Cause Of Rheumatic Diseases Research Articles

Peningkatan Pengetahuan tentang Jenis Penyakit di Usia Lansia pada Kelompok Lansia

The success of national development, especially national development in the health sector, can be seen from the increasing life expectancy of the Indonesian people. Eleven percent of the world's 6.9 billion population are elderly. Indonesia experienced an increase in the number of elderly people from 18 million (7.56%) in 2010, to 25.9 million (9.7%) in 2019, and is expected to continue to increase where in 2035 to 48.2 million people (15.77%). The elderly are identical with various decreases in health status, especially physical health status. In general, it is quite difficult to recognize health problems early on, especially diseases that usually arise in old age. Health problems can be prevented with a healthy lifestyle, so it is necessary to increase knowledge about diseases that commonly occur in old age. The method used in this community service activity is through a lecture to the Elderly Aisyiyah group in Pekalongan City. The results of this activity increased knowledge of the elderly by 36.3% for the causes of rheumatic disease, 27.3% for rheumatic symptoms and 30.3% in the diet of rheumatic diseases; 27.3% for the causes and diet of gout, and 36.3% for the symptoms of gout; 33.3% for causes of hypertension, 36.3% for symptoms and 27.3% for hypertension disease diet; as much as 27% about the cause of Diabetes Mellitus (DM), 27.3% symptoms and 30.3% for diets with diabetes mellitus.

Role of inflammasomes in inflammatory autoimmune rheumatic diseases.

Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of pyroptosis and the secretion of pro-inflammatory cytokines including interleukin (IL)-1β and IL-18. Although the inflammatory response is an innate host defense mechanism, chronic inflammation is the main cause of rheumatic diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ankylosing spondylitis (AS), and Sjögren's syndrome (SS). Since rheumatic diseases are inflammatory/autoimmune disorders, it is reasonable to hypothesize that inflammasomes activated during the inflammatory response play a pivotal role in development and progression of these diseases. Indeed, previous studies have provided important observations that inflammasomes are actively involved in the pathogenesis of inflammatory/autoimmune rheumatic diseases. In this review, we summarize the current knowledge on several types of inflammasomes during macrophage-mediated inflammatory responses and discuss recent research regarding the role of inflammasomes in the pathogenesis of inflammatory/autoimmune rheumatic diseases. This avenue of research could provide new insights for the development of promising therapeutics to treat inflammatory/autoimmune rheumatic diseases.

The role of gut microbiota in the pathogenesis of rheumatic diseases.

Rheumatic diseases refer to many diseases with a loss of immune self-tolerance, leading to a chronic inflammation, degeneration, or metabolic derangement in multiple organs or tissues. The cause of rheumatic diseases remains to be elucidated, though both environmental and genetic factors are required for the development of rheumatic diseases. Over the past decades, emerging studies suggested that alteration of intestinal microbiota, known as gut dysbiosis, contributed to the occurrence or development of a range of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, systemic sclerosis, and Sjogren's syndrome, through profoundly affecting the balance between pro- and anti-inflammatory immune responses. In this article, we discussed the role of gut microbiota in the pathogenesis of rheumatic diseases based on a large number of experimental and clinical materials, thereby providing a new insight for microbiota-targeted therapies to prevent or cure rheumatic diseases.

Mycoplasma and other Intracellular Bacterial Infections in Rheumatic Diseases: Comorbid Condition or Cause?

Although the causes of rheumatic diseases have remained relatively unknown, systemic intracellular bacterial infections are commonly found in rheumatic disease patients [1-4]. Because of this, certain nfections have been confused with comorbid conditions.

Theories and cures of the rheumatic diseases during the byzantine period (330-1453 a.D.)

Most Byzantine medical texts described the rheumatic diseases. The Byzantine physicians, based on the ancient Greek texts, explained the causes of rheumatic diseases, described their symptoms and proposed certain treatments. The Byzantine medical sources described various types of rheumatic diseases, as inflammatory arthritis, chronic deformans polyarthritis, and gout. As it can be concluded by the available medical sources, during the Byzantine period rheumatic diseases constituted a serious medical and social problem, representing a remarkable cause of disability, and this complaint was part of the epidemiological interest of the Byzantine physicians.

Update on rheumatic manifestations of infectious diseases

As infectious diseases continue to emerge, and as molecular techniques advance, the rheumatic manifestations of infectious diseases are increasingly recognized and better understood. Herein, we review important recent clinical, epidemiologic, and basic science advances within this area of rheumatology. We searched the U.S. National Library of Medicine PubMed database for relevant articles published since 1 January 2008. We identified a number of studies suggesting a potentially greater role for persistent viral and bacterial infections in the development of rheumatoid arthritis or rheumatoid arthritis-like syndromes. These include emerging pathogens like Chikungunya virus, as well as historically important pathogens like measles. New literature furthers the idea that antecedent infections with Chlamydia sp. could be causative in some cases of undifferentiated spondyloarthritis. Other studies document diagnostic methods capable of distinguishing between Hepatitis C virus and auto-immune driven arthritis allowing clinicians to better target therapy. Infectious pathogens are increasingly recognized in association with rheumatic disease. Rheumatologists should be aware of this trend as such recognition may alter the diagnosis and management of rheumatic symptoms, as well as trigger new research opportunities to better understand the causes of rheumatic disease.

Apoptotic cell blebs: Repositories of autoantigens and contributors to immune context

Autoimmune rheumatic diseases belong to a diverse group of processes in which multiple tissues are actively injured through the activity of various immune effector pathways. One of the striking observations in these diseases that gives insights into disease mechanism is that, once initiated, the processes amplify over time and are self-sustaining. The amplitude of the disease process typically varies over time, with episodes of more significant disease activity punctuated by periods of inactivity. Such periodic amplification of an immune process (which has characteristic features of an antigen-driven response) suggests that the relevant antigens which drive the disease are periodically exposed. Identifying both the source and pathways underlying such antigen exposure will provide important insights into the mechanisms and causes of rheumatic diseases.

The first descriptions of therapeutic arthrocentesis: a historical note.

The existence of synovial fluid has been known since Hippocratic times. The abnormal accumulation of liquid inside the joints has been recognized as the proximal cause of rheumatic diseases since humoral theory was the dominant paradigm in Occidental medical culture. Although evacuating the excess of the abnormal humour was the target of all therapeutic measures taken during this era, no mention of arthrocentesis is found in Occidental medical texts until 1652. We present two earlier indications of arthrocentesis to treat abnormal accumulation of liquid inside the joints. One in the Codex Badianus, an Aztec manuscript written in the 16th century, and the other in the Tractado breve de medicina, published in Mexico in 1592.

Rheumatic manifestations of neoplasia

Neoplasia in an important cause of rheumatic disease. The mechanisms are either direct infiltration of the bone and joint, or indirect infiltration with manifestations distant from the site of neoplastic involvement. Many of the reports reviewed in this article center on direct associations. In particular, there is a report on polymyositis and dermatomyositis and the link with neoplasia. Cases of reflex sympathetic dystrophy are also described in association with neoplasia. There is further discussion on the link of hairy cell leukemia and vasculitis. Other case reports highlight the multiple associations of musculoskeletal disease and neoplasia. These reports include patients with subcutaneous sarcoidosis, ankylosing spondylitis, polychondritis, and systemic sclerosis. Articular manifestations of benign pleural fibromas are described. The existence of these reports, however, does not constitute proof of a causal relationship and the possibility of chance occurrences of two conditions must be considered. Finally, various therapies for cancer are associated with rheumatologic manifestations. Intravesical bacillus Calmette-Guérin has been found to cause an inflammatory polyarthritis. This form of arthritis is similar to experimentally induced adjuvant arthritis in rats that follows immunization with Freund's adjuvant containing Mycobacterium tuberculosis.

Rheumatic manifestations of neoplasia

The important association of neoplasia and rheumatic disease was reviewed. The literature in the last year included case reports of neoplasia, particularly hematologic, causing arthritis by direct joint involvement. Immunocytologic techniques may help in the diagnosis. The evidence linking dermatomyositis and polymyositis to malignancy was reviewed, although analysis of the literature was hampered by poor documentation and lack of control subjects. HOA may occur secondary to mediastinal or pulmonary metastases from nonbronchogenic malignancies. The important association of hematologic malignancy with vasculitis was highlighted.

A VIRUS AS THE CAUSE OF RHEUMATIC DISEASE

Medical Journal of AustraliaVolume 2, Issue 20 p. 885-885 Current Comment A VIRUS AS THE CAUSE OF RHEUMATIC DISEASE First published: 01 November 1937 https://doi.org/10.5694/j.1326-5377.1937.tb45135.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume2, Issue20November 1937Pages 885-885 RelatedInformation