Cefdinir In Treatment Research Articles

Preparation and Evaluation of Floating Microspheres of Cefdinir in Treatment of Otitis Media and Respiratory Tract Infections

The main objective of the present investigation was to develop gastro retentive (floating) microsphere for Cefdinir. Cefdinir, Third-generation bactericidal cephalosporin antibiotic drugs has been chosen as a model drug in the formulation of floating drug delivery systems. It is a drug of choice in treatment of otitis media, soft tissue infections, and respiratory tract infections, including sinusitis, strep throat, community-acquired pneumonia and acute exacerbations of bronchitis. Three biocompatible polymers like HPMC, Ethyl cellulose and Eudragit were chosen in varying proportions with the drug. F5 formulation with drug: polymer (1:2) show excellent micromeritic properties, percent yield (87.22%), drug entrapment efficiency (92%), percent buoyancy (89%), and highest invitro drug release 98.9% within 12 h. In the stability studies no significant change in drug entrapment release characteristics of the microspheres.

小児急性中耳炎に対するセフゾンの効果

Cefzon® (cefdinir, CFDN, Fujisawa Pharmaceutical Co., Ltd.) is an oral cephem antibiotic which was marketed in 1991. It has been confirmed that the clinical efficacy of cefdinir in the treatment of respiratory tract infections was 85.0% or more and the safety of cefdinir was high in the field of pediatrics. In this study the clinical efficacy of cefdinir in cases of acute otitis media was investigated in 47 pediatric patients aged 3 months to 11 years and 9 months. The clinical efficacy rate was 83.0% and the bacteriological eradication rate was 79.2% in all of these patients. The main pathogens isolated from these patients were Haemophilus influenzae (41.1%), Streptococcus pneumoniae (30.4%) and coagulase negative staphylococci (CNS) (12.5%). The eradication rates of thesepathogens were 82.6% (19/23 patients) for H. influenzae and 78.6% (11/14 patients) for S. pneumoniae. The efficacy rate of cefdinir in monomicrobial infections was 89.7% (26/29 patients) but the efficacy rate in polymicrobial infections was 64.3% (9/14 patients).As adverse reactions, diarrhea was observed in 3 patients (6%) but disappeared in 1 patient 3 days after discontinuation of the drug and administration was continued in the remaining 2 patients.The superior efficacy of cefdinir in treatment of acute otitis media was attributed to the high concentrations of cefdinir which exceeded MICs against H. influenzae or S. pneumoniae in tympanic mucosa.

Place for cefdinir in treatment of acute bronchitis

Place for cefdinir in treatment of acute bronchitis