Cause Of Acute Leukemia Research Articles

Study of prevalence of acute leukemia

Introduction: Cancer of the body's blood-forming tissues, such as the lymphatic system and bone marrow, is known as leukaemia.There are various forms of leukaemia.Some leukemia types are more prevalent in children. Most cases of other types of leukemia are in adults. Usually, leukemia affects white blood cells. Although there is no known cause of acute leukemia, certain persons are at higher risk due to factors including radiation exposure. Exposure to particular chemical substances, such benzene. Viruses such as the virus that causes human T-cell leukemia. Method: This research was done via observation.82 leukemia cases that were discovered in the pathology division of the Netaji Subash Chandra Medical College in Jabalpur make up the sample size for the current prospective study. In the present study the cases were in the range of 1-70 years Clinically questionable cases were sent to the Department of Pathology, where a complete blood counts was performed using an automated hematology analyzer and a peripheral leishman stain smear investigation. Patients who have received treatment for a prior diagnosis are excluded in this study.

The relationship between blood groups and acute myeloid leukemia

Aim: Acute myeloid leukemia is an aggressive disease caused by a heterogeneous clonal disorder of hematopoietic progenitor cells that normally lose their ability to respond to differentiation and proliferation regulators. The main purpose is to identify and prevent the causes of acute leukemia. Although the etiology of acute leukemia has been investigated for many years, the exact cause is still unknown. Both ABO and Rh blood group systems have been associated with a number of diseases. The aim of this study was to investigate the relationship between AML and blood group types. Material and Method: Between February 2014 and February 2018 The blood types of 163 AML patients treated in Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital were analyzed retrospectively. Age, sex, and blood group data of healthy platelet donors were used as a control group. Results: The most common blood type in both men and women was A Rh-positive, no statistically significant difference was found between the control group and AML patients in terms of ABO blood group distribution. Rh positivity rate was similar between the patient group and healthy control group. Discussion: We found that there is no relation between AML and ABO and Rh blood groups. Although there are larger studies confirming the relationship between solid tumors and ABO blood groups, studies on hematologic malignancies are fewer. Cunclusion: A relationship between AML and ABO and Rh blood groups has not yet been clarified, more studies with more patients are needed.

Residential Proximity to Gasoline Stations and Risk of Childhood Leukemia.

Significant elevations in the risk of childhood leukemia have been associated with environmental exposure to gasoline; aromatic hydrocarbons from refinery pollution, petroleum waste sites, and mobile sources (automobile exhaust); paints, paint products, and thinners; and secondary cigarette smoke in the home. These higher risks have also been associated with parental exposure to benzene, gasoline, motor vehicle-related jobs, painting, and rubber solvents. These exposures and jobs have 1 common chemical exposure-benzene, a recognized cause of acute leukemia in adults-and raise the question of whether children represent a subpopulation in which a higher risk of leukemia is associated with very low level exposure to environmental benzene.

Relationship between exposure to pesticides and occurrence of acute leukemia in Iran.

One of the causes of acute leukemia can be exposure to certain chemicals such as pesticides. This study determined the relationship between exposure to pesticides and the occurrence of acute leukemia in Fars province, south of Iran. Between April 2011 and April 2013 in a case-control study conducted in Nemazee Hospital in Shiraz, Southern Iran; 314 subjects diagnosed with acute leukemia (94 pediatric cases and 220 adults) were enrolled to determine any correlation between exposure to pesticides and the occurrence. Controls (n=314) were matched by sex and age. There was a history of exposure to pesticides among 85% of pediatric cases and 69% of their controls and 83% of adult cases and 75% of their controls while 87.5% of pediatric cases and 90% of adult cases reported exposure to intermediate and high doses of pesticides and among the controls, the exposure to low doses of pesticides was 70.5% and 65%, respectively. Exposure to indoor pesticides was seen among most of cases and controls. Being a farmer was at a significantly more increased risk of developing acute leukemia in comparison to other jobs, especially for their children. Exposure to pesticides was shown to be one of the most important causes of acute leukemia. It seems that there is a need to educate the people on public health importance of exposure to pesticides especially during school time to reduce the risk of malignancies during childhood.

Epidemiology of leukemia and lymphoma.

The causes of acute leukemia and lymphomas are still largely unknown. These malignancies account for approximately 6% of cases of cancer in the US population, and active research efforts are now underway to define etiologically important genetic or environmental factors for these conditions. Recent epidemiologic studies have focused on international variations, secular trends, genetic syndromes, familial aggregation, chromosomal abnormalities, environmental exposures, and unique subgroups defined either demographically or biologically.

The causes of acute leukemia.

Although impressive biologic advances have increased understanding of leukemogenesis, we know little about the causes of the acute leukemias. Epidemiologic studies have focused primarily on children. Higher birth weight is associated with an increased risk of childhood acute leukemia. Several theories have been advanced that may account for these observations, and additional biologic studies are needed. Some epidemiologic studies suggest that the acute leukemias in children may have an infectious component. Again, further work, especially in the area of specific causative agents, is necessary. Another area for future epidemiologic study includes investigation of exposure to natural and synthetic DNA topoisomerase II inhibitors. Preliminary evidence suggests that exposure to these agents, which are found in certain foods and medications, may be related to the subsequent development of acute leukemia in infants.