The Lower Oligocene Kal-e-kafi (East of Anarak, Central Iran) lamprophyres occur as stocks and dikes, which cross-cut the Eocene volcanic and Cretaceous sedimentary rocks. The predominant minerals of these lamprophyres are hornblende (magnesiohastingsite) and clinopyroxene (diopside) phenocrysts set in a fine- to medium-grained matrix of the same minerals plus plagioclase (labradorite to bytownite), sanidine, apatite, and magnetite. Secondary minerals are chlorite, magnetite, calcite, and epidote. Petrography, mineral chemistry, and whole rock compositions classify these rocks as calc-alkaline lamprophyre, in general, and spessartite in particular. These samples have intermediate compositions (SiO2 ~ 58 wt %). The chondrite-normalized REE patterns and primitive mantle-normalized multi-element spider diagram of Kal-e-kafi lamprophyres are remarkably parallel and suggest that these dikes and stocks were derived from the same parental magma and underwent similar melt extraction. These rocks are enriched in alkalies, large-ion lithophile elements (e.g., Rb, Ba, K), and light rare-earth elements (e.g., La, Ce), and exhibit moderate to high fractionation in LREE patterns, with an average La/Lu ratio of 112. The large amount of hydrous fluids coming from the subducted slab rather than sediments caused to the enrichment and metasomatism of subcontinental lithospheric mantle source. Crustal contamination and assimilation of host rocks also played role in the genesis of these lamprophyres. Geochemical characteristics of the studied rocks suggest that parental magma have been derived from partial melting of a metasomatized amphibole-bearing spinel lherzolite of lithospheric mantle, which was previously modified by dehydration of a subducting slab. Subduction of oceanic crust around the Central-East Iranian Microcontinent (CEIM) is the most reasonable mechanism to explain enrichment in volatiles of the mantle, and the lamprophyric magmatism of the Kal-e-kafi area in Lower Oligocene times. Several tectonomagmatic discrimination diagrams indicate that the Kal-e-kafi lamprophyres occurred during postcollisional period of lithospheric extension.