Impulsive Change Research Articles

Glycated hemoglobin, type 2 diabetes, and poor diabetes control are positively associated with impulsivity changes in aged individuals with overweight or obesity and metabolic syndrome.

Impulsivity has been proposed to have an impact on glycemic dysregulation. However, it remains uncertain whether an unfavorable glycemic status could also contribute to an increase in impulsivity levels. This study aims to analyze associations of baseline and time-varying glycemic status with 3-year time-varying impulsivity in older adults at high risk of cardiovascular disease. A 3-year prospective cohort design was conducted within the PREDIMED-Plus-Cognition substudy. The total population includes 487 participants (mean age = 65.2 years; female = 50.5%) with overweight or obesity and metabolic syndrome. Insulin resistance (HOMA-IR), glycated hemoglobin (HbA1c), presence of type 2 diabetes mellitus, and type 2 diabetes control were evaluated. Impulsivity was measured using the Impulsive Behavior Scale questionnaire and various cognitive measurements. Impulsivity z-scores were generated to obtain Global, Trait, and Behavioral Impulsivity domains. Linear mixed models were used to study the longitudinal associations across baseline, 1-year, and 3-year follow-up visits. HOMA-IR was not significantly related to impulsivity. Participants with higher HbA1c levels, type 2 diabetes, and poor control of diabetes showed positive associations with the Global Impulsivity domain over time, and those with higher HbA1c levels were further related to increases in the Trait and Behavioral Impulsivity domains over the follow-up visits. These results suggest a potential positive feedback loop between impulsivity and glycemic-related dysregulation.

Practical pearls for management of cranial injury in the developing world.

Traumatic brain injury (TBI) remains a leading cause of morbidity and mortality, with approximately 69million individuals affected globally each year, particularly in low- and middle-income countries (LMICs) where neurosurgical resources are limited. The neurocognitive consequences of TBI range from life-threatening conditions to more subtle impairments such as cognitive deficits, impulsivity, and behavioral changes, significantly impacting patients' reintegration into society. LMICs bear about 70% of the global trauma burden, with causes of TBI differing from high-income countries (HICs). The lack of equitable neurosurgical care in LMICs exacerbates these challenges. Improving TBI care in LMICs requires targeted resource allocation, neurotrauma registries, increased education, and multidisciplinary approaches within trauma centers. Reports from successful neurotrauma initiatives in low-resource settings provide valuable insights into safe, adaptable strategies for managing TBI when "gold standard" protocols are unfeasible. This review discusses common TBI scenarios in LMICs, highlighting key epidemiological factors, diagnostic challenges, and surgical techniques applicable to resource-limited settings. Specific cases, including epidural hematoma, subdural hematoma, subarachnoid hemorrhage, and cerebrospinal fluid leaks, are explored to provide actionable insights for improving neurosurgical outcomes in LMICs.

Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations

Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms and risk factors underlying these alterations remain elusive. Given the significant global incidence of COVID-19, identifying factors that can distinguish individuals at risk of developing brain alterations is crucial for prioritizing follow-up care. Here, we report findings from a sample of patients consisting of 73 adults with a mild to moderate SARS-CoV-2 infection without signs of respiratory failure and 27 with infections attributed to other agents and no history of COVID-19. The participants underwent cognitive screening, a decision-making task, and MRI evaluations. We assessed for the presence of anosmia and the requirement for hospitalization. Groups did not differ in age or cognitive performance. Patients who presented with anosmia exhibited more impulsive alternative changes after a shift in probabilities (r = − 0.26, p = 0.001), while patients who required hospitalization showed more perseverative choices (r = 0.25, p = 0.003). Anosmia correlated with brain measures, including decreased functional activity during the decision-making task, thinning of cortical thickness in parietal regions, and loss of white matter integrity. Hence, anosmia could be a factor to be considered when identifying at-risk populations for follow-up.

Volitionally Regulated Breathing with Prolonged Expiration Influences Food Craving and Impulsivity

Introduction: Previously, an intervention involving volitional slow breathing reduced trait food craving with protective effects on cardiac vagal activity (CVA). Breathing with a low inspiration-to-expiration (i/e) ratio also increases CVA. High CVA was separately associated with low unregulated eating and lesser impulsivity. Hence, the present study assessed breathing with a low i/e for effects on state food craving, hunger and satiety, state impulsivity, and heart rate variability (HRV) in healthy obese persons. Methods: Forty obese persons were randomized to two groups. The intervention group (mean age ± SD, 41.15 ± 12.63, M:F, 10:10) practiced metronome-regulated breathing with low i/e at 12 breaths per minute (expiration 72% of total breath duration) and attained expiration 55.8% of total breath duration, while the active control group (mean age ± SD, 44.45 ± 11.06, M:F, 13:07) sat motionless and directed their gaze and awareness to the stationary metronome without modifying their breath consciously. The HRV was recorded before, during, and after breathing intervention (or control) (standard limb lead I, acquisition at 2,000 Hz, with an LF filter = 0.5 Hz and HF filter = 50 Hz). Time-domain and frequency-domain HRV parameters were obtained with Kubios software. State food craving, and hunger and satiety were recorded before and after the intervention/control. Results: The intervention group decreased total state food craving scores and the sub-domains (i.e., desire to eat, positive reinforcement, lack of control and hunger), increased current satisfaction with food, decreased total state impulsivity (repeated measures ANOVA, p < 0.05 in all cases), increased HF-HRV and RMSSD (linear mixed model analyses with age and gender as fixed factors; p < 0.05 in all cases) during the intervention compared to the preceding baseline. The intervention group also showed an increase in positive mood and a decrease in aroused and negative mood states. Conclusion: Changes in state food craving and impulsivity could be related to an increase in HRV or to changes in subjective relaxation and positive mood or to both.

What Chemsex does to the brain - neural correlates (ERP) regarding decision making, impulsivity and hypersexuality.

Chemsex describes the use of specific substances (methamphetamine, GHB/GBL, mephedrone, ketamine) which initiate or enhance sexual experiences and is mainly prevalent among men who have sex with men. Many Chemsex users experience somatic complications (for example sexually transmitted diseases) and sometimes adverse sociological, psychological, and neurological symptoms, such as depression, impulse control disorders or hypersexuality. Changes in impulsivity and deficits in executive functions have demonstrated to be associated with addiction and impulse control disorders as well as frontal brain dysfunction and behavioral control deficits. This study aims to explore the effects of neurophysiological correlates of inhibition and decision making in Chemsex users with an EEG paradigm using event-related potentials (N2, P3). 15 Chemsex users and 14 matched control subjects, all of them men who have sex with man, participated in an auditory Go/NoGo/Voluntary Selection EEG paradigm. In addition, clinical data (e.g. regarding depression), demographic information as well as measures of well-being and sexual behavior were collected. The results demonstrated that clinical symptoms, hypersexuality, and sexual risk behavior were more pronounced in Chemsex users compared to non-users. P3 amplitudes did not differ significantly between groups. However, the Chemsex users showed decreased electrophysiological N2 responses in fronto-central brain regions during decision-making, indicating compromised executive function and inhibitory control. The observed impairments may lead to increased risk behavior regarding drug abuse and hypersexuality. Understanding the neurobiological mechanisms can contribute to targeted interventions in order to mitigate the negative consequences of engaging in Chemsex and improve general well-being.

Periodic Rolling and Bumping

Abstract We consider a sphere that rolls down an inclined corrugation of identical, frictional circular cylinders in contact. We assume that the motion is a periodic succession of rolling and bumping that results in a velocity that is, on average, steady. We use balances of force and moment and impulse and momentum change to calculate the instantaneous and average velocities, the tangential and normal contact forces, and their ratio in rolling regimes that involve no sliding, some sliding and a transition between these at contact. We compare the predictions for the steady average velocity versus the inclination for different sphere to cylinders radii ratio and the predictions for the angle of inclination versus the radii ratio for stopping, initiation of sliding and loss of contact with the results of numerical simulations.

The effect of impaired unilateral ankle propulsion on contralateral knee joint loading

BackgroundImpairments in unilateral ankle propulsion may result from restriction by an external device or pathology such as lower limb amputation. Models of gait suggest this reduction may lead to increased collisional force on the contralateral side, potentially increasing force through the knee and increasing the risk of knee pain or osteoarthritis. Research questionHow do restrictions in unilateral ankle propulsive force affect contralateral knee joint loading in otherwise healthy individuals? Methods18 individuals without impairment walked on a treadmill at 1.5 m/s for two conditions: one free of restrictions, and one where a randomized limb’s ankle propulsive force was restricted using an off-the-shelf ankle-foot orthosis (AFO). Ankle propulsive power, lower extremity joint work, and ground reaction force variables were calculated for the final 3 gait cycles of each condition. Tibiofemoral joint contact force (TJCF) for the limb contralateral to the AFO was calculated through a standard OpenSim workflow utilizing the gait2392 model. Intra-limb pair-wise comparisons were made between conditions. ResultsCompared to walking unrestricted, the limb wearing the AFO demonstrated a significant reduction in peak ankle propulsive power and positive ankle work by approximately 50 % each (p<0.01). With ankle restriction, the ipsilateral knee significantly increased positive work (p<0.01). The overall propulsion produced by that limb did not change between conditions, demonstrated by a lack of change in anterior ground reaction force impulse (p=0.11). The knee of the limb contralateral to the AFO did not display differences in any TJCF variable between conditions (all p>0.07). SignificanceThese results suggest a unilateral deficit in ankle propulsion will not increase contralateral knee joint forces in individuals who are able to use other joints of the limb to compensate for the loss of ankle function. However, further research should investigate this relationship in those who display pathologies that may prevent more proximal compensations.

Correlation between parameters of suppression head impulse paradigm and changesin DHI score in acute vestibular neuritis

Objective:To explore the correlation between the parameters of suppression head impulse paradigm（SHIMP） and changes in dizziness handicap inventory（DHI） scores. Additionally, to evaluate the degree of vertigo and prognosis of patients with acute vestibular neuritis through SHIMP parameters. Methods:Thirty-three patients with acute vestibular neuritis were enrolled for DHI evaluation, vHIT and SHIMP. A secondary DHI score were evaluated after after two weeks, once patients no longer exhibited spontaneous nystagmus. The decrease in the second DHI score was used as the efficacy index（EI）. All patients were divided into significantly effective group, effective group and ineffective group based on EI. Differences of the VOR gain values of SHIMP and the anti-compensatory saccade were compared among the three groups. Results:There were 13 cases in the significant effective group, 11 cases in the effective group, and 9 cases in the ineffective group. ①The mean gain of the horizontal semicircular canal in the significant effective group, the effective group, and the ineffective group was（0.50±0.11）, （0.44±0.12）, and（0.34±0.08）, respectively. The difference between the significant effective group and the ineffective group was statistically significant（P<0.01）. The gain of horizontal semicircular canal was positively correlated with EI（r=0.538 5, P<0.01） 。②The occurrence rate of the anti-compensatory saccade in the significant effective group, the effective group, and the ineffective group was（51.23±19.59）, （33.64±17.68）, and（13.78±11.81）, respectively. Pairwise comparisons between each group showed statistical significance（P<0.05）. The occurrence rate of anti-compensatory saccade was positively correlated with EI（r=0.658 2, P<0.01）. Conclusion:The horizontal semicircular canal gain and the occurrence rate of the anti-compensatory saccade in SHIMP for patients with acute vestibular neuritis were closely correlated with decrease in DHI score.

Heavy metal pollution causes mass mortality of fish in a tropical estuary in the southwestern Bay of Bengal

A massive fish mortality of the major species, viz., Mugil cephalus, Chanos chanos, and Oreochromis mossambicus, occurred on November 27, 2017 in the Adyar estuary. This catastrophe followed a spell of heavy rainfall and flash floods. A detailed study of water quality parameters (pH, water temperature, salinity, total suspended matter, dissolved oxygen, biochemical oxygen demand, and nutrients) and heavy metals, i.e., chromium (Cr), copper (Cu), cadmium (Cd), nickel (Ni), lead (Pb), and zinc (Zn), in the sediment and fish tissues were analyzed. Pollution indices like the enrichment factor (EF), geo-accumulation index (Igeo), contamination factor (CF), pollution load index (PLI), potential ecological risk index (PERI), and biota sediment accumulation factor (BSAF) were used to measure heavy metals. The pollution indices revealed that metals were significantly enriched in the sediments. The Igeo indicates that there was moderate contamination by Cd (2.27–3.25), whereas CF shows high contamination by Cd (7.22–9.72) and moderate contamination by Pb (2.5–3.25). The PLI (1.04–1.13) suggests that heavy metal contamination of sediments has occurred. Results showed that high concentrations of the toxic metals Pb and Cd were found in the sediment as well as in fish tissues. Length and weight of fish are significantly correlated (r2 = 0.98, p < 0.05). The study revealed that the mass fish kill was due to impulsive changes in the water quality and heavy metal pollution from untreated urban sewage discharges in this region.

Current Issues Related to Biomechanics in Engineering

Motion capture was employed by Eadweard Muybridge and Etienne-Jules Marey. Industry standard for computing joint kinematics is motion capture. Kinematic analysis is a technique used in biomechanics and mechanical engineering to quantify stiff body motion. A joint moment can be computed in one of two ways: bottom-up or top-down. Joint moments measure muscle and joint tension indirectly. Researchers predicted joint moments using kinematic-based characteristics and machine learning outside of the biomechanics lab.Ankle osteoarthritis causes significant biomechanical issues in the foot and lower leg. Patients' 3D multi-segment kinematic foot models were studied. The technique used is Openpose, which recognises the human body from a single photograph.Falling fear is linked to decreased activity, despondency, and anxiety in the elderly. They adopt a hip approach to manage their GRFs and balance. The lateral ankle technique corrects minor foot placement problems by swiftly moving the pressure point. Angular momentum is affected by foot placement and ground reaction forces. Changing the body's centre of mass along a curved trajectory implies large changes in both ground reaction force impulses and ground reaction force.Lens stiffness and a ciliary muscle anterior/inward displacement produce presbyopia. By 55, the majority of folks have lost their ability to accommodate. Cataracts become common around this time, reaching over 70% by 75. The circumferential and meridional stiffnesses rose with anisotropy from pole to equator, but dropped with distance. The Holzapfel model accurately fits the data from inflation and uniaxial mechanical tests.Anatomical motions of the femur during knee flexion were examined. The data revealed morphological and physiological knee kinematic characteristics. The data led to several hypotheses about axial femoral condyle rotation. This review discusses lower limbs, foot positioning, lens capsule, femoral condyle, muscle activation, collagen fibre, knee joint, and walking speed. The purpose is to provide a general overview on the subject matter.

Development of a sensitivity analysis tool for the trajectory of multistage launch vehicles

The primary objective of this work is to create a highly accurate sensitivity analysis tool for multi-stage launch vehicle trajectories. This tool is designed to assess the impact of various parameters on the trajectory and performance of multi-stage launch vehicles. To achieve this, we have developed high-fidelity simulation software that considers all translational and angular movements by modelling the six-degrees-of-freedom (6DOF) equations of motion. The validation of this software is based on experimental data. An essential aspect of this work is the utilization of the developed sensitivity analysis tool to determine how different parameters affect the trajectory of multi-stage launch vehicles. Through the sensitivity analysis conducted using the developed tool, it is possible to identify which parameters are of critical importance during the design phase. We apply a generic mission profile for the Minotaur-I launcher to obtain parametric dependencies of the flight path. Through a comprehensive parametric study, we evaluate a range of critical parameters, including gross lift-off weight, a specific impulse of each stage, pitch-over manoeuvre initial time and angle, and ignition impulse of each stage. These parameters significantly influence the trajectory, performance, and reliability of the launch vehicle for mission design and success. The results of the sensitivity analysis underscore that even minor variations in these parameters can result in substantial deviations from the nominal insertion altitude. The acceptability of errors in specific impulse changes varies across stages, with maximum changes of 6.07%, and the fourth stage showing less sensitivity at 0.13%. However, it's important to note that variations in the parameters of the first stage tend to be challenging to rectify once they occur, with maximum changes in specific impulses reaching 75.57%. Another noteworthy discovery is that the acceptability of changes in pitch-over manoeuvre initiation times depends on the rate of change; they can be deemed either acceptable or unacceptable based on this factor, with changes ranging between 17.90% and 98.38%.

The impact of markups and wages on changes in the level of inflation in Poland

This paper analysis of the impact of markups and wages of enterprises on changes in the level of inflation in Poland in the years 2007-2022. the impact of markups and wages on changes in CPI were assessed using the VECM model, the impulse responses, and the variance decomposition. The results indicate that industrial sector, including the mining and quarrying section, showed the highest dynamics of changes in markups and wages. In the years 2005–2022, the impact of markups on changes in CPI was stronger, although it was losing importance, with a weaker but growing impact of wages. Forecasts of the degree of clarification of the CPI in Poland indicate a greater importance of markups, with the impact of wages weaker by half, but growing over time. The paper extends the state of theoretical and empirical studies on the determinants of the CPI and the inflation expectations. It also considers the context of persistent exogenous and endogenous shocks from the COVID-19 pandemic and the war in Ukraine, and changes in demand and supply impulses. The results of this study may be valuable as a contribution to the literature on inflation and its forecasts, and for monetary policy makers.

How psychopathy is associated with the level and change of impulsivity in correctional treatment

IntroductionResearch indicates that psychopathy can hinder treatment success and can lead to dropout. Impulsivity is a complex construct that overlaps with psychopathic personality traits and is often targeted in forensic psychotherapy due to its relation to the risk of reoffending.ObjectivesOur aim was to investigate the overlap between psychopathy and impulsivity and the influence of psychopathic traits on change in impulsivity.MethodsWe conducted a pre-post-study for measures of psychopathy and impulsivity in men imprisoned for sexual and non-sexual violent offenses. All participants took part in standardized pre- and post-treatment ratings shortly after admission as well as after an average of 19 months (n=370 for pre-rating, n=168 for post-rating). Psychopathy was measured via the PCL-R, impulsivity with the BIS-15.We calculated two-tailed Pearson correlations for BIS-15 Pre-, Post-, and Change Scores and the PCL-R. In a second step, the BIS-15 pre-post-differences were compared using independent t-Tests, effect sizes were calculated using Cohen’s d (small, medium, and large effect sizes are d = .20, .50, and .80). Further, unpaired t-tests were carried out to compare between participants with lower and higher PCL-R sum scores (median split, mdn= 15.8, M=15.5, SD=7.9).ResultsIn the total population a significant reduction of self assessed impuslivity can be demonstrated for total impulsivity (p&lt;.001, cohens d= .34) nonplanned (p&lt;.001, cohens d= .39) and motor impulsivity (p=.004, cohens d= .23). In both groups, with higher and lower psychopathic traits, a significant reduction in total and nonplannend impulsivity can be seen.While the reduction in total impulsivity was 0.9 points higher in the group with higher psychopathy, the difference was not significant, t(147.8)= -1.1, p = .285. Also, the nonplanned impulsivity was showed a stronger reduction in the high PCL group, though the effect was not significant, t, t(166)= -1.2, p = .243.Table 1.Correlationen between BIS-15 post-ratings and PCL-RPCL-R PCL-R Sum Interpersonal affective lifestyleantisocialBIS-15 prä (n=370)Total Impulsivity.20 **-.14 **.02.34 **.28 **BIS-15 post (n=168)Total Impulsivity.33**.04.20**.35**.36**BIS-15 Change (n=168)Total Impulsivity-.03-.15-.09.07.01Note: * correlation significant für p ≤ .05; ** correlation significant für p ≤ .001.ConclusionsWe demonstrate a significant correlation between psychopathy and impulsivity, especially regarding facets 3 and 4, but also for the sum score. Neither the PCL-R sum core, nor the facets correlate with the change in impulsivity during treatment progress in the STU. In both groups, with higher and lower psychopathy, impulsivity was reduced during therapy but there was no significant difference in the change scores. Our results underline that treatment progress can be achieved also in patients with higher psychopathic traits.Disclosure of InterestNone Declared

“Unraveling the Diagnostic Dilemma: Unusual Presentation of Huntington’s Disease with Predominant Psychiatric Symptoms and Late-Onset Motor Manifestations”

IntroductionHuntington’s Disease is a neurodegenerative disease inherited in an autosomal dominant fashion.The underlying genetic defect is unstable CAG trinucleotide repeat expansion with a repeat length longer than 36 resulting in pathological aggregation of abnormal protein causing cell death.The clinical symptoms encompass 3 main domains-motor,cognitive and psychiatric.The psychiatric symptoms often in atypical form appear decades before other symptoms causing significant impact on patient’s functioning and quality of life.Here, we discuss an unusual presentation of Huntington’s Disease causing diagnostic dilemma.ObjectivesCase report discussing the unusual presentation of Huntington’s Disease.MethodsCase: Mr X is a 61 year old Caucasian male.He had an uneventful birth and early childhood attaining milestones appropriately. He experienced childhood adversity in the form of sexual abuse between ages 2-14 years. His mental health difficulties started following sexual abuse when he attempted to end his life by hanging and overdosing at age 15. He got married twice, both of which broke down. There is a history of significant alcohol abuse between ages 40-50. Following this, he had a myocardial infarction and a stroke requiring stenting.He presented to Psychiatric Outpatient Services in 2011 with auditory hallucinations, social anxiety with panic attacks, OCD type rituals, claustrophobia and feeling hot all the time. He was started on an antipsychotic medication for psychosis ,but clinically deteriorated. He started having anger outbursts, marching on the spot ,and head banging. He was diagnosed with Huntington’s Chorea in 2021 after he had developed chorea. He currently has low mood and is head banging for hours.ResultsPsychiatric symptoms in HD can span a variety of domains but most common are symptoms of frontal lobe dysfunction-disinhibition, poor attention, irritability, impulsivity and personality change. Apathy, emotional blandness and social withdrawal are also prominent features.Mr X had strong family history of Paranoid Schizophrenia (aunt and cousin).There was no family history of HD. His mental health problems started early in life with DSH, Depression and Harmful use of Alcohol. He presented predominantly with psychotic symptoms like auditory hallucinations, social anxiety, paranoia. Motor symptoms started late which he incorporated into voluntary movements like head banging which made it difficult to differentiate from deliberate self harm.ConclusionsPsychiatric symptoms constitute the core of HD. Studies have shown that though depression and personality change are typical of HD, there are number of other psychiatric symptoms that can impair quality of life. Early diagnosis and treatment of these symptoms will help patients and families to cope better with severe symptoms of this progressive disease.Disclosure of InterestNone Declared

Analysis of Mechanical Properties of Functional Parts of Goat Hoofs under Multi-Slope

In order to improve the adhesive and passing performance of agricultural tracked vehicles under a non-structural environment, a theoretical design method of the structure of a bionic track pattern is proposed in this article. The Saanen goat is taken as the experimental subject, and the hoof tips and hoof spheres are taken as the characteristic functional parts, whose pressure is measured by thin film pressure sensors. The Qualisys Track Manager (QTM) gait analysis system was used to obtain the gait sequence of goats under multi-slope. The changes in vertical ground reaction force (GRF) and vertical impulse (VI) of the hoof tips and spheres and adhesion coefficient under multi-slope were analyzed. The results show that with the increase in slope, the GRF is transferred from the left hind hoof to the right front hoof, and the right front hoof has the most significant effect. Under the 10-degree slope, the peak vertical GRF and VI of the inner tip of the right front hoof are the largest; peak vertical GRF is 146.20 N, and VI is 127.67 N·s. The adhesion coefficient is the largest; the right front and left hind hoof are in the diagonal two-phase supported state, and μ is 0.3455. Therefore, the inner tip of the right front hoof is used as a bionic prototype to design the track pattern architecture. It provides a theoretical basis for the design and optimization of bionic patterns applied to agricultural tracked vehicles.

Changes in Restless Sleep, Self-Control, and Alcohol-Related Problems with Police from Late Adolescence to Adulthood.

Sleep quality is crucial for healthy adolescent brain development, which has downstream effects on self-control and involvement in risky behaviors, such as alcohol use. While previous studies have found that sleep and facets of self-control are associated with patterns of alcohol use, few have assessed whether these constructs are tied to alcohol-related problems with law enforcement during the transitional period from adolescence to adulthood. The current study uses self-report panel data from ages 16 to 27 from a population-based sample of U.S. youth (N = 956; 36.86% female). The goal of the current study is to assess the association between changes in restless sleep, impulsivity, sensation seeking, and problems with police during or shortly after consuming alcohol from adolescence to adulthood to begin to address this gap in the existing literature. Results from a multivariate latent growth curve model reveal that faster increases in restless sleep and slower declines in impulsivity are associated with slower declines in police contact. Correlated changes between restless sleep, impulsivity, and police contact are slightly greater from ages 16-21 than for ages 22-27, with males showing stronger associations. The reported results suggest that identifying developmental mechanisms between changes in poor sleep, impulsivity, and alcohol use behaviors during this life-course phase will be crucial moving forward to help divert youth away from alcohol-related contact with the police.

Brain changes following mindfulness: Reduced caudate volume is associated with decreased positive urgency.

Mindfulness training has been shown to improve psychological health and general well-being. However, it is unclear which brain and personality systems may be affected by this practice for improving adaptive behavior and quality of life. The present study explores the effects of a 5-week mindfulness-based intervention (MBI) at the neuroanatomical level and its relationship with dispositional mindfulness and impulsivity. Sixty-six risky drivers were quasi-randomly assigned to a mindfulness training group (MT) or a control group (N). Participants underwent magnetic resonance imaging and completed the Five Facet Mindfulness Questionnaire (FFMQ) and the UPPS-P impulsivity scale twice, at baseline and after receiving the MBI. We observed that MBI changes dispositional mindfulness in the non-reactivity and observing facets. Further, we observed that the magnitude of change in impulsivity was associated with the change in dispositional mindfulness. Whole-brain voxel-wise analysis revealed that the volume of the right caudate nucleus of the MT group (n=27) showed a reduction compared to that of the control group (n=33), which increased in terms of the pre-post measurement (MT=-1.76mm3; N=6.31mm3). We also observed that reduced caudate nucleus volume correlated with decreased positive urgency in the MT group. Taken together, our results show that MBI improves the skills of observing and non-reactivity to inner experience, while producing changes in the structure of the caudate nucleus. These structural changes are associated with a reduction in impulsivity levels, decreasing the tendency to act rashly in situations that generate positive emotions and thus facilitating more adaptive behavior.

Mitigation of the Collision Risk of a Virtual Impactor Based on the 2011 AG5 Asteroid Using a Kinetic Impactor

In recent years, the escalating risk of natural disasters caused by Near-Earth Objects (NEOs) has garnered heightened scrutiny, particularly in the aftermath of the 2013 Chelyabinsk event. This has prompted increased interest from governmental and supranational entities, leading to the formulation of various measures and strategies aimed at mitigating the potential threat posed by NEOs. This paper delves into the analysis of the 2011 AG5 asteroid within the context of small celestial bodies (e.g., asteroids, comets, or meteoroids) exhibiting resonant orbits with Earth’s heliocentric revolution. Initial observations in 2011 raised alarms regarding the asteroid’s orbital parameters, indicating a significant risk of Earth impact during its resonant encounter in 2040. Subsequent observations, however, mitigated these concerns. Here, we manipulate the orbital elements of the 2011 AG5 asteroid to simulate its behavior as a virtual impactor (a virtual asteroid whose orbit could impact Earth). This modification facilitates the assessment of impact mitigation resulting from a deflection maneuver utilizing a kinetic impactor. The deflection maneuver, characterized as an impulsive change in the asteroid’s momentum, is executed during a resonant encounter occurring approximately two decades before the potential impact date. The paper systematically evaluates the dependence of the deflection maneuver’s efficacy on critical parameters, including the position along the orbit, epoch, and momentum enhancement factor.

Inter-study reproducibility of cardiovascular magnetic resonance-derived hemodynamic force assessments

Cardiovascular magnetic resonance (CMR)-derived hemodynamic force (HDF) analyses have been introduced recently enabling more in-depth cardiac function evaluation. Inter-study reproducibility is important for a widespread clinical use but has not been quantified for this novel CMR post-processing tool yet. Serial CMR imaging was performed in 11 healthy participants in a median interval of 63 days (range 49–87). HDF assessment included left ventricular (LV) longitudinal, systolic peak and impulse, systolic/diastolic transition, diastolic deceleration as well as atrial thrust acceleration forces. Inter-study reproducibility and study sample sizes required to demonstrate 10%, 15% or 20% relative changes of HDF measurements were calculated. In addition, intra- and inter-observer analyses were performed. Intra- and inter-observer reproducibility was excellent for all HDF parameters according to intraclass correlation coefficient (ICC) values (> 0.80 for all). Inter-study reproducibility of all HDF parameters was excellent (ICC ≥ 0.80 for all) with systolic parameters showing lower coeffients of variation (CoV) than diastolic measurements (CoV 15.2% for systolic impulse vs. CoV 30.9% for atrial thrust). Calculated sample sizes to detect relative changes ranged from n = 12 for the detection of a 20% relative change in systolic impulse to n = 200 for the detection of 10% relative change in atrial thrust. Overall inter-study reproducibility of CMR-derived HDF assessments was sufficient with systolic HDF measurements showing lower inter-study variation than diastolic HDF analyses.

Modeling of Rapidly Changing Macroeconomic Processes Based on the Analysis of Jump and Generalized Functions

In recent years, the economies of many countries around the world have been in a situation of intense, rapidly changing, abrupt processes. The current situation urgently requires a change in the economic paradigm in the near future, which leads to the need to develop new conceptual models. The purpose of the article is to develop basic theoretical principles and practical approaches to modeling macroeconomic processes based on the analysis of jump and generalized functions. The objectives of the study are the following: (1) describe the main types of impulse and jump functions using examples from economic theory and practice; (2) perform an analytical representation of impulse and jump functions; (3) select macroeconomic characteristics to analyze rapidly changing processes in the economy; and (4) create models and mechanisms for forecasting impulsive and abrupt changes in the macroeconomy. The approaches to the development of macroeconomic theory and its methods proposed in the article are not associated with the use of evolutionary continuous functions; for example, power functions, which is typical for many canonical macroeconomic models. These approaches do not include management decisions to achieve optimal values of given target functions, which is typical for recursive macroeconomic models of dynamic programming. This article is about formulating the main provisions of macroeconomic theory and its methods, which, with varying degrees of accuracy, could give a forecast about the upcoming possibility of sudden changes (impulse, shock, spasmodic, and others) in the macroeconomic situation. The research methodology is statistical analysis, special methods developed by the author for studying impulse, and jump processes. As a result of this study, the basic principles of modeling macroeconomic theory based on rapid impulse and abrupt changes were formulated, approaches to constructing the tools of this theory were outlined, and problems and tasks for further research were identified.