Cell Transplantation Center Research Articles

Activity And Capacity Profile Of Hematopoietic Cell Transplant Physicians And Centers In Australia And New Zealand

Activity And Capacity Profile Of Hematopoietic Cell Transplant Physicians And Centers In Australia And New Zealand

The effectiveness of hepa filtered rooms plus fluconazol prophylaxis for preventation of invasive fungal diseases in allogenic stem cell transplant patients

In our hematopoieteic stem cell transplantation (HSCT) center, preventation of invasive fungal diseases (IFDs) for the patients who did not experience IFDs previously is based on performing allogeneic SCT in rooms with “High efficiency particulate air” (HEPA) filters and administration of fluconazole prophylaxis.

Pattern and associated factors of potential drug-drug interactions in both pre- and early post-hematopoietic stem cell transplantation stages at a referral center in the Middle East.

The aim of this study was to determine the pattern as well as associated factors of moderate and major potential drug-drug interactions (PDDIs) in both the pre- and early post-transplantation stages at a referral hematopoietic stem cell transplantation (HSCT) center. All adolescents and adults undergone HSCT within a 3-year period were screened retrospectively for potential moderate or severe PDDIs by the Lexi-Interact On-Desktop software. Among 384 patients, a total of 13,600 PDDIs were detected. The median (interquartile range) cumulative PDDIs burden was 41 (28). All (100 %) individuals experienced at least one PDDI. More than four fifths (81.8 %) of detected PDDIs were moderate. The predominant mechanism of PDDIs was pharmacokinetics (54.3 %). Interaction between sulfamethoxazole-trimethoprim and fluconazole was the most common PDDIs involving 95.3 % of the study population. More than three fifths (61.5 %) of detected PDDIs were caused by HSCT-related medications. No interaction was identified between two anticancer agents. Interactions of cyclophosphamide with phenytoin, busulfan with metronidazole, dexamethasone, or clarithromycin were the only detected PDDI between anticancer and non-anticancer medications. Type of HSCT and the numbers of administered medications were significantly associated with major PDDIs. The epidemiology, real clinical consequence, and economic burden of DDIs on patients undergone HSCT particularly around the transplantation period should be assessed further by prospective, multicenter studies.

Interview: Encouraging collaboration in cure-focused research

Camillo Ricordi is the Stacy Joy Goodman Professor of Surgery, a Professor of Medicine, a Professor of Biomedical Engineering and a Professor of Microbiology and Immunology at the University of Miami, FL, USA. At this institution, he also serves as the Director of the Diabetes Research Institute and the Cell Transplant Center. Dr Ricordi is also the Responsible Head of the NIH-funded Human Cell Processing Facility and has been chairing the Dean’s Research Cabinet at the University of Miami, Miller School of Medicine (FL, USA), since 2006. Camillo Ricordi is an acclaimed scientist in diabetes cure-focused research. He is well known for developing the procedure for isolating and extracting human islet cells from the pancreas and he performed the first series of successful clinical human donor islet transplantations. Dr Ricordi is also currently researching methods for transplanting cells and organs without the continuous requirement for antirejection drugs. Over the years, Dr Ricordi has received numerous h...

Differences in characteristics of United States hematopoietic stem cell transplant (HSCT) centers by proportion of ethnic minorities

6028 Background: The International Bone Marrow Transplant Registry has reported higher mortality in Hispanics with leukemia and received HLA-identical sibling transplantation when compared to whites. It is unknown if transplant center characteristics can partially explain this disparity. We hypothesize that transplant centers do not systematically differ according to the proportion of minorities transplanted. We compared the characteristics of transplant centers that perform a higher proportion of minorities to centers performing transplants to a predominantly white population. Methods: We obtained center characteristics on 116 U.S. transplant centers performing HLA-identical sibling transplantation and compared the following: physician and other health care provider; transplant unit procedure and resources; and, medical center organization according to the volume percentage of minorities transplanted (high ≥ 20% vs. low< 20 %) and percentage of Hispanics transplanted (high ≥10% vs. low <10 %). Results: C...

#445 Changing patterns of supportive care among pediatric stem cell transplantation (SCT) centers in North America

#445 Changing patterns of supportive care among pediatric stem cell transplantation (SCT) centers in North America