Cent Of Infants Research Articles

Breastfeeding outcomes in late preterm infants: A multi-centre prospective cohort study.

To describe (1) infant feeding practices during initial hospitalisation and up to 6 months corrected age (CA) in infants born late preterm with mothers intending to breastfeed, (2) the impact of early feeding practices on hospital length of stay and (3) maternal and infant factors associated with duration of breastfeeding. We conducted a prospective cohort study of infants born at 34+0 to 36+6 weeks gestational age during 2018-2020. Families were followed up until the infant reached 6 months of age (corrected for prematurity). Feeding practices during the birth hospitalisation, length of initial hospital stay, and the prevalence of exclusive or any breastfeeding at 6 weeks, 3 months, and 6 months CA were examined. Associations between maternal and infant characteristics and breastfeeding at 6 weeks, 3 months and 6 months CA were assessed using multivariable logistic regression models. 270 infants were enrolled, of these, 30% were multiple births. Overall, 78% of infants received only breastmilk as their first feed, and 83% received formula during the hospitalisation. Seventy-four per cent of infants were exclusively breastfed at discharge, 41% at 6 weeks CA, 35% at 3 months CA, and 29% at 6 months CA. The corresponding combined exclusive and partial breastfeeding rates (any breastfeeding) were 72%, 64%, and 53% of babies at 6 weeks CA, 3 months CA, and 6 months CA, respectively. The mean duration of hospitalisation was 2.9 days longer (95% confidence interval (CI) 0.31, 5.43 days) in infants who received any formula compared with those receiving only breastmilk (adjusted for GA, maternal age, multiple birth, site, and neonatal intensive care unit admission). In multivariable models, receipt of formula as the first milk feed was associated with a reduction in exclusive breastfeeding at 6 weeks CA (odds ratio = 0.22; 95% CI 0.09 to 0.53) and intention to breastfeed >6 months with an increase (odds ratio = 4.98; 95% CI 2.39 to 10.40). Intention to breastfeed >6 months remained an important predictor of exclusive breastfeeding at 3 and 6 months CA. Our study demonstrates that long-term exclusive breastfeeding rates were low in a cohort of women intending to provide breastmilk to their late preterm infants, with approximately half providing any breastmilk at 6 months CA. Formula as the first milk feed and intention to breastfeed >6 months were significant predictors of breastfeeding duration. Improving breastfeeding outcomes may require strategies to support early lactation and a better understanding of the ongoing support needs of this population.

EBNEO Commentary: Red blood cell transfusion thresholds in extremely low birthweight infants.

Franz AR, Engel C, Bassler D, Rüdiger M, Thome UH, Maier RF, Krägeloh-Mann I, Kron M, Essers J, Bührer C, Rellensmann G, Rossi R, Bittrich HJ, Roll C, Höhn T, Ehrhardt H, Avenarius S, Körner HT, Stein A, Buxmann H, Vochem M, Poets CF; ETTNO Investigators. Effects of Liberal vs Restrictive Transfusion Thresholds on Survival and Neurocognitive Outcomes in Extremely Low-Birth-Weight Infants: The ETTNO Randomized Clinical Trial. JAMA. 2020 Aug 11;324(6):560–570. PMID: 32780138. Erin Grace. Neonatal Fellow. Department of Neonatal Medicine, Women's and Children's Hospital, North Adelaide, South Australia. SAHMRI Women and Kids, South Australian Health and Medical Institute, North Adelaide, South Australia. Robinson Research Institute and the Adelaide Medical School, the University of Adelaide, Adelaide, South Australia. Cathie Hilditch. Paediatric Registrar. SAHMRI Women and Kids, South Australian Health and Medical Institute, North Adelaide, South Australia. Robinson Research Institute and the Adelaide Medical School, the University of Adelaide, Adelaide, South Australia. Amy Keir. Consultant Neonatologist. Department of Neonatal Medicine, Women's and Children's Hospital, North Adelaide, South Australia. Healthy Mothers, Babies and Children Theme, South Australian Health and Medical Institute, North Adelaide, South Australia. Robinson Research Institute and the Adelaide Medical School, the University of Adelaide, Adelaide, South Australia. In this European multicentre randomised controlled trial, the Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low birth Weight Infants (ETTNO), 1013 preterm infants with a birthweight less than 1000 grams were included. The study was undertaken across 2011–2014 with longer term follow-up beyond this period.1 At 24 months’ corrected age, rates of the primary outcome of death or neurodevelopmental impairment were similar in the liberal and restrictive threshold groups (44.4% and 42.9%; odds ratio, 1.05). The rates of mortality, cognitive impairment and complications including bronchopulmonary dysplasia and necrotising enterocolitis were similar between groups. To examine the study more closely, randomisation occurred with the first 72 hours of age with the majority of infants randomised at 2.5 days of age. Twenty-five per cent of infants in each group received at least one red blood cell transfusion prior to randomisation. Deferred/delayed cord clamping (DCC) for 30–45 seconds was implemented at each study site with 308/492 (63%) in the liberal group and 319/519 (61%) in the restrictive group receiving DCC. The mean difference in mean haematocrits ranged from 1.5 to 3.4% from the week of randomisation to week 11. Whether this difference is clinically meaningful is worth considering. The authors note that the separation in these haematocrit values, and consequently the potential oxygen-carrying capacity achieved, may be too small to cause a difference in study outcomes.1 The lowest mean haematocrit in the restrictive group was in week 9 at 31.7% (SD 4.6). A comprehensive list of further study limitations is well laid out by the authors. These included potential limited generalisability due to the infants being primarily from a white German population group, the changes in clinical practices that may have occurred since 2011–2014, and the proportion of infants who received a red blood cell transfusion not justified by the study protocol. Risk of bias (ROB) in the study, assessed using the Cochrane ROB tool,2 was deemed low risk overall. The potential for post randomisation confounding exists, with 14% of infants receiving a transfusion not justified by the protocol and 7% did not receive a transfusion when dictated by the protocol. Analysis of the per-protocol population was consistent with the primary analysis findings. Other postrandomisation confounding risks were deemed low as there was minimal loss to follow up with similar numbers between groups. The results of the recently published Transfusion of Prematures (TOP) trial are consistent with this trial. Combining the results will hopefully enable a much anticipated individual patient data meta-analysis.1 Anaemia of prematurity is a term used broadly across the highly variable and complex course of prematurity in relation to red blood cell transfusion practice. It is possible that a difference approach to transfusion in the first days of age requires a transfusion trigger based on optimisation of oxygen kinetics, rather than a threshold per se.4 At this point, however, lower red cell transfusion thresholds compared to more liberal thresholds seem an appropriate clinical approach, especially for those preterm infants 48–72 hours of age or older. https://ebneo.org/transfusion-thresholds-low-birthweight-infants The authors have no conflicts of interest to declare.

Instability of gross motor development during the first year in orphaned infants: a longitudinal observation study

ABSTRACT Infants in an orphanage who live in an underprivileged environment show delayed gross motor development; however longitudinal investigations of gross motor development in orphaned infants are limited. This study aimed to assess the variability of gross motor development of orphaned infants using a longitudinal observation. The gross motor development of 11 infants aged1.5 months was assessed monthly until 11.5 months of age using the Alberta Infant Motor Scale. Infants showed instability of gross motor development. The total mean range of gross motor percentile was 55.4 (SD, 18.6; 95% confidence interval = 42.9–68.0). Thirty-six per cent of infants had little fluctuation of gross motor percentile that was below the 50th percentile across 11 assessments. Infants in orphanages display less instability of gross motor percentile. Orphaned infants, especially those with biological risk factors, should have their gross motor development monitored longitudinally during the first year of life.

Systematic review and meta-analysis comparing outcomes following orchidopexy for cryptorchidism before or after 1 year of age.

BackgroundCurrent guidelines recommend orchidopexy for cryptorchidism by 12 months of age, yet this is not universally adhered to. The aim of this systematic review and meta‐analysis was to compare outcomes between orchidopexies performed before and after 1 year of age.MethodsMEDLINE and Embase were searched (September 2015) using terms relating to cryptorchidism, orchidopexy and the outcomes of interest. Studies were eligible for inclusion if they compared orchidopexy at less than 1 year of age (early) with orchidopexy at 1 year or more of age (delayed) and reported the primary outcome (testicular atrophy) or one of the secondary outcomes (fertility potential, postoperative complication, malignancy). Studies were excluded when more than 50 per cent of infants had intra‐abdominal testes, or the population included infants with disorders of sexual differentiation. Additional studies were identified through reference list searching. Unpublished data were sought from the ORCHESTRA study investigators.ResultsFifteen eligible studies were identified from 1387 titles. There was no difference in atrophy rate between early orchidopexy and delayed orchidopexy (risk ratio 0·64, 95 per cent c.i. 0·25 to 1·66; 912 testes). Testicular volume was greater (mean difference 0·06 (95 per cent c.i. 0·01 to 0·10) ml; 346 testes) and there were more spermatogonia per tubule (mean difference 0·47 (0·31 to 0·64); 382 testes) in infants undergoing early orchidopexy, with no difference in complication rate (risk ratio 0·68, 0·27 to 1·68; 426 testes). No study reported malignancy rate.ConclusionAtrophy and complication rates do not appear different between early and delayed orchidopexy, and fertility potential may be better with early orchidopexy. Imprecision of the available data limits the robustness of these conclusions.

Assessing Capacity to Change in High‐Risk Pregnant Women: A Pilot Study

Pre‐birth risk assessment is a process by which circumstances affecting an unborn child can be identified and support for mother and infant embedded. This mixed methods study describes a community‐based pre‐birth assessment and care pathway that utilised the Parents Under Pressure (PuP) programme to assess parenting capacity and provide support pre‐ and post‐birth for ‘at risk’ women. Sixty‐eight pregnant women referred to children's social care services were allocated to the pre‐birth assessment and care pathway (n = 35) or to routine care (n = 33). Standardised measures of psychological distress, social support and alcohol measured change for the women in the assessment and care pathway. Twenty women who provided pre‐ and post‐data reported significant improvements on all measures except alcohol use. Safeguarding outcomes at 12 months were obtained for both groups using administrative data. Forty‐two per cent of the infants whose mothers received the pre‐birth assessment and care pathway showed an improvement in child protection status compared to 14 per cent of the routine care infants. Safeguarding status deteriorated or stayed the same in 52 per cent of the routine cases compared to 26 per cent of those receiving the pathway. Qualitative data revealed that the pathway was acceptable and helpful to service users and service providers. Copyright © 2017 John Wiley & Sons, Ltd.‘Describes a community‐based pre‐birth assessment and care pathway that utilised the Parents Under Pressure (PuP) programme’Key Practitioner Messages The current project found that a community‐based pre‐birth assessment and care pathway with high‐risk pregnant women was feasible and acceptable for practitioners and service users. The pathway began mid‐pregnancy and support was provided following the birth of the infant for up to 12 months. Over 40 per cent of infants whose mothers were allocated to the pre‐birth risk assessment pathway showed improvements in child safeguarding status at 12 months.

Changes in exclusive breastfeeding practices and its determinants in India, 1992-2006: analysis of national survey data.

BackgroundExclusive breastfeeding up to six months is considered to be beneficial for the health and wellbeing of infants and mothers. To guide policy makers in the development of targeted breastfeeding promotion strategies, changes in the effect of predictor variables on exclusive breastfeeding practices in India were examined.MethodsData from two rounds of the National Family Health Survey (NFHS) carried out in India during 1992–93 (NFHS-1), and 2005–06 (NFHS-3) were analysed. A total of 34,176 and 25,459 births under three years of age in NFHS-1 and NFHS-3 respectively comprised the sample. Exclusive breastfeeding was defined as infants zero to five months of age who received only breast milk in previous 24 h. The practice of exclusive breastfeeding was examined at different ages (1, 4 and 6 months) against a set of predictor variables using bivariate and multinomial logistic regression in conjunction with the multiple classification analysis.ResultsOverall 46.3 per cent and 48.6 per cent of infants under six months of age were exclusively breastfed in NFHS-1 and NFHS-3 respectively. The proportion declined with each additional month of age, and at four months only 24 per cent infants in NFHS-1 and 31 per cent infants in NFHS-3 were exclusively breastfeeding. In the NFHS-1 a higher proportion of infants perceived to be small size at birth and those with mothers in gainful employment were exclusively breastfed. While in infants of mothers living in urban areas, older mothers (aged ≥ 35 years), more literate mothers, belonging to a higher standard of living index, preceding birth interval less than two years, and in those who had antenatal/natal care, a lower proportion of exclusive breastfeeding was observed at different ages of the infant. However, in the NFHS-3, children of older mothers and of those who were less educated the proportion of exclusive breastfeeding was significantly greater at one month of age. In the age segment one to four months; exclusive breastfeeding was significantly lower in infants born to older mothers, from medium standard of living households and perceived to be of small size at birth. Infants of mothers who were more educated, aged ≥ 35 years, living in urban areas and who had antenatal/natal care were the factors associated with a lower proportion of exclusive breastfeeding at six months of age.ConclusionsThe rate of exclusive breastfeeding in India continues to be sub-optimal with no appreciable gains in the last ten to fifteen years. Interventions that seek to increase exclusive breastfeeding should be timely with an increased focus on mothers with infants four to six months of age and in those who are most at risk of early discontinuation of exclusive breastfeeding.

Medical intervention in parent-reported infant gastro-oesophageal reflux: A population-based study.

To report the cumulative incidence, health-seeking behaviour and medical intervention of infants with gastro-oesophageal reflux (GOR) in the first year of life. The HealthNuts study is a longitudinal, population-based study. At 12 months of age, infants underwent skin prick testing to food allergens, including cows milk. Parents completed a questionnaire on GOR symptoms, food allergy and treatments. Factors associated with seeking health care for infants with GOR were modelled using logistic regression. Of 4674 infants, parents reported GOR in 1054 (23%; 95% confidence interval (CI) 21.4-23.8). Parents consulted a medical practitioner in 662 (64%) cases. Symptoms commenced in the first month in 411 (48%) and resolved within 6 months in 703 (75%) infants. Factors associated with doctor consultation for GOR were prematurity (adjusted odds ratio (aOR) 1.94; 95% CI 1.43-2.63) and family history of atopy (aOR 1.64; 95% CI 1.1-2.43). Eight per cent of infants (371/4674; 95% CI 7.2-8.7) received anti-reflux medication and 6% (296/4674; 95% CI 5.7-7.1) changed formula. Parents were more likely to seek treatment if they perceived their infant to be unsettled (aOR 2.55; 95% CI 1.26-5.17) and if the duration of GOR was prolonged (aOR 3.36 for symptoms >6 months; 95% CI 1.83-6.17). In the first year of life, approximately 14% of the population seek medical advice for GOR symptoms. The use of anti-reflux medication in the general community remains high, despite the absence of evidence that it is appropriate or effective for uncomplicated GOR.

How long should infants at risk of drug withdrawal be monitored after birth?

Neonatal abstinence syndrome (NAS) is an increasingly common disorder diagnosed in infants exposed to various drugs, causing immense financial and social burden. Recommendations from various bodies are for babies to be monitored for 4 to 7 days following birth so that prompt treatment can commence should symptoms develop. We aimed to determine the best post-natal observation period in babies at risk of NAS. A retrospective review was undertaken of infants ≥35 weeks' gestation who received treatment for NAS in the period 2001-2010. During this time, the standard post-natal observation period was a minimum of 7 days. Data including drug exposure, day of admission and day of treatment were collected. Two hundred and ten babies were included. Drug exposure was predominantly to opiates (99%); however, most infants (58%) were exposed to additional substances (benzodiazepines, cannabis or amphetamines). Ninety-five per cent of infants were admitted by day 5 of life. Of the babies treated by day 7, 98.5% had been admitted to the nursery by day 5. Infants with polydrug exposure were admitted significantly earlier; however, time to treatment was not significantly different to those exposed to opiate replacement therapy alone. In our hospital, babies treated for NAS often required admission before day 5. This has implications for hospital resource allocation, suggesting that routine post-natal observation for NAS could be shortened to 5 days. Further research is needed to help identify neonates who require more careful post-natal observation.

Infant feeding practices in the first 24–48 h of life in healthy term infants

To examine in-hospital infant feeding practices, focusing on initiation and prevalence of breastmilk expression and to describe the proportion of women having a breast pump immediately after birth. Postpartum women were recruited from three hospitals in Melbourne, Australia, between 2009 and 2011. having had a healthy singleton term infant, intending to breastfeed and fluency in English. Data were collected using a structured questionnaire. Just over 1000 women were recruited at 24-48 h postpartum; 50% were primiparous. Forty-seven per cent of infants had been fully breastfeeding at the breast from birth, and another 47% had received at least some expressed breastmilk. Forty per cent of first-time mothers reported having had a problem breastfeeding, and 46% already had a breast pump prior to the birth of their infant. Early breastfeeding problems were common, and less than half the infants had fed only at the breast in the first days of life. Given the normalization of breastmilk expression, more evidence is needed regarding the impact of expressing on duration of breastmilk feeding and maternal health outcomes.

An Evaluation on the Effectiveness of Structured Teaching Programme Regarding Prevention and Management of Napkin Dermatitis in Infants

The neonates are unique in several ways in comparison with older children and adults which render them highly susceptible to severe dermatological disorders. Skin diseases in infancy and childhood often-present patterns, which may diverge from the same diseases in adults. Infants can get a variety of skin diseases, and some are more common than others. Infants are particularly at risk for developing diaper dermatitis and its potential consequences. It is one of the most common skin problems in infants and children, affecting between 7 and 35 per cent of infants at some point. Diaper rash occurs most commonly in infants between ages nine and 12 months, but can occur at any time the child wears a diaper. The present study was conducted to assess the effectiveness of structured teaching programme on prevention and management of napkin dermatitis in infants’ on mothers residing at Rural Naini, Allahabad. The conceptual framework set up for the study is Conceptual framework based on modified general system theory (Bertalamffy & JW Kenny). The model which has four phases i.e. input, throughput, output and feedback, context, It provide comprehension, systematic and continuous ongoing frame work for program evaluation and hence helped the investigator to assess the effectiveness of structured teaching programme on prevention and management of napkin dermatitis in infants and assess the level of knowledge gained by the mothers regarding prevention and management of napkin dermatitis in infants. In this study various literature was reviewed which includes, the research design selected for the study was pre experimental research design of one group pre-test post-test design. The independent variable was structured teaching programme and dependent variables were level of knowledge of mothers in pre-test and post-test.

Enteral feeding practices in preterm infants in South Africa

Background. Optimal feeding regimens in babies weighing <1 000 g have not been established, and wide variations occur. In South Africa (SA) this situation is complicated by varied resource constraints. Objective. To determine the preterm enteral feeding practices of paediatricians in SA. Methods. We invited 288 paediatricians to participate in a cross-sectional web-based survey. Results. We received responses from 31.2% of the paediatricians; 43.6% were from the state sector and 56.4% from the private sector. Most participants worked in medium-sized neonatal units with 6 - 10 beds. The proportions commencing feeds within the first 24 hours were 24% in infants of <25 weeks’ gestational age, 36% in infants 25 - 27 weeks, and 65% in infants 28 - 31 weeks. Feed volumes were routinely advanced daily in 47% of infants <25 weeks, 68% of infants 25 - 27 weeks, and 90% of infants 28 - 31 weeks. Forty-five per cent of infants <25 weeks received continuous intragastric feeds, while 50% of those in the 28 - 31 weeks group were on 3-hourly bolus feeds. The majority of the participants targeted full enteral feeds of 161 - 180 ml/kg/d, 66.7% had access to donor milk, and 77% used breastmilk fortifier. Conclusion. This is the first study to survey feeding practices in SA. The survey did not highlight differences in feeding practices among paediatricians. These data could be valuable in the design of local collaborative trials to determine optimal feeding strategies.

Determinants of breastfeeding indicators among children less than 24 months of age in Tanzania: a secondary analysis of the 2010 Tanzania Demographic and Health Survey

ObjectiveTo examine the prevalence of key WHO breastfeeding indicators and identify determinants of suboptimal breastfeeding practices among children aged less than 24 months in Tanzania.Design, setting and participantsSecondary analyses of...

Commentary: HIV testing in low- and middle-income countries: An urgent need for scaling up

How can national AIDS program managers in low- and middle-income countries improve the coverage of HIV testing? In these countries heavily affected by HIV/AIDS, testing for HIV infection remains indeed critically infrequent with regard to its central role for individual care and control of the epidemic. Only 20 per cent of adults and 28 per cent of infants born from HIV-infected mothers are tested in a timely manner. The expansion of HIV testing is a prerequisite for reaching the World Health Organization's objective of universal access to HIV prevention, treatment, care, and support as well as the Millennium Development Goals related to HIV/AIDS and child mortality. The successful Rwandan experience of scaling up early infant HIV diagnosis brings hope for many countries.

Evaluating the effectiveness of IPTi on malaria using routine health information from sentinel health centres in southern Tanzania

BackgroundIntermittent preventive treatment of malaria in infants (IPTi) consists of the administration of a treatment dose of sulphadoxine-pyrimethamine (SP) at the time of routine vaccinations. The use of routine Health Management and Information Services (HMIS) data to investigate the effect of IPTi on malaria, anaemia, and all-cause attendance in children aged 2-11 months presenting to 11 health centres in southern Tanzania is described.MethodsClinical diagnosis of malaria was confirmed with a positive blood slide reading from a quality assurance laboratory. Anaemia was defined using two thresholds (mild [Hb < 11 g/dL], severe [Hb < 8 g/dL]). Incidence rates between IPTi and non-implementing health centres were calculated using Poisson regression, and all statistical testing was based on the t test due to the clustered nature of the data.ResultsSeventy two per cent of infants presenting in intervention areas received at least one dose of IPTi- 22% received all three. During March 2006 - April 2007, the incidence of all cause attendance was two attendances per person, per year (pppy), including 0.2 episodes pppy of malaria, 0.7 episodes of mild and 0.13 episodes of severe anaemia. Point estimates for the effect of IPTi on malaria varied between 18% and 52%, depending on the scope of the analysis, although adjustment for clustering rendered these not statistically significant.ConclusionsThe point estimate of the effect of IPTi on malaria is consistent with that from a large pooled analysis of randomized control trials. As such, it is plausible that the difference seen in health centre data is due to IPTi, even thought the effect did not reach statistical significance. Findings draw attention to the challenges of robust inference of effects of interventions based on routine health centre data. Analysis of routine health information can reassure that interventions are being made available and having desired effects, but unanticipated effects should trigger data collection from representative samples of the target population.

Use of neonatal post-exposure prophylaxis for prevention of mother-to-child HIV transmission in the UK and Ireland, 2001-2008

To investigate changing clinical practice with regard to antiretroviral post-exposure prophylaxis (PEP) and factors associated with the use of combination prophylaxis in infants born to HIV-infected women in the UK and Ireland. Surveillance of obstetric and paediatric HIV infection in the UK and Ireland is conducted through the National Study of HIV in Pregnancy and Childhood. Infants born to HIV-infected women between 2001 and 2008 were included in the study. Ninety-nine per cent of infants (8155 of 8205) received antiretroviral prophylaxis; 86% of those with information on type of prophylaxis (n=8050) received single, 3% dual and 11% triple drug prophylaxis. Among those who received prophylaxis, use of triple prophylaxis increased significantly between 2001-2004 and 2005-2008, from 9% (297 of 3243) to 13% (624 of 4807) overall (P<0.001); from 43% (41 of 95) to 71% (45 of 63) in infants born to untreated women; and from 13% (114 of 883) to 32% (344 of 1088) where mothers were viraemic despite highly active antiretroviral therapy (HAART) in pregnancy. In multivariable analysis, factors associated with receipt of triple prophylaxis included later time period, shorter duration or lack of antenatal antiretroviral therapy, receipt of antiretroviral drugs during labour, detectable maternal viral load, CD4 count<200 cells/μL in pregnancy, preterm delivery (<37 weeks) and unplanned (emergency caesarean or vaginal) delivery. Between 2001 and 2008, almost all infants born to HIV-infected women in the UK and Ireland received antiretroviral PEP, mostly with one drug. Use of triple PEP increased over time, particularly for infants whose mothers were untreated or viraemic despite HAART, in line with current guidelines.

Household smoking behaviours and exposure to environmental tobacco smoke among infants: are current strategies effectively protecting our young?

To determine the prevalence of infant exposure to environmental tobacco smoke (ETS) among infants attending child health clinics in regional NSW; the association between such exposure and household smoking behaviours; and the factors associated with smoking restrictions in households with infants. Parents completed a computer-based questionnaire and infant urine samples were collected. Information was obtained regarding the smoking behaviours of household members and samples were analysed for cotinine. Twenty seven per cent of infants had detectable levels of cotinine. Infant ETS exposure was significantly associated with the smoking status of household members, absence of complete smoking bans in smoking households and having more than one smoker in the home. Smoking households were significantly less likely to have a complete smoking ban in place. This study suggests that a significant proportion of the population group most vulnerable to ETS were exposed. Future efforts to reduce children's exposure to ETS need to target cessation by smoking parents, and smoking bans in households of infants where parents are smokers if desired reductions in childhood ETS-related illness are to be realised.

Sites of initial bleeding episodes, mode of delivery and age of diagnosis in babies with haemophilia diagnosed before the age of 2 years: a report from The Centers for Disease Control and Prevention’s (CDC) Universal Data Collection (UDC) project

Lack of detailed natural history and outcomes data for neonates and toddlers with haemophilia hampers the provision of optimal management of the disorder. We report an analysis of prospective data collected from 580 neonates and toddlers aged 0-2 years with haemophilia enrolled in the Universal Data Collection (UDC) surveillance project of the Centers for Disease Control and Prevention (CDC). This study focuses on a cohort of babies with haemophilia whose diagnosis was established before the age of two. The mode of delivery, type and severity of haemophilia, onset and timing of haemorrhages, site(s) of bleeding, provision of prophylaxis with coagulation factor replacement therapy, and the role played by the federally funded Haemophilia Treatment Centers (HTC) in the management of these infants with haemophilia were evaluated. Seventy-five per cent of haemophilic infants were diagnosed early, in the first month of life, especially those with a family history or whose mothers were known carriers; infants of maternal carriers were more likely to be delivered by C-section. Involvement of an HTC prior to delivery resulted in avoidance of the use of assisted deliveries with vacuum and forceps. Bleeding from the circumcision site was the most common haemorrhagic complication, followed by intra- and extra-cranial haemorrhages and bleeding from heel stick blood sampling. Eight per cent of the infants were administered factor concentrate within 24 h of birth; more than half were treated to prevent bleeding. This study highlights the significant rate and the sites of initial bleeding unique to very young children with haemophilia and underscores the need for research to identify optimal evidence-based recommendations for their management.

Extended-spectrum β lactamase-producing gram-negative bacteria: clinical profile and outcome in a neonatal intensive care unit

Multidrug-resistant extended-spectrum 3 lactamase-producing bacteria (ESBL) have emerged as a common problem globally. However, data regarding clinical profile and outcome in neonates infected with ESBL-producing gram-negative bacteria are sparse. A retrospective study was undertaken of all neonates admitted between April 2002 and May 2003 to the neonatal intensive care unit, Safdarjang Hospital, New Delhi who had blood cultures positive for gram-negative bacteria. The clinical profile and outcome in each patient was obtained from the case notes. The mortality and morbidity of the ESBL (cases) and non-ESBL groups were compared. Data were analysed using the chi(2) and Student's t-tests. There were 75 cases of gram-negative septicaemia, 46 newborns (61.3%) were infected with ESBL-producing strains and 63 case records were available. ESBL production was associated with prematurity (24/38 vs 9/25, p=0.03), prolonged rupture of membranes (14/38 vs 2/25, p=0.01) and previous antibiotic administration to the infant (15/38 vs 1/25, p=0.002). Fifty per cent of infants with early-onset sepsis and 82.1% with late-onset sepsis were infected with ESBL strains. Newborns with ESBL sepsis were more likely to manifest persistent thermal instability (13/38 vs 3/25, p=0.04) and pre-feed gastric aspirates (18/38 vs 3/25, p=0.004). More than 90% of ESBL isolates were susceptible to carbapenems, cefperazone-sulbactam and piperacillin-tazobactam. The mean length of nursery stay (15.8 vs 10.7, p=0.02) and mortality (23.6 vs 4.0%, p= 0.07) were higher in the ESBL group and onset of feeds was delayed (7.6 vs 3.9 days, p=0.007) in this group. Isolation of ESBL in cases of early-onset sepsis indicates that ESBL producers might have percolated into the community. Early suspicion of ESBL-producing isolates in cases of neonatal sepsis can facilitate prompt institution of appropriate empirical therapy and lead to an improved outcome.

Venous thromboembolic disease: A single‐centre case series study

The epidemiology of venous thromboembolism in children has likely changed since first being described a decade ago because of evolving management strategies and a greater awareness of predisposing factors for thrombosis in children. The Royal Children's Hospital commenced a 4-year prospective registry of venous thrombosis in 1999 to determine the current Australian epidemiology of venous thrombosis in infants and children. A prospective, single-centre registry was established to determine the prevalence, aetiology, diagnostic criteria, management and outcome of venous thromboembolism in an Australian tertiary paediatric centre. The incidence of venous thrombosis was 8.0/10 000 hospital admissions. Fifty-eight per cent of infants and 49% of children were male. Seventy-seven per cent of venous thromboses in infants were associated with central venous cannulation compared with 47% in children. Doppler ultrasonography was the most frequently used diagnostic tool. Treatment strategies varied between age groups. The all-cause mortality rate for infants and children in this study was 8.4% (direct thrombus-related mortality 0%). Fifteen per cent of all patients demonstrated complete resolution of their venous thrombosis at discharge, with 48% demonstrating complete resolution at follow-up assessment. Fifteen per cent of patients experienced significant thrombosis-related morbidity at follow-up assessment. In this single-centre registry, venous thrombosis in infants and children occurred with greater frequency than has previously been reported and its epidemiology varied. Central venous catheterisation continues to be a common precipitant to venous thrombosis. Optimal diagnostic and treatment interventions for venous thromboembolism have not yet been determined for infants and children, despite the significant incidence of long-term sequelae.

Atopic dermatitis is strongly associated with IgE-mediated food allergy in infants attending a dermatology department

RATIONALE: Ten per cent of infants have atopic dermatitis (AD) of moderate severity. IgE-mediated food allergy (FA) is reportedly higher in patients referred to allergy clinics compared to dermatology cohorts.