The formation and development of wine regions require unique natural conditions and hundreds of years of technical and cultural accumulation. The development of the wine industry at the eastern foot of Helan Mountain in China, in addition to the appropriate geographical environment, the technical migration, and talent flow supported by consistent policies, have improved the allocation ability of resource factors and conversion efficiency, making it a world-renowned new wine-producing region in just 40 years. This particular mechanism deserves attention as new industries develop in other parts of the world. Using the methods of spatial autocorrelation, hot spot analysis, and geographic detector, this paper comprehensively analyzes the growth and spatial evolution characteristics of wineries in the eastern foot of Helan Mountain in China and deeply discusses the mechanism of the interaction between the localization of global floating capital and China's unique regional economic policies. It is found that the local selection of global floating capital has a spatial locking effect on the formation of CHMWR, and the rolling support policies of China's central and local governments promote the rapid expansion and regional spread of the number and scale of wineries, with significant spatial agglomeration and spatial diffusion. The profound mechanism of such changes lies in the dual interaction of the local selection of global liquid capital and the Chinese government's wine-producing policies adapted to the geographical environment. In this process, a series of internal and external factors such as the innovation of grape planting and wine-making technology, consumer market, and government behavior have accelerated the continuous growth of the wine-producing region at the eastern foot of Helan Mountain in Ningxia. This paper adds a new understanding and deep understanding of the interaction between the local implantation of economic globalization and the macro-control policies of the Chinese government.