Orbital Changes Research Articles

Nearby Supernova and Cloud Crossing Effects on the Orbits of Small Bodies in the Solar System

Supernova (SN) blasts envelop many surrounding stellar systems, transferring kinetic energy to small bodies in the systems. Geologic evidence from 60Fe points to recent nearby SN activity within the past several Myr. Here, we model the transfer of energy and resulting orbital changes from these SN blasts to the Oort Cloud, the Kuiper Belt, and Saturn’s Phoebe ring. For the Oort Cloud, an impulse approximation shows that a 50 pc SN can eject approximately half of all objects less than 1 cm while altering the trajectories of larger ones, depending on their orbital parameters. For stars closest to SNe, objects up to ∼100 m can be ejected. Turning to the explored solar system, we find that SNe closer than 50 pc may affect Saturn’s Phoebe ring and can sweep away Kuiper Belt dust. It is also possible that the passage of the solar system through a dense interstellar cloud could have a similar effect; a numerical trajectory simulation shows that the location of the dust grains and the direction of the wind (from an SN or interstellar cloud) has a significant impact on whether or not the grains will become unbound from their orbit in the Kuiper Belt. Overall, nearby SNe sweep micron-sized dust from the solar system, though whether the grains are ultimately cast toward the Sun or altogether ejected depends on various factors. Evidence of SN-modified dust grain trajectories may be observed by New Horizons, though further modeling efforts are required.

Manipulation of anisotropic Zhang-Rice exciton in NiPS3 by magnetic field

The effect of external magnetic fields on the behavior of the Zhang-Rice exciton in NiPS3, which captures the physics of spin-orbital entanglement in 2D XY-type antiferromagnets, remains unclear. This study presents systematic study of angle-resolved and polarization-resolved magneto-optical photoluminescence spectra of NiPS3 in the Voigt geometry. We observed highly anisotropic, non-linear Zeeman splitting and polarization rotation of the Zhang-Rice exciton, which depends on the direction and intensity of the magnetic field and can be attributed to the spin-orbital coupling and field-induced spin reorientation. Furthermore, above the critical magnetic field, we detected additional splitting of the exciton peaks, indicating the coexistence of various orientations of Néel vector. This study characterizes orbital change of Zhang-Rice exciton and field-induced spin-reorientation phase transitions in a 2D hexagonal XY-type antiferromagnet, and it further demonstrates the continuous manipulation of the spin and polarization of the Zhang-Rice exciton.

Stability Analysis of Stable Circular Orbit in Multi-Static Black Hole Spacetime

We herein study the circular orbit stability of a static black hole system composed of multiple Reissner–Nordstrom (RN) black holes. By comparing the circular orbits of two static black holes, three static black holes (TBHs), four static black holes and five static black holes at different spacetime, we find that the continuity of their stable circular orbits changes, i.e., the peaks of the effective potentials are transformed from single-peaked to bi-peaked, and that the distance a between the black holes is the main reason for this change. This characteristic is completely different from the continuity of the stable circular orbit interval of any kind of single black hole in the past. After calculation, we obtain several critical values that lead to the change in circular orbit stability. The three fundamental frequencies (orbital frequency, radial local frequency, and vertical local frequency) are derived and compared for two different spacetimes of double and three black holes. We also analyse the effect of the black hole distance a on the three fundamental frequencies of circular orbits.

Computational Assessment of Novel Ruthenium Phenoxazine‐Based Complexes as Photosensitizers in Photodynamic Therapy

A computational examination of two new polypyridyl ruthenium complexes, containing meldola blue (MDB) and nile blue (NB) chromophores, is here reported in order to assess the applicability of phenoxazine‐containing complexes in photodynamic therapy (PDT). The designed complexes, named Ru‐3ENB and Ru‐3EMDB, are based on a recently synthesized Ru(II)‐based complex bearing a bipyridyl‐ethynyl‐Nile Red (NR) ligand and proposed for PDT applications. DFT outcomes elucidated how the replacement of NR with MDB induces a red shift of the maximum absorption wavelength within the therapeutic window, up to 638 nm. A change in the molecular orbitals involved in the population of excited states was observed upon chromophore substitution that results in ISC kinetic significantly faster than that computed for the synthesized complex Ru‐3ENR.

Biomarker reconstructions of temperature and hydroclimate variability in Vietnam during Marine Isotope Stage 3

Limited hydrological data coupled with a reliance on the monsoon rains for agriculture make Southeast (SE) Asia vulnerable to climate change. To develop a better understanding of how SE Asia responds to climatic forcings, we provide a paleoclimate perspective by reconstructing temperature and hydroclimate from a wetland outcrop in the Central Highlands of Vietnam (CHV) during Marine Isotope Stage 3 (MIS 3). Mean annual atmospheric temperatures inferred from brGDGTs (branched glycerol dialkyl glycerol tetraethers) indicate an increase from 23 to 26 °C between ∼54 and 37 cal ka BP, which follows an increase in mean annual insolation at the latitude of the site. δDwax data show a shift from a greater proportion of summer monsoon rain derived from the Bay of Bengal between 54 and 49 cal ka BP toward more autumn rain from the South China Sea (also known as the Vietnam East Sea) for most of the rest of the record. brGDGT-inferred soil pH suggests that the climate was wetter at 54 to 49 cal ka BP, then became drier, then returned to wet conditions approaching 37 cal ka BP. Both orbital forcing and changes in the exposure of the Sunda Shelf likely influenced hydroclimate in the CHV. δ13Cwax indicates that C4 plants dominate the vegetation cover during MIS 3. Comparison between our new record from the CHV with existing water isotope proxy records reveals coherent changes with nearby speleothem data, but regional differences between the history of hydroclimate in SE Asia and in the central Indian Monsoon domain. As a snapshot of glacial climate conditions, our data provide new information on the past drivers of climate in an understudied region.

Atomristor Mott Theory of Sn Adatom Adlayer on a Si Surface

We use a combination of density functional theory (DFT) and dynamical mean field theory (DMFT) to unveil orbital field-induced electronic structure reconstruction of the atomic Sn layer deposited onto a Si(111) surface (Sn/Si(111)−3×3R30∘), also referred to as α-Sn. Our DFT + DMFT results indicate that α-Sn is an ideal testing ground to explore electric field-driven orbital selectivity and Mott memory behavior, all arising from the close proximity of α-Sn to metal insulator transitions. We discuss the relevance of orbital phase changes for α-Sn in the context of the current–voltage (I−V) characteristic for future silicon-based metal semiconductor atomristors.

Investigation of the stability of the extreme low mass ratio contact binaries SX Crv and XX Sex, which are analysed photometrically

The photometric analyses of the extreme low mass ratio contact binaries SX Crv and XX Sex were conducted in detail. Light curves of SX Crv and XX Sex were retrieved from TESS, and light curve analyses were performed simultaneously with radial velocities. The mass ratios for SX Crv and XX Sex were calculated as 0.077(1) and 0.099(2). The masses of the primary components account for about 90% of the total masses of the systems and were determined to be 1.256(48) M⊙ and 1.337(37) M⊙ for SX Crv and XX Sex, respectively. It has been observed that the orbital periods of both systems have increased. The orbital period change rate of SX Crv has been calculated to be 0.39 s per century, while that of XX Sex has been calculated to be 2.68 s per century. The orbital angular momentum (Jo) determined for both systems is more than 3 times the spin angular momentum (Js), and it can be said that the SX Crv and XX Sex systems are stable. The calculated instability separation (ains.) and instability mass ratio (qins.) values for both systems are smaller than those obtained in the analyses, which supports the stability. The estimated ages of the systems are 7.4 Gyr for SX Crv and 3.9 Gyr for XX Sex. logMtot – logJ and logTeff – logL diagrams were also interpreted to better understand the evolution of the extreme low mass ratio contact binaries.

Impact of the chemical insertion of the dimethylamino group on the electronic and optical properties of the 4-(methoxyphenyl acetonitrile) monomer (MPA): a DFT theoretical investigation.

Density functional theory (DFT) calculations on the ground and the first excited state are performed on the modified and unmodified 4-(methoxyphenyl acetonitrile) monomer (referred to as MPA). The modified monomer named MFA is obtained by Knoevenagel condensation of MPA with dimethylformamide dimethyl acetal (DMF-DMA). DFT computations show that the chemical grafting of the dimethylamino group onto the MPA unit induces a great change in the geometric, electronic, and optical properties. Going from MPA to MFA monomer, a great change in the frontier orbitals of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) in the ground and the first excited state is observed. Consequently, a reduction in the energy gap HOMO-LUMO and an enhancement in the absorption and emission properties are observed under the chemical modification. The observed modifications in the electronics and optical properties are the result of the charge transfer appearing between the cyano (C≡N) acceptor group and the dimethylamino (DMF-DMA)-grafted group donor ring. Quantum chemical calculations were performed in the ground and the first excited state using the density functional theory (DFT), and it extends the time-dependent density functional theory (TD-DFT), implemented in the Gaussian 09 software package. The ground state is obtained by optimization of the studied molecular geometries by employing the DFT/M062X/6-31G(d,p) level of theory. The first excited state is obtained by re-optimization of the ground state geometries using the TD-DFT/M062X/6-31G(d,p) level of theory. The contour plots of the frontier orbitals and the molecular electrostatic potential (MEP) maps are obtained from the ground and the first excited state, optimized geometries, and drawn using Gaussview software.

What CT Findings are Predictive of Post-Traumatic Enophthalmos in Orbital Fractures?

Enophthalmos is a surgical indication for orbital fracture repair. However, guidelines to predict enophthalmos in orbital fractures are ambiguous. We systematically reviewed the existing literature on utilizing CT findings to establish objective metrics to predict enophthalmos in asymptomatic patients during initial trauma work-up. PRISMA guidelines were followed. PubMed and Embase were used to identify studies of interest. The Quality in Prognosis Studies (QUIPS) tool was used for risk of bias assessment. Random effects model meta-analyses of orbital volume change and fracture area values were completed. Regression analyses were performed to determine thresholds that predicted 2 mm enophthalmos. Of the initial 2236 abstracts, 36 met inclusion criteria. Thirty retrospective studies evaluated a total of 2851 patients and 6 prospective studies evaluated 211 patients. All 36 studies had predominantly low risk of bias. Predictors of enophthalmos assessed were orbital volume change (21 papers), fracture surface area (13 papers), inferior rectus muscle (IRM) displacements (7 papers), and fracture location (4 papers). Studies reporting on orbital volume change offered values ranging from 0.69 to 4.26 cm3. Fracture area predictor values ranged from 1.50 to 3.38 cm2. Meta-analyses confirmed the validity of both predictors. Pooled regression analyses demonstrated that 3.33 cm3 of orbital volume increase or fracture area of 3.12 cm2 were predictors of 2 mm enophthalmos. Both orbital volume change and fracture area measured on CT scan are good predictors of late post-traumatic enophthalmos. Pooled data indicates 3.12 cm2 of fracture area or 3.33 cm3 of orbital volume increase are predictive of enophthalmos.

Are Age and Trauma Mechanism Associated with Volume Change in the Fractures of the Bony Orbit?

Blowout fractures are common midfacial fractures in which one or several of the bones of orbital vault break. This is usually caused by a direct trauma to the eye with a blunt object such as a fist. Fracturing of the fragile orbital bones can lead to changes in the orbital volume, which may cause enophthalmos, diplopia, and impaired facial aesthetics. Objectives: The aim of this study is to investigate whether there is an association between volume change of the bony orbit and age, gender, or trauma mechanism. Methods: A retrospective study of patients with unilateral blowout or blow-in fractures treated and examined in Päijät-Häme Central Hospital, Lahti, Finland was conducted. Altogether, 127 patients met the inclusion criteria. Their computed tomographs (CT) were measured with an orbit-specific automated segmentation-based volume measurement tool, and the relative orbital volume change between fractured and intact orbital vault was calculated. Thereafter, a statistical analysis was performed. A p-value less than 0.05 was considered significant. Results: We found that relative increase in orbital volume and age have a statistically significant association (p = 0.022). Trauma mechanism and gender showed no significant role. Conclusions: Patient's age is associated with increased volume change in fractures of the bony orbit.

Research on the excitation force and vortex dynamics characteristics of pump-jet propulsor induced by shafting whirling vibration: Non-uniform blade tip clearance

The propulsion shafting whirling vibration causes non-uniform dynamic changes in the rotor tip clearance, which directly have a significant influence on the excitation force and vortex dynamic characteristics of the pump-jet propulsor. In the current study, based on improved delay detached eddy simulation, the influence of non-uniform blade tip clearance on the excitation force and vortex dynamics characteristics of the pump-jet propulsor is studied under design conditions. The results show that the application of propulsion shafting whirling vibration induces significant changes in the excitation force of the pump-jet propulsor. The rotor blades modulate the excitation forces of the stator blades and duct. The transverse and vertical excitation forces are more significant than the longitudinal excitation force. The magnitude change in the circular orbit shows a linear relationship with the excitation force magnitude. The characteristic frequency of the transverse and vertical excitation forces of each component is the shaft rotation frequency. In contrast, the characteristic frequency of the longitudinal excitation force is twice the shaft rotation frequency. In the elliptical orbit, the excitation force of each component is compressed or stretched in the time domain, and the dominant frequency is shifted in the frequency domain; there is no longer a linear relationship between the vibration magnitude change and the excitation force magnitude. Furthermore, an energy generation mechanism in the wake field of the pump-jet propulsor induces vortex frequency due to the whirling vibration of the propulsion shafting system.

V0405 Dra: A New Deep and Low Mass Ratio Contact Binary with Extremely Fast Decrease in the Orbital Period

V0405 Dra is a W UMa-type binary star. Based on the TESS data, we have conducted an orbital period study and performed a light curve analysis for the system. The orbital period study reveals that the O − C curve for V0405 Dra exhibits secular decrease at an extremely high rate of dP/dt = −2.71 × 10−6 day year−1, along with periodic variations characterized by an amplitude of A 3 = 0.0032 day and a period of P 3 = 1.413 years. The orbital periodic change is possibly due to the light-travel time effect resulting from an additional third body in the system, for which we estimate a minimum mass of M 3 = 0.77M ⊙. By employing the 2013 version of the Wilson-Devinney (W-D) method to synthesize a light curve, we derived photometric solutions indicating that V0405 Dra is a new deep (f = 68.7%) and low-mass ratio (q = 0.175) contact binary. The fast decrease in its orbital period is likely caused by mass transfer from the more massive primary star to the less massive secondary star, or due to angular momentum loss. With further mass transfer and loss of angular momentum, the binary will gradually evolve into a tighter contact configuration, eventually leading to a merger into a single star, following the evolutionary paths suggested for such deep and low mass ratio contact binaries.

Assessment of choroidal perfusion indices in thyroid eye disease by using optical coherence tomography.

To study choroidal vascularity changes in active and inactive TED orbits by using high-definition optical coherence tomography (HD-OCT) and correlate the changes with the duration and severity of TED and Barrets' index. A cross-sectional study wherein 37 TED orbits and 30 healthy control (HC) orbits were enrolled. Choroid was imaged using HD-OCT scans centered at the fovea, and subfoveal choroidal thickness (SFCT) was measured. The OCT images were analyzed using ImageJ software to calculate choroidal vascularity index (CVI) and associated choroidal perfusion indices. The study included eight active, 13 non-inflammatory active (NIA), and 16 inactive TED orbits. The mean age was 39.73 ± 12.91 years, and the male: female ratio was 1.18:1. Intraocular pressure and CVI were higher, while SFCT was similar in TED on comparison to healthy orbits. CVI and SFCT were raised in active as compared to inactive TED. CVI and SFCT correlated positively with Barrets' index and negatively with the duration of thyroid disease. The area under curve of CVI (95% CI: 0.651-0.864, P < 0.001) helped in differentiating TED orbits from HC, while CVI (95% CI: 0.780-0.983, P < 0.001) had the maximum discriminatory power in predicting the activity of disease. CVI has greater sensitivity than SFCT in differentiating healthy from TED orbits. The blood flow stagnation in active orbits, which improves during the course of TED and tends to worsen with increase in Barret's index, can lead to choroidal vascularity changes. CVI and SFCT can act as adjunct to existing modalities for monitoring the disease activity.

Millennial to orbital scale Indian summer monsoon evolution inferred from grain size end-members in Tengchongbeihai wetland, southwestern China

Understanding the Indian summer monsoon (ISM) variabilities under different climatic constraints on various timescales is crucial for socio-economic stabilization within the ongoing warming globe. However, aside from stalagmite records, very few terrestrial paleoclimate archives have been used to explore the last glacial ISM characteristic, which limits our understanding of the ISM natural behaviors and their underlying mechanisms on longer timescales. Here, we present a grain size end-member analysis for Tengchongbeihai wetland sediments from southwestern China to investigate the paleo-hydroclimate changes since the late MIS3. The overall low fine silt content before ∼19 cal ka BP resulted from weak catchment erosion indicating weak ISM during cold glacial while the increasing trend thereafter indicates the ISM strengthened during the last deglaciation and Holocene. Such an orbital ISM evolution resembles to the insolation gradient between 25°N and 25°S during the boreal summer periods, which implies that the transequatorial insolation difference could be an alternative explanation for the orbital scale low latitude hydroclimate changes. The remarkable peaks of coarse component around ∼9, 12, 19, 26, 32, 37 and 42 cal ka BP were related to significant water level descending indicating the millennial ISM collapse corresponding to the YD and Heinrich events. However, the absence of sawtooth feature as the NGRIP δ18O and the well correspondence to the Indian Ocean sea surface temperatures (SSTs) of the ISM collapses evidence the modulation of low latitude forcing on the North Atlantic climate effects on the millennial scale hydroclimate variabilities.

Cyclosporin A inhibits PDGF-BB induced hyaluronan synthesis in orbital fibroblasts

Orbital connective tissue changes are contributors to the pathogenesis in thyroid eye disease (TED). Activated fibroblasts respond to immune stimuli with proliferation and increased hyaluronan (HA) production. Cyclosporin A (CsA) was reported to be beneficial in the treatment of TED. PDGF isoforms are increased in orbital tissue of TED patients and enhance HA production. We aimed to study the effect of CsA on HA production and hyaluronan synthase (HAS1, 2 and 3) and hyaluronidase (HYAL1 and 2) mRNA expressions in orbital fibroblasts (OFs). Measurements were performed in the presence or absence of CsA (10 μM) in unstimulated or PDGF-BB (10 ng/ml) stimulated OFs. The HA production of TED OFs (n = 7) and NON-TED OFs (n = 6) were measured by ELISA. The levels of mRNA expressions were examined using RT-PCR. The proliferation rate and metabolic activity were measured by BrdU incorporation and MTT assays, respectively. Treatment with CsA resulted in an average 42% decrease in HA production of OFs (p < 0.0001). CsA decreased the expression levels of HAS2, HAS3 and HYAL2 (p = 0.005, p = 0.005 and p = 0.002, respectively.) PDGF-BB increased HA production (p < 0.001) and HAS2 expression (p = 0.004). CsA could reduce the PDGF-BB-stimulated HA production (p < 0.001) and HAS2 expression (p = 0.005) below the untreated level. In addition, CsA treatment caused a decrease in proliferation potential (p = 0.002) and metabolic activity (p < 0.0001). These findings point to the fact that CsA affects HA metabolism via HAS2, HAS3 and HYAL2 inhibition in OFs. In addition to its well characterized immunosuppressant properties, CsA's beneficial effect in TED may be related to its direct inhibitory effect on basal and growth factor stimulated HA production.

Orbital period change of SW Sex star TT Tri

Abstract SW Sex-type stars are the dominate population of cataclysmic variables (CVs) just above the period gap and are vital for understanding of CV evolution. We have monitored TT Tri for nearly 15 yr, and more observations yield a more reliable estimation for its orbital period variation. In this work, we present a detailed analysis about its orbital period variation. TT Tri experiences a rapid period decay with a decay rate of −5.67 × 10−11 s/s plus a period oscillation at about 9.6 years. The oscillation could be caused by the magnetic activities of the low-mass star or/and a circumbinary body, while the rapid period decrease can not be accounted for by the magnetic braking or even including an intensive disk wind. We find that mass overflow though the L3 point can take the angular momentum away effectively and that this mass overflow could account for the rapid period decay observed in TT Tri. We propose that this kind of angular momentum loss may play a crucial role in CV evolution, and further research is in progress.

The Review of Ophthalmic Symptoms in COVID-19.

The COVID-19 pandemic caused by SARS-CoV-2 had a significant impact on the health of the global human population, affecting almost every human organ, including the organ of vision. Research focus on understanding the pathophysiology, identifying symptoms and complications of the disease. Eye-related pathologies are important foci of research due to the potential for direct impact of the virus. Ophthalmologists around the world are reporting various symptoms of eye infections and ocular pathologies associated with SARS-CoV-2. The review of ophthalmic symptoms was conducted to help physicians of various specialties recognize possible ophthalmic manifestations of this viral disease. A literature review was conducted from January 2020 to July 2023 in the PubMed, MEDLINE, Science Direct, Scopus, Scielo and Google Scholar databases. The review of the literature showed that conjunctivitis is the most common ophthalmic symptom observed during the course of COVID-19 and can occur at any stage of the disease. Changes in the eye may result from the direct effect of the virus, immune response, prothrombotic states, comorbidities, and medications used. Symptoms related to the organ of vision can be divided into: changes affecting the protective apparatus of the eye, the anterior eye segment, the posterior eye segment, neuro-ophthalmic, and orbital changes. Ocular symptoms may suggest COVID-19 infection or appear several weeks after recovery. Following COVID-19 vaccinations, a diverse range of ophthalmic symptoms was observed in various locations and at different times, mirroring the ocular symptoms experienced throughout the course of the COVID-19 illness. It is important for physicians of all specialties to be aware of possible potential connections between eye diseases and SARS-CoV-2, in order to effectively diagnose and treat patients.

Orbital forcing of aridity/humidity fluctuations in the Hexi Corridor and Alxa Plateau, NW China, during the last 1.8 million years

The processes controlling aridity/humidity variations in mid-latitude Asia dust source regions on orbital timescales are unclear. Both insolation and polar ice sheets can affect the climate at mid-latitudes, but determining their individual contributions is challenging. Here we present a compilation of paleoclimate data (the content of smectite and aeolian sand, and the proportion of the hydraulic component) from sites in the Hexi Corridor and Alxa Plateau, located at the junction of the regions influenced by the mid-latitude East Asian Monsoon (EAM) and the Westerlies. Our objectives were to determine the links between aridity/humidity variations in this region and Earth orbital forcing and changes in high-latitude ice sheets. We found that the aridity/humidity variations in the Hexi Corridor and Alxa Plateau were paced mainly by the long eccentricity cycle (∼400 ka), facilitating roughly coherent beat in changes of the mass accumulation rate (MAR) and the excursions of thick/coarse loess layers L1, L5, L9, L15 and L24 on the Chinese Loess Plateau. Additionally, spectral analysis of the paleoclimate data revealed that the expression of the Mid-Pleistocene transition (MPT) was spatially variable. A transition between the dominant periodicities in the western Hexi Corridor and Alxa Plateau occurred at ∼0.9 Ma, but in the eastern Alxa Plateau this transition occurred at ∼0.7 Ma. Our data compilation also demonstrates an interval of wet climate in the Hexi Corridor and Alxa Plateau after ∼0.34 Ma, which is consistent with paleoclimate records from loess deposits in Westerlies-dominated Central Asia. We attribute this to insolation forcing via complex internal feedbacks in the Southern Ocean, involving the enhancement of the Atlantic deep-water circulation, and the interplay between Indian Monsoon and the Westerlies. Overall, our findings highlight the importance of the Earth orbital control of aridity/humidity cycles on the boundary of the EAM and the Westerlies in mid-latitude Asia.

Episodic sediment accumulation linked to global change in the endorheic Qaidam Basin of the Tibetan Plateau revealed by feldspar luminescence dating

Given its high accumulation rate in sediments, the endorheic basin in arid regions plays a crucial role in reconstructing paleo-environment. However, it would not provide high-resolution climatic records if significant wind-eroded depositional hiatuses were inevitable within a severe wind environment. Unconformable contacts have been found during field survey in the top part of the stratigraphy in the Qaidam Basin, a prototypical endorheic basin in central Asia. To elucidate whether the sediment is continuous, we employed luminescence dating methods of feldspar pIR200IR250 and quartz OSL to date sediments, including lacustrine sediments and salt crusts, from the Qarhan Playa that is the Quaternary depositional center of the Qaidam Basin. Various experiment tests, including preheat plateau, dose recovery, and residual dose, were conducted. The dating results show that the feldspar pIR200IR250 can provide dependable ages with negligible residual doses. The pIR200IR250 dating ages within the last glacial cycle reveal several environmental shifts. A Qarhan paleolake in Marine Isotope Stage (MIS) 5 was demonstrated by the cluster ages of ∼140–80 ka of lacustrine sediments. The salt crust ages of 136 ± 10 ka and 97 ± 6 ka indicate that, before completely disappeared, the paleolake with shallow dish-shape depression had been dried up more than once, illustrating “shallow——dry——shallow” cycles. The playa in the eastern Qaidam Basin evolved mainly in warm periods, such as MIS 5 and MIS 1, supported by the salt crust ages of MIS 5 (136 ± 10 ka and 97 ± 6 ka) and MIS 1 (10 ± 1 ka and 0.6 ± 0.1 ka). Depositional hiatus in the last glacial cycle were identified by unconformable contacts in three sections between the lacustrine strata and their overlying playa strata, with corresponding age gaps of 158 ± 20–97 ± 6 ka, 131 ± 10–10 ± 1 ka, and 84 ± 7–0.6 ± 0.1 ka, respectively. In all the three sections the sediments for the whole of the last glacial period is missing, eroded by wind. This process should have occurred periodically during the glacial-interglacial cycles of the orbital global climatic changes. The results also show that hiatuses are common for endorheic basins on the Earth with age gaps of up to ∼100 ka, suggesting that robust chronology should be established before any climatic correlation due to severe wind erosion leading to episodic sediment accumulation.

Long term follow-up of axial length and orbital dimensions in congenital microphthalmia and anophthalmia.

To evaluate axial length (AL), orbital width (OW) and height (OH) development in congenital microphthalmia and anophthalmia (MICA) using serial ultrasonography measurements. A longitudinal prospective cohort (n = 74) of unilaterally and bilaterally affected MICA patients was followed from 2013 to 2022 at the university hospital in Amsterdam, the Netherlands. Clinical entity, age, severity category based on axial length, conformer treatment and intra-orbital cysts were registered. The main outcome measures were the absolute and relative growth of AL, OW and OH. Surgical and intra-orbital cyst cases were described separately. Absolute microphthalmic eye size increased in 27/49 (55%) unilateral MICA eyes, but growth arrest/decrease in the remaining could shift the case to a more severe category over time. A final affected/unaffected orbital symmetry ≥80% was seen in the large majority of unilateral cases (45/46 for OW, 43/46 for OH). Cases with AL < 10.5 mm had orbital symmetry <80% more often. Most orbital symmetry changes were seen in moderate and severe unilateral cases treated with 3D-printed conformer therapy starting at age <1 year, with 6/10 (60%) symmetry increase, 30% unchanged symmetry and 10% symmetry decrease. All cases older than 6.5 years (n = 6) did not show any change anymore, regardless of treatment. For bilateral and unilateral mild cases, orbital dimensions kept the same proportions during follow-up, with or without conformer treatment. Using severity categories in MICA based on relative AL may aid the decision to start conformer treatment, as most orbital symmetry changes were seen in moderate and severe unilateral cases receiving 3D-printed conformer therapy that started under age 1.