was subsequently administered. The treatment course comprised three laser therapy sessions (treatment day, 1 month, and 2 months after the first therapy). The vulvovaginal symptoms questionnaire-21 scores were 14, 6, and 2 for the first, second, and third courses of treatment, respectively. Vulvar itching improved significantly after laser treatment – no more steroid treatment needed. After 10 months of follow-up, the condition of the vulva was maintained well. Although the treatment protocol requires further exploration, CO2 laser treatment could be considered for VLS if topical steroids are ineffective.

Perbandingan Algoritma CART dan C.4 5 Pada Citra Tandan Buah Sawit Untuk Mengetahui Tingkat Kematangan Dalam Penentuan Harga

Information technology is a means and infrastructure of a system method to organize, send, interpret, use, process, obtain, and store data in a meaningful and useful way. Oil palm is a tropical plant originating from West Africa. The advantage of this plant is that it can also be planted outside its place of origin, including Indonesia. This plant has been widely cultivated in the form of plantations and factories in various regions in Indonesia. Oil palm is an industrial plant that is used as a raw material for vegetable oil, industrial oil, and fuel. Oil palm is important for Indonesia because it creates jobs for local people and is a source of foreign currency for the country. Oil palm plants begin to flower and form fruit after 2-3 years. The fruit will ripen about 5-6 months after pollination. The ripening process of oil palm fruit can be seen from the change in color of the fruit's skin. The fruit will turn orange-red when ripe. When the fruit is ripe, the oil content in the fruit flesh is at its maximum. If it is too ripe, the oil palm fruit will fall from the stalk of the bunch. This study aims to assess the maturity of a bunch of oil palm fruit. The methods used in this study are CART and C.4 5. Each method has several stages that will produce entropy and gain values ​​that will later form a decision tree. The dataset consists of 37 data consisting of 10 criteria originating from Ramp 789 Batang Peranap. Based on the implementation of the C4.5 algorithm and the CART algorithm in determining the level of ripeness of oil palm fruit bunches on RAMP 789 Batang Peranap which produces an accuracy of 98.00%. These results are obtained based on Process data with testing using the RapidMiner application, which produces a Decision tree that is useful as a reference for decisions in determining whether or not oil palm fruit bunches are ripe, which so far have only been predicted.

Progressive Acute Lower Extremity Ischemia Resulting From Cardiac Myxoma Embolization: A Case Report.

Cardiac myxomas are the most common primary benign tumors of the heart. The occlusion of peripheral arteries and complete obstruction of the abdominal aorta by a tumor embolus presents with distinct clinical manifestations. Herein, we present the case of a 38-year-old male with acute paresthesia, muscle weakness, erythematous, and violaceous changes in skin color localized to the dorsum of the left forefoot initially treated as cutaneous vasculitis. Further studies revealed the total occlusion of the terminal abdominal aorta by a saddle embolus from a cardiac myxoma. A multidisciplinary team consisting of cardiothoracic and vascular surgeons were involved in treating the patient, which resulted in full resolution of the case. This paper details the progression of acute bilateral limb ischemia to chronic limb threatening ischemia resulting from the total occlusion of the terminal abdominal aorta by a saddle embolus.

High-Output Heart Failure Secondary to Post-Traumatic Arteriovenous Fistula

Introduction: Arteriovenous fistulas are abnormal connections between the arterial and venous systems that bypass normal anatomical capillary beds. Any device, implement, or projectile that passes through an artery and vein has the potential to lead to one, thereby preventing normal blood flow through the capillary bed. Late complications of untreated arteriovenous fistulas include proximal arterial dilation, venous congestion, congestive heart failure, and distal ischemia. Objective: Describe the clinical manifestations, diagnostic, therapeutic, prognostic complexities and complications present in post-traumatic arteriovenous fistula and its association with heart failure. Material and methods: Retrospective study presentation of a clinical case. Results: The case of a 55-year-old female patient is presented, with a 2-year history of ischemic heart disease and a gunshot wound 20 years ago. Who was admitted for bypass and coronary angiography + cardiac angiography in whom no etiology of his dilated ischemic heart disease was found until Doppler ultrasound and tomography angiography was performed due to recurrence of pain in the lower limbs and changes in skin color, which revealed presence of arteriovenous fistula. The same one that was resolved with distal ligation of the popliteal vein + exclusion of aneurysm. Conclusions: Risk factors for the development of this pathology are difficult to establish. Therefore, the shotgun trauma to the left leg 20 years ago, in addition to her obesity and female sex, led to the formation of an arteriovenous fistula that would gradually produce high-grade heart failure. Endovascular AVF repair is a treatment alternative for those patients considered high risk from anesthesia, those who have a hostile groin due to excessive scar tissue, or who cannot tolerate the consequences of bleeding that can occur with surgical control. of the FAV.

Cross-cultural comparison of the influence of skin-color change on facial impressions

Cross-cultural comparison of the influence of skin-color change on facial impressions

Harmony in nature's elixir: a comprehensive exploration of ethanol and nano-formulated extracts from Passiflora incarnata leaves: unveiling in vitro cytotoxicity, acute and sub-acute toxicity profiles in Swiss albino mice.

We analyzed the toxic effect of the ethanolic extract of Passiflora incarnata (EEP) and its nanoformulation (N-EEP) in the in vitro and in vivo models (zebrafish embryos and Swiss albino mice). The EEP composition was verified by phytochemical and GC-MS analysis. The synthesized N-EEP was characterized using UV-visible spectroscopy and scanning electron microscopy. In vitro results showed both EEP and N-EEP have a dose-dependent effect in L132 cells (normal embryonic lung cells). In zebrafish embryos, no developmental changes were observed for both EEP and N-EEP at 200µg/ml. The acute and sub-acute toxicity of EEP and N-EEP was identified by oral administration in Swiss albino mice. A single-day oral dose of EEP and N-EEP at different concentrations was administered for acute toxicity, and changes in body weight, food, water intake, temperature, respiration rate, skin color changes, and eye color till 72h was observed. In a sub-acute toxicity study, 28days oral administration of different concentrations of EEP and N-EEP was done. Hematological analysis, serum hepatic biochemical parameter analysis, and histopathological analysis for the liver, kidney, spleen, intestine, and heart were performed. The results indicated that lower than 600mg/kg of EEP and N-EEP can safely be used for the remediation of a spectrum of diseases.

Regulation of skin pigments in winter jujube fruit treated with elevated O2

Color deterioration is one of the major symptoms of postharvest senescence in winter jujube fruit. Elevated O2 (60 %) was applied to winter jujube fruit during storage at 0 °C and 90 % relative humidity. The changes in three major skin pigments, chlorophyll, carotenoid, and anthocyanin, were quantified to explain changes in skin color. The results showed that elevated O2 maintained the contents of chlorophyll and carotenoid during the initial stages of storage, which were 25 % higher chlorophyll a, 34 % higher chlorophyll b, and 18 % higher carotenoid compared to the control on day 7. The maintenance of chlorophyll content under elevated O2 was due to the inhibition of chlorophyll catabolism. Additionally, elevated O2 treatment also maintained carotenoid content by activating its biosynthesis rather than inhibiting its degradation. During the later stages of storage, the accumulation of anthocyanin was enhanced by elevated O2, with a 1.3-fold increase in anthocyanin observed in elevated O2-treated fruit compared to the control fruit on day 21. Elevated O2 treatment effectively activated phenylpropanoid biosynthesis and flavonoid biosynthesis pathways, leading to the accumulation of anthocyanin. This study elucidated the mechanism by which elevated O2 regulated color deterioration in winter jujube fruit.

Visual acuity of the summer flounder (Paralichthys dentatus) captures spatial information relevant to dynamic camouflage at close range.

Dynamic camouflage is the capacity to rapidly change skin color and pattern, often for the purpose of background-matching camouflage. Summer flounder (Paralichthys dentatus) are demersal fish with an exceptional capacity for dynamic camouflage, but with eyes that face away from the substrate, it is unknown if this behavior is mediated by vision. Past studies have shown that summer flounder skin can match the pattern (i.e., spatial detail) of substrate with a high degree of precision, and for that to be achieved using sight, one testable assumption is that the resolution of vision must match the degree of detail produced in color-change performance. To test this, approaches in morphology and behavior were used to estimate visual acuity, which is the capacity of the visual system to resolve static spatial detail. Using image processing techniques, we then compared the degree of spatial detail from a relevant substrate with what may be detectable by summer flounder spatial vision. The morphological and behavioral estimates of visual acuity were calculated as 3.62 cycles per degree (CPD) ± 0.8 (s.d.) and 4.06 CPD ± 0.4 (s.d.), respectively. These estimates fall within a range of acuities known among other flatfishes and appear adequate for detecting the spatial information needed for background-matching camouflage, though only at close distances. These data provide new knowledge about summer flounder visual acuity and suggest the capacity of flounder vision to support dynamic camouflage of the skin.

Realistic Facial Age Transformation with 3D Uplifting

AbstractWhile current facial re‐ageing methods can produce realistic results, they purely focus on the 2D age transformation. In this work, we present an approach to transform the age of a person in both facial appearance and shape across different ages while preserving their identity. We employ an α‐(de)blending diffusion network with an age‐to‐α transformation to generate coarse structure changes, such as wrinkles. Additionally, we edit biophysical skin properties, including melanin and hemoglobin, to simulate skin color changes, producing realistic re‐ageing results from ages 10 to 80 years. We also propose a geometric neural network that alters the coarse scale facial geometry according to age, followed by a lightweight and efficient network that adds appropriate skin displacement on top of the coarse geometry. Both qualitative and quantitative comparisons show that our method outperforms current state‐of‐the‐art approaches.

Targeted metabolomics revealed the seasonal plasticity of skin color and pigment metabolites in ornamental koi carp

The koi carp is an ornamental fish that was obtained through artificial selection from the common carp (Cyprinus carpio L.). The most economically important traits of koi are their beautiful skin patterns in bright colors. As seasonality is an important factor in the biology and ecology of fish, we thus assumed that seasonal changes are involved in regulating the formation of skin color and patterns of koi carp. The white, red, cyan, and black skin colors from four varieties of scaleless koi carp (Doitsu Shiromuji (W), Doitsu Kohaku (WR), Doitsu Showa Sanke (WRI), and Kumonryu (WI)) were evaluated using the CIELab color space (lightness, redness, and yellowness) in different seasons. Compared to winter, the yellowness of the white color in all koi varieties decreased in summer and autumn. The black skin color areas in WRI and WI koi increased in summer and autumn compared to winter. The yellowness of the red color decreased only in WRI koi, while no changes were observed in WR koi. Targeted metabolomics analysis revealed that the levels of the structural pigment guanine of all koi varieties showed significant seasonal variation. Of seven detected carotenoids, the zeaxanthin and tunaxanthin contents in W, WI, and WRI koi changed with the seasons, while none of the carotenoids in WR koi were altered. Of the seven potential regulatory metabolites, epinephrine, melatonin, and cyclic adenosine monophosphate (cAMP) in all four koi varieties showed the highest levels in winter. A correlation analysis suggested that the seasonal changes in white skin color occurred through the epinephrine-cAMP pathway; melanin-dependent and carotenoid-dependent skin color changes occurred through melatonin in koi carp. This study demonstrated the seasonal plasticity of skin color in koi carp regulated by melatonin and epinephrine, associating with variety and color specificity.

DEEP LEARNING FOR AUTOMATIC CLASSIFICATION OF AVOCADO FRUIT MATURITY

Avocado (Persea Americana), a fleshy fruit with a single seed, has increased in popularity globally, especially in tropical and Mediterranean climates, thanks to its commercial and nutritional value. Rich in bioactive compounds, avocados contribute to the prevention and treatment of various diseases, including cardiovascular problems and cancer. Avocado production in Indonesia, for example, is showing a significant increase, reflecting the growing demand. Avocado ripeness affects shelf life and quality, making the determination of ripeness level a critical aspect of postharvest management. Skin color and pulp firmness change during storage, affecting quality and nutritional value. Proper classification of ripeness is important to reduce post-harvest losses, improve quality and optimize export costs. Recent research shows the use of technologies such as machine learning and YOLO (You Only Look Once) version 9 in real-time detection of avocado ripeness, offering innovative solutions to reduce post-harvest losses and improve distribution efficiency. This approach not only benefits farmers and consumers but also ensures consumer satisfaction and reduces economic losses. This study highlights the importance of real-time detection in monitoring avocado ripeness, where the training process was conducted for 89,280 iterations resulting in a new model for avocado ripeness detection. The final model has a mean Average Precision (mAP) validation value of 84.3%, mAP 84.3% signifies the optimal level of accuracy in object recognition in avocado fruit maturity images using the YOLO model that has undergone an intensive training process.

The Factors Contributed of incidence phlebitis cases with patients by using cannula in National Hospital Guido Valadares Dili, Timor Leste

Phlebitis is defined as inflammation of the vein wall where 2 complications that may develop as a result of phlebitis are: infection resulting from an accumulation of neutrophils; and thrombus, which may lead to complete occlusion of the vein. As healthcare professionals cannot look inside veins during IV therapy, they must rely on what they can see, feel and ask, i.e. detectable changes in skin color, texture, temperature and sensitivity, to identify the development of phlebitis. The absence of a good blood flow and the presence of a poor infusion rate have also been cited as clinical indicators of phlebitis Observation of the patient for clinical signs and symptoms of phlebitis is therefore the key to preventing serious venous damage. Health professional hands are a common of spreading microorganisms, thus very important for health workers followed one of precaution is to attention wash your hands of properly. Phlebitis is caused by chemical factors (type of net liquids), mechanical factors (insertion measures in place), and the most common factors (hand washing techniques including the factors of the patient's age), have been caused by phlebitis. The same results in some research conducted by some researchers show that the causes of phlebitis, among them, the types of liquidity and knowledge of nurses, type of therapy, and development of children, the location and the application of these measures were not yet put in place. The design of research is a quantitative study, with a cross-sectional approach. The sampling technique in this study was accicental sampling, with a sample of 56 respondents. The study was conducted on November 2022 in National Hospital Guido Valaradres Dili, Timor Lest. The result of study showed that the cannula factor influence the phlebitis of the correlations is 0.605 and significant P value is 0.000, time/duration using cannula factor influence the phlebitis of the results correlations is 0.633 and significant P value is 0.000 and the age factor influence the phlebitis of the correlations = 0.736 and significant P value is 0.000

Evaluating the efficacy of a novel periosteal flap in cochlear implantation: a retrospective surgical audit at a tertiary teaching hospital

BackgroundThis research aimed to critically evaluate the safety and reliability of a new periosteal flap technique in cochlear implantation through a comprehensive surgical audit. A surgical audit was conducted on a cohort of 39 patients who underwent cochlear implantation at a tertiary teaching hospital from July 2020 to September 2021. The novel periosteal flap technique was utilized in all cases. Patients were followed up for a period ranging from 2 to 12 months. For comparison, outcomes were assessed by comparing 51 children who had undergone cochlear implant surgery between July 2017 and June 2019, utilizing the anteriorly based palva flap. A scoring system was employed to evaluate various aspects, including ease of surgical exposure, flap maneuverability, ease of closure after device fixation, immediate postoperative complications (up to 24 h), and delayed complications (up to 30 days). Scores ranging from 1 (fair assessment) to 4 (excellent assessment) were assigned, with a maximum score of 18 indicating optimal outcomes.ResultsThe comparison between the two groups revealed a reduced incidence of emissary vein injury and easier wound closure after device fixation in the novel periosteal flap group (p = 0.000). The mean total scores were significantly higher in the novel periosteal flap group, indicating superior outcomes. Only 2 out of 39 children with the novel flap experienced minor skin color changes during the initial postoperative period, which resolved within approximately 7 days. Major complications such as wound infection, hematoma, or device migration were not observed with the new periosteal flap. Furthermore, no flap revisions were required.ConclusionsThe novel and innovative periosteal flap demonstrated both safety and reliability in cochlear implantation procedures. This well-vascularized and robust flap offered effective device coverage with minimal flap-related complications. Its time-saving nature further enhances its clinical utility. Additional validation from different medical centers would further corroborate the advantages of this easily implemented periosteal flap technique.Level of evidenceLevel 3.

Mechanisms of complex regional pain syndrome.

Complex Regional Pain Syndrome (CRPS) is a chronic pain disorder characterized by a diverse array of symptoms, including pain that is disproportionate to the initial triggering event, accompanied by autonomic, sensory, motor, and sudomotor disturbances. The primary pathology of both types of CRPS (Type I, also known as reflex sympathetic dystrophy, RSD; Type II, also known as causalgia) is featured by allodynia, edema, changes in skin color and temperature, and dystrophy, predominantly affecting extremities. Recent studies started to unravel the complex pathogenic mechanisms of CRPS, particularly from an autoimmune and neuroimmune interaction perspective. CRPS is now recognized as a systemic disease that stems from a complex interplay of inflammatory, immunologic, neurogenic, genetic, and psychologic factors. The relative contributions of these factors may vary among patients and even within a single patient over time. Key mechanisms underlying clinical manifestations include peripheral and central sensitization, sympathetic dysregulation, and alterations in somatosensory processing. Enhanced understanding of the mechanisms of CRPS is crucial for the development of effective therapeutic interventions. While our mechanistic understanding of CRPS remains incomplete, this article updates recent research advancements and sheds light on the etiology, pathogenesis, and molecular underpinnings of CRPS.

Defatted Tenebrio molitor meal time-dependently altered sensory quality and nutritional value of turbot Scophthalmus maximus during growing-out phase

The yellow mealworm Tenebrio molitor (TM) is promising feed ingredient for aquafeed. However, consumers might reject insect-fed fish unless they know their quality. Nevertheless, reports on how TM influences fish quality were rare and yielded conflicting results; furthermore, there are no evaluations on quality of turbot Scophthalmus maximus fed TM. Therefore, turbot with an initial body weight of 150 g were fed six experimental feeds containing increasing levels of defatted TM to replace fishmeal for 85 days. The substitution levels were 0% (control), 15% (TM15), 22 30% (TM30), 45% (TM45), 60% (TM60), and 75% (TM75). The result showed TM replacing up to 45% of fishmeal did not negatively impact growth performance or fillet yield. Dietary TM optimized the health value of muscle fatty acids regarding thrombogenicity index, atherogenicity index, and hypocholesterolemic to hypercholesterolemic fatty acids ratio but linearly decreased the muscle contents of hydroxyproline, collagen, and n-3 PUFA. However, turbot fed TM15 maintained the contents of these nutrients compared with those fed the control diet. The naked eye cannot perceive skin color changes induced by TM; but the odor, flavor, and texture of cooked fillets changed by TM at both sampling times could be distinguished by sensory evaluation. Furthermore, texture analyzer reported that the hardness of raw fillets significantly decreased by the end of the experiment but not on the 56th day. Correlation analysis revealed that the fillet was softened due to the muscle water content increase and muscle ultrastructure (lengths of H band, bright band, dark band, sarcomere) alternation. In conclusion, there were time-dependent effects of TM on turbot growth performance and fillet texture. Substitution of fishmeal with TM at 15% or less level did not influence the nutritional quality, but TM at any dose softened the fillet, which could be attributed to its influence on moisture content and myofibrillar structure.