Central Mucoepidermoid Carcinoma Research Articles

Assessment of MUC5AC and MUC2 Immunoexpression in Glandular Odontogenic Cysts, Dentigerous Cysts, and Mucoepidermoid Carcinomas.

Glandular odontogenic cysts (GOCs) and dentigerous cysts may show mucous metaplasia. Central mucoepidermoid carcinoma is very rare and mostly associated with dental cysts. It is hypothesized that odontogenic cysts showing mucus differentiation in their lining, have a propensity to transform into MEC. The present study is the first attempt to explore the relationship between odontogenic cysts [GOCs and dentigerous cysts with mucus metaplasia (DCMM)] and MEC by evaluating immunoexpression of MUC5AC and MUC2. Immunoexpression of MUC5AC and MUC2 was evaluated semiquantitatively in GOCs (20 cases), DCMMs (20 cases), and MECs (20 cases). The percentage of positive cells, intensity, and localization of immunoexpression were assessed for each marker in all cases. Of GOCs, DCMMs, and MECs cases, 85%, 70%, and 80%, respectively, were immunopositive for MUC5AC. Strong cytoplasmic immunoreactivity for MUC5AC was noted, particularly in mucous cells present diffusely within MECs. However, the immunoreactivity was limited to the epithelial lining of GOCs and DCMMs. Most of the MECs (60%) showed more than 25% positivity for MUC5AC, followed by GOCs, and the least in DMMCs. Mild cytoplasmic and nuclear positivity of MUC2 was noted only in epithelial lining cells of 70% GOCs and 45% DCMMs. Whereas, 55% of MECs displayed moderate to strong cytoplasmic and membranous immunopositivity for MUC2 exclusively within mucous cells. As MECs showed strong MUC5AC immunoreactivity in mucous cells, immunoexpression of MUC5AC in odontogenic cysts with mucus cells can possibly explain the pathogenesis of MEC from cysts. However, the variable expression of MUC2 did not give any strong evidence regarding its role as a marker.

Central mucoepidermoid carcinoma of the mandible: a case report

Mucoepidermoid carcinoma is the most common malignant tumour of the salivary glands. It usually occurs in the parotid glands. Primary intraosseous mucoepidermoid carcinoma is rare, making up 2-3% of all mucoepidermoid carcinoma. They usually affect the mandible, with the common clinical presentation being jaw swelling. We report a case of a primary intraosseous mucoepidermoid carcinoma in a 48-year-old African male, who was managed surgically by left hemimandibulectomy, on account of a provisional diagnosis of ameloblastoma.

Central mucoepidermoid carcinoma of maxilla a case report and review of literature

MEC is the most commonly occurring malignant salivary gland neoplasm, comprising 2.8–15% of all salivary gland tumors. Its behavior is like mucoepidermoid cancers elsewhere and maxillary cancers in general. These cancers typically impact the mandible and exhibit histological characteristics indicating low-grade malignancy. This paper reports the case of 50-year-old female with facial swelling, which on FNAC showed intermediate-grade epithelial malignancy. mucoepidermoid carcinoma. MRI showed lytic lesion in right maxilla. She underwent right subtotal maxillectomy and had good prognosis on one year follow up.

Sclerosing Central Mucoepidermoid Carcinoma: Rare Case Series and Review

Introduction:
 The most frequent malignant tumour of the salivary glands is mucoepidermoid carcinoma which accounts for 30% of all malignancies of the salivary glands. There are numerous histologic variations with various levels of differentiation. Sclerosing MEC (SMEC) is a rare subtype of MEC that has the potential to be misdiagnosed as a low-grade non-SMEC malignancy or a benign reactive condition. There have been no cases of the extremely rare sclerosing variant of central or intraosseous MEC reported as of yet.
 Case reports:
 We present two cases of Sclerosing Central MEC, in which histologic analysis revealed relatively well-circumscribed, nonencapsulated tumours made up of dispersed epithelial islands of low-grade MEC and extensive central sclerosis. Similar sclerotic stroma was present in the tumor in the second case, but the epithelial component was of intermediate grade. Both cases showed abundant intracytoplasmic mucin and positive Mayer mucicarmine and PAS stains.
 Conclusions:
 Sclerosing central mucoepidermoid carcinoma was identified as the cause. Both cases underwent a complete resection of the tumor and have since been free of the disease.

Central mucoepidermoid carcinoma of the maxilla, a challenging diagnosis

Objective: To present a pictorial review on central mucoepidermoid carcinoma.
 Case report: Central mucoepidermoid carcinoma (CMEC), also known as intraosseous mucoepidermoid carcinoma (IMEC), is an extremely rare disease (less than 2-4% of all MEC). However, CMEC is the most frequent malignant salivary gland tumour found in intraosseous locations. Due to this unusual location, diagnosis of CMEC can be challenging. Therefore, CMEC is often mistaken for other intraosseous or odontogenic pathologies. Radiological assessment shouldinclude panoramic X-Ray, CBCT and thoracic CT, which should be performed after diagnosis. The recommended treatment includes radical resection surgery, followed by radiotherapy if indicated. A long-term follow-up is recommended for up to 10 years.
 Conclusion: The authors experienced the challenging diagnosis of CMEC through the case of a patient who presented with a slowly growing palatal mass.

A RARE CASE OF INTRAOSSEOUS MUCOEPIDERMOID CARCINOMA OF MAXILLA TREATED AT OUR CENTRE.

Occurrence of Primary intraosseous mucoepidermoid carcinoma (PIOC) within the jaw bones from aberrant salivary tissues is extremely rare. Mandible is more commonly affected but occurrence in maxilla is very rare. The origin of mucoepidermoid carcinoma is controversial and debatable. Primary Intraosseous mucoepidermoid carcinoma is frequently misdiagnosed radiographically and clinically as a benign odontogenic tumor or cyst.Primary Intraosseous Mucoepidermoid Carcinoma has distinct and specic radiological and morphological features for its diagnosis. The main modality of treatment is surgery and appropriate patients are offered adjuvant radiotherapy. This paper reports a case of central mucoepidermoid carcinoma of the Maxilla which was presented as complaints of pain and swelling of upper jaw.Then, he was treated with surgery followed by adjuvant treatment as per specimen pathological report. Here, we have used Simultaneous Integrated Boost technique with helical IMRT for Radiotherapy along with concurrent chemotherapy for treatment of revised margins following positive margins status. Central mucoepider Summary: moid carcinoma is a rare entity with highly selective radiological, histological and immunohistochemical criteria with overall around 150 cases reported. Due to rarity of occurrence, consensus guidelines for treatment protocol have not been established. Here we have described a similar case of a 25yrs old male patient that was diagnosed, surgically resected and has completed adjuvant chemo-radiation therapy at our centre

Central mucoepidermoid carcinoma in mandible: Case report of a clear cell variant with immunohistochemistry analysis

Central mucoepidermoid carcinoma in mandible: Case report of a clear cell variant with immunohistochemistry analysis

Central mucoepidermoid carcinoma of the mandible: report of a rare case with a demystification of the management strategies

article: Central mucoepidermoid carcinoma of the mandible: report of a rare case with a demystification of the management strategies - European Journal of Oral and Maxillofacial Surgery 2022 December;6(3):141-4 - Minerva Medica - Journals

A RARE FORM OF SYNCHRONOUS LUNG CANCER: MUCOEPIDERMOID CARCINOMA

TOPIC: Lung Cancer TYPE: Medical Student/Resident Case Reports INTRODUCTION: We report a unique case of lung cancer involving two different histologic variants. Mucoepidermoid carcinoma (MEC) a salivary gland-type tumor and conventional adenocarcinoma CASE PRESENTATION: The patient in this case study is a 57-year-old male non-smoker with history of hypertension, prostate cancer and deep venous thrombosis, who was incidentally found to have chest x-ray findings concerning for diaphragmatic eventration. Computed tomography (CT) of the chest revealed a linear area of scarring in the left upper lobe and a 5 mm nodule in the left lower lobe (Figure 1, 2). Positron emission tomography-CT (PET-CT) was obtained to evaluate the nodule which revealed a metabolically active 2.8 x 1.5 cm opacity in the left upper lobe, suspicious for malignancy (Figure 3). He underwent CT guided biopsy of the left upper lobe nodule. After the diagnosis, he underwent left Video-Assisted Thoracic Surgery which converted into an open thoracotomy with left upper lobe lobectomy. Microscopic examination revealed that the tumor was located in the peribronchial area of the lung and compromised of two different histologic components: A central MEC component, containing mucin producing cells. The MEC part was negative for cytokeratin 7 (CK7), thyroid transcription factor-1 (TTF-1) and Napsin. The central MEC part of the tumor is surrounded by adenocarcinoma component. The adenocarcinoma component presented with mixed lepidic and acinar patterns positive for TTF-1, Napsin and CK7 but negative for P63 and P40 stains. According to the seventh edition of TNM staging for lung tumors, the clinical stage of this patient was pT2aNO Stage IV. DISCUSSION: Salivary gland-type lung cancers are relatively rare neoplasms of the lung. They represent about 0.1 to 0.2% of primary lung tumors and are detected incidentally. CT findings usually include a well-defined endobronchial mass with or without obstructive pneumonia or atelectasis (1). The genetic analysis of cancer cells is the standard of care in order to select the most effective therapy; however, the genetic characteristics of MEC are not yet fully understood. Mutations in EGFR and ALK genes are routinely tested to identify lung adenocarcinoma patients who could benefit from treatment with target therapies. Treatment of choice is complete surgical excision as its controversial if pulmonary MEC is responsive to chemotherapy and radiotherapy; however, in cases of high-grade PMEC, adjuvant chemotherapy has been reserved when complete resection is impossible. Patients with unresectable disease have responded to EGFR-targeted therapy. CONCLUSIONS: This case report serves to illustrate the rare combination of MEC and adenocarcinoma. Early surgical intervention has shown to be favorable in low-grade MEC; however, further investigation is required to evaluate for the need for adjunct therapy in the future given the risks of developing high-grade MEC and adenocarcinoma. REFERENCE #1: Li X, Zhang W, Wu X, et al. Mucoepidermoid carcinoma of the lung: common findings and unusual appearances on CT. Clin Imaging. 2012;36:8–13. REFERENCE #2: Yousem, S.A. and Hochholzer, L. (1987), Mucoepidermoid tumors of the lung. Cancer, 60: 1346-1352. https://doi.org/10.1002/1097-0142(19870915)60:6<1346::AID-CNCR2820600631>3.0.CO;2-0 REFERENCE #3: Leonardi HK, Jung-Legg Y, Legg MA, Neptune WB. Tracheobronchial mucoepidermoid carcinoma. Clinicopathological features and results of treatment. J Thorac Cardiovasc Surg. 1978;76(4):431–8. DISCLOSURES: No relevant relationships by Chandan Buttar, source=Web Response No relevant relationships by Debra Ferman, source=Web Response No relevant relationships by Sofia Lakhdar, source=Web Response No relevant relationships by Theo Trandafirescu, source=Web Response

Central mucoepidermoid carcinoma arising directly from a glandular odontogenic cyst of the mandible: a case report

BackgroundCentral mucoepidermoid carcinoma (MEC) is a rare salivary gland tumor that affects the jawbone. Glandular odontogenic cyst (GOC) is also a rare odontogenic developmental cyst with glandular differentiation. GOC shares some histological features with central MEC, and a pre-existing GOC can develop into central MEC. Here, we present a rare case of central MEC developed directly from a pre-existing GOC of the mandible.Case presentationA 67-year-old Japanese man presented with a cystic lesion in the right third molar region. Histologically, the biopsy specimen demonstrated both typical findings of a GOC component lined with non-keratinized squamous epithelium and a recognizable component of central MEC consisting of polycystic nests with mucous cells, intermediate cells, and epidermoid cells in the cyst wall. The results from the immunohistochemistry for cytokeratin (CK) profiling demonstrated that, while both central MEC and GOC expressed CKs 7, 14, 18, and 19, CK13 was interestingly exclusively expressed in GOC. Fluorescence in-situ hybridization (FISH) revealed the rearrangement of the Mastermind like (MAML)-2 gene in both the MEC and GOC components.ConclusionsOur case suggests that central MEC and GOC may be in the same spectrum of diseases caused by the rearrangement of the MAML-2 gene. However, given that the expression profile of CK13 was completely different between central MEC and GOC, they can be considered as separate tumors. Overall, we demonstrated a rare case in which central MEC may have originated directly from the GOC.

Origens do carcinoma mucoepidermoide central: revisão sistemática

O carcinoma mucoepidermoide é um tumor maligno geralmente associado a glândulas salivares. Apenas de 2-4% de todos os carcinomas mucoepidermoides apresentam sítio primário intraósseo (carcinoma mucoepidermoide central), cuja etiogenia permanece obscura, justificando a importância de se pesquisar o assunto. Objetivo: Conhecer a(s) etiologia(s) mais provável(is) do carcinoma mucoepidermoide intraósseo. Método: revisão sistemática de acordo com as recomendações do PRISMA (Preferred Reporting itens for Systemstic Review and Meta-analysis Statement). As bases de dados consultadas foram: PubMed, Portal CAPES e Google acadêmico, e após aplicação dos critérios de inclusão e exclusão foram selecionados sete artigos que atenderam o objetivo da pesquisa, para os quais aplicaram-se a ferramenta Newcastle-Ottawa para análise de risco de viés e qualidade metodológica. A busca, seleção, extração e risco de viés foram feitas por três pesquisadores independentes Resultados: São duas as principais hipóteses etiológicas do carcinoma mucoepidermoide intraósseo: (1) derivado de um cisto odontogênico e (2) derivado de restos ectópicos. Conclusões: Ao que as evidências indicam o potencial pluripotente de células contidas nos cistos odontogênicos seria o responsável pela metaplasia e posterior carcinogênese. Nos casos derivados de restos ectópicos é clara a associação com a translocação t(11;19) e o transcrito de fusão CTRC1-MAML2 como um evento precoce ou etiológico.

Oncocytic variant of central mucoepidermoid carcinoma: a rare case report

Oncocytic variant of central mucoepidermoid carcinoma: a rare case report

Bilateral mandibular dentigerous cyst in non-syndromic patient: technical strategy and literature review

Bilateral mandibular dentigerous cyst in non-syndromic patient: technical strategy and literature review

Ameloblastoma with mucous cells: A clinicopathological, BRAF mutation, and MAML2 rearrangement study.

To investigate the clinicopathological features, BRAF V600E mutation, and MAML2 rearrangement of ameloblastoma with mucous cell differentiation. Five cases of ameloblastoma with mucous cell differentiation were retrospectively studied. Clinicopathological features, BRAF V600E mutation, and MAML2 rearrangement were analyzed. Follow-up information was available for all cases. Of five cases, two cases were male and three were female, aged 18-55years. Four cases were located in the mandible and one case in the maxilla. Histologically, four of the five cases (80%) presented with cystic features and three of the five cases (60%) with varying degrees of squamous metaplasia. The mucous cells were located in the epithelial islands or the luminal aspect of the cystic cavities. The BRAF V600E mutation was found in three of five cases (60%). All the cases showed no MAML2 rearrangement. Two cases were recurrent lesions, and one case had a local recurrence during the follow-up. Ameloblastoma with mucous cell differentiation is closely related to the cystic features, squamous metaplasia, and shows a high prevalence of BRAF V600E mutation. The absence of MAML2 rearrangement reveals that ameloblastoma with mucous cell differentiation and central mucoepidermoid carcinoma (MEC) are two distinct tumor entities.

Central mucoepidermoid carcinoma arising in a dentigerous cyst: A challenging case report

Central mucoepidermoid carcinoma (MEC) is a rare neoplasm of the jaw which is more common in the posterior of mandible, and the most likely origin is odontogenic epithelium. The aim of the present report is to describe a case of maxillary MEC arising in a dentigerous cyst in a 57-year-old female. It is crucial for pathologists to aware of the histopathologic features of this rare neoplasm to have a correct diagnosis.

Locally advanced primary intraosseous mucoepidermoid carcinoma of the mandible: radiological aspects

Primary intraosseous mucoepidermoid carcinoma (PIOC) or Central Mucoepidermoid Carcinoma (CMC) of the jaw bones is an extremely rare malignant salivary gland tumor, comprising 2-3% of all mucoepidermoid carcinomas reported. We report a rare case of a 55 year-old female patient with advanced low-grade primary intraosseous mucoepidermoid carcinoma of the mandible. The patient was referred with a chief complaint of slowly progressive painless swelling in right cheek region for 2 years. On physical examination, a stony hard swelling was found, measuring 47x46x33 mm, fixed to the right posterior mandible and extending to the parotid region. Oral cavity examination showed an induration of the oral mucosa with poor state of dental health. No palpable lymph node was noticed in the neck on extraoral examination. Computed tomography (CT) with three-dimensional (3D) reconstruction (A,B,C,D) showed an agressive lytic process of the right mandibular ramus, with heterogeneous tissue density, blowing the cortical, having clear polycylic contours and extending into the surrounding soft parts without invading them. The patient underwent tumoral biopsy. Histopathological and immunohistochemical examination confirmed the diagnosis of a low-grade mucoepidermoid carcinoma (MEC). Surgery is the treatment of choice, as mucoepidermoid carcinoma is considered globally resistant to radiotherapy and chemotherapy. Due to the advanced stage of the disease, the tumor was unresectable. The next best treatment option planned was exclusive conformal radiation therapy.

Central mucoepidermoid carcinoma of the mandible associated with Systemic lupus erythematosus: Central mucoepidermoid carcinoma

Central mucoepidermoid carcinoma of the mandible associated with Systemic lupus erythematosus: Central mucoepidermoid carcinoma

Central unilocular mucoepidermoid carcinoma of the mandible: A case report and literature review

Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Central MEC (CMEC) is a rare tumor which affects women more than men and is more common in the mandible. Most cases are histologically classified as low-grade tumor and radiographically appear as well-defined unilocular or multilocular radiolucent lesion, although this tumor causes destruction and metastasis to other organs. In this article, we present a rare case of CMEC in a 47-year-old woman with unilocular radiolucent lesion of the mandible. Early and accurate diagnostic approach in all lesions with clinical/radiographical bland appearance is important, and all possibilities such as a malignant lesion should be considered.

A Case of Central Mucoepidermoid Carcinoma of the Mandible in which the Primary Site was Difficult to Locate

A Case of Central Mucoepidermoid Carcinoma of the Mandible in which the Primary Site was Difficult to Locate

Glandular odontogenic cyst of the mandible: A case report and literature review

Glandular odontogenic cyst (GOC) is a rare developmental odontogenic cyst that has gained special attention primarily due to its aggressive potential and the microscopic features, it shares with central mucoepidermoid carcinoma of the jaws. This relatively new entity has a prevalence rate of 0.17% and lacks pathognomonic clinicoradiographic features, making the correct diagnosis a major challenge. This report describes a case of GOC presenting as a solitary osteodestructive lesion in the anterior mandible of a 54-year-old male. Cone-beam computed tomography (CBCT) images revealed a multilocular radiolucent lesion with bicortical expansion, cortical thinning, and perforation, indicating an aggressive potential. Histopathology revealed pseudoglandular epithelium with daughter cysts within the stroma, suggesting an invasive nature. The patient was diagnosed and treated in our institution. In view of the high probability of recurrence of GOC, CBCT evaluation and histopathological examination are essential. An aggressive treatment approach is recommended followed by long-term follow-up.