BackgroundCentral venous (CV) port is an integral part of chemotherapy and parenteral treatment, for long-term venous access. It is still unclear whether there is a correlation between venipuncture sites, and complications and patency of the CV port placed in the chest wall. MethodsTwo-hundred and sixty-nine patients, who underwent CV port placement in their chest wall, were reviewed retrospectively in this study. They were divided into two groups, the S (subclavian vein) group and I (internal jugular vein) group, according to the venipuncture site. We analyzed the data from the medical records and examined the differences in complications between the two groups. ResultsThe median event free period among all patients was 228 days (range: 5–1877), the cumulative follow-up period was 97,176 catheter days. There were no significant differences between the two groups in terms of sex, age, body mass index (BMI), primary disease, reason for implant, past history of diabetes mellitus and occurrence of procedural complications. The median event free days were 200.0 (6–1846) in the S group and 246.0 (5–1877) days in the I group. The rate of event-free port availability after one, two and three years was 84.6, 74.0 and 66.5% in the S group, and 84.4, 80.3 and 80.3% in the I group respectively, which were not significantly different between the two groups. ConclusionsComplications of CV port placement have no correlation with the subclavian or jugular vein puncture sites.