The purpose of this in vitro study was to evaluate the influence of the ceramic thickness, cement shade, and airborne-particle abrasion of the titanium on the final color of titanium base cemented lithium disilicate glass-ceramic restorations. In total, 144 lithium disilicate glass-ceramic disks of three thicknesses (0.5, 1.0, and 1.5 mm) were cemented to airborne-particle-abraded and non-airborne-particle-abraded titanium disks with six adhesive resin cements. The color measurements were performed with a clinical spectrophotometer. The mean and standard deviation of evaluated ΔE values were calculated. A three-way analysis of variance (ANOVA) was used for analyzing the data. Statistical analyses were computed with a significance level of α = .05 using a statistical software program (Minitab 17, Minitab). The 0.5- and 1-mm-thick ceramic specimens cemented with Panavia V5 Opaque showed the lowest ΔE values when cemented on both non-airborne-particle-abraded (5.62 ± 1.66, 3.15 ± 1.28) and airborne-particle-abraded (5.55 ± 0.86, 3.16 ± 0.49) surfaces, while the highest values were seen in the groups cemented with RelyX U200 A2 (29.22 ± 0.83, 17.23 ± 0.45) and Panavia V5 A2 (29.94 ± 1.17, 16.71 ± 0.44) on airborne-particle-abraded surfaces. For the 1.5-mm-thick ceramics, the lowest ΔE values were seen when Multilink MO 0 cement was used on non-airborne-particle-abraded surfaces (1.56 ± 0.29) and when Panavia V5 Opaque was used on airborne-particle-abraded surfaces (1.56 ± 0.66). The highest values were seen when RelyX U200 A2 (9.77 ± 1.13), PA2 (9.24 ± 0.25), and Multilink HO 0 (9.19 ± 1.33) were used on airborne-particle-abraded surfaces, and when Multilink HO 0 (9.61 ± 1.70) was used on non-airborne-particle-abraded surfaces. The 1-mm-thick ceramics cemented with Multilink HO 0 showed higher ΔE values (12.05 ± 1.99) for airborne-particle-abraded and non-airborne-particle-abraded (12.58 ± 1.06) than thinner (0.5 mm) or thicker (1.5 mm) ceramics. Thinnest ceramic superstructures resulted in the highest ΔE values. Cements that mask the underlying color reflect their own shade under thin superstructures. Airborne-particle abrasion of titanium surfaces increases the grayish reflectance if cement shade does not have the color masking ability.