Thin-walled vacuum chamber internally supported by ceramic spacers is a promising approach to provide sufficiently robust, ultra-high vacuum compatible and low gap vacuum devices for high energy, high current, heavy ions accelerators. The mechanical performance of the ring shaped ceramic spacers is a key factor in the structural design of these vacuum chambers. An extensive campaign was devoted to develop methodologies and equipment for evaluating the mechanical and structural properties of the ceramic spacers and to optimize the chamber design. To this aim, a force analysis on single ceramic rings was first conducted, and formulas for calculating the elastic modulus and bending strength of the ceramic rings were derived. The elastic modulus and critical position strength limits of alumina and zirconia ceramic rings were tested using a mechanical testing platform. Based on the test results of a single ceramic ring, a preliminary design and processing of ceramic lined thin-walled vacuum chamber test samples was finalized. A testing device capable to apply known water pressure values was then designed and built to test the chamber ability to withstand externally applied forces and measure the mechanical parameters of the ceramic spacers. Thanks to this, the acceptable stress limits of alumina and zirconia ceramic rings as the supporting components of the vacuum chamber were obtained. Knowing these values, through an iteration process, the whole design and properties of the ceramic lined thin-wall vacuum chamber was optimized. Finally, to reduce the impact of eddy current heat effect on ceramic strength and outgassing, a suitable cooling structure was designed and implemented.