Background. Gait analysis is a systematic study of human locomotion that involves evaluating body motions, body mechanics, and muscle activity Objective. To analyze spatiotemporal and kinematics variables in schizophrenia. Methodology. Non-Experimental study, convenient sampling, sample size was 15. Both men and women with 18 to 45 years of age were included in the study. Procedure. subjects were selected based on inclusion and exclusion criteria for analyzing the kinematic and spatio temporal parameters of gait in schizophrenia. Outcome measures. Spatiotemporal and kinematics variables were assessed by using 2D gait analysis with software from Auptimo technologies. Results. Gait analysis of schizophrenia shows significant increase in ankle plantar flexion p < 0.05, significant increase in knee flexion p < 0.05, and significant increase in hip flexion p < 0.05 shows in lateral view and in anterior view significant increase in knee abduction/ adduction p < 0.05, and in posterior view significant increase in contralateral pelvic drop p < 0.05, and significant increase in rear foot angle eversion p < 0.05. In spatiotemporal parameters of schizophrenia shows non significant changes in cadence p > 0.05, and shows significant changes in right and lest stance time, right and left swing, and gait cycle time p < 0.05. Conclusion. This study concluded that schizophrenia shows marked kinematic changes in ankle, knee and hip joint, in anterior view knee abduction and adduction shows notable changes, and in posterior view, significant changes in pelvic drop and rear foot angle, and spatio temporal parameters no apparent changes noted in cadence, and significant increases in stance phase time, swing phase time and gait cycle time.