The soils of uplands and partially isolated landforms located in the central Volga region were investigated in terms morphology, diversity and geogenic factor specificity. The Samarskaya Luka area is characterized by extreme spatial inhomogeneity and contrast of geogenic (lithological and topographic) conditions, and at the same time is located on the ecotone-transitional border of several natural zones. This territory is a part of two federal protected areas because of its peculiar nature. It is established that the diversity of geogenic (geological and topographic) conditions leads to the differentiation of the soil cover. Key soil types are presented by Leptosols, Cambisols, Retisols, Chernozems, Fluvisols and Technosols. By the example of the recognized upland macrolandscape, it is shown that the usual gradual course of soil zonation significantly changes due to the transformation of the soil-forming potential of the environment. The obtained data can be used for further regional verification of soil taxonomy. In addition, since the role of parent materials increases as they move from the west to the east of the East European Plain, parameterization of the role of this process becomes particularly important. Information about the diversity of chemical parameters and the granulometric composition of the key soil types of the studied area is also given.