The development of efficient thermal management techniques in cooling systems will lead to achieving a higher power capacity for electronic devices. Extended surfaces such as fins and riblets effectively improve the heat transfer rate in heat sinks, but they can cause increasing the friction factor. In this numerical study, a novel configuration of fins is introduced according to the shark scales’ geometry to provide a trade-off between heat transfer rate and friction losses compared to simple fins in a microchannel cooling system. Also, the cooling effect of concentrations of graphene oxide (GO)+ silver (Ag)/water (H2O) and molybdenum disulfide (MoS2) + cobalt oxide Co3O4/water (H2O) nanofluids (1, 3, and 5 wt%) are investigated for the Reynolds number ranging from 130 to 525. The geometrical parameters and different materials such as copper, nickel, and silver are evaluated by ANSYS-FLUENT under steady-state conditions. The comparison of outlet temperature, pressure drop, and temperature difference by experimental results verifies the accuracy of the numerical model. The results indicate that increasing arc width from 1 mm to 1.5 mm reduces the maximum CPU (central processing unit) temperature by 5 K while the temperature uniformity index decreased by 9.96 % at 0.3 m/s of inlet flow rate. The novel configuration of fins results in a performance evaluation criterion (PEC) greater than 1 for GO+Ag/water nanofluids in all cases compared to simple circular fins.